Search Results - "DUFRASNE, François"

Baloxavir Marboxil: An Original New Drug against Influenza by Dufrasne, François

“…Baloxavir marboxil is a new drug developed in Japan by Shionogi to treat seasonal flu infection. This cap-dependent endonuclease inhibitor is a prodrug that…”
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Immune Diseases: Challenges, Hopes and Recent Achievements by Dufrasne, François

“…Although they have been greatly described for about 50 years, we have gained a much greater understanding of immune diseases since the beginning of this…”
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A patent review of myeloperoxidase inhibitors for treating chronic inflammatory syndromes (focus on cardiovascular diseases, 2013-2019) by Soubhye, Jalal, Van Antwerpen, Pierre, Dufrasne, François

“…Myeloperoxidase (MPO) is an immune enzyme found in neutrophils and macrophages. It produces the highly oxidative compound HOCl from H O and Cl ions inside the…”
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Identification of New Mycobacterium bovis antigens and development of a multiplexed serological bead-immunoassay for the diagnosis of bovine tuberculosis in cattle by Moens, Charlotte, Filée, Patrice, Boes, Adrien, Alie, Christian, Dufrasne, François, André, Emmanuel, Marché, Sylvie, Fretin, David

“…Serological assays for bovine tuberculosis diagnosis require the use of multiple Mycobacterium bovis specific antigens to ensure the detection of infected…”
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A survey of the mechanisms of action of anticancer transition metal complexes by Marloye, Mickaël, Berger, Gilles, Gelbcke, Michel, Dufrasne, François

“…Metal complexes have been the subject of numerous investigations in oncology but, despite the plethora of newly synthesized compounds, their precise mechanisms…”
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Analysis of the Involvement of the Isoleucine Biosynthesis Pathway in Photoheterotrophic Metabolism of Rhodospirillum rubrum by Bayon-Vicente, Guillaume, Marchand, Elie, Ducrotois, Jeson, Dufrasne, François E., Hallez, Regis, Wattiez, Ruddy, Leroy, Baptiste

“…Purple non-sulfur bacteria (PNSB) are recognized as a highly versatile group of bacteria that assimilate a broad range of carbon sources. Growing…”
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The prevalence of pathogens in ticks collected from humans in Belgium, 2021, versus 2017 by Philippe, Camille, Geebelen, Laurence, Hermy, Marie R G, Dufrasne, François E, Tersago, Katrien, Pellegrino, Alessandro, Fonville, Manoj, Sprong, Hein, Mori, Marcella, Lernout, Tinne

“…Ticks carry a variety of microorganisms, some of which are pathogenic to humans. The human risk of tick-borne diseases depends on, among others, the prevalence…”
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Myeloperoxidase as a Target for the Treatment of Inflammatory Syndromes: Mechanisms and Structure Activity Relationships of Inhibitors by Soubhye, Jalal, Aldib, Iyas, Delporte, Cédric, Prévost, Martine, Dufrasne, François, Antwerpen, Pierre Van

“…Inflammation is an initial response of the body to a harmful stimuli and it is achieved by the increased movement of leukocytes (especially granulocytes) from…”
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Synthesis, structure and anticancer properties of new biotin- and morpholine-functionalized ruthenium and osmium half-sandwich complexes by Marloye, Mickaël, Inam, Haider, Moore, Connor J., Debaille, Vinciane, Pritchard, Justin R., Gelbcke, Michel, Meyer, Franck, Dufrasne, François, Berger, Gilles

“…Ruthenium (Ru) and osmium (Os) complexes are of sustained interest in cancer research and may be alternative to platinum-based therapy. We detail here three…”
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Development of Digital Droplet PCR Targeting the Influenza H3N2 Oseltamivir-Resistant E119V Mutation and Its Performance through the Use of Reverse Genetics Mutants by Van Poelvoorde, Laura A E, Dufrasne, François E, Van Gucht, Steven, Saelens, Xavier, Roosens, Nancy H C

“…The monitoring of antiviral-resistant influenza virus strains is important for public health given the availability and use of neuraminidase inhibitors and…”
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Structure–Activity Relationship Analysis of Bufadienolide-Induced in Vitro Growth Inhibitory Effects on Mouse and Human Cancer Cells by Moreno Y. Banuls, Laetitia, Urban, Ernst, Gelbcke, Michel, Dufrasne, François, Kopp, Brigitte, Kiss, Robert, Zehl, Martin

“…The in vitro growth inhibitory effects of 27 bufadienolides and eight degradation products, with two cardenolides (ouabain and digoxin) chosen as reference…”
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Correction: First evaluation of the Next-Generation Sequencing platform for the detection of HIV-1 drug resistance mutations in Belgium by Dessilly, Géraldine, Goeminne, Léonie, Vandenbroucke, Anne-Thérèse, Dufrasne, François E, Martin, Anandi, Kabamba-Mukadi, Benoît

“…[This corrects the article DOI: 10.1371/journal.pone.0209561.]…”
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Discovery of Novel Potent Reversible and Irreversible Myeloperoxidase Inhibitors Using Virtual Screening Procedure by Soubhye, Jalal, Chikh Alard, Ibaa, Aldib, Iyas, Prévost, Martine, Gelbcke, Michel, De Carvalho, Annelise, Furtmüller, Paul G, Obinger, Christian, Flemmig, Jörg, Tadrent, Sara, Meyer, Franck, Rousseau, Alexandre, Nève, Jean, Mathieu, Véronique, Zouaoui Boudjeltia, Karim, Dufrasne, François, Van Antwerpen, Pierre

