Search Results - "DUNCAN, Melinda K"

A simple method for quantitating confocal fluorescent images by Shihan, Mahbubul H., Novo, Samuel G., Le Marchand, Sylvain J., Wang, Yan, Duncan, Melinda K.

“…Western blotting (WB), enzyme-linked immunosorbent assay (ELISA) and flow cytometry (FC) have long been used to assess and quantitate relative protein…”
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Genetic and epigenetic mechanisms of gene regulation during lens development by Cvekl, Ales, Duncan, Melinda K.

“…Recent studies demonstrated a number of links between chromatin structure, gene expression, extracellular signaling and cellular differentiation during lens…”
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Prox1 and fibroblast growth factor receptors form a novel regulatory loop controlling lens fiber differentiation and gene expression by Audette, Dylan S, Anand, Deepti, So, Tammy, Rubenstein, Troy B, Lachke, Salil A, Lovicu, Frank J, Duncan, Melinda K

“…Lens epithelial cells differentiate into lens fibers (LFs) in response to a fibroblast growth factor (FGF) gradient. This cell fate decision requires the…”
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β1-Integrin Deletion From the Lens Activates Cellular Stress Responses Leading to Apoptosis and Fibrosis by Wang, Yichen, Terrell, Anne M, Riggio, Brittany A, Anand, Deepti, Lachke, Salil A, Duncan, Melinda K

“…Previous research showed that the absence of β1-integrin from the mouse lens after embryonic day (E) 13.5 (β1MLR10) leads to the perinatal apoptosis of lens…”
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Abnormal Expression of Collagen IV in Lens Activates Unfolded Protein Response Resulting in Cataract by Firtina, Zeynep, Danysh, Brian P., Bai, Xiaoyang, Gould, Douglas B., Kobayashi, Takehiro, Duncan, Melinda K.

“…Human diseases caused by mutations in extracellular matrix genes are often associated with an increased risk of cataract and lens capsular rupture. However,…”
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Attenuation of Junctional Adhesion Molecule-A Is a Contributing Factor for Breast Cancer Cell Invasion by NAIK, Meghna U, NAIK, Tejal U, SUCKOW, Arthur T, DUNCAN, Melinda K, NAIK, Ulhas P

“…The metastatic potential of cancer cells is directly attributed to their ability to invade through the extracellular matrix. The mechanisms regulating this…”
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ATF4 May Be Essential for Adaption of the Ocular Lens to Its Avascular Environment by Xiang, Jiawen, Pompetti, Anthony J, Faranda, Adam P, Wang, Yan, Novo, Samuel G, Li, David Wan-Cheng, Duncan, Melinda K

“…The late embryonic mouse lens requires the transcription factor ATF4 for its survival although the underlying mechanisms were unknown. Here, RNAseq analysis…”
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The Immediate Early Response of Lens Epithelial Cells to Lens Injury by Novo, Samuel G, Faranda, Adam P, Shihan, Mahbubul H, Wang, Yan, Garg, Ananya, Duncan, Melinda K

“…Cataracts are treated by lens fiber cell removal followed by intraocular lens (IOL) implantation into the lens capsule. While effective, this procedure leaves…”
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αVβ8 integrin targeting to prevent posterior capsular opacification by Shihan, Mahbubul H, Novo, Samuel G, Wang, Yan, Sheppard, Dean, Atakilit, Amha, Arnold, Thomas D, Rossi, Nicole M, Faranda, Adam P, Duncan, Melinda K

“…Fibrotic posterior capsular opacification (PCO), a major complication of cataract surgery, is driven by transforming growth factor-β (TGF-β). Previously, αV…”
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Junctional adhesion molecule-A regulates vascular endothelial growth factor receptor-2 signaling-dependent mouse corneal wound healing by Chatterjee, Sharmila, Wang, Yan, Duncan, Melinda K, Naik, Ulhas P

“…Inflammation and angiogenesis are integral parts of wound healing. However, excessive and persistent wound-induced inflammation and angiogenesis in an…”
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Beta-1 integrin is important for the structural maintenance and homeostasis of differentiating fiber cells by Scheiblin, David A., Gao, Junyuan, Caplan, Jeffrey L., Simirskii, Vladimir N., Czymmek, Kirk J., Mathias, Richard T., Duncan, Melinda K.

“…•Lenses lacking β1-integrin are cataractous or transparent with refractive defects.•β1-Integrin F/F MLR 39 CRE+ lenses have abnormal fiber cell…”
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Lens Epithelial Cells Initiate an Inflammatory Response Following Cataract Surgery by Jiang, Jian, Shihan, Mahbubul H, Wang, Yan, Duncan, Melinda K

“…Lens epithelial cell (LEC) conversion to myofibroblast is responsible for fibrotic cataract surgery complications including posterior capsular opacification…”
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Lens Extrusion from Laminin Alpha 1 Mutant Zebrafish by Pathania, Mallika, Duncan, Melinda K., Semina, Elena V.

“…We report analysis of the ocular lens phenotype of the recessive, larval lethal zebrafish mutant, lama1 a69/a69. Previous work revealed that this mutant has a…”
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Requirement for Pax6 in corneal morphogenesis: a role in adhesion by Davis, Janine, Duncan, Melinda K, Robison, Jr, W Gerald, Piatigorsky, Joram

“…The Pax6 transcription factor functions early during embryogenesis to control key steps in brain, pancreas, olfactory and ocular system development. A…”
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Reduction of lens size in PAX6-related aniridia by Duncan, Melinda K., Daruich, Alejandra, Valleix, Sophie, Bremond-Gignac, Dominique

“…Heterozygous mutation of PAX6 in humans leads to congenital aniridia (OMIM 106210) which is typified by congenital iris and foveal defects, and later onset…”
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The aging mouse lens transcriptome by Faranda, Adam P., Shihan, Mahbubul H., Wang, Yan, Duncan, Melinda K.

“…Abstract Age is a major risk factor for cataract (ARC). However, the influence of aging on the lens transcriptome is under studied. Lens epithelial (LEC) and…”
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Fibronectin has multifunctional roles in posterior capsular opacification (PCO) by Shihan, Mahbubul H., Kanwar, Mallika, Wang, Yan, Jackson, Erin E., Faranda, Adam P., Duncan, Melinda K.

“…Fibrotic posterior capsular opacification (PCO), one of the major complications of cataract surgery, occurs when lens epithelial cells (LCs) left behind post…”
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The lens capsule by Danysh, Brian P., Duncan, Melinda K.

“…The lens capsule is a modified basement membrane that completely surrounds the ocular lens. It is known that this extracellular matrix is important for both…”
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The effect of sex on the mouse lens transcriptome by Faranda, Adam P., Shihan, Mahbubul H., Wang, Yan, Duncan, Melinda K.

“…The transcriptome of mammalian tissues differs between males and females, and these differences can change across the lifespan, likely regulating known sexual…”
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Modeling Cataract Surgery in Mice by O'Neill, Leah M, Wang, Yan, Duncan, Melinda K

“…Cataract surgery (CS) is an effective treatment for cataracts, a major cause of visual disability worldwide. However, CS leads to ocular inflammation, and in…”
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