Search Results - "DUMAN, S"

Prefrontal cortex circuits in depression and anxiety: contribution of discrete neuronal populations and target regions by Hare, Brendan D., Duman, Ronald S.

“…Our understanding of depression and its treatment has advanced with the advent of ketamine as a rapid-acting antidepressant and the development and refinement…”
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Altered Connectivity in Depression: GABA and Glutamate Neurotransmitter Deficits and Reversal by Novel Treatments by Duman, Ronald S., Sanacora, Gerard, Krystal, John H.

“…The mechanisms underlying the pathophysiology and treatment of depression and stress-related disorders remain unclear, but studies in depressed patients and…”
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Neurotrophic mechanisms underlying the rapid and sustained antidepressant actions of ketamine by Deyama, Satoshi, Duman, Ronald S.

“…Clinical and preclinical studies have demonstrated that depression, one of the most common psychiatric illnesses, is associated with reduced levels of…”
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Role of BDNF in the pathophysiology and treatment of depression: Activity‐dependent effects distinguish rapid‐acting antidepressants by Duman, Ronald S., Deyama, Satoshi, Fogaça, Manoela Viar

“…The pathophysiology and treatment of depression have been the focus of intense research and while there is much that remains unknown, modern neurobiological…”
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Synaptic Dysfunction in Depression: Potential Therapeutic Targets by Duman, Ronald S., Aghajanian, George K.

“…Basic and clinical studies demonstrate that depression is associated with reduced size of brain regions that regulate mood and cognition, including the…”
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Signaling pathways underlying the pathophysiology and treatment of depression: novel mechanisms for rapid-acting agents by Duman, Ronald S, Voleti, Bhavya

“…Basic and clinical studies demonstrate that stress and depression are associated with atrophy and loss of neurons and glia, which contribute to the decreased…”
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Ketamine and rapid-acting antidepressants: a new era in the battle against depression and suicide [version 1; peer review: 3 approved] by Duman, Ronald S

“…Therapeutic medications for the treatment of depression have serious limitations, particularly delayed onset and low rates of efficacy. However, the discovery…”
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Pathophysiology of depression and innovative treatments: remodeling glutamatergic synaptic connections by Duman, Ronald S.

“…Despite the complexity and heterogeneity of mood disorders, basic and clinical research studies have begun to elucidate the pathophysiology of depression and…”
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Can melatonin be used for bruxism in children? by Duman, S.

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A neurotrophic hypothesis of depression: role of synaptogenesis in the actions of NMDA receptor antagonists by Duman, Ronald S., Li, Nanxin

“…Molecular and cellular studies have demonstrated opposing actions of stress and antidepressant treatment on the expression of neurotrophic factors,…”
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Synaptic plasticity and depression: new insights from stress and rapid-acting antidepressants by Duman, Ronald S, Aghajanian, George K, Sanacora, Gerard, Krystal, John H

“…Ron Duman and colleagues discuss recent insights into a role for circuit disruption in the mechanisms of stress-induced depression. Furthermore they discuss…”
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Metaverse in paediatric dentistry by Duman, S., Çelik Özen, D., Duman, Ş. B.

“…(2020) developed with augmented reality techniques to encourage children to brush their teeth. [...]the mental and physical development of children is…”
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Stress, Depression, and Neuroplasticity: A Convergence of Mechanisms by Pittenger, Christopher, Duman, Ronald S

“…Increasing evidence demonstrates that neuroplasticity, a fundamental mechanism of neuronal adaptation, is disrupted in mood disorders and in animal models of…”
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Cortical GABAergic Dysfunction in Stress and Depression: New Insights for Therapeutic Interventions by Fogaça, Manoela V, Duman, Ronald S

“…Major depressive disorder (MDD) is a debilitating illness characterized by neuroanatomical and functional alterations in limbic structures, notably the…”
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How do antidepressants work? New perspectives for refining future treatment approaches by Harmer, Catherine J, Prof, Duman, Ronald S, Prof, Cowen, Philip J, Prof

“…Summary Most currently available antidepressants target monoamine neurotransmitter function. However, a purely neurotransmitter-based explanation for…”
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Depression and sterile inflammation: Essential role of danger associated molecular patterns by Franklin, Tina C., Xu, Chelsea, Duman, Ronald S.

“…•Stress promotes the release of endogenous factors known as danger associated molecular patterns (DAMP).•DAMP-mediated sterile inflammation influence mood and…”
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Glial Loss in the Prefrontal Cortex Is Sufficient to Induce Depressive-like Behaviors by Banasr, Mounira, Duman, Ronald S

“…Background Postmortem studies have repeatedly found decreased density and number of glia in cortical regions, including the prefrontal and cingulate areas,…”
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Rapid-Acting Glutamatergic Antidepressants: The Path to Ketamine and Beyond by Krystal, John H, Sanacora, Gerard, Duman, Ronald S

“…Traditional antidepressants require many weeks to reveal their therapeutic effects. However, the widely replicated observation that a single subanesthetic dose…”
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Stress-Induced Neuronal Colony Stimulating Factor 1 Provokes Microglia-Mediated Neuronal Remodeling and Depressive-like Behavior by Wohleb, Eric S., Terwilliger, Rosemarie, Duman, Catharine H., Duman, Ronald S.

“…Chronic stress exposure causes neuronal atrophy and synaptic deficits in the medial prefrontal cortex (PFC), contributing to development of anxiety- and…”
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The inflammasome: Pathways linking psychological stress, depression, and systemic illnesses by Iwata, Masaaki, Ota, Kristie T, Duman, Ronald S

“…Highlight ► The inflammasome is a broad range sensor of danger signals and mediator of psychological and physical stressors that can lead to depression and…”
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