Search Results - "DUBINSKY, Barry"

5-ethoxymethyl-7-fluoro-3-oxo-1,2,3,5-tetrahydrobenzo[4,5]imidazo[1,2a]pyridine-4-N-(2-fluorophenyl)carboxamide (RWJ-51204), a new nonbenzodiazepine anxiolytic by Dubinsky, Barry, Vaidya, Anil H, Rosenthal, Daniel I, Hochman, Coralie, Crooke, Jeffrey J, DeLuca, Samantha, DeVine, Ann, Cheo-Isaacs, Cathy T, Carter, Alexandre R, Jordan, Alfonzo D, Reitz, Allen B, Shank, Richard P

“…5-ethoxymethyl-7-fluoro-3-oxo-1,2,3,5-tetrahydrobenzo[4,5] imidazo[1,2a]pyridine-4-N-(2-fluorophenyl)carboxamide) (RWJ-51204) binds selectively and with high…”
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Potential anxiolytic agents. Part 4: novel orally-active N(5)-substituted pyrido[1,2-a]benzimidazoles with high GABA-A receptor affinity by Jordan, Alfonzo D, Vaidya, Anil H, Rosenthal, Daniel I, Dubinsky, Barry, Kordik, Cheryl P, Sanfilippo, Pauline J, Wu, Wu-Nan, Reitz, Allen B

“…A series of pyrido[1,2-a]benzimidazoles (PBIs) with substitution on the N(5)-nitrogen has been synthesized and found to possess high affinity for the…”
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Potential anxiolytic agents. 3. Novel A-ring modified pyrido[1,2- a]benzimidazoles by Maryanoff, Bruce E., Nortey, Samuel O., McNally, James J., Sanfilippo, Pauline J., McComsey, David F., Dubinsky, Barry, Shank, Richard P., Reitz, Allen B.

“…A variety of pyrido[1,2- a]benzimidazoles (PBIs) modified on the A-ring were prepared and evaluated for affinity to the benzodiazepine binding site on the…”
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Potential anxiolytic agents. Part 4: Novel orally-active N5-substituted pyrido[1,2-a]benzimidazoles with high GABA-A receptor affinity by JORDAN, Alfonzo D, VAIDYA, Anil H, ROSENTHAL, Daniel I, DUBINSKY, Barry, KORDIK, Cheryl P, SANFILIPPO, Pauline J, WU, Wu-Nan, REITZ, Allen B

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γ-Aminobutyrate-A Receptor Modulation by 3-Aryl-1-(arylsulfonyl)- 1,4,5,6-tetrahydropyridazines by Rybczynski, Philip J, Combs, Donald W, Jacobs, Kimberly, Shank, Richard P, Dubinsky, Barry

“…A series of 3-aryl-1-(arylsulfonyl)-1,4,5,6-tetrahydropyridazine allosteric modulators of the GABAA receptor was synthesized, and biological activity was…”
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Potential Anxiolytic Agents. Part 4: Novel Orally-Active N 5-Substituted Pyrido[1,2- a]benzimidazoles with High GABA-A Receptor Affinity by Jordan, Alfonzo D, Vaidya, Anil H, Rosenthal, Daniel I, Dubinsky, Barry, Kordik, Cheryl P, Sanfilippo, Pauline J, Wu, Wu-Nan, Reitz, Allen B

“…A series of pyrido[1,2- a]benzimidazoles (PBIs) with substitution on the N 5-nitrogen has been synthesized and found to possess high affinity for the…”
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Potential Anxiolytic Agents. Pyrido[1,2-a]benzimidazoles: A New Structural Class of Ligands for the Benzodiazepine Binding Site on GABA-A Receptors by Maryanoff, Bruce E, Ho, Winston, McComsey, David F, Reitz, Allen B, Grous, Philip P, Nortey, Samuel O, Shank, Richard P, Dubinsky, Barry, Taylor, Russell J. Jr, Gardocki, Joseph F

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Potential anxiolytic agents. 2. Improvement of oral efficacy for the pyrido[1,2- a]benzimidazole (PBI) class of GABA-A receptor modulators by Maryanoff, Bruce E, McComsey, David F, Ho, Winston, Shank, Richard P, Dubinsky, Barry

“…We have further explored the structure-activity relationships of pyrido[1,2- a]benzimidazole (PBI) derivatives (viz. prototype 1), a novel series of central…”
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Synthesis of (aryloxy)alkylamines. 2. Novel imidazo-fused heterocycles with calcium channel blocking and local anesthetic activity by Sanfilippo, Pauline J, Urbanski, Maud, Press, Jeffery B, Dubinsky, Barry, Moore, John B

“…A series of imidazo-fused heterocycles substituted with an aryloxy)alkylamine side chain were prepared as modifications to butoprozine (I) and found to possess…”
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Flunarizine and verapamil: effects on central nervous system and peripheral consequences of cytotoxic hypoxia in rats by Dubinsky, B, Sierchio, J N, Temple, D E, Ritchie, D M

“…Flunarizine is a calcium entry blocking drug possessing antihypoxic activity in animal models of cerebral and peripheral ischemia-anoxia and has clinical…”
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Peripheral antialgesics: a review by Capetola, R J, Rosenthale, M E, Dubinsky, B, McGuire, J L

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Synthesis and Pharmacological Study of Pyridazines. I. Alkoxypyridazines1 by Coad, Peter, Coad, Raylene Adams, Dubinsky, Barry, Buckley, Joseph P., Kinnard, William

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Synthesis and Pharmacological Study of Pyridazines. I. Alkoxypyridazines 1 by Coad, Peter, Coad, Raylene Adams, Dubinsky, Barry, Buckley, Joseph P., Kinnard, William

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Correlation of analgesia with levels of tilidine and a biologically active metabolite in rat plasma and brain by Dubinsky, B, Crew, M C, Melgar, M D, Karpowicz, J K, Di Carlo, F J

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