Search Results - "DUFFY, Tomas"

Nuclear receptor HNF4A transrepresses CLOCK: BMAL1 and modulates tissue-specific circadian networks by Qu, Meng, Duffy, Tomas, Hirota, Tsuyoshi, Kay, Steve A.

“…Either expression level or transcriptional activity of various nuclear receptors (NRs) have been demonstrated to be under circadian control. With a few…”
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FOXO1 transcription factor regulates chondrogenic differentiation through transforming growth factor β1 signaling by Kurakazu, Ichiro, Akasaki, Yukio, Hayashida, Mitsumasa, Tsushima, Hidetoshi, Goto, Norio, Sueishi, Takuya, Toya, Masakazu, Kuwahara, Masanari, Okazaki, Ken, Duffy, Tomas, Lotz, Martin K., Nakashima, Yasuharu

“…The forkhead box O (FOXO) proteins are transcription factors involved in the differentiation of many cell types. Type II collagen (Col2) Cre-Foxo1-knockout and…”
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Multi-level Modulation of Light Signaling by GIGANTEA Regulates Both the Output and Pace of the Circadian Clock by Nohales, Maria A., Liu, Wanlu, Duffy, Tomas, Nozue, Kazunari, Sawa, Mariko, Pruneda-Paz, Jose L., Maloof, Julin N., Jacobsen, Steven E., Kay, Steve A.

“…Integration of environmental signals with endogenous biological processes is essential for organisms to thrive in their natural environment. Being entrained by…”
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International study to evaluate PCR methods for detection of Trypanosoma cruzi DNA in blood samples from Chagas disease patients by Schijman, Alejandro G, Bisio, Margarita, Orellana, Liliana, Sued, Mariela, Duffy, Tomás, Mejia Jaramillo, Ana M, Cura, Carolina, Auter, Frederic, Veron, Vincent, Qvarnstrom, Yvonne, Deborggraeve, Stijn, Hijar, Gisely, Zulantay, Inés, Lucero, Raúl Horacio, Velazquez, Elsa, Tellez, Tatiana, Sanchez Leon, Zunilda, Galvão, Lucia, Nolder, Debbie, Monje Rumi, María, Levi, José E, Ramirez, Juan D, Zorrilla, Pilar, Flores, María, Jercic, Maria I, Crisante, Gladys, Añez, Néstor, De Castro, Ana M, Gonzalez, Clara I, Acosta Viana, Karla, Yachelini, Pedro, Torrico, Faustino, Robello, Carlos, Diosque, Patricio, Triana Chavez, Omar, Aznar, Christine, Russomando, Graciela, Büscher, Philippe, Assal, Azzedine, Guhl, Felipe, Sosa Estani, Sergio, DaSilva, Alexandre, Britto, Constança, Luquetti, Alejandro, Ladzins, Janis

“…A century after its discovery, Chagas disease still represents a major neglected tropical threat. Accurate diagnostics tools as well as surrogate markers of…”
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Accurate real-time PCR strategy for monitoring bloodstream parasitic loads in chagas disease patients by Duffy, Tomas, Bisio, Margarita, Altcheh, Jaime, Burgos, Juan Miguel, Diez, Mirta, Levin, Mariano Jorge, Favaloro, Roberto Rene, Freilij, Hector, Schijman, Alejandro Gabriel

“…This report describes a real-time PCR (Q-PCR) strategy to quantify Trypanosoma cruzi (T. cruzi) DNA in peripheral blood samples from Chagas disease patients…”
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Changes in ambient temperature are the prevailing cue in determining Brachypodium distachyon diurnal gene regulation by MacKinnon, Kirk J-M., Cole, Benjamin J., Yu, Chang, Coomey, Joshua H., Hartwick, Nolan T., Remigereau, Marie-Stanislas, Duffy, Tomas, Michael, Todd P., Kay, Steve A., Hazen, Samuel P.

“…• Plants are continuously exposed to diurnal fluctuations in light and temperature, and spontaneous changes in their physical or biotic environment. The…”
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Transcriptional regulation of tocopherol biosynthesis in tomato by Quadrana, Leandro, Almeida, Juliana, Otaiza, Santiago N., Duffy, Tomas, Corrêa da Silva, Junia V., de Godoy, Fabiana, Asís, Ramon, Bermúdez, Luisa, Fernie, Alisdair R., Carrari, Fernando, Rossi, Magdalena

