Search Results - "Da Costa Pereira, Daniel"

Generation and characterization of iPSC-derived renal proximal tubule-like cells with extended stability by Chandrasekaran, Vidya, Carta, Giada, da Costa Pereira, Daniel, Gupta, Rajinder, Murphy, Cormac, Feifel, Elisabeth, Kern, Georg, Lechner, Judith, Cavallo, Anna Lina, Gupta, Shailesh, Caiment, Florian, Kleinjans, Jos C. S., Gstraunthaler, Gerhard, Jennings, Paul, Wilmes, Anja

“…The renal proximal tubule is responsible for re-absorption of the majority of the glomerular filtrate and its proper function is necessary for whole-body…”
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A Photoswitchable Agonist for the Histamine H 3 Receptor, a Prototypic Family A G-Protein-Coupled Receptor by Hauwert, Niels J, Mocking, Tamara A M, Da Costa Pereira, Daniel, Lion, Ken, Huppelschoten, Yara, Vischer, Henry F, De Esch, Iwan J P, Wijtmans, Maikel, Leurs, Rob

“…Spatiotemporal control over biochemical signaling processes involving G protein-coupled receptors (GPCRs) is highly desired for dissecting their complex…”
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Development of a high-throughput in vitro screening method for the assessment of cell-damaging activities of snake venoms by Bittenbinder, Matyas A, Capinha, Liliana, Da Costa Pereira, Daniel, Slagboom, Julien, van de Velde, Bas, Casewell, Nicholas R, Jennings, Paul, Kool, Jeroen, Vonk, Freek J

“…Snakebite envenoming is a globally important public health issue that has devastating consequences on human health and well-being, with annual mortality rates…”
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Interaction of 14-3-3 proteins with the Estrogen Receptor Alpha F domain provides a drug target interface by De Vries-van Leeuwen, Ingrid J., da Costa Pereira, Daniel, Flach, Koen D., Piersma, Sander R., Haase, Christian, Bier, David, Yalcin, Zeliha, Michalides, Rob, Feenstra, K. Anton, Jiménez, Connie R., de Greef, Tom F. A., Brunsveld, Luc, Ottmann, Christian, Zwart, Wilbert, de Boer, Albertus H.

“…Estrogen receptor alpha (ERα) is involved in numerous physiological and pathological processes, including breast cancer. Breast cancer therapy is therefore…”
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Photoswitching the Efficacy of a Small‐Molecule Ligand for a Peptidergic GPCR: from Antagonism to Agonism by Gómez‐Santacana, Xavier, de Munnik, Sabrina M., Vijayachandran, Prashanna, Da Costa Pereira, Daniel, Bebelman, Jan Paul M., de Esch, Iwan J. P., Vischer, Henry F., Wijtmans, Maikel, Leurs, Rob

“…For optical control of GPCR function, we set out to develop small‐molecule ligands with photoswitchable efficacy in which both configurations bind the target…”
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Characterization of Organic Anion and Cation Transport in Three Human Renal Proximal Tubular Epithelial Models by Meijer, Tamara, da Costa Pereira, Daniel, Klatt, Olivia C, Buitenhuis, Joanne, Jennings, Paul, Wilmes, Anja

“…The polarised expression of specific transporters in proximal tubular epithelial cells is important for the renal clearance of many endogenous and exogenous…”
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The use of carotenoid pigments as food additives for aquatic organisms and their functional roles by Pereira da Costa, Daniel, Campos Miranda-Filho, Kleber

“…Aquatic organisms have various pigments contained in their body and may be an important characteristic for the consumer choice. Carotenoids are the main group…”
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Dual role for 14-3-3 proteins and ABF transcription factors in gibberellic acid and abscisic acid signalling in barley (Hordeum vulgare) aleurone cells by SCHOONHEIM, PETER J, COSTA PEREIRA, DANIEL DA, DE BOER, ALBERTUS H

“…The balance of gibberellins [gibberellic acid (GA)] and abscisic acid (ABA) is a determining factor during transition of embryogenesis and seed germination…”
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2,2′-Dihydroxy- N , N ′-(ethane-1,2-diyl)dibenzamide by Costa, Daniel Pereira da, Nobre, Sabrina Madruga, Lisboa, Bruna Gonçalves, Vicenti, Juliano Rosa de Menezes, Back, Davi Fernando

“…The asymmetric unit of the title compound, C 16 H 16 N 2 O 4 , contains one half-molecule, the whole molecule being generated by an inversion center located at…”
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Capturing time-dependent activation of genes and stress-response pathways using transcriptomics in iPSC-derived renal proximal tubule cells by Jennings, Paul, Carta, Giada, Singh, Pranika, da Costa Pereira, Daniel, Feher, Anita, Dinnyes, Andras, Exner, Thomas E., Wilmes, Anja

“…Transcriptomic analysis is a powerful method in the utilization of New Approach Methods (NAMs) for identifying mechanisms of toxicity and application to hazard…”
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A Photoswitchable Agonist for the Histamine H3 Receptor, a Prototypic Family A G‐Protein‐Coupled Receptor by Hauwert, Niels J., Mocking, Tamara A. M., Da Costa Pereira, Daniel, Lion, Ken, Huppelschoten, Yara, Vischer, Henry F., De Esch, Iwan J. P., Wijtmans, Maikel, Leurs, Rob

“…Spatiotemporal control over biochemical signaling processes involving G protein‐coupled receptors (GPCRs) is highly desired for dissecting their complex…”
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Structural and Molecular Determinants for Isoform Bias at Human Histamine H3 Receptor Isoforms by Rahman, Sabrina N., McNaught-Flores, Daniel A., Huppelschoten, Yara, da Costa Pereira, Daniel, Christopoulos, Arthur, Leurs, Rob, Langmead, Christopher J.

