Search Results - "DUFFY, Michael F"

Decreased K13 Abundance Reduces Hemoglobin Catabolism and Proteotoxic Stress, Underpinning Artemisinin Resistance by Yang, Tuo, Yeoh, Lee M., Tutor, Madel V., Dixon, Matthew W., McMillan, Paul J., Xie, Stanley C., Bridgford, Jessica L., Gillett, David L., Duffy, Michael F., Ralph, Stuart A., McConville, Malcolm J., Tilley, Leann, Cobbold, Simon A.

“…Increased tolerance of Plasmodium falciparum to front-line artemisinin antimalarials (ARTs) is associated with mutations in Kelch13 (K13), although the precise…”
Get full text

Author Correction: Population genomics of virulence genes of Plasmodium falciparum in clinical isolates from Uganda by Ruybal-Pesántez, Shazia, Tiedje, Kathryn E., Tonkin-Hill, Gerry, Rask, Thomas S., Kamya, Moses R., Greenhouse, Bryan, Dorsey, Grant, Duffy, Michael F., Day, Karen P.

Get full text

Plasmodium falciparum gametocytes display global chromatin remodelling during sexual differentiation by Jeninga, Myriam D, Tang, Jingyi, Selvarajah, Shamista A, Maier, Alexander G, Duffy, Michael F, Petter, Michaela

“…The protozoan malaria parasite Plasmodium falciparum has a complex life cycle during which it needs to differentiate into multiple morphologically distinct…”
Get full text

PfSET10, a Plasmodium falciparum Methyltransferase, Maintains the Active var Gene in a Poised State during Parasite Division by Volz, Jennifer C., Bártfai, Richard, Petter, Michaela, Langer, Christine, Josling, Gabrielle A., Tsuboi, Takafumi, Schwach, Frank, Baum, Jake, Rayner, Julian C., Stunnenberg, Henk G., Duffy, Michael F., Cowman, Alan F.

“…A major virulence factor of the malaria parasite Plasmodium falciparum is erythrocyte membrane protein 1 (PfEMP1), a variant protein expressed on the infected…”
Get full text

Controlled human malaria infection with Plasmodium falciparum demonstrates impact of naturally acquired immunity on virulence gene expression by Bachmann, Anna, Bruske, Ellen, Krumkamp, Ralf, Turner, Louise, Wichers, J Stephan, Petter, Michaela, Held, Jana, Duffy, Michael F, Sim, B Kim Lee, Hoffman, Stephen L, Kremsner, Peter G, Lell, Bertrand, Lavstsen, Thomas, Frank, Matthias, Mordmüller, Benjamin, Tannich, Egbert

“…The pathogenesis of Plasmodium falciparum malaria is linked to the variant surface antigen PfEMP1, which mediates tethering of infected erythrocytes to the…”
Get full text

Targets of antibodies against Plasmodium falciparum-infected erythrocytes in malaria immunity by Chan, Jo-Anne, Howell, Katherine B, Reiling, Linda, Ataide, Ricardo, Mackintosh, Claire L, Fowkes, Freya J I, Petter, Michaela, Chesson, Joanne M, Langer, Christine, Warimwe, George M, Duffy, Michael F, Rogerson, Stephen J, Bull, Peter C, Cowman, Alan F, Marsh, Kevin, Beeson, James G

“…Plasmodium falciparum is the major cause of malaria globally and is transmitted by mosquitoes. During parasitic development, P. falciparum-infected…”
Get full text

A Plasmodium Falciparum Bromodomain Protein Regulates Invasion Gene Expression by Josling, Gabrielle A., Petter, Michaela, Oehring, Sophie C., Gupta, Archna P., Dietz, Olivier, Wilson, Danny W., Schubert, Thomas, Längst, Gernot, Gilson, Paul R., Crabb, Brendan S., Moes, Suzette, Jenoe, Paul, Lim, Shu Wei, Brown, Graham V., Bozdech, Zbynek, Voss, Till S., Duffy, Michael F.

