Search Results - "DYCK, Jason R. B."

Metabolomic fingerprint of heart failure with preserved ejection fraction by Zordoky, Beshay N, Sung, Miranda M, Ezekowitz, Justin, Mandal, Rupasri, Han, Beomsoo, Bjorndahl, Trent C, Bouatra, Souhaila, Anderson, Todd, Oudit, Gavin Y, Wishart, David S, Dyck, Jason R B

“…Heart failure (HF) with preserved ejection fraction (HFpEF) is increasingly recognized as an important clinical entity. Preclinical studies have shown…”
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Inhibition of the Unfolded Protein Response Mechanism Prevents Cardiac Fibrosis by Groenendyk, Jody, Lee, Dukgyu, Jung, Joanna, Dyck, Jason R B, Lopaschuk, Gary D, Agellon, Luis B, Michalak, Marek

“…Cardiac fibrosis attributed to excessive deposition of extracellular matrix proteins is a major cause of heart failure and death. Cardiac fibrosis is extremely…”
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Impaired branched chain amino acid oxidation contributes to cardiac insulin resistance in heart failure by Uddin, Golam M, Zhang, Liyan, Shah, Saumya, Fukushima, Arata, Wagg, Cory S, Gopal, Keshav, Al Batran, Rami, Pherwani, Simran, Ho, Kim L, Boisvenue, Jamie, Karwi, Qutuba G, Altamimi, Tariq, Wishart, David S, Dyck, Jason R B, Ussher, John R, Oudit, Gavin Y, Lopaschuk, Gary D

“…Branched chain amino acids (BCAA) can impair insulin signaling, and cardiac insulin resistance can occur in the failing heart. We, therefore, determined if…”
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AMPK phosphorylation of ACC2 is required for skeletal muscle fatty acid oxidation and insulin sensitivity in mice by O’Neill, Hayley M., Lally, James S., Galic, Sandra, Thomas, Melissa, Azizi, Paymon D., Fullerton, Morgan D., Smith, Brennan K., Pulinilkunnil, Thomas, Chen, Zhiping, Samaan, M. Constantine, Jorgensen, Sebastian B., Dyck, Jason R. B., Holloway, Graham P., Hawke, Thomas J., van Denderen, Bryce J., Kemp, Bruce E., Steinberg, Gregory R.

“…Aims/hypothesis Obesity is characterised by lipid accumulation in skeletal muscle, which increases the risk of developing insulin resistance and type 2…”
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Circulating levels of tumor necrosis factor-alpha receptor 2 are increased in heart failure with preserved ejection fraction relative to heart failure with reduced ejection fraction: evidence for a divergence in pathophysiology by Putko, Brendan N, Wang, Zuocheng, Lo, Jennifer, Anderson, Todd, Becher, Harald, Dyck, Jason R B, Kassiri, Zamaneh, Oudit, Gavin Y

“…Various pathways have been implicated in the pathogenesis of heart failure (HF) with preserved ejection fraction (HFPEF). Inflammation in response to comorbid…”
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Novel Biomarkers for Inflammatory Bowel Disease and Colorectal Cancer: An Interplay between Metabolic Dysregulation and Excessive Inflammation by Salla, Mohamed, Guo, Jimmy, Joshi, Harshad, Gordon, Marilyn, Dooky, Hitesh, Lai, Justine, Capicio, Samantha, Armstrong, Heather, Valcheva, Rosica, Dyck, Jason R B, Thiesen, Aducio, Wine, Eytan, Dieleman, Levinus A, Baksh, Shairaz

“…Persistent inflammation can trigger altered epigenetic, inflammatory, and bioenergetic states. Inflammatory bowel disease (IBD) is an idiopathic disease…”
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Benzodiazepine use in medical cannabis authorization adult patients from 2013 to 2021: Alberta, Canada by Dubois, Cerina, Fernandes, Heidi, Lin, Mu, Martins, Karen J B, Dyck, Jason R B, Klarenbach, Scott W, Richer, Lawrence, Jess, Ed, Hanlon, John G, Hyshka, Elaine, Eurich, Dean T

“…Benzodiazepines are a class of medications that are being frequently prescribed in Canada but carry significant risk of harm. There has been increasing…”
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Changes in patient health questionnaire (PHQ-9) scores in adults with medical authorization for cannabis by Round, Jessica M, Lee, Cerina, Hanlon, John G, Hyshka, Elaine, Dyck, Jason R. B, Eurich, Dean T

“…Background Legal access to medical cannabis is increasing world-wide. Despite this, there is a lack of evidence surrounding its efficacy on mental health…”
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Opioid use in medical cannabis authorization adult patients from 2013 to 2018: Alberta, Canada by Lee, Cerina, Lin, Mu, Martins, Karen J B, Dyck, Jason R B, Klarenbach, Scott, Richer, Lawrence, Jess, Ed, Hanlon, John G, Hyshka, Elaine, Eurich, Dean T

“…The opioid overdose epidemic in Canada and the United States has become a public health crisis - with exponential increases in opioid-related morbidity and…”
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Layer-specific strain in patients with heart failure using cardiovascular magnetic resonance: not all layers are the same by Xu, Lingyu, Pagano, Joseph J, Haykowksy, Mark J, Ezekowitz, Justin A, Oudit, Gavin Y, Mikami, Yoko, Howarth, Andrew, White, James A, Dyck, Jason R B, Anderson, Todd, Paterson, D Ian, Thompson, Richard B

“…Global longitudinal strain (GLS), most commonly measured at the endocardium, has been shown to be superior to left ventricular (LV) ejection fraction (LVEF)…”
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Integration of longitudinal and circumferential strain predicts volumetric change across the cardiac cycle and differentiates patients along the heart failure continuum by Samuel, T. Jake, Oneglia, Andrew P., Cipher, Daisha J., Ezekowitz, Justin A., Dyck, Jason R.B., Anderson, Todd, Howlett, Jonathan G., Paterson, D. Ian, Thompson, Richard B., Nelson, Michael D.

