Search Results - "DUTKO, F. J"

Adherence to assigned dosing regimen and sustained virological response among chronic hepatitis C genotype 1 patients treated with boceprevir plus peginterferon alfa‐2b/ribavirin by Gordon, S. C., Yoshida, E. M., Lawitz, E. J., Bacon, B. R., Sulkowski, M. S., Davis, M., Poordad, F., Bronowicki, J.‐P., Esteban, R., Sniukiene, V., Burroughs, M. H., Deng, W., Dutko, F. J., Brass, C. A., Albrecht, J. K., Rajender Reddy, K.

“…Summary Background Adherence to therapeutic regimens affects the efficacy of peginterferon alfa (P) and ribavirin (R) therapy in patients with chronic…”
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Conformational change in the floor of the human rhinovirus canyon blocks adsorption to HeLa cell receptors by PEVEAR, D. C, FANCHER, M. J, FELOCK, P. J, ROSSMANN, M. G, MILLER, M. S, DIANA, G, TREASURYWALA, A. M, MCKINLAY, M. A, DUTKO, F. J

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Self-emulsifying drug delivery systems: formulation and biopharmaceutic evaluation of an investigational lipophilic compound by Charman, S A, Charman, W N, Rogge, M C, Wilson, T D, Dutko, F J, Pouton, C W

“…Self-emulsifying drug delivery systems (SEDDSs) represent a possible alternative to traditional oral formulations of lipophilic compounds. In the present…”
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Genetic and molecular analyses of spontaneous mutants of human rhinovirus 14 that are resistant to an antiviral compound by HEINZ, B. A, RUECKERT, R. R, SHEPARD, D. A, DUTKO, F. J, MCKINLAY, M. A, FANCHER, M, ROSSMANN, M. G, BADGER, J, SMITH, T. J

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Efficacy of oral WIN 54954 for prophylaxis of experimental rhinovirus infection by Turner, R B, Dutko, F J, Goldstein, N H, Lockwood, G, Hayden, F G

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Selective inactivation of eukaryotic beta-galactosidase in assays for inhibitors of HIV-1 TAT using bacterial beta-galactosidase as a reporter enzyme by Young, D C, Kingsley, S D, Ryan, K A, Dutko, F J

“…Bacterial beta-galactosidase is one of several reporter enzymes used in studying the transcriptional activity of eukaryotic promoters. Although it is one of…”
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Picornavirus Inhibitors: Trifluoromethyl Substitution Provides a Global Protective Effect against Hepatic Metabolism by Diana, Guy D, Rudewicz, Patrick, Pevear, Daniel C, Nitz, Theodore J, Aldous, Suzanne C, Aldous, David J, Robinson, David T, Draper, Tandy, Dutko, Frank J

“…Several modifications of the oxazoline ring of WIN 54954, a broad spectrum antipicornavirus compound, have been prepared in order to address the acid lability…”
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Genomic and Biological Variation among Commonly Used Lymphocytic Choriomeningitis Virus Strains by Dutko, Francis J, Oldstone, Michael B. A

“…Department of Immunology, Scripps Clinic and Research Foundation, La Jolla, California 92037, U.S.A. Six commonly used strains of lymphocytic choriomeningitis…”
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Crystal structure of human rhinovirus serotype 1A (HRV1A) by Kim, S S, Smith, T J, Chapman, M S, Rossmann, M C, Pevear, D C, Dutko, F J, Felock, P J, Diana, G D, McKinlay, M A

“…The structure of human rhinovirus 1A (HRV1A) has been determined to 3.2 A resolution using phase refinement and extension by symmetry averaging starting with…”
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In vitro and in vivo activities of WIN 54954, a new broad-spectrum antipicornavirus drug by WOODS, M. G, DIANA, G. D, ROGGE, M. C, OTTO, M. J, DUTKO, F. J, MCKINLAY, M. A

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Binding affinities of structurally related human rhinovirus capsid-binding compounds are related to their activities against human rhinovirus type 14 by FOX, M. P, MCKINLAY, M. A, DIANA, G. D, DUTKO, F. J