“…The human histamine H3 receptor (hH3R) is predominantly expressed in the CNS, where it regulates the synthesis and release of histamine and other…”
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Synthesis and Characterization of a Bidirectional Photoswitchable Antagonist Toolbox for Real-Time GPCR Photopharmacology by Hauwert, Niels J, Mocking, Tamara A. M, Da Costa Pereira, Daniel, Kooistra, Albert J, Wijnen, Lisa M, Vreeker, Gerda C. M, Verweij, Eléonore W. E, De Boer, Albertus H, Smit, Martine J, De Graaf, Chris, Vischer, Henry F, de Esch, Iwan J. P, Wijtmans, Maikel, Leurs, Rob

“…Noninvasive methods to modulate G protein-coupled receptors (GPCRs) with temporal and spatial precision are in great demand. Photopharmacology uses photons to…”
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Fusicoccin‑A Targets Cancerous Inhibitor of Protein Phosphatase 2A by Stabilizing a C‑Terminal Interaction with 14-3‑3 by Brink, Hendrik J., van Senten, Jeffrey R., De Vries-van Leeuwen, Ingrid J., da Costa Pereira, Daniel, Piersma, Sander R., Jimenez, Connie R., Centorrino, Federica, Ottmann, Christian, Siderius, Marco, Smit, Martine J., de Boer, Albertus H.

“…The cancerous inhibitor of protein phosphatase 2A (CIP2A) is an oncoprotein found overexpressed in many types of cancer. CIP2A has been shown to stabilize…”
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Emerging Contaminants Related to Brazilian Aquaculture by da Mota, Juliana Barros, Neves, Thiago de Alencar, da Costa, Daniel Pereira, Starling, Maria Clara Vieira Martins, de Amorim, Camila Costa, Miranda‐Filho, Kleber Campos

“…Research efforts around the world have focused on identifying the occurrence of emerging contaminants in aquaculture areas. In the Brazilian context, studies…”
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4-(3-Aminoazetidin-1-yl)pyrimidin-2-amines as High-Affinity Non-imidazole Histamine H 3 Receptor Agonists with in Vivo Central Nervous System Activity by Wágner, Gábor, Mocking, Tamara A M, Arimont, Marta, Provensi, Gustavo, Rani, Barbara, Silva-Marques, Bruna, Latacz, Gniewomir, Da Costa Pereira, Daniel, Karatzidou, Christina, Vischer, Henry F, Wijtmans, Maikel, Kieć-Kononowicz, Katarzyna, de Esch, Iwan J P, Leurs, Rob

“…Despite the high diversity of histamine H receptor (H R) antagonist/inverse agonist structures, partial or full H R agonists have typically been imidazole…”
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SAR exploration of the non-imidazole histamine H 3 receptor ligand ZEL-H16 reveals potent inverse agonism by Wágner, Gábor, Mocking, Tamara A M, Ma, Xiaoyuan, Slynko, Inna, Da Costa Pereira, Daniel, Breeuwer, Robin, Rood, Niek J N, van der Horst, Cas, Vischer, Henry F, de Graaf, Chris, de Esch, Iwan J P, Wijtmans, Maikel, Leurs, Rob

“…Histamine H receptor (H R) agonists without an imidazole moiety remain very scarce. Of these, ZEL-H16 (1) has been reported previously as a high-affinity…”
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Multicomponent synthesis of spiro 1,3,4‐thiadiazolines with anticancer activity by using deep eutectic solvent under microwave irradiation by Castro, Aleff, Andrade, Isadora Maria Gouveia, Coelho, Maísa Cavalcanti, Costa, Daniel Pereira, Moreira, Dayse das Neves, Maia, Rachel Azevedo, Lima, Gesiane da Silva, Santos, Gabriel Franco, Vaz, Boniek Gontijo, Militão, Gardênia Carmen Gadelha, Silva, Paulo Bruno Norberto, Vasconcellos, Mário Luiz Araujo de Almeida, Lima‐Junior, Claudio Gabriel

“…This work describes a simple and efficient alternative method for obtaining 1,3,4‐thiadialzolinic spirocompounds, combining the use of deep eutectic solvents…”
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Microwave‐assisted synthesis and antimicrobial activity of novel spiro 1,3,4‐thiadiazolines from isatin derivatives by Costa, Daniel Pereira, Castro, Aleff Cruz, Silva, Girlyanderson Araújo, Lima‐Junior, Claudio Gabriel, Andrade Júnior, Francisco Patricio, Oliveira Lima, Edeltrudes, Vaz, Boniek Gontijo, Silva, Lidya Cardoso

“…This work describes the synthesis of spiro 1,3,4‐thiadiazolines from isatin‐β‐thiosemicarbazone acetylation, using microwave irradiation as a source of heating…”
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Development of a membrane-disruption assay using phospholipid vesicles as a proxy for the detection of cellular membrane degradation by Bittenbinder, Mátyás A., Wachtel, Eric, Pereira, Daniel Da Costa, Slagboom, Julien, Casewell, Nicholas R., Jennings, Paul, Kool, Jeroen, Vonk, Freek J.

“…Snakebite envenoming is a global health issue that affects millions of people worldwide, and that causes morbidity rates surpassing 450,000 individuals…”
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