Search Results - "DURING, Matthew"

Distinct Modes of AMPA Receptor Suppression at Developing Synapses by GluN2A and GluN2B: Single-Cell NMDA Receptor Subunit Deletion In Vivo by Gray, John A., Shi, Yun, Usui, Hiroshi, During, Matthew J., Sakimura, Kenji, Nicoll, Roger A.

“…During development there is an activity-dependent switch in synaptic N-Methyl-D-aspartate (NMDA) receptor subunit composition from predominantly GluN2B to…”
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White to Brown Fat Phenotypic Switch Induced by Genetic and Environmental Activation of a Hypothalamic-Adipocyte Axis by Cao, Lei, Choi, Eugene Y., Liu, Xianglan, Martin, Adam, Wang, Chuansong, Xu, Xiaohua, During, Matthew J.

“…Living in an enriched environment with complex physical and social stimulation leads to improved cognitive and metabolic health. In white fat, enrichment…”
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Retinal gene therapy in patients with choroideremia: initial findings from a phase 1/2 clinical trial by MacLaren, Robert E, Prof, Groppe, Markus, PhD, Barnard, Alun R, PhD, Cottriall, Charles L, PhD, Tolmachova, Tanya, PhD, Seymour, Len, Prof, Clark, K Reed, PhD, During, Matthew J, Prof, Cremers, Frans P M, Prof, Black, Graeme C M, Prof, Lotery, Andrew J, Prof, Downes, Susan M, FRCOphth, Webster, Andrew R, Prof, Seabra, Miguel C, Prof

“…Summary Background Choroideremia is an X-linked recessive disease that leads to blindness due to mutations in the CHM gene, which encodes the Rab escort…”
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Subunit Composition of Synaptic AMPA Receptors Revealed by a Single-Cell Genetic Approach by Lu, Wei, Shi, Yun, Jackson, Alexander C., Bjorgan, Kirsten, During, Matthew J., Sprengel, Rolf, Seeburg, Peter H., Nicoll, Roger A.

“…The precise subunit composition of synaptic ionotropic receptors in the brain is poorly understood. This information is of particular importance with regard to…”
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Adipose VEGF Links the White-to-Brown Fat Switch With Environmental, Genetic, and Pharmacological Stimuli in Male Mice by During, Matthew J, Liu, Xianglan, Huang, Wei, Magee, Daniel, Slater, Andrew, McMurphy, Travis, Wang, Chuansong, Cao, Lei

“…Living in an enriched environment (EE) decreases adiposity, increases energy expenditure, causes resistance to diet induced obesity, and induces brown-like…”
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Environmental and Genetic Activation of a Brain-Adipocyte BDNF/Leptin Axis Causes Cancer Remission and Inhibition by Cao, Lei, Liu, Xianglan, Lin, En-Ju D., Wang, Chuansong, Choi, Eugene Y., Riban, Veronique, Lin, Benjamin, During, Matthew J.

“…Cancer is influenced by its microenvironment, yet broader, environmental effects also play a role but remain poorly defined. We report here that mice living in…”
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Soticlestat, a novel cholesterol 24-hydroxylase inhibitor shows a therapeutic potential for neural hyperexcitation in mice by Nishi, Toshiya, Kondo, Shinichi, Miyamoto, Maki, Watanabe, Sayuri, Hasegawa, Shigeo, Kondo, Shigeru, Yano, Jason, Watanabe, Etsurou, Ishi, Tsuyoshi, Yoshikawa, Masato, Ando, Haruhi Kamisaki, Farnaby, William, Fujimoto, Shinji, Sunahara, Eiji, Ohori, Momoko, During, Matthew J., Kuroita, Takanobu, Koike, Tatsuki

“…Cholesterol 24-hydroxylase (CH24H) is a brain-specific enzyme that converts cholesterol into 24 S -hydroxycholesterol, the primary mechanism of cholesterol…”
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AAV2- GAD gene therapy for advanced Parkinson's disease: a double-blind, sham-surgery controlled, randomised trial by LeWitt, Peter A, Prof, Rezai, Ali R, Prof, Leehey, Maureen A, Prof, Ojemann, Steven G, MD, Flaherty, Alice W, MD, Eskandar, Emad N, MD, Kostyk, Sandra K, MD, Thomas, Karen, DO, Sarkar, Atom, MD, Siddiqui, Mustafa S, MD, Tatter, Stephen B, Prof, Schwalb, Jason M, MD, Poston, Kathleen L, MD, Henderson, Jaimie M, MD, Kurlan, Roger M, Prof, Richard, Irene H, MD, Van Meter, Lori, MS, Sapan, Christine V, PhD, During, Matthew J, Prof, Kaplitt, Michael G, MD, Feigin, Andrew, Dr

“…Summary Background Gene transfer of glutamic acid decarboxylase ( GAD ) and other methods that modulate production of GABA in the subthalamic nucleus improve…”
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Safety and tolerability of gene therapy with an adeno-associated virus (AAV) borne GAD gene for Parkinson's disease: an open label, phase I trial by Kaplitt, Michael G, MDPhD, Feigin, Andrew, MD, Tang, Chengke, MD, Fitzsimons, Helen L, PhD, Mattis, Paul, PhD, Lawlor, Patricia A, PhD, Bland, Ross J, PhD, Young, Deborah, PhD, Strybing, Kristin, MSc, Eidelberg, David, MD, During, Matthew J, MDDSc

