Search Results - "DUNTEN, Pete"

Structure of Cinaciguat (BAY 58–2667) Bound to Nostoc H-NOX Domain Reveals Insights into Heme-mimetic Activation of the Soluble Guanylyl Cyclase by Martin, Faye, Baskaran, Padmamalini, Ma, Xiaolei, Dunten, Pete W., Schaefer, Martina, Stasch, Johannes-Peter, Beuve, Annie, van den Akker, Focco

“…Heme is a vital molecule for all life forms with heme being capable of assisting in catalysis, binding ligands, and undergoing redox changes. Heme-related…”
Get full text

Structural Variations and Solvent Structure of r(UGGGGU) Quadruplexes Stabilized by Sr(2+) Ions by Fyfe, Alastair C, Dunten, Pete W, Martick, Monika M, Scott, William G

“…Guanine-rich sequences can, under appropriate conditions, adopt a distinctive, four-stranded, helical fold known as a G-quadruplex. Interest in quadruplex…”
Get full text

New paradigm for macromolecular crystallography experiments at SSRL: automated crystal screening and remote data collection by Soltis, S. Michael, Cohen, Aina E., Deacon, Ashley, Eriksson, Thomas, González, Ana, McPhillips, Scott, Chui, Hsui, Dunten, Pete, Hollenbeck, Michael, Mathews, Irimpan, Miller, Mitch, Moorhead, Penjit, Phizackerley, R. Paul, Smith, Clyde, Song, Jinhu, Van Dem Bedem, Henry, Ellis, Paul, Kuhn, Peter, McPhillips, Timothy, Sauter, Nicholas, Sharp, Kenneth, Tsyba, Irina, Wolf, Guenter

“…Complete automation of the macromolecular crystallography experiment has been achieved at SSRL through the combination of robust mechanized experimental…”
Get full text

Domain swapping in allosteric modulation of DNA specificity by Park, Chad K, Joshi, Hemant K, Agrawal, Alka, Ghare, M Imran, Little, Elizabeth J, Dunten, Pete W, Bitinaite, Jurate, Horton, Nancy C

“…SgrAI is a type IIF restriction endonuclease that cuts an unusually long recognition sequence and exhibits allosteric self-modulation of cleavage activity and…”
Get full text

Discovery of piperidin-4-yl-aminopyrimidines as HIV-1 reverse transcriptase inhibitors. N-Benzyl derivatives with broad potency against resistant mutant viruses by Kertesz, Denis J., Brotherton-Pleiss, Christine, Yang, Minmin, Wang, Zhanguo, Lin, Xianfeng, Qiu, Zongxing, Hirschfeld, Donald R., Gleason, Shelley, Mirzadegan, Taraneh, Dunten, Pete W., Harris, Seth F., Villaseñor, Armando G., Hang, Julie Qi, Heilek, Gabrielle M., Klumpp, Klaus

“…An analysis of the binding motifs of known HIV-1 non-nucleoside reverse transcriptase inhibitors has led to discovery of novel piperidine-linked…”
Get full text

Structure of an archaeal-type phosphoenolpyruvate carboxylase sensitive to inhibition by aspartate by Dharmarajan, Lakshmi, Kraszewski, Jessica L., Mukhopadhyay, Biswarup, Dunten, Pete W.

“…The crystal structure of an archaeal‐type phosphoenolpyruvate carboxylase from Clostridium perfringens has been determined based on X‐ray data extending to 3…”
Get full text

New clues in the allosteric activation of DNA cleavage by SgrAI: structures of SgrAI bound to cleaved primary-site DNA and uncleaved secondary-site DNA by Little, Elizabeth J., Dunten, Pete W., Bitinaite, Jurate, Horton, Nancy C.

“…SgrAI is a type II restriction endonuclease that cuts an unusually long recognition sequence and exhibits allosteric self‐activation with expansion of…”
Get full text

structure of SgrAI bound to DNA; recognition of an 8 base pair target by Dunten, Pete W, Little, Elizabeth J, Gregory, Mark T, Manohar, Veena M, Dalton, Michael, Hough, David, Bitinaite, Jurate, Horton, Nancy C

“…The three-dimensional X-ray crystal structure of the 'rare cutting' type II restriction endonuclease SgrAI bound to cognate DNA is presented. SgrAI forms a…”
Get full text

X-ray Structure of a Hydroxylase−Regulatory Protein Complex from a Hydrocarbon-Oxidizing Multicomponent Monooxygenase, Pseudomonas sp. OX1 Phenol Hydroxylase by Sazinsky, Matthew H, Dunten, Pete W, McCormick, Michael S, DiDonato, Alberto, Lippard, Stephen J

“…Phenol hydroxylase (PH) belongs to a family of bacterial multicomponent monooxygenases (BMMs) with carboxylate-bridged diiron active sites. Included are…”
Get full text

Structural Variations and Solvent Structure of r(UGGGGU) Quadruplexes Stabilized by Sr2+ Ions by Fyfe, Alastair C., Dunten, Pete W., Martick, Monika M., Scott, William G.

