Search Results - "DUNNING, Alison"

Beyond GWASs: Illuminating the Dark Road from Association to Function by Edwards, Stacey L., Beesley, Jonathan, French, Juliet D., Dunning, Alison M.

“…Genome-wide association studies (GWASs) have enabled the discovery of common genetic variation contributing to normal and pathological traits and clinical drug…”
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From candidate gene studies to GWAS and post-GWAS analyses in breast cancer by Fachal, Laura, Dunning, Alison M

“…There are now more than 90 established breast cancer risk loci, with 57 new ones, revealed through genome-wide-association studies (GWAS) during the last two…”
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Shortened telomere length is associated with increased risk of cancer: a meta-analysis by Ma, Hongxia, Zhou, Ziyuan, Wei, Sheng, Liu, Zhensheng, Pooley, Karen A, Dunning, Alison M, Svenson, Ulrika, Roos, Göran, Hosgood, 3rd, H Dean, Shen, Min, Wei, Qingyi

“…Telomeres play a key role in the maintenance of chromosome integrity and stability, and telomere shortening is involved in initiation and progression of…”
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Germline BRCA mutation and outcome in young-onset breast cancer (POSH): a prospective cohort study by Copson, Ellen R, Maishman, Tom C, Tapper, Will J, Cutress, Ramsey I, Greville-Heygate, Stephanie, Altman, Douglas G, Eccles, Bryony, Gerty, Sue, Durcan, Lorraine T, Jones, Louise, Evans, D Gareth, Thompson, Alastair M, Pharoah, Paul, Easton, Douglas F, Dunning, Alison M, Hanby, Andrew, Lakhani, Sunil, Eeles, Ros, Gilbert, Fiona J, Hamed, Hisham, Hodgson, Shirley, Simmonds, Peter, Stanton, Louise, Eccles, Diana M

“…Retrospective studies provide conflicting interpretations of the effect of inherited genetic factors on the prognosis of patients with breast cancer. The…”
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Reproducibility of telomere length assessment: an international collaborative study by Martin-Ruiz, Carmen M, Baird, Duncan, Roger, Laureline, Boukamp, Petra, Krunic, Damir, Cawthon, Richard, Dokter, Martin M, van der Harst, Pim, Bekaert, Sofie, de Meyer, Tim, Roos, Goran, Svenson, Ulrika, Codd, Veryan, Samani, Nilesh J, McGlynn, Liane, Shiels, Paul G, Pooley, Karen A, Dunning, Alison M, Cooper, Rachel, Wong, Andrew, Kingston, Andrew, von Zglinicki, Thomas

“…Telomere length is a putative biomarker of ageing, morbidity and mortality. Its application is hampered by lack of widely applicable reference ranges and…”
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DNA damage and hormone-related cancer: a repair pathway view by Pooley, Karen A, Dunning, Alison M

“…Abstract In this short review, we examine the overlap between genes known to be mutated in the germlines of individuals at risk of breast, ovarian and prostate…”
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Normal tissue reactions to radiotherapy: towards tailoring treatment dose by genotype by Barnett, Gillian C, West, Catherine M. L, Dunning, Alison M, Elliott, Rebecca M, Coles, Charlotte E, Pharoah, Paul D. P, Burnet, Neil G

“…Variation in sensitivity to radiation is an inherited genetic trait. This Perspective explores the possibility of genome-wide association studies to…”
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Identification of 19 new risk loci and potential regulatory mechanisms influencing susceptibility to testicular germ cell tumor by Litchfield, Kevin, Levy, Max, Orlando, Giulia, Loveday, Chey, Law, Philip J, Migliorini, Gabriele, Holroyd, Amy, Broderick, Peter, Karlsson, Robert, Haugen, Trine B, Kristiansen, Wenche, Nsengimana, Jérémie, Fenwick, Kerry, Assiotis, Ioannis, Kote-Jarai, ZSofia, Dunning, Alison M, Muir, Kenneth, Peto, Julian, Eeles, Rosalind, Easton, Douglas F, Dudakia, Darshna, Orr, Nick, Pashayan, Nora, Bishop, D Timothy, Reid, Alison, Huddart, Robert A, Shipley, Janet, Grotmol, Tom, Wiklund, Fredrik, Houlston, Richard S, Turnbull, Clare

“…Clare Turnbull and colleagues report discovery of 19 new susceptibility loci for testicular germ cell tumor (TGCT) and provide evidence for a network of…”
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Telomere length and common disease: study design and analytical challenges by Barrett, Jennifer H., Iles, Mark M., Dunning, Alison M., Pooley, Karen A.

