Search Results - "DULL, T. J"

Human proto‐oncogene c‐kit: a new cell surface receptor tyrosine kinase for an unidentified ligand by Yarden, Y., Kuang, W. J., Yang‐Feng, T., Coussens, L., Munemitsu, S., Dull, T. J., Chen, E., Schlessinger, J., Francke, U., Ullrich, A.

“…Structural features of v‐kit, the oncogene of HZ4 feline sarcoma virus, suggested that this gene arose by transduction and truncation of cellular sequences…”
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Functionally distinct insulin receptors generated by tissue‐specific alternative splicing by Mosthaf, L., Grako, K., Dull, T. J., Coussens, L., Ullrich, A., McClain, D. A.

“…Cloning of the insulin receptor cDNA has earlier revealed the existence of two alternative forms of the receptor differing by the presence or absence of 12…”
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Human insulin receptors mutated at the ATP-binding site lack protein tyrosine kinase activity and fail to mediate postreceptor effects of insulin by Chou, C K, Dull, T J, Russell, D S, Gherzi, R, Lebwohl, D, Ullrich, A, Rosen, O M

“…Transfected Chinese hamster ovary cell lines were developed that expressed equivalent numbers of either normal human receptor or receptor that had alanine…”
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A mutant insulin receptor with defective tyrosine kinase displays no biologic activity and does not undergo endocytosis by McClain, D A, Maegawa, H, Lee, J, Dull, T J, Ulrich, A, Olefsky, J M

“…The cDNAs encoding the normal human insulin receptor (HIRc) and a receptor that had lysine residue 1018 replaced by alanine (A/K1018) were used to transfect…”
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Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes by Ullrich, A, Bell, J. R, Chen, E. Y, Herrera, R, Petruzzelli, L. M, Dull, T. J, Gray, A, Coussens, L, Liao, Y.-C, Tsubokawa, M, Mason, A, Seeburg, P. H, Grunfeld, C, Rosen, O. M, Ramachandran, J

“…We have deduced the entire 1,370-amino-acid sequence of the human insulin receptor precursor from a single complementary DNA clone. The precursor starts with a…”
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Point mutation at the ATP binding site of EGF receptor abolishes protein-tyrosine kinase activity and alters cellular routing by Honegger, A M, Dull, T J, Felder, S, Van Obberghen, E, Bellot, F, Szapary, D, Schmidt, A, Ullrich, A, Schlessinger, J

“…Cultured NIH 3T3 cells devoid of endogenous EGF receptors were transfected with cDNA constructs encoding either the human EGF receptor or an EGF receptor…”
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Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells by Ullrich, A, Coussens, L, Hayflick, J. S, Dull, T. J, Gray, A, Tam, A. W, Lee, J, Yarden, Y, Libermann, T. A, Schlessinger, J, Downward, J, Mayes, E. L. V, Whittle, N, Waterfield, M. D, Seeburg, P. H

“…The complete 1,210-amino acid sequence of the human epidermal growth factor (EGF) receptor precursor, deduced from cDNA clones derived from placental and A431…”
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kat: A High-Efficiency Retroviral Transduction System for Primary Human T Lymphocytes by Finer, Mitchell H., Dull, Thomas J., Qin, Lu, Farson, Deborah, Roberts, Margo R.

“…We describe a novel retroviral packaging system in which high titer amphotropic retrovirus was produced without the need to generate stable producer clones,…”
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HER2 cytoplasmic domain generates normal mitogenic and transforming signals in a chimeric receptor by Lee, J., Dull, T. J., Lax, I., Schlessinger, J., Ullrich, A.

“…We have investigated the biological function of an unidentified human growth factor, the ligand of the putative HER2 receptor, by characterizing the signalling…”
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Truncation of the human EGF receptor leads to differential transforming potentials in primary avian fibroblasts and erythroblasts by Khazaie, K., Dull, T. J., Graf, T., Schlessinger, J., Ullrich, A., Beug, H., Vennström, B.

