Search Results - "DUBYAK, George R."

P2X7 receptor regulation of non‐classical secretion from immune effector cells by Dubyak, George R.

“…Summary P2X7 receptors (P2X7R) are extracellular ATP‐gated ion channels expressed in the immune effector cells that carry out critical protective responses…”
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Neutrophil P2X7 receptors mediate NLRP3 inflammasome-dependent IL-1β secretion in response to ATP by Karmakar, Mausita, Katsnelson, Michael A., Dubyak, George R., Pearlman, Eric

“…Although extracellular ATP is abundant at sites of inflammation, its role in activating inflammasome signalling in neutrophils is not well characterized. In…”
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N-GSDMD trafficking to neutrophil organelles facilitates IL-1β release independently of plasma membrane pores and pyroptosis by Karmakar, Mausita, Minns, Martin, Greenberg, Elyse N., Diaz-Aponte, Jose, Pestonjamasp, Kersi, Johnson, Jennifer L., Rathkey, Joseph K., Abbott, Derek W., Wang, Kun, Shao, Feng, Catz, Sergio D., Dubyak, George R., Pearlman, Eric

“…Gasdermin-D (GSDMD) in inflammasome-activated macrophages is cleaved by caspase-1 to generate N-GSDMD fragments. N-GSDMD then oligomerizes in the plasma…”
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K+ efflux agonists induce NLRP3 inflammasome activation independently of Ca2+ signaling by Katsnelson, Michael A, Rucker, L Graham, Russo, Hana M, Dubyak, George R

“…Perturbation of intracellular ion homeostasis is a major cellular stress signal for activation of NLRP3 inflammasome signaling that results in…”
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Locally Produced Complement Fragments C5a and C3a Provide Both Costimulatory and Survival Signals to Naive CD4+ T Cells by Strainic, Michael G., Liu, Jinbo, Huang, Danping, An, Fengqi, Lalli, Peter N., Muqim, Nasima, Shapiro, Virginia S., Dubyak, George R., Heeger, Peter S., Medof, M. Edward

“…Costimulatory signals are critical to T cell activation, but how their effects are mediated remains incompletely characterized. Here, we demonstrate that…”
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Pyroptosis in neutrophils: Multimodal integration of inflammasome and regulated cell death signaling pathways by Dubyak, George R., Miller, Brandon A., Pearlman, Eric

“…Summary Pyroptosis is a proinflammatory mode of lytic cell death mediated by accumulation of plasma membrane (PM) macropores composed of gasdermin‐family…”
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Caspase-8 as an Effector and Regulator of NLRP3 Inflammasome Signaling by Antonopoulos, Christina, Russo, Hana M., El Sanadi, Caroline, Martin, Bradley N., Li, Xiaoxia, Kaiser, William J., Mocarski, Edward S., Dubyak, George R.

“…We recently described the induction of noncanonical IL-1β processing via caspase-8 recruited to ripoptosome signaling platforms in myeloid leukocytes. Here, we…”
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CD40 in Retinal Müller Cells Induces P2X7-Dependent Cytokine Expression in Macrophages/Microglia in Diabetic Mice and Development of Early Experimental Diabetic Retinopathy by Portillo, Jose-Andres C, Lopez Corcino, Yalitza, Miao, Yanling, Tang, Jie, Sheibani, Nader, Kern, Timothy S, Dubyak, George R, Subauste, Carlos S

“…Müller cells and macrophages/microglia are likely important for the development of diabetic retinopathy; however, the interplay between these cells in this…”
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Chemical disruption of the pyroptotic pore-forming protein gasdermin D inhibits inflammatory cell death and sepsis by Rathkey, Joseph K, Zhao, Junjie, Liu, Zhonghua, Chen, Yinghua, Yang, Jie, Kondolf, Hannah C, Benson, Bryan L, Chirieleison, Steven M, Huang, Alex Y, Dubyak, George R, Xiao, Tsan S, Li, Xiaoxia, Abbott, Derek W

“…Dysregulation of inflammatory cell death is a key driver of many inflammatory diseases. Pyroptosis, a highly inflammatory form of cell death, uses…”
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NLRP3 inflammasome signaling is activated by low-level lysosome disruption but inhibited by extensive lysosome disruption: roles for K+ efflux and Ca2+ influx by Katsnelson, Michael A, Lozada-Soto, Kristen M, Russo, Hana M, Miller, Barbara A, Dubyak, George R

“…Nucleotide-binding domain, leucine-rich-repeat-containing family, pyrin domain-containing 3 (NLRP3) is a cytosolic protein that nucleates assembly of…”
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Chemotherapeutic Drugs Induce ATP Release via Caspase-gated Pannexin-1 Channels and a Caspase/Pannexin-1-independent Mechanism by Boyd-Tressler, Andrea, Penuela, Silvia, Laird, Dale W., Dubyak, George R.