“…Left ventricular (LV) circumferential and longitudinal strain provide important insight into LV mechanics and function, each contributing to volumetric changes…”
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Increased Hepatic CD36 Expression Contributes to Dyslipidemia Associated With Diet-Induced Obesity by KOONEN, Debby P. Y, JACOBS, René L, FEBBRAIO, Maria, YOUNG, Martin E, SOLTYS, Carrie-Lynn M, ONG, Huy, VANCE, Dennis E, DYCK, Jason R. B

“…Increased Hepatic CD36 Expression Contributes to Dyslipidemia Associated With Diet-Induced Obesity Debby P.Y. Koonen 1 , René L. Jacobs 2 , Maria Febbraio 3 ,…”
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Breast cancer diagnosis is associated with relative left ventricular hypertrophy and elevated endothelin-1 signaling by Maayah, Zaid H, Takahara, Shingo, Alam, Abrar S, Ferdaoussi, Mourad, Sutendra, Gopinath, El-Kadi, Ayman O S, Mackey, John R, Pituskin, Edith, Paterson, D Ian, Dyck, Jason R B

“…The survival rates of women with breast cancer have improved significantly over the last four decades due to advances in breast cancer early diagnosis and…”
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Disruption of the circadian clock within the cardiomyocyte influences myocardial contractile function, metabolism, and gene expression by Bray, Molly S, Shaw, Chad A, Moore, Michael W S, Garcia, Rodrigo A P, Zanquetta, Melissa M, Durgan, David J, Jeong, William J, Tsai, Ju-Yun, Bugger, Heiko, Zhang, Dongfang, Rohrwasser, Andreas, Rennison, Julie H, Dyck, Jason R B, Litwin, Sheldon E, Hardin, Paul E, Chow, Chi-Wing, Chandler, Margaret P, Abel, E Dale, Young, Martin E

“…Virtually every mammalian cell, including cardiomyocytes, possesses an intrinsic circadian clock. The role of this transcriptionally based molecular mechanism…”
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Liver-Specific Inhibition of ChREBP Improves Hepatic Steatosis and Insulin Resistance in ob/ob Mice by DENTIN, Renaud, BENHAMED, Fadila, HAINAULT, Isabelle, FAUVEAU, Véronique, FOUFELLE, Fabienne, DYCK, Jason R. B, GIRARD, Jean, POSTIC, Catherine

“…Liver-Specific Inhibition of ChREBP Improves Hepatic Steatosis and Insulin Resistance in ob/ob Mice Renaud Dentin 1 , Fadila Benhamed 1 , Isabelle Hainault 2 ,…”
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Quantification of lung water in heart failure using cardiovascular magnetic resonance imaging by Thompson, Richard B, Chow, Kelvin, Pagano, Joseph J, Sekowski, Viktor, Michelakis, Evangelos D, Tymchak, Wayne, Haykowsky, Mark J, Ezekowitz, Justin A, Oudit, Gavin Y, Dyck, Jason R B, Kaul, Padma, Savu, Anamaria, Paterson, D Ian

“…Pulmonary edema is a cardinal feature of heart failure but no quantitative tests are available in clinical practice. The goals of this study were to develop a…”
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A Pivotal Role for Endogenous TGF-β-Activated Kinase-1 in the LKB1/AMP-Activated Protein Kinase Energy-Sensor Pathway by Xie, Min, Zhang, Dou, Dyck, Jason R. B., Li, Yi, Zhang, Hui, Morishima, Masae, Mann, Douglas L., Taffet, George E., Baldini, Antonio, Khoury, Dirar S., Schneider, Michael D.

“…TGF-β-activated kinase-1 (TAK1), also known as MAPKK kinase-7 (MAP3K7), is a candidate effector of multiple circuits in cardiac biology and disease. Here, we…”
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Medical cannabis authorization and the risk of cardiovascular events: a longitudinal cohort study by Zongo, Arsene, Lee, Cerina, Dyck, Jason R B, El-Mourad, Jihane, Hyshka, Elaine, Hanlon, John G, Eurich, Dean T

“…Cannabis is increasingly used for therapeutic purpose. However, its safety profile is not well known. This study assessed the risk of cardiovascular-related…”
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Gaps in evidence for the use of medically authorized cannabis: Ontario and Alberta, Canada by Lee, Cerina, Round, Jessica M, Klarenbach, Scott, Hanlon, John G, Hyshka, Elaine, Dyck, Jason R. B, Eurich, Dean T

“…Background With legal access to medical cannabis in Canada since 2001, there is a need to fully characterize its use at both the individual and population…”
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Intracellular long-chain acyl CoAs activate TRPV1 channels by Yu, Yi, Carter, Chris R J, Youssef, Nermeen, Dyck, Jason R B, Light, Peter E

“…TRPV1 channels are an important class of membrane proteins that play an integral role in the regulation of intracellular cations such as calcium in many…”
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