Search Results - "DWYER, J"

Source mechanisms of terrestrial gamma-ray flashes by Dwyer, J. R.

“…The source of terrestrial gamma‐ray flashes (TGFs) has remained a mystery since their discovery in 1994. Recent Reuven Ramaty High‐Energy Solar Spectroscopic…”
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How antibiotics kill bacteria: from targets to networks by Collins, James J, Kohanski, Michael A, Dwyer, Daniel J

“…Key Points Substantial progress has been made in our understanding of the mechanistic details of bacterial cell death induced by bactericidal antibiotics. In…”
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Antibiotic-Induced Bacterial Cell Death Exhibits Physiological and Biochemical Hallmarks of Apoptosis by Dwyer, Daniel J., Camacho, Diogo M., Kohanski, Michael A., Callura, Jarred M., Collins, James J.

“…Programmed cell death is a gene-directed process involved in the development and homeostasis of multicellular organisms. The most common mode of programmed…”
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Unraveling the Physiological Complexities of Antibiotic Lethality by Dwyer, Daniel J, Collins, James J, Walker, Graham C

“…We face an impending crisis in our ability to treat infectious disease brought about by the emergence of antibiotic-resistant pathogens and a decline in the…”
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Cell therapy for advanced liver diseases: Repair or rebuild by Dwyer, Benjamin J., Macmillan, Mark T., Brennan, Paul N., Forbes, Stuart J.

“…Advanced liver disease presents a significant worldwide health and economic burden and accounts for 3.5% of global mortality. When liver disease progresses to…”
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Estimating the annual attack rate of seasonal influenza among unvaccinated individuals: A systematic review and meta-analysis by Somes, Mitchell P., Turner, Robin M., Dwyer, Liam J., Newall, Anthony T.

“…Seasonal influenza affects millions of people globally each year, causing significant morbidity and mortality. However, there remains substantial uncertainty…”
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A fundamental limit on electric fields in air by Dwyer, J. R.

“…By modifying the avalanche mode of runaway breakdown to include positive feedback from gamma‐rays and positrons, it is found that enormous bursts of energetic…”
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When worlds collide: Th17 and Treg cells in cancer and autoimmunity by Knochelmann, Hannah M., Dwyer, Connor J., Bailey, Stefanie R., Amaya, Sierra M., Elston, Dirk M., Mazza-McCrann, Joni M., Paulos, Chrystal M.

“…The balance between Th17 cells and regulatory T cells (Tregs) has emerged as a prominent factor in regulating autoimmunity and cancer. Th17 cells are vital for…”
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Antibiotic efficacy is linked to bacterial cellular respiration by Lobritz, Michael A, Peter Belenky, Caroline B. M. Porter, Arnaud Gutierrez, Jason H. Yang, Eric G. Schwarz, Daniel J. Dwyer, Ahmad S. Khalil, James J. Collins

“…Bacteriostatic and bactericidal antibiotic treatments result in two fundamentally different phenotypic outcomes—the inhibition of bacterial growth or,…”
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Cholangiocytes act as facultative liver stem cells during impaired hepatocyte regeneration by Raven, Alexander, Lu, Wei-Yu, Man, Tak Yung, Ferreira-Gonzalez, Sofia, O’Duibhir, Eoghan, Dwyer, Benjamin J., Thomson, John P., Meehan, Richard R., Bogorad, Roman, Koteliansky, Victor, Kotelevtsev, Yuri, ffrench-Constant, Charles, Boulter, Luke, Forbes, Stuart J.

“…Two independent systems impairing hepatocyte proliferation during liver injury cause physiologically significant levels of functional hepatocyte regeneration…”
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A Common Mechanism of Cellular Death Induced by Bactericidal Antibiotics by Kohanski, Michael A., Dwyer, Daniel J., Hayete, Boris, Lawrence, Carolyn A., Collins, James J.

“…Antibiotic mode-of-action classification is based upon drug-target interaction and whether the resultant inhibition of cellular function is lethal to bacteria…”
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Changing duration and spatial extent of midlatitude precipitation extremes across different climates by Dwyer, J. G., O'Gorman, P. A.

