Search Results - "DYROFF, Martin C"

Pyridazinoquinolinetriones as NMDA Glycine-Site Antagonists with Oral Antinociceptive Activity in a Model of Neuropathic Pain by Bare, Thomas M, Brown, Dean G, Horchler, Carey L, Murphy, Megan, Urbanek, Rebecca A, Alford, Vernon, Barlaam, Christine, Dyroff, Martin C, Empfield, James B, Forst, Janet M, Herzog, Keith J, Keith, Richard A, Kirschner, Alan S, Lee, Chi-Ming C, Lewis, Joseph, McLaren, Frances M, Neilson, Kathy L, Steelman, Gary B, Trivedi, Shephali, Vacek, Edward P, Xiao, Wenhua

“…A series of 7-chloro-2,3-dihydro-2-[1-(pyridinyl)alkyl]-pyridazino[4,5-b]quinoline-1,4,10(5H)-triones were synthesized and found to have potent activity at the…”
Get full text

Inhibition of Human Drug Metabolizing Cytochromes P450 by Anastrozole, a Potent and Selective Inhibitor of Aromatase by GRIMM, S. W, DYROFF, M. C

“…Anastrozole (2,2′[5-(1H-1,2,4-triazol-1-ylmethyl)-1,3-phenylene]bis(2-methylproprionitrile)) is a potent third-generation inhibitor of aromatase, currently…”
Get full text

Synthesis of 7-chloro-2,3-dihydro-2-[1-(pyridinyl)alkyl]-pyridazino[4,5-b]quinoline-1,4,10(5h )-triones as NMDA glycine-site antagonists by BROWN, Dean G, URBANEK, Rebecca A, XIAO, Wenhua, DYROFF, Martin C, LEE, Chi-Ming C, TRIVEDI, Shephali, NEILSON, Kathy L, KEITH, Richard A, BARE, Thomas M, MCLAREN, Frances M, HORCHLER, Carey L, MURPHY, Megan, STEELMAN, Gary B, EMPFIELD, James R, FORST, Janet M, HERZOG, Keith J

“…Several members of the 7-chloro-2,3-dihydro-2-[1-(pyridinyl)alkyl]-pyridazino[4,5-b]quinoline-1,4,10(5H)-triones (2) have been identified as being potent and…”
Get full text

N-Aryl-3,3,3-trifluoro-2-hydroxy-2-methylpropanamides:  KATP Potassium Channel Openers. Modifications on the Western Region by Ohnmacht, Cyrus J, Russell, Keith, Empfield, James R, Frank, Cathy A, Gibson, Keith H, Mayhugh, Daniel R, McLaren, Frances M, Shapiro, Howard S, Brown, Frederick J, Trainor, Diane A, Ceccarelli, Christopher, Lin, Margaret M, Masek, Brian B, Forst, Janet M, Harris, Robert J, Hulsizer, James M, Lewis, Joseph J, Silverman, Stuart M, Smith, Reed W, Warwick, Paul J, Kau, Sen T, Chun, Alexa L, Grant, Thomas L, Howe, Burton B, Li, Jack H, Trivedi, Shephali, Halterman, Tracy J, Yochim, Christopher, Dyroff, Martin C, Neilson, Kathleen L

Get full text

Identification of the major protein adduct formed in rat liver after thioacetamide administration by Dyroff, M C, Neal, R A

“…The in vivo covalent binding of the hepatocarcinogen thioacetamide to rat liver protein has been examined. Following administration of 3H- or 14C-labeled…”
Get full text

Biochemical and morphologic studies of heterogeneous lobe responses in hepatocarcinogenesis by Richardson, F C, Boucheron, J A, Dyroff, M C, Popp, J A, Swenberg, J A

“…Experiments have demonstrated interlobe differences in the incidence of diethylnitrosamine (DEN)-induced hepatocellular carcinoma (HCCA), with a 100% incidence…”
Get more information

Hepatic macromolecular covalent binding of the hepatocarcinogen 2,6-dinitrotoluene and its 2,4-isomer in vivo: modulation by the sulfotransferase inhibitors pentachlorophenol and 2,6-dichloro-4-nitrophenol by Kedderis, G L, Dyroff, M C, Rickert, D E

“…The sulfotransferase inhibitors 2,6-dichloro-4-nitrophenol and pentachlorophenol were used to investigate the role of sulfate ester formation during the in…”
Get more information

Correlation of O4-ethyldeoxythymidine accumulation, hepatic initiation and hepatocellular carcinoma induction in rats continuously administered diethylnitrosamine by Dyroff, M C, Richardson, F C, Popp, J A, Bedell, M A, Swenberg, J A

“…Recent experiments have demonstrated that O6-ethyldeoxyguanosine (O6-EtdG) is efficiently repaired while O4-ethyldeoxythymidine (O4-EtdT) accumulates in…”
Get more information

Determination of ZD9583, a thromboxane receptor antagonist, in human plasma and urine by liquid chromatography atmospheric pressure chemical ionization tandem mass spectrometry by Xin Gao, Chun, Bui, Khanh H, Martz, Angela S, LeDonne, Norman C, Dyroff, Martin C

“…A liquid chromatography–atmospheric pressure chemical ionization tandem mass spectrometry (LC–APCI-MS–MS) method is described for the determination of a…”
Get full text

N -Aryl-3,3,3-trifluoro-2-hydroxy-2-methylpropanamides:  K ATP Potassium Channel Openers. Modifications on the Western Region by Ohnmacht, Cyrus J., Russell, Keith, Empfield, James R., Frank, Cathy A., Gibson, Keith H., Mayhugh, Daniel R., McLaren, Frances M., Shapiro, Howard S., Brown, Frederick J., Trainor, Diane A., Ceccarelli, Christopher, Lin, Margaret M., Masek, Brian B., Forst, Janet M., Harris, Robert J., Hulsizer, James M., Lewis, Joseph J., Silverman, Stuart M., Smith, Reed W., Warwick, Paul J., Kau, Sen T., Chun, Alexa L., Grant, Thomas L., Howe, Burton B., Li, Jack H., Trivedi, Shephali, Halterman, Tracy J., Yochim, Christopher, Dyroff, Martin C., Kirkland, M., Neilson, Kathleen L.