“…Summary Background Dopaminergic neuronal loss in Parkinson's disease leads to changes in the circuitry of the basal ganglia, such as decreased inhibitory…”
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What Is the Brain-Cancer Connection? by LEI CAO, DURING, Matthew J

“…A focus of much cancer research is at the molecular and cellular levels. In contrast, the effects of social interactions and psychological state are less…”
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OV329, a novel highly potent γ‐aminobutyric acid aminotransferase inactivator, induces pronounced anticonvulsant effects in the pentylenetetrazole seizure threshold test and in amygdala‐kindled rats by Feja, Malte, Meller, Sebastian, Deking, Lillian S., Kaczmarek, Edith, During, Matthew J., Silverman, Richard B., Gernert, Manuela

“…Summary Objective An attractive target to interfere with epileptic brain hyperexcitability is the enhancement of γ‐aminobutyric acidergic (GABAergic)…”
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Restoration of Hearing in the VGLUT3 Knockout Mouse Using Virally Mediated Gene Therapy by Akil, Omar, Seal, Rebecca P., Burke, Kevin, Wang, Chuansong, Alemi, Aurash, During, Matthew, Edwards, Robert H., Lustig, Lawrence R.

“…Mice lacking the vesicular glutamate transporter-3 (VGLUT3) are congenitally deaf due to loss of glutamate release at the inner hair cell afferent synapse…”
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Long-term restoration of visual function in end-stage retinal degeneration using subretinal human melanopsin gene therapy by De Silva, Samantha R., Barnard, Alun R., Hughes, Steven, Tam, Shu K. E., Martin, Chris, Singh, Mandeep S., Barnea-Cramer, Alona O., McClements, Michelle E., During, Matthew J., Peirson, Stuart N., Hankins, Mark W., MacLaren, Robert E.

“…Optogenetic strategies to restore vision in patients who are blind from end-stage retinal degenerations aim to render remaining retinal cells light sensitive…”
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Soticlestat, a novel cholesterol 24‐hydroxylase inhibitor, reduces seizures and premature death in Dravet syndrome mice by Hawkins, Nicole A., Jurado, Manuel, Thaxton, Tyler T., Duarte, Samantha E., Barse, Levi, Tatsukawa, Tetsuya, Yamakawa, Kazuhiro, Nishi, Toshiya, Kondo, Shinichi, Miyamoto, Maki, Abrahams, Brett S., During, Matthew J., Kearney, Jennifer A.

“…Objective Dravet syndrome is a severe developmental and epileptic encephalopathy (DEE) most often caused by de novo pathogenic variants in SCN1A. Individuals…”
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Long-term follow-up after gene therapy for canavan disease by Leone, Paola, Shera, David, McPhee, Scott W J, Francis, Jeremy S, Kolodny, Edwin H, Bilaniuk, Larissa T, Wang, Dah-Jyuu, Assadi, Mitra, Goldfarb, Olga, Goldman, H Warren, Freese, Andrew, Young, Deborah, During, Matthew J, Samulski, R Jude, Janson, Christopher G

“…Canavan disease is a hereditary leukodystrophy caused by mutations in the aspartoacylase gene (ASPA), leading to loss of enzyme activity and increased…”
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Efficient Gene Delivery and Selective Transduction of Glial Cells in the Mammalian Brain by AAV Serotypes Isolated From Nonhuman Primates by Lawlor, Patricia A, Bland, Ross J, Mouravlev, Alexandre, Young, Deborah, During, Matthew J

“…Adeno-associated viral (AAV) vectors have become the primary delivery agent for somatic gene transfer into the central nervous system (CNS). To date,…”
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VEGF, a mediator of the effect of experience on hippocampal neurogenesis by During, Matthew J, Cao, Lei

“…Rodents housed in an enriched environment, exercise by running or perform learning and memory tasks show an increase in hippocampal neurogenesis. We show that…”
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Network modulation following sham surgery in Parkinson's disease by Ko, Ji Hyun, Feigin, Andrew, Mattis, Paul J, Tang, Chris C, Ma, Yilong, Dhawan, Vijay, During, Matthew J, Kaplitt, Michael G, Eidelberg, David

“…Patient responses to placebo and sham effects are a major obstacle to the development of therapies for brain disorders, including Parkinson's disease (PD)…”
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The STARS Phase 2 Study: A Randomized Controlled Trial of Gaboxadol in Angelman Syndrome by Bird, Lynne M., Ochoa-Lubinoff, Cesar, Tan, Wen-Hann, Heimer, Gali, Melmed, Raun D., Rakhit, Amit, Visootsak, Jeannie, During, Matthew J., Holcroft, Christina, Burdine, Rebecca D., Kolevzon, Alexander, Thibert, Ronald L.

“…To evaluate safety and tolerability and exploratory efficacy end points for gaboxadol (OV101) compared with placebo in individuals with Angelman syndrome (AS)…”
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NMDA receptors inhibit synapse unsilencing during brain development by Adesnik, Hillel, Li, Guangnan, During, Matthew J, Pleasure, Samuel J, Nicoll, Roger A

“…How the billions of synapses in the adult mammalian brain are precisely specified remains one of the fundamental questions of neuroscience. Although a genetic…”
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