Search Results - "DUNCAN CAMPBELL, R"

Discovery of novel GPVI receptor antagonists by structure-based repurposing by Taylor, Lewis, Vasudevan, Sridhar R, Jones, Chris I, Gibbins, Jonathan M, Churchill, Grant C, Campbell, R Duncan, Coxon, Carmen H

“…Inappropriate platelet aggregation creates a cardiovascular risk that is largely managed with thienopyridines and aspirin. Although effective, these drugs…”
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An investigation of hierachical protein recruitment to the inhibitory platelet receptor, G6B-b by Coxon, Carmen H, Sadler, Amanda J, Huo, Jiandong, Campbell, R Duncan

“…Platelet activation is regulated by both positive and negative signals. G6B-b is an inhibitory platelet receptor with an immunoreceptor tyrosine-based…”
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The novel inhibitory receptor G6B is expressed on the surface of platelets and attenuates platelet function in vitro by Newland, Stephen A., Macaulay, Iain C., Floto, Andres R., de Vet, Edwin C., Ouwehand, Willem H., Watkins, Nicholas A., Lyons, Paul A., Campbell, Duncan R.

“…The G6B cell-surface receptor, which contains a single Ig-like domain, has been shown to bind to SHP-1 and SHP-2 after phosphorylation of 2 immunoreceptor…”
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NAADP regulates human platelet function by Coxon, Carmen H, Lewis, Alexander M, Sadler, Amanda J, Vasudevan, Sridhar R, Thomas, Andrew, Dundas, Kirsten A, Taylor, Lewis, Campbell, R Duncan, Gibbins, Jonathan M, Churchill, Grant C, Tucker, Katherine L

“…Platelets play a vital role in maintaining haemostasis. Human platelet activation depends on Ca2+ release, leading to cell activation, granule secretion and…”
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Organization and evolution of a gene-rich region of the mouse genome: a 12.7-Mb region deleted in the Del(13)Svea36H mouse by Mallon, Ann-Marie, Wilming, Laurens, Weekes, Joseph, Gilbert, James G R, Ashurst, Jennifer, Peyrefitte, Sandrine, Matthews, Lucy, Cadman, Matthew, McKeone, Richard, Sellick, Chris A, Arkell, Ruth, Botcherby, Marc R M, Strivens, Mark A, Campbell, R Duncan, Gregory, Simon, Denny, Paul, Hancock, John M, Rogers, Jane, Brown, Steve D M

“…Del(13)Svea36H (Del36H) is a deletion of approximately 20% of mouse chromosome 13 showing conserved synteny with human chromosome 6p22.1-6p22.3/6p25. The human…”
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Genetic Variability of Immunomodulatory Genes in Ectromelia Virus Isolates Detected by Denaturing High-Performance Liquid Chromatography by Ribas, Gloria, Rivera, Jose, Saraiva, Margarida, Campbell, R Duncan, Alcami, Antonio

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Mycobacterial Cells Have Dual Nickel-Cobalt Sensors: SEQUENCE RELATIONSHIPS AND METAL SITES OF METAL-RESPONSIVE REPRESSORS ARE NOT CONGRUENT by Campbell, Duncan R, Chapman, Kaye E, Waldron, Kevin J, Tottey, Stephen, Kendall, Sharon, Cavallaro, Gabriele, Andreini, Claudia, Hinds, Jason, Stoker, Neil G, Robinson, Nigel J, Cavet, Jennifer S

“…A novel ArsR-SmtB family transcriptional repressor, KmtR, has been characterized from mycobacteria. Mutants of Mycobacterium tuberculosis lacking kmtR show…”
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Characterization of the five novel Ly‐6 superfamily members encoded in the MHC, and detection of cells expressing their potential ligands by Mallya, Meera, Campbell, R. Duncan, Aguado, Begoña

“…Lymphocyte Antigen 6 (Ly‐6) superfamily members are cysteine‐rich, generally GPI‐anchored cell surface proteins, which have definite or putative immune related…”
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Antisense transcripts in the human genome by Lehner, Ben, Williams, Gary, Campbell, R.Duncan, Sanderson, Christopher M.