Get full text

Catalytic selectivity and mechanism-based inactivation of stably expressed and hepatic cytochromes P450 2B4 and 2B5: implications of the cytochrome P450 2B5 polymorphism by Grimm, S W, Dyroff, M C, Philpot, R M, Halpert, J R

“…Cytochrome P450 (P450) 2B5 was recently found to be functionally distinct from three other rabbit P450 2B forms, based on androstenedione hydroxylase…”
Get more information

Relationships between DNA Adduct Formation and Carcinogenesis by Swenberg, James A., Richardson, Frank C., Boucheron, Joyce A., Dyroff, Martin C.

“…An impressive array of evidence has been obtained during the past decade establishing correlations between specific DNA adducts and carcinogenesis. Many of the…”
Get full text

Differential repair of O4-alkylthymidine following exposure to methylating and ethylating hepatocarcinogens by Richardson, F C, Dyroff, M C, Boucheron, J A, Swenberg, J A

“…Recent experiments have demonstrated that O6-alkylguanine is rapidly removed from hepatocyte DNA following continuous exposure to 1,2-dimethylhydrazine or…”
Get more information

N -Aryl-3,3,3-trifluoro-2-hydroxy-2-methylpropanamides:  K ATP Potassium Channel Openers. Modifications on the Western Region by Ohnmacht, Cyrus J., Russell, Keith, Empfield, James R., Frank, Cathy A., Gibson, Keith H., Mayhugh, Daniel R., McLaren, Frances M., Shapiro, Howard S., Brown, Frederick J., Trainor, Diane A., Ceccarelli, Christopher, Lin, Margaret M., Masek, Brian B., Forst, Janet M., Harris, Robert J., Hulsizer, James M., Lewis, Joseph J., Silverman, Stuart M., Smith, Reed W., Warwick, Paul J., Kau, Sen T., Chun, Alexa L., Grant, Thomas L., Howe, Burton B., Li, Jack H., Trivedi, Shephali, Halterman, Tracy J., Yochim, Christopher, Dyroff, Martin C., M.Kirkland, and, Neilson, Kathleen L.

Get full text

N-Aryl-3,3,3-trifluoro-2-hydroxy-2-methylpropanamides:  KATP Potassium Channel Openers. Modifications on the Western Region by Ohnmacht, Cyrus J, Russell, Keith, Empfield, James R, Frank, Cathy A, Gibson, Keith H, Mayhugh, Daniel R, McLaren, Frances M, Shapiro, Howard S, Brown, Frederick J, Trainor, Diane A, Ceccarelli, Christopher, Lin, Margaret M, Masek, Brian B, Forst, Janet M, Harris, Robert J, Hulsizer, James M, Lewis, Joseph J, Silverman, Stuart M, Smith, Reed W, Warwick, Paul J, Kau, Sen T, Chun, Alexa L, Grant, Thomas L, Howe, Burton B, Li, Jack H, Trivedi, Shephali, Halterman, Tracy J, Yochim, Christopher, Dyroff, Martin C, Kirkland, M, Neilson, Kathleen L

“…A subset of antiandrogen compounds, the N-aryl-3,3,3-trifluoro-2-hydroxy-2-methylpropanamides 1, were found to activate ATP sensitive potassium channels (KATP)…”
Get full text

Hepatic macromolecular covalent binding of mononitrotoluenes in Fischer-344 rats by Rickert, D E, Long, R M, Dyroff, M C, Kedderis, G L

“…The mononitrotoluenes are important industrial chemicals which display isomeric specificity in their ability to induce hepatic DNA excision repair in…”
Get more information

O4-ethyldeoxythymidine, but not O6-ethyldeoxyguanosine, Accumulates in Hepatocyte DNA of Rats Exposed Continuously to Diethylnitrosamine by Swenberg, James A., Dyroff, Martin C., Bedell, Mary A., Popp, James A., Huh, Namho, Kirstein, Uwe, Rajewsky, Manfred F.

“…In previous investigations into the mechanisms responsible for cell specificity in hepatocarcinogenesis, we have demonstrated that O6-methylguanine accumulates…”
Get full text

Dose response for DNA alkylation, [3H]thymidine uptake into DNA, and O6-methylguanine-DNA methyltransferase activity in hepatocytes of rats and mice continuously exposed to dimethylnitrosamine by LINDAMOOD, C. L. III, BEDELL, M. R, BILLINGS, K. C, DYROFF, M. C, SWENBERG, J. A

“…The objectives of these experiments were to determine N-7-methylguanine (m7Gua) and O6-methylguanine (O6mGua) concentrations in DNA, [3H]thymidine uptake into…”
Get full text

O6-alkylguanine alkyl acceptor protein activity in hepatocytes of C3H and C57BL mice during dimethylnitrosamine exposure by Lindamood, 3rd, C, Bedell, M A, Billings, K C, Dyroff, M C, Swenberg, J A

Get more information