“…Tocopherols, compounds with vitamin E (VTE) activity, are potent lipid-soluble antioxidants synthesized only by photosynthetic organisms. Their biosynthesis…”
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Multiplex Real-Time PCR Assay Using TaqMan Probes for the Identification of Trypanosoma cruzi DTUs in Biological and Clinical Samples by Cura, Carolina I, Duffy, Tomas, Lucero, Raúl H, Bisio, Margarita, Péneau, Julie, Jimenez-Coello, Matilde, Calabuig, Eva, Gimenez, María J, Valencia Ayala, Edward, Kjos, Sonia A, Santalla, José, Mahaney, Susan M, Cayo, Nelly M, Nagel, Claudia, Barcán, Laura, Málaga Machaca, Edith S, Acosta Viana, Karla Y, Brutus, Laurent, Ocampo, Susana B, Aznar, Christine, Cuba Cuba, Cesar A, Gürtler, Ricardo E, Ramsey, Janine M, Ribeiro, Isabela, VandeBerg, John L, Yadon, Zaida E, Osuna, Antonio, Schijman, Alejandro G

“…Trypanosoma cruzi has been classified into six Discrete Typing Units (DTUs), designated as TcI-TcVI. In order to effectively use this standardized…”
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Selective blockade of trypanosomatid protein synthesis by a recombinant antibody anti-Trypanosoma cruzi P2β protein by Ayub, Maximiliano Juri, Nyambega, Benson, Simonetti, Leandro, Duffy, Tomas, Longhi, Silvia A, Gómez, Karina A, Hoebeke, Johan, Levin, Mariano J, Smulski, Cristian R

“…The ribosomal P proteins are located on the stalk of the ribosomal large subunit and play a critical role during the elongation step of protein synthesis. The…”
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Natural occurring epialleles determine vitamin E accumulation in tomato fruits by Quadrana, Leandro, Almeida, Juliana, Asís, Ramon, Duffy, Tomás, Dominguez, Pia Guadalupe, Bermúdez, Luisa, Conti, Gabriela, Corrêa da Silva, Junia V., Peralta, Iris E., Colot, Vincent, Asurmendi, Sebastian, Fernie, Alisdair R., Rossi, Magdalena, Carrari, Fernando

“…Vitamin E (VTE) content is a low heritability nutritional trait for which the genetic determinants are poorly understood. Here, we focus on a previously…”
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Multiomics analyses reveal the roles of the ASR1 transcription factor in tomato fruits by Dominguez, Pia Guadalupe, Conti, Gabriela, Duffy, Tomás, Insani, Marina, Alseekh, Saleh, Asurmendi, Sebastián, Fernie, Alisdair R, Carrari, Fernando

“…The transcription factor ASR1 (ABA, STRESS, RIPENING 1) plays multiple roles in plant responses to abiotic stresses as well as being involved in the regulation…”
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Molecular Identification of Trypanosoma cruzi Discrete Typing Units in End-Stage Chronic Chagas Heart Disease and Reactivation after Heart Transplantation by Burgos, Juan Miguel, Diez, Mirta, Vigliano, Carlos, Bisio, Margarita, Risso, Marikena, Duffy, Tomás, Cura, Carolina, Brusses, Betina, Favaloro, Liliana, Leguizamon, María Susana, Lucero, Raul Horacio, Laguens, Ruben, Levin, Mariano Jorge, Favaloro, Roberto, Schijman, Alejandro Gabriel

“…Background. One hundred years after the discovery of Chagas disease, it remains a major neglected tropical disease. Chronic Chagas heart disease (cChHD) is the…”
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Genome‐Wide Occupancy Profiling Reveals Critical Roles of FoxO1 in Regulating Extracellular Matrix and Circadian Rhythm Genes in Human Chondrocytes by Duffy, Tomas, Bekki, Hirofumi, Lotz, Martin K.

“…Objective Osteoarthritis (OA) is the most common age‐related joint disease. With aging and in OA, the expression of FoxO transcription factors is reduced,…”
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Alterations in Placental Gene Expression of Pregnant Women with Chronic Chagas Disease by Juiz, Natalia A., Torrejón, Irma, Burgos, Marianela, Torres, Ana M.F., Duffy, Tomás, Cayo, Nelly M., Tabasco, Anahí, Salvo, Miriam, Longhi, Silvia A., Schijman, Alejandro G.

“…Trypanosoma cruzi infection in women of reproductive age is associated with congenital transmission and adverse pregnancy outcomes. The placenta is a key…”
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Trypanosoma cruzi I genotypes in different geographical regions and transmission cycles based on a microsatellite motif of the intergenic spacer of spliced-leader genes by Cura, Carolina I., Mejía-Jaramillo, Ana M., Duffy, Tomás, Burgos, Juan M., Rodriguero, Marcela, Cardinal, Marta V., Kjos, Sonia, Gurgel-Gonçalves, Rodrigo, Blanchet, Denis, De Pablos, Luis M., Tomasini, Nicolás, da Silva, Alexandre, Russomando, Graciela, Cuba, Cesar A. Cuba, Aznar, Christine, Abate, Teresa, Levin, Mariano J., Osuna, Antonio, Gürtler, Ricardo E., Diosque, Patricio, Solari, Aldo, Triana-Chávez, Omar, Schijman, Alejandro G.

