Search Results - "Da Costa César, Isabela"
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Development and validation of a RP-HPLC method for quantification of isoflavone aglycones in hydrolyzed soy dry extracts
Published in Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (19-05-2006)“…Isoflavones are widely used as an alternative treatment to hormone replacement therapy and also for prevention of several chronic diseases, including cancers…”
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2
Toxicity and in vivo release profile of sirolimus from implants into the vitreous of rabbits’ eyes
Published in Documenta ophthalmologica (01-02-2019)“…Purpose To assess the in vivo release profile and the retinal toxicity of a poly (lactic-co-glycolic acid) (PLGA) sustained-release sirolimus (SRL)…”
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3
Evaluation of the Effects of Maytenus ilicifolia on the Activities of Cytochrome P450 3A and P-glycoprotein
Published in Current drug metabolism (01-01-2020)“…Maytenus ilicifolia is a Brazilian popular medicine commonly used to treat ulcer and gastritis. Despite the absence of toxicity regarding its consumption,…”
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4
Determination of Ketoconazole in Capsules by High-Performance Liquid Chromatography and Microbiological Assay
Published in Journal of AOAC International (01-07-2009)“…The development and validation of an HPLC-UV method and a microbiological assay were performed for the analysis of ketoconazole in capsule formulations. The…”
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Enhancing oral bioavailability of an antifungal thiazolylhydrazone derivative: Development and characterization of a self-emulsifying drug delivery system
Published in International journal of pharmaceutics (25-04-2024)“…[Display omitted] RN104 (2-[2-(cyclohexylmethylene)hydrazinyl)]-4-phenylthiazole) is a thiazolylhydrazone derivative with prominent antifungal activity. This…”
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Robustness evaluation of the chromatographic method for the quantitation of lumefantrine using Youden's test
Published in Brazilian Journal of Pharmaceutical Sciences (01-06-2009)“…Youden's test is a reliable method to evaluate the robustness of analytical methods, by means of an experiment design which involves seven analytical…”
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Quantitation of artemether in pharmaceutical raw material and injections by high performance liquid chromatography
Published in Brazilian Journal of Pharmaceutical Sciences (01-12-2009)“…The quantitation of artemether in both pharmaceutical raw material and injections was carried out by high performance liquid chromatography (HPLC) with…”
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8
Discovery of Lead 2‑Thiazolylhydrazones with Broad-Spectrum and Potent Antifungal Activity
Published in Journal of medicinal chemistry (28-12-2023)“…Opportunistic fungal infections represent a global health problem, mainly for immunocompromised individuals. New therapeutical options are needed since several…”
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9
Influence of PEG coating on the biodistribution and tumor accumulation of pH-sensitive liposomes
Published in Drug delivery and translational research (01-02-2019)“…Liposomes are lipid vesicles widely used as nanocarriers in targeted drug delivery systems for therapeutic and/or diagnostic purposes. A strategy to prolong…”
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Rapid Simultaneous Separation of Four Oral Antidiabetic Drugs and Quantitative Determination of Glibenclamide Using Conventional and Fused-Core Silica Columns
Published in Journal of AOAC International (01-09-2017)“…Diabetes mellitus is a chronic disease with high and growing prevalence worldwide. Therefore, the development of fast and efficient methods for the QC of…”
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Validation of a HPLC method for quantification of midazolam in rat plasma: Application during a Maytenus ilicifolia–drug interaction study
Published in Biomedical chromatography (01-03-2021)“…Midazolam (MDZ) is routinely employed as a marker compound of cytochrome P450 3A (CYP3A) activity. Despite the many HPLC–UV methods described to quantify MDZ…”
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12
Electrochemical evidence of nitrate release from the nitrooxy compound 4-((nitrooxy) methyl)-3-nitrobenzoic acid and its antinociceptive and anti-inflammatory activities in mice
Published in Biomedicine & pharmacotherapy (01-01-2021)“…[Display omitted] •Nitrooxy compound 1 (NC1) potentially releases nitric oxide.•Plasma nitrite concentration was increased after administration of NC1.•NC1…”
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Simultaneous determination of artemether and lumefantrine in fixed dose combination tablets by HPLC with UV detection
Published in Journal of pharmaceutical and biomedical analysis (04-11-2008)“…This paper describes the development and validation of a HPLC-UV method (210 nm) for the simultaneous quantitation of artemether and lumefantrine in fixed dose…”
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14
Comparison of HPLC, UV spectrophotometry and potentiometric titration methods for the determination of lumefantrine in pharmaceutical products
Published in Journal of pharmaceutical and biomedical analysis (10-09-2008)“…This paper describes the development and evaluation of a HPLC, UV spectrophotometry and potentiometric titration methods to quantify lumefantrine in raw…”
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15
Development and validation of an HPLC method for the simultaneous determination of artesunate and mefloquine hydrochloride in fixed-dose combination tablets
Published in Brazilian Journal of Pharmaceutical Sciences (01-12-2013)“…The present study developed and validated an HPLC method for the simultaneous determination of artesunate (AS) and mefloquine hydrochloride (MQ) in fixed-dose…”
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Quantitation of genistein and genistin in soy dry extracts by UV-Visible spectrophotometric method
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Simultaneous quantitation of levodopa and 3- O-methyldopa in human plasma by HPLC–ESI-MS/MS: Application for a pharmacokinetic study with a levodopa/benserazide formulation
Published in Journal of pharmaceutical and biomedical analysis (15-12-2011)“…A sensitive and simple method was developed for the quantitation of levodopa and its metabolite 3- O-methyldopa, in human plasma, after oral administration of…”
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Molecularly imprinted polymer for determination of lumefantrine in human plasma through chemometric-assisted solid-phase extraction and liquid chromatography
Published in Talanta (Oxford) (01-07-2018)“…Lumefantrine is the first-choice treatment of Falciparum uncomplicated malaria. Recent findings of resistance to lumefantrine has brought attention for the…”
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Development and Validation of an HPLC Method for Mefloquine Hydrochloride Determination in Tablet Dosage Form
Published in Journal of AOAC International (01-07-2011)“…A simple HPLC method for determination of mefloquine hydrochloride in tablets was developed and validated. The separation was carried out on an Xterra RP18…”
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20
Randomized, phase 1/2, double-blind pioglitazone repositioning trial combined with antifungals for the treatment of cryptococcal meningitis – PIO study
Published in Contemporary clinical trials communications (01-06-2021)“…Cryptococcosis affects more than 220,000 patients/year, with high mortality even when the standard treatment [amphotericin B (AMB), 5-flucytosin (5-FC) and…”
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