“…The transforming capacity of the normal and mutant human EGF receptor (EGFR) was investigated in primary chicken cells. In fibroblasts, both N‐ and C‐terminal…”
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Kinetic parameters of the protein tyrosine kinase activity of EGF‐receptor mutants with individually altered autophosphorylation sites by Honegger, A., Dull, T. J., Szapary, D., Komoriya, A., Kris, R., Ullrich, A., Schlessinger, J.

“…Epidermal growth factor (EGF)‐receptor mutants in which individual autophosphorylation sites (Tyr1068, Tyr1148 or Tyr1173) have been replaced by phenylalanine…”
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Mutation of the insulin receptor at tyrosine 960 inhibits signal transmission but does not affect its tyrosine kinase activity by White, M F, Livingston, J N, Backer, J M, Lauris, V, Dull, T J, Ullrich, A, Kahn, C R

“…Tyrosyl phosphorylation is implicated in the mechanism of insulin action. Mutation of the beta-subunit of the insulin receptor by substitution of tyrosyl…”
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Characterization of an endogenous substrate of the insulin receptor in cultured cells by White, M F, Stegmann, E W, Dull, T J, Ullrich, A, Kahn, C R

“…Using antiphosphotyrosine antibodies, we have characterized the tyrosine phosphorylation of an endogenous substrate of the insulin receptor in Fao hepatoma…”
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Properties of a human insulin receptor with a COOH-terminal truncation. II. Truncated receptors have normal kinase activity but are defective in signaling metabolic effects by Maegawa, H, McClain, D A, Freidenberg, G, Olefsky, J M, Napier, M, Lipari, T, Dull, T J, Lee, J, Ullrich, A

“…We have previously shown that a mutant human insulin receptor with a COOH-terminal 43-amino acid deletion (HIR delta CT), when expressed in Rat 1 fibroblasts,…”
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Biological activities of EGF‐receptor mutants with individually altered autophosphorylation sites by Honegger, A., Dull, T. J., Bellot, F., Van Obberghen, E., Szapary, D., Schmidt, A., Ullrich, A., Schlessinger, J.

“…In vitro site‐directed mutagenesis was used to replace individually the three known autophosphorylation sites of the epidermal growth factor (EGF)‐receptor…”
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A mutant epidermal growth factor receptor with defective protein tyrosine kinase is unable to stimulate proto-oncogene expression and DNA synthesis by HONEGGER, A. M, SZAPARY, D, SCHMIDT, A, LYALL, R, VAN OBBERGHEN, E, DULL, T. J, ULLRICH, A, SCHLESSINGER, J

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Release of a phorbol ester-induced mitogenic block by mutation at Thr-654 of the epidermal growth factor receptor by LIVNEH, E, DULL, T. J, BERENT, E, PRYWES, R, ULLRICH, A, SCHLESSINGER, J

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Cytoplasmic domains determine signal specificity, cellular routing characteristics and influence ligand binding of epidermal growth factor and insulin receptors by Riedel, H., Dull, T.J., Honegger, A.M., Schlessinger, J., Ullrich, A.

“…The cell surface receptors for insulin and epidermal growth factor (EGF) both employ a tyrosine‐specific protein kinase activity to fulfil their distinct…”
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Complete Nucleotide Sequence of a 23S Ribosomal RNA Gene from Escherichia coli by Brosius, Jurgen, Dull, Thomas J., Noller, Harry F.

“…The complete nucleotide sequence of the 23S RNA gene from the rrnB operon of Escherichia coli has been determined. The sequences of both strands of the entire…”
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Properties of a human insulin receptor with a COOH-terminal truncation. I. Insulin binding, autophosphorylation, and endocytosis by McClain, D A, Maegawa, H, Levy, J, Huecksteadt, T, Dull, T J, Lee, J, Ullrich, A, Olefsky, J M

“…In order to test the contribution of the insulin receptor COOH terminus to insulin action, a truncation of 43 COOH-terminal amino acids was engineered by…”
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