“…Anti-tumor immune responses have been linked to the regulated release of ATP from apoptotic cancer cells to engage P2 purinergic receptor signaling cascades in…”
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NLRP3 selectively drives IL-1β secretion by Pseudomonas aeruginosa infected neutrophils and regulates corneal disease severity by Minns, Martin S., Liboro, Karl, Lima, Tatiane S., Abbondante, Serena, Miller, Brandon A., Marshall, Michaela E., Tran Chau, Jolynn, Roistacher, Alicia, Rietsch, Arne, Dubyak, George R., Pearlman, Eric

“…Macrophages infected with Gram-negative bacteria expressing Type III secretion system (T3SS) activate the NLRC4 inflammasome, resulting in Gasdermin D…”
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Live-cell visualization of gasdermin D-driven pyroptotic cell death by Rathkey, Joseph K., Benson, Bryan L., Chirieleison, Steven M., Yang, Jie, Xiao, Tsan S., Dubyak, George R., Huang, Alex Y., Abbott, Derek W.

“…Pyroptosis is a form of cell death important in defenses against pathogens that can also result in a potent and sometimes pathological inflammatory response…”
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Differential Requirement of P2X7 Receptor and Intracellular K+ for Caspase-1 Activation Induced by Intracellular and Extracellular Bacteria by Franchi, Luigi, Kanneganti, Thirumala-Devi, Dubyak, George R., Núñez, Gabriel

“…Interleukin-1β (IL-1β) is a pro-inflammatory cytokine that plays an important role in host defense and inflammatory diseases. The maturation and secretion of…”
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Extracellular pyrophosphate metabolism and calcification in vascular smooth muscle by Villa-Bellosta, Ricardo, Wang, Xiaonan, Millán, José Luis, Dubyak, George R, O'Neill, W Charles

“…Extracellular inorganic pyrophosphate (ePP(i)) is an important endogenous inhibitor of vascular calcification, but it is not known whether systemic or local…”
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Mechanisms of caspase-1 activation by P2X7 receptor-mediated K+ release by Kahlenberg, J Michelle, Dubyak, George R

“…The mechanisms underlying caspase-1 activation and IL-1beta processing during inflammatory activation of monocytes and macrophages are not well defined. Here,…”
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Function without form: an ongoing search for maxi-anion channel proteins. Focus on "Maxi-anion channel and pannexin 1 hemichannel constitute separate pathways for swelling-induced ATP release in murine L929 fibrosarcoma cells" by Dubyak, George R

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P2X7 Receptor-Stimulated Secretion of MHC Class II-Containing Exosomes Requires the ASC/NLRP3 Inflammasome but Is Independent of Caspase-1 by Qu, Yan, Ramachandra, Lakshmi, Mohr, Susanne, Franchi, Luigi, Harding, Clifford V, Nunez, Gabriel, Dubyak, George R

“…We recently reported that P2X7 receptor (P2X7R)-induced activation of caspase-1 inflammasomes is accompanied by release of MHC class II (MHC-II) protein into…”
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Mycobacterium tuberculosis Synergizes with ATP To Induce Release of Microvesicles and Exosomes Containing Major Histocompatibility Complex Class II Molecules Capable of Antigen Presentation by Ramachandra, Lakshmi, Qu, Yan, Wang, Ying, Lewis, Colleen J, Cobb, Brian A, Takatsu, Kiyoshi, Boom, W. Henry, Dubyak, George R, Harding, Clifford V

“…Major histocompatibility complex class II (MHC-II) molecules are released by murine macrophages upon lipopolysaccharide (LPS) stimulation and ATP signaling…”
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Purinergic regulation of high-glucose-induced caspase-1 activation in the rat retinal Müller cell line rMC-1 by Trueblood, Katherine E, Mohr, Susanne, Dubyak, George R

“…Chronic activation of proinflammatory caspase-1 in the retinas of diabetic animals and patients in vivo and retinal Müller cells in vitro is well documented…”
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