Search Results - "DYER, S. J"

Concurrent up-regulation of BCL-XL and BCL2A1 induces approximately 1000-fold resistance to ABT-737 in chronic lymphocytic leukemia by Vogler, Meike, Butterworth, Michael, Majid, Aneela, Walewska, Renata J., Sun, Xiao-Ming, Dyer, Martin J.S., Cohen, Gerald M.

“…ABT-737 and its orally active analog, ABT-263, are rationally designed inhibitors of BCL2 and BCL-XL. ABT-263 shows promising activity in early phase 1…”
Get full text

The PARP inhibitor olaparib induces significant killing of ATM-deficient lymphoid tumor cells in vitro and in vivo by Weston, Victoria J., Oldreive, Ceri E., Skowronska, Anna, Oscier, David G., Pratt, Guy, Dyer, Martin J.S., Smith, Graeme, Powell, Judy E., Rudzki, Zbigniew, Kearns, Pamela, Moss, Paul A.H., Taylor, A. Malcolm R., Stankovic, Tatjana

“…The Ataxia Telangiectasia Mutated (ATM) gene is frequently inactivated in lymphoid malignancies such as chronic lymphocytic leukemia (CLL), T-prolymphocytic…”
Get full text

Safety and efficacy of abexinostat, a pan-histone deacetylase inhibitor, in non-Hodgkin lymphoma and chronic lymphocytic leukemia: results of a phase II study by Ribrag, Vincent, Kim, Won Seog, Bouabdallah, Reda, Lim, Soon Thye, Coiffier, Bertrand, Illes, Arpad, Lemieux, Bernard, Dyer, Martin J S, Offner, Fritz, Felloussi, Zakia, Kloos, Ioana, Luan, Ying, Vezan, Remus, Graef, Thorsten, Morschhauser, Franck

“…Histone deacetylase inhibitors are members of a class of epigenetic drugs that have proven activity in T-cell malignancies, but little is known about their…”
Get full text

Voltage-gated proton channels maintain pH in human neutrophils during phagocytosis by Morgan, Deri, Capasso, Melania, Musset, Boris, Cherny, Vladimir V, Ríos, Eduardo, Dyer, Martin J.S, DeCoursey, Thomas E

“…Phagocytosis of microbial invaders represents a fundamental defense mechanism of the innate immune system. The subsequent killing of microbes is initiated by…”
Get full text

Enhanced activation of an amino-terminally truncated isoform of the voltage-gated proton channel HVCN1 enriched in malignant B cells by Hondares, Elayne, Brown, Mark Adrian, Musset, Boris, Morgan, Deri, Cherny, Vladimir V., Taubert, Christina, Bhamrah, Mandeep K., Coe, David, Marelli-Berg, Federica, Gribben, John G., Dyer, Martin J. S., DeCoursey, Thomas E., Capasso, Melania

“…HVCN1 (Hydrogen voltage-gated channel 1) is the only mammalian voltage-gated proton channel. In human B lymphocytes, HVCN1 associates with the B-cell receptor…”
Get full text

Identification of a novel form of caspase-independent cell death triggered by BH3-mimetics in diffuse large B-cell lymphoma cell lines by Yildirim, Nahide, Sarojam, Lakshmi, Smith, Victoria M., Pieper, Nadja M., Anders, Marius, Jackson, Ross A., Fuhrmann, Dominik C., Särchen, Vinzenz, Brücher, Daniela, Weigert, Andreas, Dyer, Martin J. S., Vogler, Meike

“…BH3-mimetics represent promising anti-cancer agents in tumors that rely on the anti-apoptotic function of B-Cell Lymphoma 2 (BCL2) proteins, particularly in…”
Get full text

Role of NOXA and its ubiquitination in proteasome inhibitor-induced apoptosis in chronic lymphocytic leukemia cells by BAOU, Maria, KOHLHAAS, Susan L, BUTTERWORTH, Michael, VOGLER, Meike, DINSDALE, David, WALEWSKA, Renata, MAJID, Aneela, ELDERING, Eric, DYER, Martin J. S, COHEN, Gerald M

“…Bortezomib has been successfully used in the treatment of multiple myeloma and has been proposed as a potential treatment for chronic lymphocytic leukemia. In…”
Get full text

A comprehensive microarray-based DNA methylation study of 367 hematological neoplasms by Martin-Subero, Jose I, Ammerpohl, Ole, Bibikova, Marina, Wickham-Garcia, Eliza, Agirre, Xabier, Alvarez, Sara, Brüggemann, Monika, Bug, Stefanie, Calasanz, Maria J, Deckert, Martina, Dreyling, Martin, Du, Ming Q, Dürig, Jan, Dyer, Martin J S, Fan, Jian-Bing, Gesk, Stefan, Hansmann, Martin-Leo, Harder, Lana, Hartmann, Sylvia, Klapper, Wolfram, Küppers, Ralf, Montesinos-Rongen, Manuel, Nagel, Inga, Pott, Christiane, Richter, Julia, Román-Gómez, José, Seifert, Marc, Stein, Harald, Suela, Javier, Trümper, Lorenz, Vater, Inga, Prosper, Felipe, Haferlach, Claudia, Cruz Cigudosa, Juan, Siebert, Reiner

“…Alterations in the DNA methylation pattern are a hallmark of leukemias and lymphomas. However, most epigenetic studies in hematologic neoplasms (HNs) have…”
Get full text

Phase IA/II, multicentre, open‐label study of the CD40 antagonistic monoclonal antibody lucatumumab in adult patients with advanced non‐Hodgkin or Hodgkin lymphoma by Fanale, Michelle, Assouline, Sarit, Kuruvilla, John, Solal‐Céligny, Philippe, Heo, Dae S., Verhoef, Gregor, Corradini, Paolo, Abramson, Jeremy S., Offner, Fritz, Engert, Andreas, Dyer, Martin J. S., Carreon, Daniel, Ewald, Brett, Baeck, Johan, Younes, Anas, Freedman, Arnold S.

