Search Results - "DUGGAN, M"

A Convolutional Neural Network-Based Approach for the Rapid Annotation of Molecularly Diverse Natural Products by Reher, Raphael, Kim, Hyun Woo, Zhang, Chen, Mao, Huanru Henry, Wang, Mingxun, Nothias, Louis-Félix, Caraballo-Rodriguez, Andres Mauricio, Glukhov, Evgenia, Teke, Bahar, Leao, Tiago, Alexander, Kelsey L, Duggan, Brendan M, Van Everbroeck, Ezra L, Dorrestein, Pieter C, Cottrell, Garrison W, Gerwick, William H

“…This report describes the first application of the novel NMR-based machine learning tool “Small Molecule Accurate Recognition Technology” (SMART 2.0) for…”
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Editorial to the Special Issue-"Technology for Natural Products Research" by Duggan, Brendan M

“…Natural product research continues to be a productive source of unusual chemistry, producing novel compounds for biomedical applications and, increasingly,…”
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The Arginine-Rich RNA-Binding Motif of HIV-1 Rev Is Intrinsically Disordered and Folds upon RRE Binding by Casu, Fabio, Duggan, Brendan M., Hennig, Mirko

“…Arginine-rich motifs (ARMs) capable of binding diverse RNA structures play critical roles in transcription, translation, RNA trafficking, and RNA packaging…”
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RIPK2 Dictates Insulin Responses to Tyrosine Kinase Inhibitors in Obese Male Mice by Duggan, Brittany M, Cavallari, Joseph F, Foley, Kevin P, Barra, Nicole G, Schertzer, Jonathan D

“…Abstract Tyrosine kinase inhibitors (TKIs) used in cancer are also being investigated in diabetes. TKIs can improve blood glucose control in diabetic cancer…”
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Use of zebrafish to study Shigella infection by Duggan, Gina M, Mostowy, Serge

“…is a leading cause of dysentery worldwide, responsible for up to 165 million cases of shigellosis each year. is also recognised as an exceptional model…”
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Muramyl Dipeptide-Based Postbiotics Mitigate Obesity-Induced Insulin Resistance via IRF4 by Cavallari, Joseph F., Fullerton, Morgan D., Duggan, Brittany M., Foley, Kevin P., Denou, Emmanuel, Smith, Brennan K., Desjardins, Eric M., Henriksbo, Brandyn D., Kim, Kalvin J., Tuinema, Brian R., Stearns, Jennifer C., Prescott, David, Rosenstiel, Philip, Coombes, Brian K., Steinberg, Gregory R., Schertzer, Jonathan D.

“…Intestinal dysbiosis contributes to obesity and insulin resistance, but intervening with antibiotics, prebiotics, or probiotics can be limited by specificity…”
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Interkingdom metabolic transformations captured by microbial imaging mass spectrometry by Moree, Wilna J., Phelan, Vanessa V., Wu, Cheng-Hsuan, Bandeira, Nuno, Cornett, Dale S., Duggan, Brendan M., Dorrestein, Pieter C.

“…In polymicrobial infections, microbes can interact with both the host immune system and one another through direct contact or the secretion of metabolites,…”
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Long term but not short term exposure to obesity related microbiota promotes host insulin resistance by Foley, Kevin P., Zlitni, Soumaya, Denou, Emmanuel, Duggan, Brittany M., Chan, Rebecca W., Stearns, Jennifer C., Schertzer, Jonathan D.

“…The intestinal microbiota and insulin sensitivity are rapidly altered after ingestion of obesogenic diets. We find that changes in the composition of the fecal…”
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Chronic TLR7 and TLR9 signaling drives anemia via differentiation of specialized hemophagocytes by Akilesh, Holly M, Buechler, Matthew B, Duggan, Jeffrey M, Hahn, William O, Matta, Bharati, Sun, Xizhang, Gessay, Griffin, Whalen, Elizabeth, Mason, Michael, Presnell, Scott R, Elkon, Keith B, Lacy-Hulbert, Adam, Barnes, Betsy J, Pepper, Marion, Hamerman, Jessica A

“…Cytopenias are an important clinical problem associated with inflammatory disease and infection. We show that specialized phagocytes that internalize red blood…”
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A multitime‐steps‐ahead prediction approach for scheduling live migration in cloud data centers by Duggan, M., Shaw, R., Duggan, J., Howley, E., Barrett, E.

