Search Results - "DU TOIT, EUGENE F."

A gut microbiome metabolite paradoxically depresses contractile function while activating mitochondrial respiration by Naghipour, Saba, Fisher, Joshua J, Perkins, Anthony V, Peart, Jason N, Headrick, John P, Toit, Eugene F Du

“…Trimethylamine-N-oxide (TMAO) is an end-product of gut microbiome metabolism linked to cardiovascular disease (CVD). However, precise cardiovascular influences…”
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Stress‐induced body weight loss and improvements in cardiometabolic risk factors do not translate to improved myocardial ischemic tolerance in western diet‐fed mice by Hatton‐Jones, Kyle, Cox, Amanda J., Peart, Jason N., Headrick, John P., Toit, Eugene F.

“…Although both diet‐induced obesity and psychological stress are recognized as significant independent contributors to cardiometabolic and behavioral disorders,…”
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Myocardial susceptibility to ischemic-reperfusion injury in a prediabetic model of dietary-induced obesity by du Toit, Eugene F, Smith, Wayne, Muller, Christo, Strijdom, Hans, Stouthammer, Bernadette, Woodiwiss, Angela J, Norton, Gavin R, Lochner, Amanda

“…We assessed the myocardial susceptibility to ischemic-reperfusion injury in obese rat hearts in the absence and the presence of predicted circulating…”
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Chronic melatonin consumption prevents obesity-related metabolic abnormalities and protects the heart against myocardial ischemia and reperfusion injury in a prediabetic model of diet-induced obesity by Nduhirabandi, Frederic, Du Toit, Eugene F., Blackhurst, Dee, Marais, David, Lochner, Amanda

“…:  Obesity, a major risk factor for ischemic heart disease, is associated with increased oxidative stress and reduced antioxidant status. Melatonin, a potent…”
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Circulating TMAO, the gut microbiome and cardiometabolic disease risk: an exploration in key precursor disorders by Naghipour, Saba, Cox, Amanda J, Fisher, Joshua J, Plan, Manuel, Stark, Terra, West, Nic, Peart, Jason N, Headrick, John P, Du Toit, Eugene F

“…Elevations in the gut metabolite trimethylamine-N-oxide (TMAO) have been linked to cardiovascular and metabolic diseases. Whether elevated TMAO levels reflect…”
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Dietary α-Linolenic Acid Counters Cardioprotective Dysfunction in Diabetic Mice: Unconventional PUFA Protection by Russell, Jake S, Griffith, Tia A, Naghipour, Saba, Vider, Jelena, Du Toit, Eugene F, Patel, Hemal H, Peart, Jason N, Headrick, John P

“…Whether dietary omega-3 (n-3) polyunsaturated fatty acid (PUFA) confers cardiac benefit in cardiometabolic disorders is unclear. We test whether dietary…”
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Myocyte membrane and microdomain modifications in diabetes: determinants of ischemic tolerance and cardioprotection by Russell, Jake, Du Toit, Eugene F, Peart, Jason N, Patel, Hemal H, Headrick, John P

“…Cardiovascular disease, predominantly ischemic heart disease (IHD), is the leading cause of death in diabetes mellitus (DM). In addition to eliciting…”
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Impact of Diet-Induced Obesity and Testosterone Deficiency on the Cardiovascular System: A Novel Rodent Model Representative of Males with Testosterone-Deficient Metabolic Syndrome (TDMetS) by Donner, Daniel G, Elliott, Grace E, Beck, Belinda R, Bulmer, Andrew C, Du Toit, Eugene F

“…Current models of obesity utilise normogonadic animals and neglect the strong relationships between obesity-associated metabolic syndrome (MetS) and male…”
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Obesity improves myocardial ischaemic tolerance and RISK signalling in insulin-insensitive rats by Donner, Daniel, Headrick, John P, Peart, Jason N, du Toit, Eugene F

“…Obesity with associated metabolic disturbances worsens ischaemic heart disease outcomes, and rodent studies confirm that obesity with insulin-resistance…”
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Dependence of Cardiac Systolic Function on Elevated Fatty Acid Availability in Obese, Insulin-Resistant Rats by Smith, Wayne, PhD, Norton, Gavin R., PhD, MD, Woodiwiss, Angela J., PhD, Lochner, Amanda, DSc, du Toit, Eugene F., PhD

