Search Results - "DUMENCO, L. L"

The prevention of thymic lymphomas in transgenic mice by human O6-alkylguanine-DNA alkyltransferase by DUMENCO, L. L, ALLAY, E, NORTON, K, GERSON, S. L

“…Nitrosoureas form O6-alkylguanine-DNA adducts that are converted to G to A transitions, the mutation found in the activated ras oncogenes of…”
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Transgenic expression of human MGMT protects against azoxymethane-induced aberrant crypt foci and G to A mutations in the K-ras oncogene of mouse colon by Zaidi, N H, Pretlow, T P, O'Riordan, M A, Dumenco, L L, Allay, E, Gerson, S L

“…Transgenic mice over-expressing MGMT, which codes for the human protein O6-alkylguanine-DNA alkyltransferase, are protected from methylating agent-induced…”
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Retroviral Transduction and Expression of the Human Alkyltransferase cDNA Provides Nitrosourea Resistance to Hematopoietic Cells by Allay, James A., Dumenco, Luba L., Koc, Omer N., Liu, Lili, Gerson, Stanton L.

“…Myelosuppression is the dose-limiting toxicity for nitrosourea chemotherapy. This toxicity predominantly involves modification of the O6 position of guanine…”
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Determinants of O6-alkylguanine-DNA alkyltransferase activity in human colon cancer by GERSON, S. L, ALLAY, E, VITANTONIO, K, DUMENCO, L. L

“…The DNA repair protein O6-alkylguanine-DNA alkyltransferase (alkyltransferase) repairs cytotoxic DNA O6-alkylguanine adducts induced by the nitrosoureas,…”
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Analysis of the tumorigenicity of the X gene of hepatitis B virus in a nontransformed hepatocyte cell line and the effects of cotransfection with a murine p53 mutant equivalent to human codon 249 by Oguey, D, Dumenco, L L, Pierce, R H, Fausto, N

“…Chronic infection with hepatitis B virus (HBV) is associated with the development of human hepatocellular carcinoma (HCC). One of the HBV genes, HBx, may have…”
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Comparison of the inactivation of mammalian and bacterial O6-alkylguanine-DNA alkyltransferases by O6-benzylguanine and O6-methylguanine by Dolan, M E, Pegg, A E, Dumenco, L L, Moschel, R C, Gerson, S L

“…The inactivation of human and Escherichia coli O6-alkylguanine-DNA alkyltransferase by O6-methylguanine and O6-benzylguanine was compared. When HT29 cell…”
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The results of diagnostic studies for thrombophilia in a large group of patients with a personal or family history of thrombosis by DUMENCO, L. L, BLAIR, A. J, SWEENEY, J. D

“…The range of tests used in the evaluation of thrombophilia has been altered by the recent recognition of common genetic defects predisposing to thrombosis such…”
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Fetal Liver Hematopoietic Stem Cells As a Target for In Utero Retroviral Gene Transfer by Clapp, D.Wade, Dumenco, Luba L., Hatzoglou, Maria, Gerson, Stanton L.

“…Retroviral-mediated gene transfer into hematopoietic precur sors often results in only short-term gene transduction in vivo. Loss of the transduced genetic…”
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Opioid Overdose Hospitalizations among Medicare-Disability Beneficiaries by Peters, Jillian L, Durand, Wesley M, Monteiro, Kristina A, Dumenco, Luba, George, Paul

“…As the opioid epidemic progresses, a better understanding of those at elevated risk of opioid overdose is needed, particularly for populations whose growing…”
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Specificity of bischloroethylnitrosourea-induced mutation in a Chinese hamster ovary cell line transformed to express human O6-alkylguanine-DNA alkyltransferase by MINNICK, D. T, GERSON, S. L, DUMENCO, L. L, VEIGL, M. L, SEDWICK, W. D

“…The human O6-alkylguanine-DNA alkyltransferase complementary DNA was transfected into the alkyltransferase-deficient Chinese hamster ovary cell line, D422, in…”
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The immature thymocyte is protected from N-methylnitrosourea-induced lymphoma by the human MGMT-CD2 transgene by Zaidi, N H, Allay, E, Ayi, T C, Li, B F, Dumenco, L L, Sy, M S, Gerson, S L