“…During red-blood-cell-stage infection of Plasmodium falciparum, the parasite undergoes repeated rounds of replication, egress, and invasion. Erythrocyte…”
Get full text

The Plasmodium falciparum transcriptome in severe malaria reveals altered expression of genes involved in important processes including surface antigen-encoding var genes by Tonkin-Hill, Gerry Q, Trianty, Leily, Noviyanti, Rintis, Nguyen, Hanh H T, Sebayang, Boni F, Lampah, Daniel A, Marfurt, Jutta, Cobbold, Simon A, Rambhatla, Janavi S, McConville, Malcolm J, Rogerson, Stephen J, Brown, Graham V, Day, Karen P, Price, Ric N, Anstey, Nicholas M, Papenfuss, Anthony T, Duffy, Michael F

“…Within the human host, the malaria parasite Plasmodium falciparum is exposed to multiple selection pressures. The host environment changes dramatically in…”
Get full text

The P. falciparum alternative histones Pf H2A.Z and Pf H2B.Z are dynamically acetylated and antagonized by PfSir2 histone deacetylases at heterochromatin boundaries by Azizan, Suffian, Selvarajah, Shamista A, Tang, Jingyi, Jeninga, Myriam D, Schulz, Danae, Pareek, Kapil, Herr, Tamara, Day, Karen P, De Koning-Ward, Tania F, Petter, Michaela, Duffy, Michael F

“…The alternative histones Pf H2A.Z and Pf H2B.Z are enriched in the same nucleosomes in intergenic euchromatin but depleted from heterochromatin. They occupy…”
Get full text

Identifying Targets of Protective Antibodies against Severe Malaria in Papua, Indonesia, Using Locally Expressed Domains of Plasmodium falciparum Erythrocyte Membrane Protein 1 by Rambhatla, Janavi S, Tonkin-Hill, Gerry Q, Takashima, Eizo, Tsuboi, Takafumi, Noviyanti, Rintis, Trianty, Leily, Sebayang, Boni F, Lampah, Daniel A, Marfurt, Jutta, Price, Ric N, Anstey, Nicholas M, Papenfuss, Anthony T, Damelang, Timon, Chung, Amy W, Duffy, Michael F, Rogerson, Stephen J

“…Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1), a diverse family of multidomain proteins expressed on the surface of malaria-infected…”
Get full text

A systems serology approach to identifying key antibody correlates of protection from cerebral malaria in Malawian children by Walker, Isobel S, Dini, Saber, Aitken, Elizabeth H, Damelang, Timon, Hasang, Wina, Alemu, Agersew, Jensen, Anja T R, Rambhatla, Janavi S, Opi, D Herbert, Duffy, Michael F, Takashima, Eizo, Harawa, Visopo, Tsuboi, Takafumi, Simpson, Julie A, Mandala, Wilson, Taylor, Terrie E, Seydel, Karl B, Chung, Amy W, Rogerson, Stephen J

“…Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) proteins are expressed on the surface of infected erythrocytes, mediating parasite sequestration…”
Get full text

Evolutionary analyses of the major variant surface antigen-encoding genes reveal population structure of Plasmodium falciparum within and between continents by Tonkin-Hill, Gerry, Ruybal-Pesántez, Shazia, Tiedje, Kathryn E, Rougeron, Virginie, Duffy, Michael F, Zakeri, Sedigheh, Pumpaibool, Tepanata, Harnyuttanakorn, Pongchai, Branch, OraLee H, Ruiz-Mesía, Lastenia, Rask, Thomas S, Prugnolle, Franck, Papenfuss, Anthony T, Chan, Yao-Ban, Day, Karen P

“…Malaria remains a major public health problem in many countries. Unlike influenza and HIV, where diversity in immunodominant surface antigens is understood…”
Get full text

Mosquito Passage Dramatically Changes var Gene Expression in Controlled Human Plasmodium falciparum Infections by Bachmann, Anna, Petter, Michaela, Krumkamp, Ralf, Esen, Meral, Held, Jana, Scholz, Judith A M, Li, Tao, Sim, B Kim Lee, Hoffman, Stephen L, Kremsner, Peter G, Mordmüller, Benjamin, Duffy, Michael F, Tannich, Egbert

