Search Results - "DUBOIS, R. N"

The role of COX-2 in intestinal inflammation and colorectal cancer by Wang, D, DuBois, R N

“…Colorectal cancer (CRC) is a heterogeneous disease, including at least three major forms: hereditary, sporadic and colitis-associated CRC. A large body of…”
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PROSTAGLANDINS AND CANCER by Wang, D, DuBois, R N

“…Chemoprevention has been considered as a possible approach for cancer prevention. A significant effort has been made in the development of novel drugs for both…”
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Inhibition of human colon cancer cell growth by selective inhibition of cyclooxygenase-2 by Sheng, H, Shao, J, Kirkland, S C, Isakson, P, Coffey, R J, Morrow, J, Beauchamp, R D, DuBois, R N

“…A considerable amount of evidence collected from several different experimental systems indicates that cyclooxygenase-2 (COX-2) may play a role in colorectal…”
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Increased cyclooxygenase-2 levels in carcinogen-induced rat colonic tumors by DuBois, RN, Radhika, A, Reddy, BS, Entingh, AJ

“…BACKGROUND & AIMS: Multiple studies show that continuous use of nonsteroidal anti-inflammatory drugs (NSAIDs) lowers the risk of colon cancer in humans and…”
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Colorectal cancer prevention and treatment by inhibition of cyclooxygenase-2 by DuBois, Raymond N, Gupta, Rajnish A

“…Population-based studies have established that long-term intake of non-steroidal anti-inflammatory drugs (NSAIDs), compounds that inhibit the enzymatic…”
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Elevated cyclooxygenase-2 levels in Min mouse adenomas by Williams, CS, Luongo, C, Radhika, A, Zhang, T, Lamps, LW, Nanney, LB, Beauchamp, RD, DuBois, RN

“…BACKGROUND & AIMS: Mutations in the APC gene result in an increased propensity to develop intestinal neoplasia; however, a complete understanding of the…”
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K-Ras-mediated increase in cyclooxygenase 2 mRNA stability involves activation of the protein kinase B by HONGMIAO SHENG, JINYI SHAO, DUBOIS, Raymond N

“…Cyclooxygenase (COX) 2 expression is regulated via the Ras signaling pathway, and induction of mutated Ras rapidly increases COX-2 levels in intestinal…”
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Activation of PPARγ leads to inhibition of anchorage-independent growth of human colorectal cancer cells by Brockman, Jeffrey A., Gupta, Rajnish A., DuBois, Raymond N.

“…Background & Aims: Peroxisomal proliferator–activated receptor γ (PPARγ) is a nuclear hormone receptor that provides a direct link between fatty acid…”
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Eicosanoids and the gastrointestinal tract by Eberhart, C E, Dubois, R N

“…Determining the role of eicosanoids in gastrointestinal physiology and pathophysiology has been an active area of investigation over the past 20 years. The…”
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Cyclooxygenase in biology and disease by DuBois, Raymond N., Abramson, Steven B., Crofford, Leslie, Gupta, Rajnish A., Simon, Lee S., Putte, Leo B. A., Lipsky, Peter E.

“…ABSTRACT Cyclooxygenase (COX), the key enzyme required for the conversion of arachidonic acid to prostaglandins was first identified over 20 years ago. Drugs,…”
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A selective cyclooxygenase 2 inhibitor suppresses the growth of H-ras-transformed rat intestinal epithelial cells by Sheng, GG, Shao, J, Sheng, H, Hooton, EB, Isakson, PC, Morrow, JD, Coffey, RJ, DuBois, RN, Beauchamp, RD

“…BACKGROUND & AIMS: Constitutive expression of cyclooxygenase 2 (COX-2) has been found in 85% of colorectal cancers. Ras mutations are found in 50% of…”
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Aspirin use and potential mechanisms for colorectal cancer prevention by Williams, C S, Smalley, W, DuBois, R N

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Review article: cyclooxygenase – a target for colon cancer prevention by Dubois, R. N.

“…Summary Use of nonsteroidal anti‐inflammatory drugs such as aspirin, which are known to inhibit cyclooxygenase activity, reduces the relative risk of…”
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Cloning, expression, and regulation of rabbit cyclooxygenase-2 in renal medullary interstitial cells by Guan, Y, Chang, M, Cho, W, Zhang, Y, Redha, R, Davis, L, Chang, S, DuBois, R N, Hao, C M, Breyer, M

“…Prostaglandin synthesis requires cyclooxygenase-1 (COX1) or -2 (COX2), which mediate the conversion of arachidonate to prostaglandin H2. COX1 is the…”
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Cooperative effects of matrix metalloproteinase and cyclooxygenase-2 inhibition on intestinal adenoma reduction by WAGENAAR-MILLER, R. A, HANLEY, G, SHATTUCK-BRANDT, R, DUBOIS, R. N, BELL, R. L, MATRISIAN, L. M, MORGAN, D. W

“…Matrix metalloproteinases (MMPs) and cyclooxygenase-2 (COX-2) are expressed in both sporadic and familial adenomatous colonic polyps and tumours and have been…”
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The nuclear eicosanoid receptor, PPARγ, is aberrantly expressed in colonic cancers by DUBOIS, R. N, GUPTA, R, BROCKMAN, J, REDDY, B. S, KRAKOW, S. L, LAZAR, M. A

“…Continuous use of nonsteroidal anti-inflammatory drugs (NSAIDs) lowers the relative risk of colorectal cancer in humans and decreases tumor yield in rodents…”
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The classification of cyclooxygenase inhibitors by Lipsky, L P, Abramson, S B, Crofford, L, Dubois, R N, Simon, L S, van de Putte, L B

“…In summary, precise classification of COX inhibitors has important clinical implications for efficacy and toxicity. However, classification of these agents…”
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Cyclooxygenase 2 expression is increased in the stroma of colon carcinomas from IL–10 −/− mice by Shattuck-Brandt, Rebecca L., Varilek, Gary W., Radhika, Aramandla, Yang, Fajun, Washington, M.Kay, DuBois, Raymond N.

“…Background & Aims: The pathological and molecular changes associated with colitis-associated colorectal cancer and sporadic colorectal cancer are considered to…”
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Associations between obesity and cancer: the role of fatty acid synthase by Wang, Dingzhi, Dubois, Raymond N

“…Wang discusses the association of obesity with cancer. Obesity is a common metabolic disorder and rapidly becoming a global public health problem in the 21st…”
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Epidermal growth factor-related peptides and their relevance to gastrointestinal pathophysiology by Barnard, J A, Beauchamp, R D, Russell, W E, Dubois, R N, Coffey, R J

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