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Structural Analysis of a Series of Antiviral Agents Complexed with Human Rhinovirus 14 by Badger, John, Minor, Iwona, Kremer, Marcia J., Oliveira, Marcos A., Smith, Thomas J., Griffith, James P., Diego M. A. Guerin, Krishnaswamy, S., Luo, Ming, Rossmann, Michael G., McKinlay, Mark A., Diana, Guy D., Dutko, Frank J., Fancher, Marilyn, Rueckert, Roland R., Heinz, Beverly A.

“…The binding to human rhinovirus 14 of a series of eight antiviral agents that inhibit picornaviral uncoating after entry into host cells has been characterized…”
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The S RNA segment of lymphocytic choriomeningitis virus codes for the nucleoprotein and glycoproteins 1 and 2 by RIVIERE, Y, RAFI AHMED, SOUTHERN, P. J, BUCHMEIER, M. J, DUTKO, F. J, OLDSTONE, M. B. A

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CoMFA analysis of the interactions of antipicornavirus compounds in the binding pocket of human rhinovirus-14 by Diana, Guy D, Kowalczyk, Paul, Treasurywala, Adi M, Oglesby, Richard C, Pevear, Daniel C, Dutko, Frank J

“…A CoMFA analysis of eight compounds related to disoxaril whose X-ray structures bound to HRV-14 had been determined resulted in a strong positive correlation…”
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Human rhinovirus 14 complexed with fragments of active antiviral compounds by Bibler-Muckelbauer, J K, Kremer, M J, Rossmann, M G, Diana, G D, Dutko, F J, Pevear, D C, McKinlay, M A

“…Crystallographic studies of human rhinovirus 14 (HRV14) crystals soaked with fragments of antiviral WIN compounds, at high concentrations (82-200…”
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Oxadiazoles as Ester Bioisosteric Replacements in Compounds Related to Disoxaril. Antirhinovirus Activity by Diana, Guy D, Volkots, Deborah L, Nitz, Theodore J, Bailey, Thomas R, Long, Melody A, Vescio, Niranjan, Aldous, Suzanne, Pevear, Daniel C, Dutko, Frank J

“…A series of 1,2,4-oxadiazoles has been prepared as ester bioisosteres and tested against 15 human rhinovirus serotypes, and the MIC80, the concentration which…”
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An Evaluation of the Antirhinoviral Activity of Acylfuran Replacements for 3-Methylisoxazoles. Are 2-Acetylfurans Bioisosteres for 3-Methylisoxazoles? by Bailey, Thomas R, Diana, Guy D, Mallamo, John P, Vescio, Niranjan, Draper, Tandy L, Carabateas, Philip M, Long, Melody A, Giranda, Vincent L, Dutko, Frank J, Pevear, Daniel C

“…As a probe of the 3-methylisoxazole portion of our broad-spectrum antipicornaviral series, a panel of 2-acetylfuran analogues was prepared as replacements for…”
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Does the major histocompatibility complex serve as a specific receptor for Semliki Forest virus? by Oldstone, M B, Tishon, A, Dutko, F J, Kennedy, S I, Holland, J J, Lampert, P W

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A model for compounds active against human rhinovirus-14 based on x-ray crystallography data by Diana, Guy D, Treasurywala, Adi M, Bailey, Thomas R, Oglesby, Richard C, Pevear, Daniel C, Dutko, Frank J

“…A number of (oxazolinylphenyl)isoxazoles have been synthesized and tested against human rhinovirus-14 (HRV-14). Several of the more active compounds have been…”
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Arenavirus Defective Interfering Particles Mask the Cell-Killing Potential of Standard Virus by Dutko, F. J, Pfau, C. J

“…Department of Biology, Rensselaer Polytechnic Institute, Troy, New York 12181, U.S.A. Lymphocytic choriomeningitis virus (LCM) and Pichinde virus grew readily…”
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