Search Results - "DWYER, M"

Exosome‐encapsulated microRNAs as circulating biomarkers for breast cancer by Joyce, Doireann P., Kerin, Michael J., Dwyer, Róisín M.

“…Breast cancer is a highly prevalent disease, accounting for 29% of invasive cancers in women. Survival from this disease depends on the stage at diagnosis,…”
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Constraints on trait combinations explain climatic drivers of biodiversity: the importance of trait covariance in community assembly by Dwyer, John M., Laughlin, Daniel C., Fukami, Tadashi

“…Trade‐offs maintain diversity and structure communities along environmental gradients. Theory indicates that if covariance among functional traits sets a limit…”
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Inhibition of IRE1 RNase activity modulates the tumor cell secretome and enhances response to chemotherapy by Logue, Susan E., McGrath, Eoghan P., Cleary, Patricia, Greene, Stephanie, Mnich, Katarzyna, Almanza, Aitor, Chevet, Eric, Dwyer, Róisín M., Oommen, Anup, Legembre, Patrick, Godey, Florence, Madden, Emma C., Leuzzi, Brian, Obacz, Joanna, Zeng, Qingping, Patterson, John B., Jäger, Richard, Gorman, Adrienne M., Samali, Afshin

“…Triple-negative breast cancer (TNBC) lacks targeted therapies and has a worse prognosis than other breast cancer subtypes, underscoring an urgent need for new…”
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Engineering Exosomes for Cancer Therapy by Gilligan, Katie E, Dwyer, Róisín M

“…There remains an urgent need for novel therapeutic strategies to treat metastatic cancer, which results in over 8 million deaths annually worldwide. Following…”
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Licking and liking: The assessment of hedonic responses in rodents by Dwyer, Dominic M.

“…Affective processes are a key determinant of behaviour: At its simplest, liked stimuli are approached while disliked stimuli are avoided. Although assessing…”
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Specific leaf area responses to environmental gradients through space and time by Dwyer, John M, Hobbs, Richard J, Mayfield, Margaret M

“…Plant communities can respond to environmental changes by altering their species composition and by individuals (within species) adjusting their physiology…”
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Fast-acting antidepressants rapidly stimulate ERK signaling and BDNF release in primary neuronal cultures by Lepack, Ashley E., Bang, Eunyoung, Lee, Boyoung, Dwyer, Jason M., Duman, Ronald S.

“…Recent preclinical and clinical studies demonstrate that three functionally different compounds, the NMDA receptor channel blocker ketamine, mGlu2/3 receptor…”
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mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists by Li, Nanxin, Lee, Boyoung, Liu, Rong-Jian, Banasr, Mounira, Dwyer, Jason M., Iwata, Masaaki, Li, Xiao-Yuan, Aghajanian, George, Duman, Ronald S.

“…The rapid antidepressant response after ketamine administration in treatment-resistant depressed patients suggests a possible new approach for treating mood…”
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Glutamate N -methyl-D-aspartate Receptor Antagonists Rapidly Reverse Behavioral and Synaptic Deficits Caused by Chronic Stress Exposure by Li, Nanxin, Liu, Rong-Jian, Dwyer, Jason M, Banasr, Mounira, Lee, Boyoung, Son, Hyeon, Li, Xiao-Yuan, Aghajanian, George, Duman, Ronald S

“…Background Despite widely reported clinical and preclinical studies of rapid antidepressant actions of glutamate N -methyl-D-aspartate (NMDA) receptor…”
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Activation of Mammalian Target of Rapamycin and Synaptogenesis: Role in the Actions of Rapid-Acting Antidepressants by Dwyer, Jason M, Duman, Ronald S

“…Antidepressants that produce rapid and robust effects, particularly for severely ill patients, represent one of the largest unmet medical needs for the…”
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BDNF Release Is Required for the Behavioral Actions of Ketamine by Lepack, Ashley E., Fuchikami, Manabu, Dwyer, Jason M., Banasr, Mounira, Duman, Ronald S.