“…Precipitation extremes intensify with climate warming in observations and simulations, but changes in their duration or spatial extent are not well understood…”
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Inflammation and immunomodulation in central nervous system injury – B cells as a novel therapeutic opportunity by Maheshwari, Saumya, Dwyer, Liam J., Sîrbulescu, Ruxandra F.

“…Acute injury to the central nervous system (CNS) remains a complex and challenging clinical need. CNS injury initiates a dynamic neuroinflammatory response,…”
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Mistranslation of Membrane Proteins and Two-Component System Activation Trigger Antibiotic-Mediated Cell Death by Kohanski, Michael A., Dwyer, Daniel J., Wierzbowski, Jamey, Cottarel, Guillaume, Collins, James J.

“…Aminoglycoside antibiotics, such as gentamicin and kanamycin, directly target the ribosome, yet the mechanisms by which these bactericidal drugs induce cell…”
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Antibiotics induce redox-related physiological alterations as part of their lethality by Dwyer, Daniel J, Belenky, Peter A, Yang, Jason H, MacDonald, I Cody, Martell, Jeffrey D, Takahashi, Noriko, Chan, Clement T Y, Lobritz, Michael A, Braff, Dana, Schwarz, Eric G, Ye, Jonathan D, Pati, Mekhala, Vercruysse, Maarten, Ralifo, Paul S, Allison, Kyle R, Khalil, Ahmad S, Ting, Alice Y, Walker, Graham C, Collins, James J

“…Deeper understanding of antibiotic-induced physiological responses is critical to identifying means for enhancing our current antibiotic arsenal. Bactericidal…”
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STM-Induced Desorption and Lithographic Patterning of Cl–Si(100)-(2 × 1) by Dwyer, K. J, Dreyer, Michael, Butera, R. E

“…A scanning tunneling microscope (STM) was used to investigate tip-induced chlorine desorption and lithographic patterning of Cl-terminated Si(100)-(2 × 1)…”
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CAR T Cells in Solid Tumors: Blueprints for Building Effective Therapies by Knochelmann, Hannah M, Smith, Aubrey S, Dwyer, Connor J, Wyatt, Megan M, Mehrotra, Shikhar, Paulos, Chrystal M

“…Genetic redirection of T lymphocytes with chimeric antigen receptors (CARs) has soared from treating cancers preclinically to FDA approval for hematologic…”
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Safety profile of autologous macrophage therapy for liver cirrhosis by Moroni, Francesca, Dwyer, Benjamin J., Graham, Catriona, Pass, Chloe, Bailey, Laura, Ritchie, Lisa, Mitchell, Donna, Glover, Alison, Laurie, Audrey, Doig, Stuart, Hargreaves, Emily, Fraser, Alasdair R., Turner, Marc L., Campbell, John D. M., McGowan, Neil W. A., Barry, Jacqueline, Moore, Joanna K., Hayes, Peter C., Leeming, Diana J., Nielsen, Mette J., Musa, Kishwar, Fallowfield, Jonathan A., Forbes, Stuart J.

“…Therapies to reduce liver fibrosis and stimulate organ regeneration are urgently needed. We conducted a first-in-human, phase 1 dose-escalation trial of…”
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Predictive Model of Avian Electrocution Risk on Overhead Power Lines by DWYER, J. F, HARNESS, R. E, DONOHUE, K

“…Electrocution on overhead power structures negatively affects avian populations in diverse ecosystems worldwide, contributes to the endangerment of raptor…”
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Free and open-access satellite data are key to biodiversity conservation by Turner, W., Rondinini, C., Pettorelli, N., Mora, B., Leidner, A.K., Szantoi, Z., Buchanan, G., Dech, S., Dwyer, J., Herold, M., Koh, L.P., Leimgruber, P., Taubenboeck, H., Wegmann, M., Wikelski, M., Woodcock, C.

“…•Satellite remote sensing increases understanding of global biodiversity change.•Data continuity, affordability, and access determine its utility in this…”
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