Search Results - "DUXON, Mark"

SB-649915-B, a novel 5-HT1A/B autoreceptor antagonist and serotonin reuptake inhibitor, is anxiolytic and displays fast onset activity in the rat high light social interaction test by Starr, Kathryn R, Price, Gary W, Watson, Jeannette M, Atkinson, Peter J, Arban, Roberto, Melotto, Sergio, Dawson, Lee A, Hagan, Jim J, Upton, Neil, Duxon, Mark S

“…Preclinically, the combination of an SSRI and 5-HT autoreceptor antagonist has been shown to reduce the time to onset of anxiolytic activity compared to an…”
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LABORAS™: Initial pharmacological validation of a system allowing continuous monitoring of laboratory rodent behaviour by Quinn, Leann P, Stean, Tania O, Trail, Brenda, Duxon, Mark S, Stratton, Sharon C, Billinton, Andrew, Upton, Neil

“…A newly developed apparatus for automated behavioural analysis, Laboratory Animal Behaviour Observation, Registration and Analysis System (LABORAS™), has been…”
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Repeated sensory contact with aggressive mice rapidly leads to an anticipatory increase in core body temperature and physical activity that precedes the onset of aversive responding by Pardon, Marie-Christine, Kendall, David A., Pérez-Diaz, Fernando, Duxon, Mark S., Marsden, Charles A.

“…The present study investigated whether the ‘psychological threat’ induced by sensory contact with an aggressive conspecific would be a sufficient factor in…”
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3,4-Dihydro-2H-benzoxazinones are 5-HT1A receptor antagonists with potent 5-HT reuptake inhibitory activity by ATKINSON, Peter J, BROMIDGE, Steven M, RAMI, Harshad K, RILEY, Graham J, SCOTT, Claire M, SHAW, Tracey E, STARR, Kathryn R, STEMP, Geoffrey, THEWLIS, Kevin M, THOMAS, David R, THOMPSON, Mervyn, VONG, Antonio K. K, DUXON, Mark S, WATSON, Jeannette M, GASTER, Laramie M, HADLEY, Michael S, HAMMOND, Beverley, JOHNSON, Christopher N, MIDDLEMISS, Derek N, NORTH, Stephanie E, PRICE, Gary W

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Ethopharmacological analysis of the unstable elevated exposed plus maze, a novel model of extreme anxiety: predictive validity and sensitivity to anxiogenic agents by JONES, Nicholas, DUXON, Mark S, KING, Sheila M

“…The unstable elevated exposed plus maze (UEEPM) has been proposed as a novel model of anxiety which elicits unconditioned escape-related behaviour in rats…”
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5-HT2C receptor mediation of unconditioned escape behaviour in the unstable elevated exposed plus maze by JONES, Nicholas, DUXON, Mark S, KING, Sheila M

“…m-Chlorophenylpiperazine (mCPP) induces panic in humans and dose dependently increases unconditioned escape behaviour in a novel pre-clinical model of extreme…”
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Ketamine supresses REM sleep and markedly increases EEG gamma oscillations in the Wistar Kyoto rat model of treatment-resistant depression by Kantor, Sandor, Lanigan, Michael, Giggins, Lauren, Lione, Lisa, Magomedova, Lilia, de Lannoy, Inés, Upton, Neil, Duxon, Mark

“…Wistar–Kyoto (WKY) rats exhibit depression-like characteristics and decreased sensitivity to monoamine-based antidepressants, making them a suitable model of…”
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A novel behavioural registration system LABORAS™ and the social interaction paradigm detect long-term functional deficits following middle cerebral artery occlusion in the rat by Quinn, Leann P., Grundy, Robert I., Campbell, Colin A., Collier, Sarah, Lawman, Amanda, Stean, Tania O., Billinton, Andrew, Parsons, Andrew A., Upton, Neil, Duxon, Mark S., Irving, Elaine A.

“…Following stroke, patients suffer a wide range of disabilities including motor impairment, anxiety and depression. However, to date, characterisation of rodent…”
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How good are current approaches to nonclinical evaluation of abuse and dependence? by Moser, Paul, Wolinsky, Toni, Duxon, Mark, Porsolt, Roger D

“…Nonclinical assessment of drug abuse and dependence is the subject of several recent regulatory guidelines, which are generally aligned on the methods to be…”
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Current approaches and issues in non-clinical evaluation of abuse and dependence by Moser, Paul, Wolinsky, Toni, Castagné, Vincent, Duxon, Mark

“…Preclinical assessment of drug abuse and dependence has been the subject of several recent regulatory guidelines. Both the European and US authorities…”
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Immunohistochemical localisation of the 5-HT2C receptor protein in the rat CNS by CLEMETT, D. A, PUNHANI, T, DUXON, M. S, BLACKBURN, T. P, FONE, K. C. F

“…5-HT2C receptor mRNA has a widespread distribution in the human and rat CNS but the absence of a specific high affinity ligand has made autoradiographic…”
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The development of an Irwin-like test in the nonhuman primate for CNS safety assessment by Froget, Guillaume, Cruz, Christopher, Hubert, Isabelle, Virley, David, Lemaire, Martine, Duxon, Mark S., Porsolt, Roger D.