“…Summary Despite advancements in the treatment of non‐Hodgkin lymphoma (NHL) and Hodgkin lymphoma (HL), patients continue to relapse and thus a need for new…”
Get full text

Enhancement of CD154/IL4 proliferation by the T follicular helper (Tfh) cytokine, IL21 and increased numbers of circulating cells resembling Tfh cells in chronic lymphocytic leukaemia by Ahearne, Matthew J., Willimott, Shaun, Piñon, Lucia, Kennedy, D. Benjamin, Miall, Fiona, Dyer, Martin J. S., Wagner, Simon D.

“…Summary Chronic lymphocytic leukaemia (CLL) cells encounter T‐cells and proliferate in response to T‐cell signals in the lymph node microenvironment. In this…”
Get full text

Men leave me as I cannot have children': women's experiences with involuntary childlessness by Dyer, S.J., Abrahams, N., Hoffman, M., van der Spuy, Z.M.

“…BACKGROUND: This study explores the concerns and experiences related to involuntary childlessness of infertile women living in a diverse cultural urban…”
Get full text

Computational modeling of DLBCL predicts response to BH3-mimetics by Cloete, Ielyaas, Smith, Victoria M., Jackson, Ross A., Pepper, Andrea, Pepper, Chris, Vogler, Meike, Dyer, Martin J. S., Mitchell, Simon

“…In healthy cells, pro- and anti-apoptotic BCL2 family and BH3-only proteins are expressed in a delicate equilibrium. In contrast, this homeostasis is…”
Get full text

Breaking good: the inexorable rise of BTK inhibitors in the treatment of chronic lymphocytic leukaemia by Hutchinson, Claire V., Dyer, Martin J. S.

“…Summary Although expressed in several haematological lineages and involved in multiple different signalling pathways, Bruton tyrosine kinase (BTK) plays an…”
Get full text

Monitoring of molecular responses to tirabrutinib in a cohort of exceptional responders with relapsed/refractory mantle cell lymphoma by Alqahtani, Abdullah N. M., Jayne, Sandrine, Ahearne, Matthew J., Trethewey, Christopher S., Duraisingham, Sai S., Lehmann, Susann, Cowley, Caroline M., Dyer, Martin J. S., Walter, Harriet S.

Get full text

Immunoglobulin heavy chain locus chromosomal translocations in B-cell precursor acute lymphoblastic leukemia: rare clinical curios or potent genetic drivers? by Dyer, Martin J.S., Akasaka, Takashi, Capasso, Melania, Dusanjh, Palminder, Lee, Yin Fai, Karran, E. Loraine, Nagel, Inga, Vater, Inga, Cario, Gunnar, Siebert, Reiner

“…Chromosomal translocations involving the immunoglobulin heavy chain (IGH) locus define common subgroups of B-cell lymphoma but are rare in B-cell precursor…”
Get full text

‘You are a man because you have children’: experiences, reproductive health knowledge and treatment‐seeking behaviour among men suffering from couple infertility in South Africa by Dyer, S.J., Abrahams, N., Mokoena, N.E., van der Spuy, Z.M.

“…BACKGROUND: In Africa, infertility traditionally has been viewed as a female problem. This study explores reproductive health knowledge, health‐seeking…”
Get full text

BCL2/BCL-XL inhibition induces apoptosis, disrupts cellular calcium homeostasis, and prevents platelet activation by Vogler, Meike, Hamali, Hassan A., Sun, Xiao-Ming, Bampton, Edward T.W., Dinsdale, David, Snowden, Roger T., Dyer, Martin J.S., Goodall, Alison H., Cohen, Gerald M.

“…Apoptosis in megakaryocytes results in the formation of platelets. The role of apoptotic pathways in platelet turnover and in the apoptotic-like changes seen…”
Get full text

Psychological distress among women suffering from couple infertility in South Africa: a quantitative assessment by Dyer, S.J., Abrahams, N., Mokoena, N.E., Lombard, C.J., van der Spuy, Z.M.

“…BACKGROUND: Infertility in Africa is commonly associated with negative psycho-social consequences. To date, most studies from African countries addressing…”
Get full text

Diminished Sensitivity of Chronic Lymphocytic Leukemia Cells to ABT-737 and ABT-263 Due to Albumin Binding in Blood by VOGLER, Meike, FURDAS, Silviya D, JUNG, Manfred, KUWANA, Tomomi, DYER, Martin J. S, COHEN, Gerald M

“…Inhibition of the antiapoptotic BCL2 family is one of the most promising areas of anticancer drug development. However, ABT-737, a specific BCL2 inhibitor, is…”
Get full text

Deregulation of the telomerase reverse transcriptase (TERT) gene by chromosomal translocations in B-cell malignancies by Nagel, Inga, Szczepanowski, Monika, Martín-Subero, José I., Harder, Lana, Akasaka, Takashi, Ammerpohl, Ole, Callet-Bauchu, Evelyne, Gascoyne, Randy D., Gesk, Stefan, Horsman, Doug, Klapper, Wolfram, Majid, Aneela, Martinez-Climent, José A., Stilgenbauer, Stephan, Tönnies, Holger, Dyer, Martin J.S., Siebert, Reiner

“…Sequence variants at the TERT-CLPTM1L locus in chromosome 5p have been recently associated with disposition for various cancers. Here we show that this locus…”
Get full text