“…By a systematic search of vertebrate mRNA sequences, we have identified a surprisingly large number of human antisense transcripts. These data suggest that…”
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Large-scale chromatin organization of the major histocompatibility complex and other regions of human chromosome 6 and its response to interferon in interphase nuclei by Volpi, E V, Chevret, E, Jones, T, Vatcheva, R, Williamson, J, Beck, S, Campbell, R D, Goldsworthy, M, Powis, S H, Ragoussis, J, Trowsdale, J, Sheer, D

“…The large-scale chromatin organization of the major histocompatibility complex and other regions of chromosome 6 was studied by three-dimensional image…”
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Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse by Xie, Tao, Rowen, Lee, Aguado, Begoña, Ahearn, Mary Ellen, Madan, Anup, Qin, Shizhen, Campbell, R Duncan, Hood, Leroy

“…In mammals, the Major Histocompatibility Complex class I and II gene clusters are separated by an approximately 700-kb stretch of sequence called the MHC class…”
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The G11 Gene Located in the Major Histocompatibility Complex Encodes a Novel Nuclear Serine/Threonine Protein Kinase by Gomez-Escobar, Natalia, Chou, Chun-Fen, Lin, Wan-Wan, Hsieh, Shie-Liang, Campbell, R. Duncan

“…Protein kinases are involved in signal transduction pathways and play fundamental roles in the regulation of cell functions. Here we report that the gene G11…”
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Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region by Lehner, Ben, Semple, Jennifer I, Brown, Stephanie E, Counsell, Damian, Campbell, R.Duncan, Sanderson, Christopher M

“…High-throughput (HTP) protein-interaction assays, such as the yeast two-hybrid (Y2H) system, are enormously useful in predicting the functions of novel…”
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Regulation of expression of two LY-6 family genes by intron retention and transcription induced chimerism by Calvanese, Vincenzo, Mallya, Meera, Campbell, R Duncan, Aguado, Begoña

“…Regulation of the expression of particular genes can rely on mechanisms that are different from classical transcriptional and translational control. The LY6G5B…”
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A molecular map of the human major histocompatibility complex class III region linking complement genes C4, C2 and factor B by Carroll, Michael C, Campbell, R. Duncan, Bentley, David R, Porter, Rodney R

“…Four human complement genes, which have previously been mapped between HLA-D and HLA-B on chromosome 6, have now been aligned on a 98-kilobase (kb) section of…”
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Characterization of a Human Lysophosphatidic Acid Acyltransferase That Is Encoded by a Gene Located in the Class III Region of the Human Major Histocompatibility Complex by Aguado, B, Campbell, R D

“…Sequence analysis of cDNA clones corresponding to a number of genes located in the class III region of the human major histocompatibility complex (MHC), in the…”
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Association of a haplotype for tumor necrosis factor in siblings with late-onset Alzheimer disease: The NIMH Alzheimer disease genetics initiative by Collins, Julianne S., Perry, Rodney T., Watson Jr, Bracie, Harrell, Lindy E., Acton, Ronald T., Blacker, Deborah, Albert, Marilyn S., Tanzi, Rudolph E., Bassett, Susan S., McInnis, Melvin G., Campbell, R. Duncan, Go, Rodney C.P.

“…Tumor necrosis factor (TNF), a proinflammatory cytokine, may be involved in the pathogenesis of Alzheimer disease (AD) based on observations that senile…”
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G6b, a Novel Immunoglobulin Superfamily Member Encoded in the Human Major Histocompatibility Complex, Interacts with SHP-1 and SHP-2 by de Vet, Edwin C.J.M., Aguado, Begoña, Campbell, R. Duncan

“…The G6b gene, located in the class III region of the human major histocompatibility complex, has been suggested to encode a putative receptor of the…”
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Transcriptional Analysis of a Novel Cluster of LY-6 Family Members in the Human and Mouse Major Histocompatibility Complex: Five Genes with Many Splice Forms by Mallya, Meera, Campbell, R.Duncan, Aguado, Begoña

“…Lymphocyte antigen-6 (LY-6) superfamily members are cysteine-rich, generally GPI-anchored cell surface proteins, which have definite or putative immune related…”
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The cell surface receptor G6b, a member of the immunoglobulin superfamily, binds heparin by de Vet, Edwin C.J.M., Newland, Stephen A.B., Lyons, Paul A., Aguado, Begoña, Campbell, R. Duncan

“…The G6b gene, located in the human Major Histocompatibility Complex, encodes a receptor of the immunoglobulin (Ig) superfamily. In this study, we show using a…”
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