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Localisation of NMU1R and NMU2R in human and rat central nervous system and effects of neuromedin-U following central administration in rats by GARTLON, Jane, SZEKERES, Philip, DUXON, Mark, ASHMEADE, Tracey E, HARRISON, David C, MURDOCK, Paul, WILSON, Shelagh, ENNACEUR, Abdel, ATKINS, Alan, HEIDBREDER, Christian, HAGAN, Jim J, HUNTER, A. Jackie, PULLEN, Mark, JONES, Declan N. C, SARAU, Henry M, AIYAR, Nambi, SHABON, Usman, MICHALOVICH, David, STEPLEWSKI, Klaudia, ELLIS, Cathy, ELSHOURBAGY, Nabil

“…Neuromedin-U (NmU) is an agonist at NMU1R and NMU2R. The brain distribution of NmU and its receptors, in particular NMU2R, suggests widespread central roles…”
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5-HT 2C receptor mediation of unconditioned escape behaviour in the unstable elevated exposed plus maze by Jones, Nicholas, Duxon, Mark, King, Sheila

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Evidence that orexin-A-evoked grooming in the rat is mediated by orexin-1 (OX1) receptors, with downstream 5-HT2C receptor involvement by DUXON, Mark S, STRETTON, Jennifer, WAI CHAN, PORTER, Rod A, UPTON, Neil, STARR, Kathryn, JONES, Declan N. C, HOLLAND, Vicky, RILEY, Graham, JERMAN, Jeff, BROUGH, Stephen, SMART, Darren, JOHNS, Amanda

“…Orexins A and B have recently been discovered and shown to be derived from preproorexin, primarily expressed in the rat hypothalamus. Orexin-A has been…”
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SB-649915-B, a novel s-HTIA/B autoreceptor antagonist and serotonin reuptake inhibitor, is anxiolytic and displays fast onset activity in the rat high light social interaction test by STARR, Kathryn R, PRICE, Gary W, WATSON, Jeannette M, ATKINSON, Peter J, ARBAN, Roberto, MELOTTO, Sergio, DAWSON, Lee A, HAGAN, Jim J, UPTON, Neil, DUXON, Mark S

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Pharmacological profile of SB-357134: A potent, selective, brain penetrant, and orally active 5-HT6 receptor antagonist by Stean, Tania O, Hirst, Warren D, Thomas, David R, Price, Gary W, Rogers, Derek, Riley, Graham, Bromidge, Steven M, Serafinowska, Halina T, Smith, Douglas R, Bartlett, Sarah, Deeks, Nigel, Duxon, Mark, Upton, Neil

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Urotensin-II, a neuropeptide ligand for GPR14, induces c- fos in the rat brain by Gartlon, Jane E., Ashmeade, Tracey, Duxon, Mark, Hagan, Jim J., Jones, Declan N.C.

“…The vasoactive peptide urotensin-II and its receptor, GPR14 (now known as UT receptor), are localised in the mammalian central nervous system. Accordingly,…”
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3,4-Dihydro-2H-benzoxazinones are 5-HT(1A) receptor antagonists with potent 5-HT reuptake inhibitory activity by Atkinson, Peter J, Bromidge, Steven M, Duxon, Mark S, Gaster, Laramie M, Hadley, Michael S, Hammond, Beverley, Johnson, Christopher N, Middlemiss, Derek N, North, Stephanie E, Price, Gary W, Rami, Harshad K, Riley, Graham J, Scott, Claire M, Shaw, Tracey E, Starr, Kathryn R, Stemp, Geoffrey, Thewlis, Kevin M, Thomas, David R, Thompson, Mervyn, Vong, Antonio K K, Watson, Jeannette M

“…Starting from a high throughput screening hit, a series of 3,4-dihydro-2H-benzoxazinones has been identified with both high affinity for the 5-HT(1A) receptor…”
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3,4-Dihydro-2 H-benzoxazinones are 5-HT 1A receptor antagonists with potent 5-HT reuptake inhibitory activity by Atkinson, Peter J., Bromidge, Steven M., Duxon, Mark S., Gaster, Laramie M., Hadley, Michael S., Hammond, Beverley, Johnson, Christopher N., Middlemiss, Derek N., North, Stephanie E., Price, Gary W., Rami, Harshad K., Riley, Graham J., Scott, Claire M., Shaw, Tracey E., Starr, Kathryn R., Stemp, Geoffrey, Thewlis, Kevin M., Thomas, David R., Thompson, Mervyn, Vong, Antonio K.K., Watson, Jeannette M.

“…The discovery of the potent 5-HT 1A receptor antagonist and 5-HT reuptake inhibitor 31 is reported. Starting from a high throughput screening hit, a series of…”
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