Search Results - "DUCOMMUN, Bernard"

CDC25 phosphatases in cancer cells: key players? Good targets? by Ducommun, Bernard, Boutros, Rose, Lobjois, Valérie

“…Cell division cycle 25 (CDC25) phosphatases regulate key transitions between cell cycle phases during normal cell division, and in the event of DNA damage they…”
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Short and long time effects of low temperature Plasma Activated Media on 3D multicellular tumor spheroids by Judée, Florian, Fongia, Céline, Ducommun, Bernard, Yousfi, Mohammed, Lobjois, Valérie, Merbahi, Nofel

“…This work investigates the regionalized antiproliferative effects of plasma-activated medium (PAM) on colon adenocarcinoma multicellular tumor spheroid (MCTS),…”
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Cell-Cell Adhesion and Cytoskeleton Tension Oppose Each Other in Regulating Tumor Cell Aggregation by Saias, Laure, Gomes, Aurélie, Cazales, Martine, Ducommun, Bernard, Lobjois, Valérie

“…Cell aggregation is frequently impaired during the growth of primary tumors and the formation of metastatic lesions. Cell aggregation depends on cell-cell…”
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Characterization of the physical properties of tumor-derived spheroids reveals critical insights for pre-clinical studies by Guillaume, Ludivine, Rigal, Lise, Fehrenbach, Jérôme, Severac, Childérick, Ducommun, Bernard, Lobjois, Valérie

“…Three-dimensional spheroids are widely used as cancer models to study tumor cell proliferation and to evaluate new anticancer drugs. Growth-induced stress…”
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Cell cycle control by the CDC25 phosphatases by Aressy, Bernadette, Ducommun, Bernard

“…Cell division cycle 25 (CDC25) phosphatases are key actors in eukaryotic cell cycle control. They are responsible for the dephosphorylations that activate the…”
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Impact of physical confinement on nuclei geometry and cell division dynamics in 3D spheroids by Desmaison, Annaïck, Guillaume, Ludivine, Triclin, Sarah, Weiss, Pierre, Ducommun, Bernard, Lobjois, Valérie

“…Multicellular tumour spheroids are used as a culture model to reproduce the 3D architecture, proliferation gradient and cell interactions of a tumour…”
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Multicellular tumor spheroid model to evaluate spatio-temporal dynamics effect of chemotherapeutics: application to the gemcitabine/CHK1 inhibitor combination in pancreatic cancer by Dufau, Isabelle, Frongia, Céline, Sicard, Flavie, Dedieu, Laure, Cordelier, Pierre, Ausseil, Frédéric, Ducommun, Bernard, Valette, Annie

“…The multicellular tumor spheroid (MCTS) is an in vitro model associating malignant-cell microenvironment and 3D organization as currently observed in avascular…”
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Mechanical stress impairs mitosis progression in multi-cellular tumor spheroids by Desmaison, Annaïck, Frongia, Céline, Grenier, Katia, Ducommun, Bernard, Lobjois, Valérie

“…Growing solid tumors are subjected to mechanical stress that influences their growth rate and development. However, little is known about its effects on tumor…”
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Multicellular tumor spheroid models to explore cell cycle checkpoints in 3D by Laurent, Jennifer, Frongia, Céline, Cazales, Martine, Mondesert, Odile, Ducommun, Bernard, Lobjois, Valérie

“…MultiCellular Tumor Spheroid (MCTS) mimics the organization of a tumor and is considered as an invaluable model to study cancer cell biology and to evaluate…”
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Oxygen Partial Pressure Is a Rate-Limiting Parameter for Cell Proliferation in 3D Spheroids Grown in Physioxic Culture Condition by Gomes, Aurélie, Guillaume, Ludivine, Grimes, David Robert, Fehrenbach, Jérôme, Lobjois, Valérie, Ducommun, Bernard

“…The in situ oxygen partial pressure in normal and tumor tissues is in the range of a few percent. Therefore, when studying cell growth in 3D culture systems,…”
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Measure and characterization of the forces exerted by growing multicellular spheroids using microdevice arrays by Aoun, Laurene, Larnier, Stanislas, Weiss, Pierre, Cazales, Martine, Herbulot, Ariane, Ducommun, Bernard, Vieu, Christophe, Lobjois, Valérie