“…Guanine-rich sequences can, under appropriate conditions, adopt a distinctive, four-stranded, helical fold known as a G-quadruplex. Interest in quadruplex…”
Get full text

Remote access to crystallography beamlines at SSRL: novel tools for training, education and collaboration by Smith, Clyde A., Card, Graeme L., Cohen, Aina E., Doukov, Tzanko I., Eriksson, Thomas, Gonzalez, Ana M., McPhillips, Scott E., Dunten, Pete W., Mathews, Irimpan I., Song, Jinhu, Soltis, S. Michael

“…For the past five years, the Structural Molecular Biology group at the Stanford Synchrotron Radiation Lightsource (SSRL) has provided general users of the…”
Get full text

Insights into the Structure and Regulation of Glucokinase from a Novel Mutation (V62M), Which Causes Maturity-onset Diabetes of the Young by Gloyn, Anna L., Odili, Stella, Zelent, Dorothy, Buettger, Carol, Castleden, Harriet A.J., Steele, Anna M., Stride, Amanda, Shiota, Chyio, Magnuson, Mark A., Lorini, Renata, d'Annunzio, Giuseppe, Stanley, Charles A., Kwagh, Jae, van Schaftingen, Emile, Veiga-da-Cunha, Maria, Barbetti, Fabrizio, Dunten, Pete, Han, Yi, Grimsby, Joseph, Taub, Rebecca, Ellard, Sian, Hattersley, Andrew T., Matschinsky, Franz M.

“…Glucokinase (GCK) serves as the pancreatic glucose sensor. Heterozygous inactivating GCK mutations cause hyperglycemia, whereas activating mutations cause…”
Get full text

Crystal structure of human cytosolic phosphoenolpyruvate carboxykinase reveals a new GTP-binding site by Dunten, Pete, Belunis, Charles, Crowther, Robert, Hollfelder, Kurt, Kammlott, Ursula, Levin, Wayne, Michel, Hanspeter, Ramsey, Gwendolyn B, Swain, Amy, Weber, David, Wertheimer, Stanley J

“…We report crystal structures of the human enzyme phosphoenolpyruvate carboxykinase (PEPCK) with and without bound substrates. These structures are the first to…”
Get full text

The restriction enzyme SgrAI: structure solution via combination of poor MIRAS and MR phases by Dunten, Pete W., Little, Elizabeth J., Horton, Nancy C.

“…Uninterpretable electron‐density maps were obtained using either MIRAS phases or MR phases in attempts to determine the structure of the type II restriction…”
Get full text

Expression, purification and crystallization of an archaeal-type phosphoenolpyruvate carboxylase by Dharmarajan, Lakshmi, Kraszewski, Jessica L., Mukhopadhyay, Biswarup, Dunten, Pete W.

“…An archaeal‐type phosphoenolpyruvate carboxylase (PepcA) from Clostridium perfringens has been expressed in Escherichia coli in a soluble form with an…”
Get full text

Structural insights into sGC activation by different activators by van den Akker, Focco, Martin, Faye, Kumar, Vijay, Ma, Xiaolei, Stasch, Johannes-Peter, Schaefer, Martina, Baskaran, Padmamalini, Beuve, Annie, van Dunten, Pete W

Get full text

Crystal structure of the dipeptide binding protein from Escherichia coli involved in active transport and chemotaxis by Dunten, Pete, Mowbray, Sherry L.

“…The Escherichia coli periplasmic dipeptide binding protein functions in both peptide transport and taxis toward peptides. The structure of the dipeptide…”
Get full text

Mutations That Affect Ligand Binding to the Escherichia coli Aspartate Receptor by Björkman, A. Malin, Dunten, Pete, Sandgren, Mats O.J., Dwarakanath, Vangipuram N., Mowbray, Sherry L.

“…Three arginine residues of the binding site of the Escherichia coli aspartate receptor contribute to its high affinity for aspartate (Kd ∼3 μm). Site-directed…”
Get full text

Structure and specificity of FEN-1 from Methanopyrus kandleri by Shah, Santosh, Dunten, Pete, Stiteler, Amanda, Park, Chad K., Horton, Nancy C.

“…ABSTRACT DNA repair is fundamental to genome stability and is found in all three domains of life. However many archaeal species, such as Methanopyrus kandleri,…”
Get full text

Discovery of potent and bioavailable GSK-3β inhibitors by Gong, Leyi, Hirschfeld, Don, Tan, Yun-Chou, Heather Hogg, J., Peltz, Gary, Avnur, Zafrira, Dunten, Pete

“…A series of maleimides was discovered with high potency and good selectivity for GSK-3β. The most potent compound 34 has an IC 50 of 0.6 nM for GSK-3β, over…”
Get full text