“…N-methylnitrosourea (MNU) induces thymic lymphoma in a high proportion of susceptible C57BL/6xSJL (C57/SJL) mice. Expression of the human DNA repair gene, MGMT…”
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Human CD34+ hematopoietic progenitors have low, cytokine-unresponsive O6-alkylguanine-DNA alkyltransferase and are sensitive to O6-benzylguanine plus BCNU by GERSON, S. L, PHILLIPS, W, KASTAN, M, DUMENCO, L. L, DONOVAN, C

“…Human bone marrow (BM) cells contain low levels of the DNA repair protein, O6-alkylguanine-DNA alkyltransferase, which may explain their susceptibility to…”
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Increase in nitrosourea resistance in mammalian cells by retrovirally mediated gene transfer of bacterial O6-alkylguanine-DNA alkyltransferase by Dumenco, L L, Warman, B, Hatzoglou, M, Lim, I K, Abboud, S L, Gerson, S L

“…Maloney murine leukemia virus-based, replication-defective retroviral vectors containing the neomycin resistance gene (neo) were developed to transfer the…”
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Enhanced repair of O6-methylguanine DNA adducts in the liver of transgenic mice expressing the ada gene by DUMENCO, L. L, ARCE, C, NORTON, K, JEUNG YUN, WAGNER, T, GERSON, S. L

“…The capacity to repair O6-methylguanine-DNA adducts was measured in the liver of transgenic mice expressing a chimeric gene consisting of the inducible…”
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Introduction of a murine p53 mutation corresponding to human codon 249 into a murine hepatocyte cell line results in growth advantage, but not in transformation by Dumenco, L, Oguey, D, Wu, J, Messier, N, Fausto, N

“…The p53 gene is frequently mutated in human tumors; in hepatocellular carcinomas, there is a high frequency of a specific mutation at codon 249 in regions with…”
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Predicting United States Medical Licensure Examination Step 2 clinical knowledge scores from previous academic indicators by Monteiro, Kristina A, George, Paul, Dollase, Richard, Dumenco, Luba

“…The use of multiple academic indicators to identify students at risk of experiencing difficulty completing licensure requirements provides an opportunity to…”
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High level, regulated expression of the chimeric P-enolpyruvate carboxykinase (GTP)-bacterial O6-alkylguanine-DNA alkyltransferase (ada) gene in transgenic mice by IN KYOUNG LIM, DUMENCO, L. L, YUN, J, DONOVAN, C, WARMAN, B, GORODETZKAYA, N, WAGNER, T. E, WADE CLAPP, D, HANSON, R. W, GERSON, S. L

“…Transgenic animals expressing genes capable of repairing DNA may be a valuable tool to study the effect of DNA-damaging agents on tissue-specific…”
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Increased drug resistance following retroviral gene transfer of a chimeric P-enolpyruvate carboxykinase (GTP)-bacterial O6-alkylguanine-DNA alkyltransferase gene into NRK cells by Lim, I K, Dumenco, L L, Hatzoglou, M, Hanson, R W, Gerson, S L

“…Transfection of the Escherichia coli ada gene coding for O6-alkylguanine-DNA alkyltransferase results in expression of ada in mammalian cells and transmission…”
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Analysis of the tumorigenicity of the X gene of hepatitis B virus in a nontransformed hepatocyte cell line and the effects of cotransfection with a murine p53 mutant equivalent to human codon 249 by Oguey, D, Dumenco, LL, Pierce, RH, Fausto, N

“…Chronic infection with hepatitis B virus (HBV) is associated with the development of human hepatocellular carcinoma (HCC). One of the HBV genes, HBx, may have…”
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Rapid repair of O6-methylguanine-DNA adducts protects transgenic mice from N-methylnitrosourea-induced thymic lymphomas by Liu, L, Allay, E, Dumenco, L L, Gerson, S L

“…The methylating agent N-methylnitrosourea (MNU) is biased, surprisingly, in its carcinogenic potential toward the mouse thymus. Previous studies have shown…”
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