“…Virulence of the most deadly malaria parasite Plasmodium falciparum is linked to the variant surface antigen PfEMP1, which is encoded by about 60 var genes per…”
Get full text

Sir2 paralogues cooperate to regulate virulence genes and antigenic variation in Plasmodium falciparum by Tonkin, Christopher J, Carret, Céline K, Duraisingh, Manoj T, Voss, Till S, Ralph, Stuart A, Hommel, Mirja, Duffy, Michael F, Silva, Liliana Mancio da, Scherf, Artur, Ivens, Alasdair, Speed, Terence P, Beeson, James G, Cowman, Alan F

“…Cytoadherance of Plasmodium falciparum-infected erythrocytes in the brain, organs and peripheral microvasculature is linked to morbidity and mortality…”
Get full text

Relationship of circulating Plasmodium falciparum lifecycle stage to circulating parasitemia and total parasite biomass by Duffy, Michael F., Tonkin-Hill, Gerry Q., Trianty, Leily, Noviyanti, Rintis, Nguyen, Hanh H. T., Rambhatla, Janavi S., McConville, Malcolm J., Rogerson, Stephen J., Brown, Graham V., Price, Ric N., Anstey, Nicholas M., Day, Karen P., Papenfuss, Anthony T.

Get full text

Common virulence gene expression in adult first-time infected malaria patients and severe cases by Wichers, J Stephan, Tonkin-Hill, Gerry, Thye, Thorsten, Krumkamp, Ralf, Kreuels, Benno, Strauss, Jan, von Thien, Heidrun, Scholz, Judith Am, Smedegaard Hansson, Helle, Weisel Jensen, Rasmus, Turner, Louise, Lorenz, Freia-Raphaella, Schöllhorn, Anna, Bruchhaus, Iris, Tannich, Egbert, Fendel, Rolf, Otto, Thomas D, Lavstsen, Thomas, Gilberger, Tim W, Duffy, Michael F, Bachmann, Anna

“…Sequestration of ( )-infected erythrocytes to host endothelium through the parasite-derived erythrocyte membrane protein 1 ( EMP1) adhesion proteins is central…”
Get full text

The role of bromodomain proteins in regulating gene expression by Josling, Gabrielle A, Selvarajah, Shamista A, Petter, Michaela, Duffy, Michael F

“…Histone modifications are important in regulating gene expression in eukaryotes. Of the numerous histone modifications which have been identified, acetylation…”
Get full text

A novel computational pipeline for var gene expression augments the discovery of changes in the Plasmodium falciparum transcriptome during transition from in vivo to short-term in vitro culture by Andradi-Brown, Clare, Wichers-Misterek, Jan Stephan, von Thien, Heidrun, Höppner, Yannick D, Scholz, Judith A M, Hansson, Helle, Filtenborg Hocke, Emma, Gilberger, Tim Wolf, Duffy, Michael F, Lavstsen, Thomas, Baum, Jake, Otto, Thomas D, Cunnington, Aubrey J, Bachmann, Anna

“…The pathogenesis of severe malaria involves cytoadhesive microvascular sequestration of infected erythrocytes, mediated by erythrocyte membrane protein 1…”
Get full text

Expression of P. falciparum var genes involves exchange of the histone variant H2A.Z at the promoter by Petter, Michaela, Lee, Chin Chin, Byrne, Timothy J, Boysen, Katja E, Volz, Jennifer, Ralph, Stuart A, Cowman, Alan F, Brown, Graham V, Duffy, Michael F

“…Plasmodium falciparum employs antigenic variation to evade the human immune response by switching the expression of different variant surface antigens encoded…”
Get full text

Heterochromatin Silencing and Locus Repositioning Linked to Regulation of Virulence Genes in Plasmodium falciparum by Duraisingh, Manoj T., Voss, Till S., Marty, Allison J., Duffy, Michael F., Good, Robert T., Thompson, Jennifer K., Freitas-Junior, Lucio H., Scherf, Artur, Crabb, Brendan S., Cowman, Alan F.

“…The malaria parasite Plasmodium falciparum undergoes antigenic variation to evade host immune responses through switching expression of variant surface…”
Get full text