“…Telomeres, the repetitive sequences that protect the ends of chromosomes, help to maintain genomic integrity and are of key importance to human health. The aim…”
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Evidence of a Causal Association Between Insulinemia and Endometrial Cancer: A Mendelian Randomization Analysis by Nead, Kevin T, Sharp, Stephen J, Thompson, Deborah J, Painter, Jodie N, Savage, David B, Semple, Robert K, Barker, Adam, Perry, John R B, Attia, John, Dunning, Alison M, Easton, Douglas F, Holliday, Elizabeth, Lotta, Luca A, O'Mara, Tracy, McEvoy, Mark, Pharoah, Paul D P, Scott, Rodney J, Spurdle, Amanda B, Langenberg, Claudia, Wareham, Nicholas J, Scott, Robert A

“…Insulinemia and type 2 diabetes (T2D) have been associated with endometrial cancer risk in numerous observational studies. However, the causality of these…”
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Rare, protein-truncating variants in ATM , CHEK2 and PALB2 , but not XRCC2 , are associated with increased breast cancer risks by Decker, Brennan, Allen, Jamie, Luccarini, Craig, Pooley, Karen A, Shah, Mitul, Bolla, Manjeet K, Wang, Qin, Ahmed, Shahana, Baynes, Caroline, Conroy, Don M, Brown, Judith, Luben, Robert, Ostrander, Elaine A, Pharoah, Paul Dp, Dunning, Alison M, Easton, Douglas F

“…Breast cancer (BC) is the most common malignancy in women and has a major heritable component. The risks associated with most rare susceptibility variants are…”
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Genome-wide association study identifies five new breast cancer susceptibility loci by Turnbull, Clare, Ahmed, Shahana, Morrison, Jonathan, Pernet, David, Renwick, Anthony, Maranian, Mel, Seal, Sheila, Ghoussaini, Maya, Hines, Sarah, Healey, Catherine S, Hughes, Deborah, Warren-Perry, Margaret, Tapper, William, Eccles, Diana, Evans, D Gareth, Hooning, Maartje, Schutte, Mieke, van den Ouweland, Ans, Houlston, Richard, Ross, Gillian, Langford, Cordelia, Pharoah, Paul D P, Stratton, Michael R, Dunning, Alison M, Rahman, Nazneen, Easton, Douglas F

“…Douglas Easton and colleagues report a genome-wide association study for breast cancer, identifying five new susceptibility loci. Breast cancer is the most…”
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Independent validation of genes and polymorphisms reported to be associated with radiation toxicity: a prospective analysis study by Barnett, Gillian C, Dr, Coles, Charlotte E, PhD, Elliott, Rebecca M, MRes, Baynes, Caroline, Luccarini, Craig, BSc, Conroy, Don, Wilkinson, Jennifer S, BSc, Tyrer, Jonathan, PhD, Misra, Vivek, MB BS, Platte, Radka, BSc, Gulliford, Sarah L, PhD, Sydes, Matthew R, MSc, Hall, Emma, PhD, Bentzen, Søren M, Prof, Dearnaley, David P, Prof, Burnet, Neil G, PhD, Pharoah, Paul DP, PhD, Dunning, Alison M, PhD, West, Catharine ML, Prof

“…Summary Background Several studies have reported associations between radiation toxicity and single nucleotide polymorphisms (SNPs) in candidate genes. Few…”
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A three-stage genome-wide association study identifies a susceptibility locus for late radiotherapy toxicity at 2q24.1 by Fachal, Laura, Gómez-Caamaño, Antonio, Barnett, Gillian C, Peleteiro, Paula, Carballo, Ana M, Calvo-Crespo, Patricia, Kerns, Sarah L, Sánchez-García, Manuel, Lobato-Busto, Ramón, Dorling, Leila, Elliott, Rebecca M, Dearnaley, David P, Sydes, Matthew R, Hall, Emma, Burnet, Neil G, Carracedo, Ángel, Rosenstein, Barry S, West, Catharine M L, Dunning, Alison M, Vega, Ana

“…Ana Vega and colleagues report the results of a three-stage genome-wide association study of radiotherapy toxicity following treatment for prostate cancer…”
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A Mendelian randomization analysis of circulating lipid traits and breast cancer risk by Beeghly-Fadiel, Alicia, Khankari, Nikhil K, Delahanty, Ryan J, Shu, Xiao-Ou, Lu, Yingchang, Schmidt, Marjanka K, Bolla, Manjeet K, Michailidou, Kyriaki, Wang, Qin, Dennis, Joe, Yannoukakos, Drakoulis, Dunning, Alison M, Pharoah, Paul D P, Chenevix-Trench, Georgia, Milne, Roger L, Hunter, David J, Per, Hall, Kraft, Peter, Simard, Jacques, Easton, Douglas F, Zheng, Wei