“…The intergenic region of spliced-leader (SL-IR) genes from 105 Trypanosoma cruzi I (Tc I) infected biological samples, culture isolates and stocks from 11…”
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Senescent cell population with ZEB1 transcription factor as its main regulator promotes osteoarthritis in cartilage and meniscus by Swahn, Hannah, Li, Kun, Duffy, Tomas, Olmer, Merissa, D'Lima, Darryl D, Mondala, Tony S, Natarajan, Padmaja, Head, Steven R, Lotz, Martin K

“…Single-cell level analysis of articular cartilage and meniscus tissues from human healthy and osteoarthritis (OA) knees. Single-cell RNA sequencing (scRNA-seq)…”
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Treatment of adult chronic indeterminate Chagas disease with benznidazole and three E1224 dosing regimens: a proof-of-concept, randomised, placebo-controlled trial by Torrico, Faustino, Gascon, Joaquim, Ortiz, Lourdes, Alonso-Vega, Cristina, Pinazo, María-Jesús, Schijman, Alejandro, Almeida, Igor C, Alves, Fabiana, Strub-Wourgaft, Nathalie, Ribeiro, Isabela, Santina, Glaucia, Blum, Bethania, Correia, Erika, Garcia-Bournisen, Facundo, Vaillant, Michel, Morales, Jimena Ramos, Pinto Rocha, Jimy Jose, Rojas Delgadillo, Gimena, Magne Anzoleaga, Helmut Ramon, Mendoza, Nilce, Quechover, Roxana Challapa, Caballero, Maria Yurly Escobar, Lozano Beltran, Daniel Franz, Zalabar, Albert Mendoza, Rojas Panozo, Lizeth, Palacios Lopez, Alejandro, Torrico Terceros, Dunia, Fernandez Galvez, Violeta Alejandra, Cardozo, Letty, Cuellar, Gabriela, Vasco Arenas, Rudy Nelson, Gonzales, Isabel, Hoyos Delfin, Carlos Florencio, Garcia, Lineth, Parrado, Rudy, de la Barra, Anabelle, Montano, Nair, Villarroel, Sandro, Duffy, Tomas, Bisio, Margarita, Ramirez, Juan Carlos, Duncanson, Fred, Everson, Michael, Daniels, Antonia, Asada, Makoto, Cox, Eugene, Wesche, David, Diderichsen, Paul Matthias, Marques, Alexandre F, Izquierdo, Luis, Sender, Silvia Sanz, Reverter, Joan Carlos, Morales, Manuel, Jimenez, Wladimiro

“…Chagas disease is a major neglected vector-borne disease. In this study, we investigated the safety and efficacy of three oral E1224 (a water-soluble…”
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Impairment of Infectivity and Immunoprotective Effect of a LYT1 Null Mutant of Trypanosoma cruzi by Zago, M. Paola, Barrio, Alejandra B, Cardozo, Rubén M, Duffy, Tomás, Schijman, Alejandro G, Basombrío, Miguel A

“…Trypanosoma cruzi infection of host cells is a complex process in which many proteins participate but only a few of these proteins have been identified…”
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Suppression of circadian clock protein cryptochrome 2 promotes osteoarthritis by Bekki, H., Duffy, T., Okubo, N., Olmer, M., Alvarez-Garcia, O., Lamia, K., Kay, S., Lotz, M.

“…Abnormal chondrocyte gene expression promotes osteoarthritis (OA) pathogenesis. A previous RNA-sequencing study revealed that circadian rhythm pathway and…”
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Analytical performance of a multiplex Real-Time PCR assay using TaqMan probes for quantification of Trypanosoma cruzi satellite DNA in blood samples by Duffy, Tomas, Cura, Carolina I, Ramirez, Juan C, Abate, Teresa, Cayo, Nelly M, Parrado, Rudy, Bello, Zoraida Diaz, Velazquez, Elsa, Muñoz-Calderon, Arturo, Juiz, Natalia A, Basile, Joaquín, Garcia, Lineth, Riarte, Adelina, Nasser, Julio R, Ocampo, Susana B, Yadon, Zaida E, Torrico, Faustino, de Noya, Belkisyole Alarcón, Ribeiro, Isabela, Schijman, Alejandro G

“…The analytical validation of sensitive, accurate and standardized Real-Time PCR methods for Trypanosoma cruzi quantification is crucial to provide a reliable…”
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