“…Background: Recent studies demonstrate that the rapid antidepressant ketamine increases spine number and function in the medial prefrontal cortex (mPFC), and…”
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Nanoparticle-Based Delivery of Tumor Suppressor microRNA for Cancer Therapy by O'Neill, Clodagh P, Dwyer, Róisín M

“…Improved understanding of microRNA expression and function in cancer has revealed a range of microRNAs that negatively regulate many oncogenic pathways, thus…”
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GSK-3 Inhibition Potentiates the Synaptogenic and Antidepressant-Like Effects of Subthreshold Doses of Ketamine by LIU, Rong-Jian, FUCHIKAMI, Manabu, DWYER, Jason M, LEPACK, Ashley E, DUMAN, Ronald S, AGHAJANIAN, George K

“…A single dose of the short-acting NMDA antagonist ketamine produces rapid and prolonged antidepressant effects in treatment-resistant patients with major…”
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Face masks have emotion-dependent dissociable effects on accuracy and confidence in identifying facial expressions of emotion by Grenville, Emily, Dwyer, Dominic M.

“…The coronavirus pandemic has resulted in increased use of face masks worldwide. Here, we examined the effect of wearing a face mask on the ability to recognise…”
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Anti-CD73 antibody therapy inhibits breast tumor growth and metastasis by Stagg, John, Divisekera, Upulie, McLaughlin, Nicole, Sharkey, Janelle, Pommey, Sandra, Denoyer, Delphine, Dwyer, Karen M, Smyth, Mark J

“…Extracellular adenosine is a potent immunosuppressor that accumulates during tumor growth. We performed proof-of-concept studies investigating the therapeutic…”
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Handling method alters the hedonic value of reward in laboratory mice by Clarkson, Jasmine M., Dwyer, Dominic M., Flecknell, Paul A., Leach, Matthew C., Rowe, Candy

“…Mice are the most widely used model species for drug discovery and scientific research. Consequently, it is important to refine laboratory procedures and…”
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Role of Neuronal VEGF Signaling in the Prefrontal Cortex in the Rapid Antidepressant Effects of Ketamine by Deyama, Satoshi, Bang, Eunyoung, Wohleb, Eric S, Li, Xiao-Yuan, Kato, Taro, Gerhard, Danielle M, Dutheil, Sophie, Dwyer, Jason M, Taylor, Seth R, Picciotto, Marina R, Duman, Ronald S

“…Objective:The N-methyl-d-aspartate receptor antagonist ketamine produces rapid and sustained antidepressant actions even in patients with treatment-resistant…”
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Role of Extracellular Vesicles (EVs) in Cell Stress Response and Resistance to Cancer Therapy by O'Neill, Clodagh P, Gilligan, Katie E, Dwyer, Róisín M

“…Extracellular vesicles (EVs) are nanosized particles released by all cells that have been heralded as novel regulators of cell-to-cell communication. It is…”
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Animal welfare with Chinese characteristics: Chinese poultry producers' perceptions of, and attitudes towards, animal welfare by Yang, Qing, Dwyer, Cathy M, Vigors, Belinda, Zhao, Ruqian, Langford, Fritha M

“…China's poultry industry faces challenges in adopting and sustaining cage-free systems for poultry production. Effective interventions are crucial to support…”
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Subcortical and Cortical Gray Matter Atrophy in a Large Sample of Patients with Clinically Isolated Syndrome and Early Relapsing-Remitting Multiple Sclerosis by BERGSLAND, N, HORAKOVA, D, DWYER, M. G, DOLEZAL, O, SEIDL, Z. K, VANECKOVA, M, KRASENSKY, J, HAVRDOVA, E, ZIVADINOV, R

“…Recent studies have shown that selective regional, but not global, GM atrophy occurs from clinical onset to conversion to clinically definite MS. Our aim was…”
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