Search Results - "DUTCHER, J. S"
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Species differences in the disposition of inhaled butadiene
Published in Toxicology and applied pharmacology (01-07-1986)“…Recent chronic inhalation carcinogenicity studies of butadiene indicated that B6C3F1 mice are more sensitive to the tumorigenic effects of inhaled butadiene…”
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2
Renal toxicity due to reactive metabolites formed in situ in the kidney: investigations with 4-ipomeanol in the mouse
Published in The Journal of pharmacology and experimental therapeutics (01-03-1981)“…The in vitro metabolism and covalent binding of the furan derivative, 4-ipomeanol, was mediated by oxygen-requiring, NADPH-dependent, CO-inhibitable microsomal…”
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3
Uptake and excretion of [14C]methyl bromide as influenced by exposure concentration
Published in Toxicology and applied pharmacology (01-01-1985)“…Methyl bromide is a widely used soil fumigant and poses potential inhalation hazard to workers. Uptake of methyl bromide and pathways for excretion of 14C were…”
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4
Disposition of [14C]methyl bromide in Fischer-344 rats after oral or intraperitoneal administration
Published in Toxicology (Amsterdam) (01-01-1984)“…Methyl bromide is used as a disinfectant to fumigate soil. The intent of our study was to determine the disposition of methyl bromide following a single acute…”
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5
Disposition of [14C]2,3-dichloropropene in Fischer-344 rats after oral or intraperitoneal administration
Published in Toxicology letters (01-10-1984)“…2,3-Dichloropropene (2,3-DCP), a component of commercial fumigants and nematocides, was mixed with [14C]2,3-DCP and given to rats by peroral (p.o.) or…”
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6
Fractionation of diesel particle extracts by sephadex LH-20 and thin-layer chromatography
Published in Journal of applied toxicology (01-10-1985)“…A method was developed to concentrate fractions high in bacterial mutagenicity from diesel exhaust particle (DEP) extracts. The two-step fractionation of…”
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7
Ipomeanol 4-glucuronide, a major urinary metabolite of 4-ipomeanol in the rat
Published in Drug metabolism and disposition (01-05-1982)“…Urinary excretion and metabolism of 4-ipomeanol was studied in rats injected ip with the radiolabeled compound. There was a rapid elimination of radioactivity…”
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8
Fractionation, chemical analysis, and mutagenicity testing of low-Btu coal gasifier tar
Published in Environmental research (01-08-1983)“…A tar from a low-Btu coal gasifier was subjected to parallel fractionation, chemical analysis, and bacterial mutagenicity (Salmonella) assay. Like other…”
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9
Metabolism of 1-[14C]nitropyrene in isolated perfused rat livers
Published in Toxicology and applied pharmacology (30-09-1984)“…1-Nitropyrene (1-NP), a constituent of diesel exhaust, is carcinogenic to rats and is a bacterial and mammalian mutagen. Biliary and fecal excretion of 1-NP…”
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10
Determination of plasma procainamide and N-acetylprocainamide concentration by high-pressure liquid chromatography
Published in Clinical chemistry (Baltimore, Md.) (01-07-1977)“…We describe a routine method for determining concentrations of the antiarrhythmic drug procainamide and its active metabolite, N-acetylprocainamide, in plasma…”
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11
Distribution and elimination of inhaled phenanthridone in Fischer-344 rats
Published in Journal of toxicology and environmental health (01-10-1983)“…Aza-arenes are widely distributed in the environment. Certain members of this chemical class are biologically active and therefore could pose health hazards to…”
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12
Binding of nitropyrenes and benzo[a]pyrene to mouse lung deoxyribonucleic acid after pretreatment with inducing agents
Published in Biochemical pharmacology (01-07-1986)“…In assessing the biological effects of exposure to a complex chemical mixture, it is important to determine how the behavior of one compound may be influenced…”
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13
In vitro cytotoxicity to alveolar macrophages of tar from a low-Btu coal gasifier
Published in Environmental research (1983)“…The cytotoxicity of fractions, subfractions, and some individual components present in tar from a low-Btu coal gasifier was determined in vitro with cultured…”
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14
Mutagenicity of used crankcase oils from diesel and spark ignition automobiles
Published in Environmental research (01-06-1986)“…The Salmonella mutagenicity assay was used to compare the mutagenic activity of used crankcase oil (UCO) from diesel and spark-ignition (gasoline) engine…”
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15
Detection of nitroaromatic compounds on coal combustion particles
Published in Journal of toxicology and environmental health (01-04-1983)“…Mutagenic and nonmutagenic extracts of fly ash from fluidized bed combustion were analyzed to determine the compounds responsible for the direct mutagenic…”
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16
Disposition and metabolism of 2,3-[14C]dichloropropene in rats after inhalation
Published in Toxicology and applied pharmacology (30-03-1985)“…2,3-Dichloropropene (2,3-DCP) is a constituent of some commercially available preplant soil fumigants for the control of plant parasitic nematodes. Human…”
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17
Chemical and biological characterization of volatile components of environmental samples after fractionation by vacuum line cryogenic distillation
Published in Archives of environmental contamination and toxicology (01-05-1985)“…Volatile components from diesel exhaust particles and coal gasifier process gas condensate were vacuum fractionated by cryogenic distillation and identified by…”
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18
Contribution of primary aromatic amines to the mutagenicity of gasifier tars and coal oils
Published in Mutation research (01-01-1985)“…Two reactions that chemically alter primary aromatic amines (PAA) were used to assess the contribution of these compounds to the indirect bacterial…”
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19
Generation and characterization of radiolabeled diesel exhaust
Published in American Industrial Hygiene Association journal (01-07-1984)“…To evaluate the potential health risks associated with increased use of diesel engines, information is needed on the biological fate of inhaled diesel exhaust…”
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20
A sensitive and specific assay for pentamethylmelamine in plasma: applicability to clinical studies
Published in Cancer treatment reports (01-01-1980)“…A sensitive and specific procedure for measuring plasma levels of pentamethylmelamine (PMM), a chemotherapeutic agent currently undergoing phase I trials, has…”
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