Search Results - "DVORAK, Ann M"

Eosinophil extracellular DNA trap cell death mediates lytic release of free secretion-competent eosinophil granules in humans by Ueki, Shigeharu, Melo, Rossana C.N., Ghiran, Ionita, Spencer, Lisa A., Dvorak, Ann M., Weller, Peter F.

“…Eosinophils release their granule proteins extracellularly through exocytosis, piecemeal degranulation, or cytolytic degranulation. Findings in diverse human…”
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Lipid body-phagosome interaction in macrophages during infectious diseases: host defense or pathogen survival strategy? by Melo, Rossana C N, Dvorak, Ann M

“…Phagocytosis of invading microorganisms by specialized cells such as macrophages and neutrophils is a key component of the innate immune response. These cells…”
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VEGF-A and the induction of pathological angiogenesis by Nagy, Janice A, Dvorak, Ann M, Dvorak, Harold F

“…Tumors, wounds, and chronic inflammatory disorders generate a new vascular supply by a process known as pathological angiogenesis. Whereas formation of the…”
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Pathological angiogenesis is induced by sustained Akt signaling and inhibited by rapamycin by Phung, Thuy L., Ziv, Keren, Dabydeen, Donnette, Eyiah-Mensah, Godfred, Riveros, Marcela, Perruzzi, Carole, Sun, Jingfang, Monahan-Earley, Rita A., Shiojima, Ichiro, Nagy, Janice A., Lin, Michelle I., Walsh, Kenneth, Dvorak, Ann M., Briscoe, David M., Neeman, Michal, Sessa, William C., Dvorak, Harold F., Benjamin, Laura E.

“…Endothelial cells in growing tumors express activated Akt, which when modeled by transgenic endothelial expression of myrAkt1 was sufficient to recapitulate…”
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The tetraspanin CD63 is required for efficient IgE-mediated mast cell degranulation and anaphylaxis by Kraft, Stefan, Jouvin, Marie-Hélène, Kulkarni, Nitin, Kissing, Sandra, Morgan, Ellen S, Dvorak, Ann M, Schröder, Bernd, Saftig, Paul, Kinet, Jean-Pierre

“…Mast cell (MC) activation through the high-affinity IgE receptor FcεRI leads to the release of mediators involved in immediate-type allergic reactions…”
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Ultrastructural Studies of Human Basophils and Mast Cells by Dvorak, Ann M

“…Ultrastructural studies of human mast cells (HMCs) and basophils (HBs) are reviewed. Sources of HMCs include biopsies of tissue sites and in situ study of…”
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Identification of extant vertebrate Myxine glutinosa VWF: evolutionary conservation of primary hemostasis by Grant, Marianne A., Beeler, David L., Spokes, Katherine C., Chen, Junmei, Dharaneeswaran, Harita, Sciuto, Tracey E., Dvorak, Ann M., Interlandi, Gianluca, Lopez, José A., Aird, William C.

“…Hemostasis in vertebrates involves both a cellular and a protein component. Previous studies in jawless vertebrates (cyclostomes) suggest that the protein…”
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Early Actions of Anti–Vascular Endothelial Growth Factor/Vascular Endothelial Growth Factor Receptor Drugs on Angiogenic Blood Vessels by Sitohy, Basel, Chang, Sunghee, Sciuto, Tracey E., Masse, Elizabeth, Shen, Mei, Kang, Peter M., Jaminet, Shou-Ching, Benjamin, Laura E., Bhatt, Rupal S., Dvorak, Ann M., Nagy, Janice A., Dvorak, Harold F.

“…Tumors induce their heterogeneous vasculature by secreting vascular endothelial growth factor (VEGF)-A. Anti-VEGF/VEGF receptor (VEGFR) drugs treat cancer, but…”
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Mechanisms of eosinophil secretion: large vesiculotubular carriers mediate transport and release of granule-derived cytokines and other proteins by Melo, Rossana C. N., Spencer, Lisa A., Dvorak, Ann M., Weller, Peter F.