“…Summary One of the major challenges facing cloud computing is to accurately predict future resource usage to provision data centers for future demands. Cloud…”
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Changes in Internal Structure and Dynamics upon Binding Stabilise the Nematode Anticoagulant NAPc2 by Woodward, Elaine, Duggan, Brendan M

“…Abnormal blood coagulation is a major health problem and natural anticoagulants from blood-feeding organisms have been investigated as novel therapeutics…”
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Gastric cancer epidemiology and risk factors by Kelley, Jon R., Duggan, John M.

“…We performed a detailed analysis of the epidemiology of gastric carcinoma, based upon a review of the literature in English. The analysis reveals many puzzling…”
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Small Molecule Accurate Recognition Technology (SMART) to Enhance Natural Products Research by Zhang, Chen, Idelbayev, Yerlan, Roberts, Nicholas, Tao, Yiwen, Nannapaneni, Yashwanth, Duggan, Brendan M., Min, Jie, Lin, Eugene C., Gerwick, Erik C., Cottrell, Garrison W., Gerwick, William H.

“…Various algorithms comparing 2D NMR spectra have been explored for their ability to dereplicate natural products as well as determine molecular structures…”
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N‐Heterocyclic Carbene Catalyzed (5+1) Annulations Exploiting a Vinyl Dianion Synthon Strategy by Nguyen, Xuan B., Nakano, Yuji, Duggan, Nisharnthi M., Scott, Lydia, Breugst, Martin, Lupton, David W.

“…Direct polarity inversion of conjugate acceptors provides a valuable entry to homoenolates. N‐heterocyclic carbene (NHC) catalyzed reactions, in which…”
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Comparison of outcomes following treatment of septic calcaneal bursitis by needle or bursoscopic lavage: A retrospective study of 29 horses by Duggan, M. J. S., Mair, T. S.

“…Summary Sepsis of the calcaneal bursae (CB) presents significant treatment challenges with limited clinical data available in the literature. The objective of…”
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Fluvastatin causes NLRP3 inflammasome-mediated adipose insulin resistance by Henriksbo, Brandyn D, Lau, Trevor C, Cavallari, Joseph F, Denou, Emmanuel, Chi, Wendy, Lally, James S, Crane, Justin D, Duggan, Brittany M, Foley, Kevin P, Fullerton, Morgan D, Tarnopolsky, Mark A, Steinberg, Gregory R, Schertzer, Jonathan D

“…Statins reduce lipid levels and are widely prescribed. Statins have been associated with an increased incidence of type 2 diabetes, but the mechanisms are…”
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Attenuated Familial Adenomatous Polyposis: A Phenotypic Diagnosis but Obsolete Term? by Anele, Chukwuemeka C., Martin, Isabel, McGinty Duggan, Patricia M., Chauhan, Jeshu, Clark, Susan K., Faiz, Omar D., Latchford, Andrew R.

“…Attenuated familial adenomatous polyposis is characterised by low number (≤100) and delayed development of colorectal adenomas. Various definitions have been…”
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Emergency cricothyroidotomy: an observational study to estimate optimal incision position and length by Fennessy, P, Drew, T, Husarova, V, Duggan, M, McCaul, C L

“…A vertical incision is recommended for cricothyroidotomy when the anatomy is impalpable, but no evidence-based guideline exists regarding optimum site or…”
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Novice-performed point-of-care ultrasound for home-based imaging by Duggan, Nicole M., Jowkar, Nick, Ma, Irene W. Y., Schulwolf, Sara, Selame, Lauren A., Fischetti, Chanel E., Kapur, Tina, Goldsmith, Andrew J.

“…Patient-performed point-of-care ultrasound (POCUS) may be feasible for use in home-based healthcare. We investigated whether novice users can obtain lung…”
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Glycogenomics as a mass spectrometry-guided genome-mining method for microbial glycosylated molecules by Kersten, Roland D, Ziemert, Nadine, Gonzalez, David J, Duggan, Brendan M, Nizet, Victor, Dorrestein, Pieter C, Moore, Bradley S

“…Glycosyl groups are an essential mediator of molecular interactions in cells and on cellular surfaces. There are very few methods that directly relate…”
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