“…Abstract Background Conventional epidemiologic studies have evaluated associations between circulating lipid levels and breast cancer risk, but results have…”
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Most common 'sporadic' cancers have a significant germline genetic component by Lu, Yi, Ek, Weronica E, Whiteman, David, Vaughan, Thomas L, Spurdle, Amanda B, Easton, Douglas F, Pharoah, Paul D, Thompson, Deborah J, Dunning, Alison M, Hayward, Nicholas K, Chenevix-Trench, Georgia, Macgregor, Stuart

“…Common cancers have been demarcated into 'hereditary' or 'sporadic' ('non-hereditary') types historically. Such distinctions initially arose from work…”
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A genome-wide association study of radiotherapy induced toxicity in head and neck cancer patients identifies a susceptibility locus associated with mucositis by Schack, Line M. H., Naderi, Elnaz, Fachal, Laura, Dorling, Leila, Luccarini, Craig, Dunning, Alison M., Ong, Enya H. W., Chua, Melvin L. K., Langendijk, Johannes A., Alizadeh, Behrooz Z., Overgaard, Jens, Eriksen, Jesper Grau, Andreassen, Christian Nicolaj, Alsner, Jan

“…Purpose A two-stage genome-wide association study was carried out in head and neck cancer (HNC) patients aiming to identify genetic variants associated with…”
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Chromatin interactome mapping at 139 independent breast cancer risk signals by Beesley, Jonathan, Sivakumaran, Haran, Moradi Marjaneh, Mahdi, Lima, Luize G, Hillman, Kristine M, Kaufmann, Susanne, Tuano, Natasha, Hussein, Nehal, Ham, Sunyoung, Mukhopadhyay, Pamela, Kazakoff, Stephen, Lee, Jason S, Michailidou, Kyriaki, Barnes, Daniel R, Antoniou, Antonis C, Fachal, Laura, Dunning, Alison M, Easton, Douglas F, Waddell, Nicola, Rosenbluh, Joseph, Möller, Andreas, Chenevix-Trench, Georgia, French, Juliet D, Edwards, Stacey L

“…Genome-wide association studies have identified 196 high confidence independent signals associated with breast cancer susceptibility. Variants within these…”
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A novel recurrent mutation in MITF predisposes to familial and sporadic melanoma by Yokoyama, Satoru, Woods, Susan L., Boyle, Glen M., Aoude, Lauren G., MacGregor, Stuart, Zismann, Victoria, Gartside, Michael, Cust, Anne E., Haq, Rizwan, Harland, Mark, Taylor, John C., Duffy, David L., Holohan, Kelly, Dutton-Regester, Ken, Palmer, Jane M., Bonazzi, Vanessa, Stark, Mitchell S., Symmons, Judith, Law, Matthew H., Schmidt, Christopher, Lanagan, Cathy, O’Connor, Linda, Holland, Elizabeth A., Schmid, Helen, Maskiell, Judith A., Jetann, Jodie, Ferguson, Megan, Jenkins, Mark A., Kefford, Richard F., Giles, Graham G., Armstrong, Bruce K., Aitken, Joanne F., Hopper, John L., Whiteman, David C., Pharoah, Paul D., Easton, Douglas F., Dunning, Alison M., Newton-Bishop, Julia A., Montgomery, Grant W., Martin, Nicholas G., Mann, Graham J., Bishop, D. Timothy, Tsao, Hensin, Trent, Jeffrey M., Fisher, David E., Hayward, Nicholas K., Brown, Kevin M.

“…Whole-genome sequencing identifies a novel germline variant in the oncogene MITF , which is associated with the development of melanoma. MITF , a melanoma…”
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Non-coding RNAs underlie genetic predisposition to breast cancer by Moradi Marjaneh, Mahdi, Beesley, Jonathan, O'Mara, Tracy A, Mukhopadhyay, Pamela, Koufariotis, Lambros T, Kazakoff, Stephen, Hussein, Nehal, Fachal, Laura, Bartonicek, Nenad, Hillman, Kristine M, Kaufmann, Susanne, Sivakumaran, Haran, Smart, Chanel E, McCart Reed, Amy E, Ferguson, Kaltin, Saunus, Jodi M, Lakhani, Sunil R, Barnes, Daniel R, Antoniou, Antonis C, Dinger, Marcel E, Waddell, Nicola, Easton, Douglas F, Dunning, Alison M, Chenevix-Trench, Georgia, Edwards, Stacey L, French, Juliet D

“…Genetic variants identified through genome-wide association studies (GWAS) are predominantly non-coding and typically attributed to altered regulatory elements…”
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