“…Eosinophils generate and store a battery of proteins, including classical cationic proteins, cytokines, chemokines, and growth factors. Rapid secretion of…”
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Vascular Permeability and Pathological Angiogenesis in Caveolin-1-Null Mice by Chang, Sung-Hee, Feng, Dian, Nagy, Janice A, Sciuto, Tracey E, Dvorak, Ann M, Dvorak, Harold F

“…Caveolin-1, the signature protein of endothelial cell caveolae, has many important functions in vascular cells. Caveolae are thought to be the transcellular…”
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Eosinophil granules function extracellularly as receptor-mediated secretory organelles by Neves, Josiane S, Perez, Sandra A.C, Spencer, Lisa A, Melo, Rossana C.N, Reynolds, Lauren, Ghiran, Ionita, Mahmudi-Azer, Salahaddin, Odemuyiwa, Solomon O, Dvorak, Ann M, Moqbel, Redwan, Weller, Peter F

“…Intracellular granules in several types of leukocytes contain preformed proteins whose secretions contribute to immune and inflammatory functions of…”
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Vascular permeability, vascular hyperpermeability and angiogenesis by NAGY, Janice A, BENJAMIN, Laura, HUIYAN ZENG, DVORAK, Ann M, DVORAK, Harold F

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Vascular permeability factor/vascular endothelial growth factor induces lymphangiogenesis as well as angiogenesis by Nagy, Janice A, Vasile, Eliza, Feng, Dian, Sundberg, Christian, Brown, Lawrence F, Detmar, Michael J, Lawitts, Joel A, Benjamin, Laura, Tan, Xiaolian, Manseau, Eleanor J, Dvorak, Ann M, Dvorak, Harold F

“…Vascular permeability factor/vascular endothelial growth factor (VPF/VEGF, VEGF-A) is a multifunctional cytokine with important roles in pathological…”
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Pericytes Elicit Resistance to Vemurafenib and Sorafenib Therapy in Thyroid Carcinoma via the TSP-1/TGFβ1 Axis by Prete, Alessandro, Lo, Agnes S, Sadow, Peter M, Bhasin, Swati S, Antonello, Zeus A, Vodopivec, Danica M, Ullas, Soumya, Sims, Jennifer N, Clohessy, John, Dvorak, Ann M, Sciuto, Tracey, Bhasin, Manoj, Murphy-Ullrich, Joanne E, Lawler, Jack, Karumanchi, S Ananth, Nucera, Carmelo

“…The BRAF oncogene modulates the papillary thyroid carcinoma (PTC) microenvironment, in which pericytes are critical regulators of tyrosine-kinase…”
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X-linked gray platelet syndrome due to a GATA1 Arg216Gln mutation by Tubman, Venée N., Levine, Jason E., Campagna, Dean R., Monahan-Earley, Rita, Dvorak, Ann M., Neufeld, Ellis J., Fleming, Mark D.

“…We identified a family with gray platelet syndrome (GPS) segregating as a sex-linked trait. Affected males had a mild bleeding disorder, thrombocytopenia, and…”
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The internal architecture of leukocyte lipid body organelles captured by three-dimensional electron microscopy tomography by Melo, Rossana C N, Paganoti, Guillherme F, Dvorak, Ann M, Weller, Peter F

“…Lipid bodies (LBs), also known as lipid droplets, are complex organelles of all eukaryotic cells linked to a variety of biological functions as well as to the…”
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The Vesiculo-Vacuolar Organelle (VVO): A New Endothelial Cell Permeability Organelle by Dvorak, Ann M, Feng, Dian

“…A newly defined endothelial cell permeability structure, termed the Vesiculo–Vacuolar organelle (VVO), has been identified in the microvasculature that…”
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Vesicle-mediated secretion of human eosinophil granule-derived major basic protein by Melo, Rossana C N, Spencer, Lisa A, Perez, Sandra A C, Neves, Josiane S, Bafford, Staci P, Morgan, Ellen S, Dvorak, Ann M, Weller, Peter F

“…Major basic protein (MBP), the predominant cationic protein of human eosinophil specific granules, is stored within crystalloid cores of these granules…”
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Cytokine Receptor-Mediated Trafficking of Preformed IL-4 in Eosinophils Identifies an Innate Immune Mechanism of Cytokine Secretion by Spencer, Lisa A., Melo, Rossana C. N., Perez, Sandra A. C., Bafford, Staci P., Dvorak, Ann M., Weller, Peter F.

“…Although leukocytes of the innate immune system, including eosinophils, contain within their granules preformed stores of cytokines available for selective and…”
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Microvascular Patterning Is Controlled by Fine-Tuning the Akt Signal by Sun, Jing Fang, Phung, Thuy, Shiojima, Ichiro, Felske, Terri, Upalakalin, J. Nalinee, Feng, Dian, Kornaga, Tad, Dor, Talia, Dvorak, Ann M., Walsh, Kenneth, Benjamin, Laura E., Folkman, Judah

“…We investigated the functions of Akt during vascular development and remodeling by using an inducible endothelial cell-specific driver of the dominant-active…”
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