Search Results - "DUTHIE, Susan J"

Folate and cancer: how DNA damage, repair and methylation impact on colon carcinogenesis by Duthie, Susan J

“…Inappropriate diet may contribute to one third of cancer deaths. Folates, a group of water-soluble B vitamins present in high concentrations in green, leafy…”
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Epigenetic modifications and human pathologies: cancer and CVD by Duthie, Susan J.

“…Epigenetic changes are inherited alterations in DNA that affect gene expression and function without altering the DNA sequence. DNA methylation is one…”
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Berry phytochemicals, genomic stability and cancer: Evidence for chemoprotection at several stages in the carcinogenic process by Duthie, Susan J.

“…Consumption of a diet high in plant‐based foods is associated with a decreased risk of epithelial cell cancers at several sites. Cytoprotectants in fruits and…”
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Season, storage and extraction method impact on the phytochemical profile of Terminalia ivorensis by Moomin, Aliu, Russell, Wendy R, Knott, Rachel M, Scobbie, Lorraine, Mensah, Kwesi Boadu, Adu-Gyamfi, Paa Kofi Tawiah, Duthie, Susan J

“…Terminalia ivorensis (TI) is used in West African ethnomedicine for the treatment of conditions including ulcers, malaria and wounds. Despite its widespread…”
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Roadmap for investigating epigenome deregulation and environmental origins of cancer by Herceg, Zdenko, Ghantous, Akram, Wild, Christopher P., Sklias, Athena, Casati, Lavinia, Duthie, Susan J., Fry, Rebecca, Issa, Jean‐Pierre, Kellermayer, Richard, Koturbash, Igor, Kondo, Yukata, Lepeule, Johanna, Lima, Sheila C.S., Marsit, Carmen J, Rakyan, Vardhman, Saffery, Richard, Taylor, Jack A., Teschendorff, Andrew E., Ushijima, Toshikazu, Vineis, Paolo, Walker, Cheryl Lyn, Waterland, Robert A., Wiemels, Joe, Ambatipudi, Srikant, Degli Esposti, Davide, Hernandez‐Vargas, Hector

“…The interaction between the (epi)genetic makeup of an individual and his/her environmental exposure record (exposome) is accepted as a determinant factor for a…”
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Impact of folate deficiency on DNA stability by Duthie, Susan J, Narayanan, Sabrina, Brand, Gillian M, Pirie, Lynn, Grant, George

“…Convincing evidence links folate deficiency with colorectal cancer incidence. Currently, it is believed that folate deficiency affects DNA stability…”
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Homocysteine, B vitamin status, and cognitive function in the elderly by Duthie, Susan J, Whalley, Lawrence J, Collins, Andrew R, Leaper, Steve, Berger, Kerstin, Deary, Ian J

“…Background: Old age is associated with reduced cognitive performance. Nutritional factors may contribute to this association. Objective: We tested associations…”
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Suboptimal dietary zinc intake promotes vascular inflammation and atherogenesis in a mouse model of atherosclerosis by Beattie, John H., Gordon, Margaret-Jane, Duthie, Susan J., McNeil, Chris J., Horgan, Graham W., Nixon, Graeme F., Feldmann, Jörg, Kwun, In-Sook

“…Scope Cardiovascular health is strongly influenced by diet. Zinc has antioxidant and anti‐inflammatory properties but its long‐term influence on vascular…”
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Kaempferol induced inhibition of HL-60 cell growth results from a heterogeneous response, dominated by cell cycle alterations by Bestwick, Charles S., Milne, Lesley, Duthie, Susan J.

“…Dietary flavonoids may be exploitable as chemotherapeutics and preventatives for critical health conditions, including cancer. Antiproliferative effects are…”
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Symposium 1: Nutrition and epigenetics Epigenetic modifications and human pathologies: cancer and CVD by DUTHIE, Susan J

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Metabolomics of prolonged fasting in humans reveals new catabolic markers by Rubio-Aliaga, Isabel, de Roos, Baukje, Duthie, Susan J., Crosley, L. Katie, Mayer, Claus, Horgan, Graham, Colquhoun, Ian J., Le Gall, Gwénaëlle, Huber, Fritz, Kremer, Werner, Rychlik, Michael, Wopereis, Suzan, van Ommen, Ben, Schmidt, Gabriele, Heim, Carolin, Bouwman, Freek G., Mariman, Edwin C., Mulholland, Francis, Johnson, Ian T., Polley, Abigael C., Elliott, Ruan M., Daniel, Hannelore

“…Fasting is one of the simplest metabolic challenges that can be performed in humans. We here report for the first time a comprehensive analysis of the human…”
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Associations between Two Common Variants C677T and A1298C in the Methylenetetrahydrofolate Reductase Gene and Measures of Folate Metabolism and DNA Stability (Strand Breaks, Misincorporated Uracil, and DNA Methylation Status) in Human Lymphocytes In vivo by NARAYANAN, Sabrina, MCCONNELL, Josie, LITTLE, Julian, SHARP, Linda, PIYATHILAKE, Chandrika J, POWERS, Hilary, BASTEN, Graham, DUTHIE, Susan J