“…Growing multicellular spheroids recapitulate many features of expanding microtumours, and therefore they are an attractive system for biomechanical studies…”
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High-resolution in-depth imaging of optically cleared thick samples using an adaptive SPIM by Masson, Aurore, Escande, Paul, Frongia, Céline, Clouvel, Grégory, Ducommun, Bernard, Lorenzo, Corinne

“…Today, Light Sheet Fluorescence Microscopy (LSFM) makes it possible to image fluorescent samples through depths of several hundreds of microns. However, LSFM…”
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Gap junctions contribute to anchorage-independent clustering of breast cancer cells by Gava, Fabien, Rigal, Lise, Mondesert, Odile, Pesce, Elise, Ducommun, Bernard, Lobjois, Valérie

“…Cancer cell aggregation is a key process involved in the formation of clusters of circulating tumor cells. We previously reported that cell-cell adhesion…”
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Low-temperature plasma-induced antiproliferative effects on multi-cellular tumor spheroids by Plewa, Joseph-Marie, Yousfi, Mohammed, Frongia, Céline, Eichwald, Olivier, Ducommun, Bernard, Merbahi, Nofel, Lobjois, Valérie

“…Biomedical applications of low-temperature plasmas are of growing interest, especially in the field of plasma-induced anti-tumor effects. The present work is…”
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Deep and clear optical imaging of thick inhomogeneous samples by Jorand, Raphael, Le Corre, Gwénaële, Andilla, Jordi, Maandhui, Amina, Frongia, Céline, Lobjois, Valérie, Ducommun, Bernard, Lorenzo, Corinne

“…Inhomogeneity in thick biological specimens results in poor imaging by light microscopy, which deteriorates as the focal plane moves deeper into the specimen…”
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Live cell division dynamics monitoring in 3D large spheroid tumor models using light sheet microscopy by Lorenzo, Corinne, Frongia, Céline, Jorand, Raphaël, Fehrenbach, Jérôme, Weiss, Pierre, Maandhui, Amina, Gay, Guillaume, Ducommun, Bernard, Lobjois, Valérie

“…Multicellular tumor spheroids are models of increasing interest for cancer and cell biology studies. They allow considering cellular interactions in exploring…”
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Mitotic arrest affects clustering of tumor cells by Bonnet, Julia, Rigal, Lise, Mondesert, Odile, Morin, Renaud, Corsaut, Gaëlle, Vigneau, Mathieu, Ducommun, Bernard, Lobjois, Valérie

“…Cancer cell aggregation is a key process involved in the formation of tumor cell clusters. It has recently been shown that clusters of circulating tumor cells…”
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CDC25B Involvement in the Centrosome Duplication Cycle and in Microtubule Nucleation by BOUTROS, Rose, LOBJOIS, Valérie, DUCOMMUN, Bernard

“…Centrosome amplification is frequently reported in human cancers, although the molecular mechanisms that are responsible for this remain unclear. There is…”
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Mitotic Phosphorylation of Cdc25B Ser321 Disrupts 14-3-3 Binding to the High Affinity Ser323 Site by Astuti, Puji, Boutros, Rose, Ducommun, Bernard, Gabrielli, Brian

“…Cdc25B is a key regulator of entry into mitosis, and its activity and localization are regulated by binding of the 14-3-3 dimer. There are three 14-3-3 binding…”
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Microcephalin and pericentrin regulate mitotic entry via centrosome-associated Chk1 by Tibelius, Alexandra, Marhold, Joachim, Zentgraf, Hanswalter, Heilig, Christoph E, Neitzel, Heidemarie, Ducommun, Bernard, Rauch, Anita, Ho, Anthony D, Bartek, Jiri, Krämer, Alwin

“…Primary microcephaly, Seckel syndrome, and microcephalic osteodysplastic primordial dwarfism type II (MOPD II) are disorders exhibiting marked microcephaly,…”
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