“…The heme enzyme myeloperoxidase (MPO) participates in innate immune defense mechanism through formation of microbicidal reactive oxidants. However, evidence…”
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Crystal Structures of a Series of Hydroxamic Acids by Sow, Ibrahima Sory, Gelbcke, Michel, Dufrasne, François, Robeyns, Koen

“…The structure of four hydroxamic acids (HA) that show antifungal activities in complexes with several metals is revealed by single crystal diffraction. The…”
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Effectiveness of the adapted bivalent mRNA COVID-19 vaccines against hospitalisation in individuals aged ≥ 60 years during the Omicron XBB lineage-predominant period: VEBIS SARI VE network, Europe, February to August, 2023 by Antunes, Liliana, Mazagatos, Clara, Martínez-Baz, Iván, Gomez, Verónica, Borg, Maria-Louise, Petrović, Goranka, Duffy, Róisín, Dufrasne, François E, Dürrwald, Ralf, Lazar, Mihaela, Jancoriene, Ligita, Oroszi, Beatrix, Husa, Petr, Howard, Jennifer, Melo, Aryse, Pozo, Francisco, Pérez-Gimeno, Gloria, Castilla, Jesús, Machado, Ausenda, Džiugytė, Aušra, Karabuva, Svjetlana, Fitzgerald, Margaret, Fierens, Sébastien, Tolksdorf, Kristin, Popovici, Silvia-Odette, Mickienė, Auksė, Túri, Gergő, Součková, Lenka, Nicolay, Nathalie, Rose, Angela Mc

“…We conducted a multicentre hospital-based test-negative case-control study to measure the effectiveness of adapted bivalent COVID-19 mRNA vaccines against…”
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Evaluation of the analytical performance of six rapid diagnostic tests for the detection of viral hepatitis B and C in Lubumbashi, Democratic Republic of Congo by Kabamba, Arsène T., Mwamba, Claude M., Dessilly, Géraldine, Dufrasne, François, Kabamba, Benoit M., Longanga, Albert O.

“…•This study notes the performance of rapid diagnostic tests used for screening for viral hepatitis B and / or C;•It shows how sensitive these rapid diagnostic…”
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Genomic monitoring of SARS-CoV-2 variants using sentinel SARI hospital surveillance by Denayer, Sarah, Dufrasne, François E, Monsieurs, Bert, van Eycken, Reinout, Houben, Sarah, Seyler, Lucie, Demuyser, Thomas, van Nedervelde, Els, Bourgeois, Marc, Delaere, Bénédicte, Magerman, Koen, Jouck, Door, Lissoir, Bénédicte, Sion, Catherine, Reynders, Marijke, Petit, Evelyn, Dauby, Nicolas, Hainaut, Marc, Laenen, Lies, Maes, Piet, Baele, Guy, Dellicour, Simon, Cuypers, Lize, André, Emmanuel, Couvreur, Simon, Brondeel, Ruben, Barbezange, Cyril, Bossuyt, Nathalie, van Gucht, Steven

“…To support the COVID-19 pandemic response, many countries, including Belgium, implemented baseline genomic surveillance (BGS) programs aiming to early detect…”
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Synthesis and biological activity of iron(II), iron(III), nickel(II), copper(II) and zinc(II) complexes of aliphatic hydroxamic acids by Sow, Ibrahima Sory, Gelbcke, Michel, Meyer, Franck, Vandeput, Marie, Marloye, Mickael, Basov, Sergey, Van Bael, Margriet J., Berger, Gilles, Robeyns, Koen, Hermans, Sophie, Yang, Dong, Fontaine, Véronique, Dufrasne, François

“…Aliphatic hydroxamic acids (HA) with varying numbers of carbon atoms, C 2 , C 6 , C 8 , C 10 , C 12 and C 17 , and corresponding Fe(II), Fe(III), Ni(II),…”
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Short Communication: An Insertion of Seven Amino Acids in the Envelope Cytoplasmic Tail of HIV-2 Selected During Disease Progression Enhances Viral Replication by Dufrasne, François E, Lucchetti, Mara, Dessilly, Géraldine, Ruelle, Jean, Martin, Anandi, Kabamba-Mukadi, Benoit

“…The cytoplasmic tail (CT) of the HIV-2 envelope glycoprotein (Env) includes amino acid (aa) sequences that are similar to lentiviral lytic peptides (LLP)…”
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Antimycobacterial Activities of Hydroxamic Acids and Their Iron(II/III), Nickel(II), Copper(II) and Zinc(II) Complexes by Yang, Dong, Zhang, Yanfang, Sow, Ibrahima Sory, Liang, Hongping, El Manssouri, Naïma, Gelbcke, Michel, Dong, Lina, Chen, Guangxin, Dufrasne, François, Fontaine, Véronique, Li, Rongshan

“…Hydroxamic acid (HA) derivatives display antibacterial and antifungal activities. HA with various numbers of carbon atoms (C2, C6, C8, C10, C12 and C17),…”
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