“…Objective: Homozygosity for variants of the methylenetetrahydrofolate reductase ( MTHFR ) gene is associated with decreased risk for colorectal cancer. We have…”
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Nutritional B vitamin deficiency disrupts lipid metabolism causing accumulation of proatherogenic lipoproteins in the aorta adventitia of ApoE null mice by McNeil, Christopher J., Beattie, John H., Gordon, Margaret-Jane, Pirie, Lynn P., Duthie, Susan J.

“…ScopeCardiovascular disease is the major cause of death in the world. Low dietary folate, elevated homocysteine, and high circulating cholesterol are risk…”
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The influence of bisnaphthalimidopropyl polyamines on DNA instability and repair in Caco-2 colon epithelial cells by Bestwick, Charles Stuart, Ralton, Lynda D., Milne, Lesley, Kong Thoo Lin, Paul, Duthie, Susan J.

“…Bisnaphthalimido compounds bis-intercalate to DNA via the major groove and are potentially potent cancer therapeutics. Previously, we incorporated natural…”
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Effect of increasing fruit and vegetable intake by dietary intervention on nutritional biomarkers and attitudes to dietary change: a randomised trial by Duthie, Susan J., Duthie, Garry G., Russell, Wendy R., Kyle, Janet A. M., Macdiarmid, Jennie I., Rungapamestry, Vanessa, Stephen, Sylvia, Megias-Baeza, Cristina, Kaniewska, Joanna J., Shaw, Lindsey, Milne, Lesley, Bremner, David, Ross, Karen, Morrice, Philip, Pirie, Lynn P., Horgan, Graham, Bestwick, Charles S.

“…Purpose Low fruit and vegetable consumption is linked with an increased risk of death from vascular disease and cancer. The benefit of eating fruits and…”
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2D-electrophoresis and multiplex immunoassay proteomic analysis of different body fluids and cellular components reveal known and novel markers for extended fasting by Bouwman, Freek G, de Roos, Baukje, Rubio-Aliaga, Isabel, Crosley, L Katie, Duthie, Susan J, Mayer, Claus, Horgan, Graham, Polley, Abigael C, Heim, Carolin, Coort, Susan L M, Evelo, Chris T, Mulholland, Francis, Johnson, Ian T, Elliott, Ruan M, Daniel, Hannelore, Mariman, Edwin C M

“…Proteomic technologies applied for profiling human biofluids and blood cells are considered to reveal new biomarkers of exposure or provide insights into novel…”
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Folate, genomic stability and colon cancer: The use of single cell gel electrophoresis in assessing the impact of folate in vitro, in vivo and in human biomonitoring by Catala, Gema Nadal, Bestwick, Charles S., Russell, Wendy R., Tortora, Katia, Giovannelli, Lisa, Moyer, Mary Pat, Lendoiro, Elena, Duthie, Susan J.

“…•The comet assay in assessing genomic stability in relation to folate status and human cancer.•Impact of folate deficiency/supplementation on genomic stability…”
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Variation in protein levels obtained from human blood cells and biofluids for platelet, peripheral blood mononuclear cell, plasma, urine and saliva proteomics by Crosley, L Katie, Duthie, Susan J, Polley, Abigael C, Bouwman, Freek G, Heim, Carolin, Mulholland, Francis, Horgan, Graham, Johnson, Ian T, Mariman, Edwin C, Elliott, Ruan M, Daniel, Hannelore, de Roos, Baukje

“…Blood cells and biofluid proteomics are emerging as a valuable tool to assess effects of interventions on health and disease. This study is aimed to assess the…”
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The nutritional and cardiovascular health benefits of rapeseed oil-fed farmed salmon in humans are not decreased compared with those of traditionally farmed salmon: a randomized controlled trial by de Roos, Baukje, Wood, Sharon, Bremner, David, Bashir, Shabina, Betancor, Monica B., Fraser, William D., Duthie, Susan J., Horgan, Graham W., Sneddon, Alan A.

“…Purpose Farmed fish are increasingly raised on feeds containing vegetable oils, which affects their composition and possibly health properties. We investigated…”
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Caspase-independence and characterization of bisnaphthalimidopropyl spermidine induced cytotoxicity in HL60 cells by Bestwick, Charles S., Milne, Lesley, Dance, Anne-Marie, Cochennec, Gaela, Cruickshank, Gillian, Allain, Eflamm, Constable, Lynda, Duthie, Susan J., Thoo Lin, Paul Kong

“…Bisnaphthalimides are DNA intercalators of potential use as chemotherapeutics but for which the range of mechanism of action is only gradually being…”
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