“…Highlights • Ex vivo cardiac pump function of obese rats is compromised when glucose is the only substrate • Fatty acids normalise cardiac pump function ex…”
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Health Benefits of a Natural Carotenoid Rich Oil: A Proposed Mechanism Of Protection Against Ischaemia/Reperfusion Injury by van Rooyen, Jacques, Esterhuyse, Adriaan J, Engelbrecht, Anna-Mart, du Toit, Eugene F

“…Numerous studies have reported the protective properties of carotenoid supplementation against skin and eye associated diseases. However, conflicting data…”
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Trimethylamine N-oxide: heart of the microbiota–CVD nexus? by Naghipour, Saba, Cox, Amanda J., Peart, Jason N., Du Toit, Eugene F., Headrick, John P.

“…We critically review potential involvement of trimethylamine N-oxide (TMAO) as a link between diet, the gut microbiota and CVD. Generated primarily from…”
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Opioid receptors and cardioprotection – ‘opioidergic conditioning’ of the heart by Headrick, John P, See Hoe, Louise E, Du Toit, Eugene F, Peart, Jason N

“…Ischaemic heart disease (IHD) remains a major cause of morbidity/mortality globally, firmly established in Westernized or ‘developed’ countries and rising in…”
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Bilirubin acts as a multipotent guardian of cardiovascular integrity: more than just a radical idea by Bulmer, Andrew C, Bakrania, Bhavisha, Du Toit, Eugene F, Boon, Ai-Ching, Clark, Paul J, Powell, Lawrie W, Wagner, Karl-Heinz, Headrick, John P

“…Bilirubin, a potentially toxic catabolite of heme and indicator of hepatobiliary insufficiency, exhibits potent cardiac and vascular protective properties…”
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The brain-adipocyte-gut network: Linking obesity and depression subtypes by Patist, Carla M., Stapelberg, Nicolas J. C., Du Toit, Eugene F., Headrick, John P.

“…Major depressive disorder (MDD) and obesity are dominant and inter-related health burdens. Obesity is a risk factor for MDD, and there is evidence MDD…”
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Proposed mechanisms for red palm oil induced cardioprotection in a model of hyperlipidaemia in the rat by Esterhuyse, Johan S., van Rooyen, Jacques, Strijdom, Hans, Bester, Dirk, du Toit, Eugene F.

“…High-cholesterol diets alter myocardial and vascular NO-cGMP signaling and have been implicated in ischaemic/reperfusion injury. We investigated the effects of…”
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Diet‐induced obesity alters signalling pathways and induces atrophy and apoptosis in skeletal muscle in a prediabetic rat model by Sishi, Balindiwe, Loos, Benjamin, Ellis, Beverly, Smith, Wayne, du Toit, Eugene F., Engelbrecht, Anna‐Mart

“…Pro‐inflammatory and stress‐activated signalling pathways are important role players in the pathogenesis of obesity and insulin resistance. Obesity and type II…”
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Effect of chronic restraint stress and western‐diet feeding on colonic regulatory gene expression in mice by Hatton‐Jones, Kyle M., Toit, Eugene F., Cox, Amanda J.

“…Background Diet‐induced obesity (DIO) and psychological stress are significant independent regulators of gastrointestinal physiology; however, our…”
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Pravastatin improves risk factors but not ischaemic tolerance in obese rats by Oi, Massa, Donner, Daniel, Peart, Jason, Beck, Belinda, Wendt, Lauren, Headrick, John P., du Toit, Eugene F.

“…Statins are effective in management of dyslipidaemia, and a cornerstone of CVD prevention strategies. However, the impacts of their pleiotropic effects on…”
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Behavioural disruption in diabetic mice: Neurobiological correlates and influences of dietary α-linolenic acid by Griffith, Tia A., Russell, Jake S., Naghipour, Saba, Helman, Tessa J., Peart, Jason N., Stapelberg, Nicolas J.C., Headrick, John P., Du Toit, Eugene F.

“…Evolving type 2 diabetes (T2D) may influence locomotion and affective state, promoting metabolic dysfunction. We examined behaviour and neurobiology in a model…”
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