Search Results - "DS, Samiulla"

Abstract 1713: Novel, potent and orally bioavailable small molecule CD73 inhibitors for cancer immunotherapy by Venkateshappa, Chandregowda, Narayanan, Kishore, Kothandaraman, Prasath, Priyadarshani, Garima, Nair, Rashmi, Goyal, Megha, Ahuja, Vijay Kamal, Dadhania, Sagar, Aravind, AB, Samiulla, DS, Daginakkatte, Girish, Antony, Thomas, Nellore, Kavitha, Panigrahi, Sunil, Chikkanna, Dinesh, Samajdar, Susanta, Ramachandra, Murali

“…Abstract CD73 is a cell surface ectoenzyme, which is overexpressed in many types of human and mouse cancers. CD73 is the primary enzymatic producer of…”
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Development of an orally bioavailable mSWI/SNF ATPase degrader and acquired mechanisms of resistance in prostate cancer by He, Tongchen, Cheng, Caleb, Qiao, Yuanyuan, Cho, Hanbyul, Young, Eleanor, Mannan, Rahul, Mahapatra, Somnath, Miner, Stephanie J, Zheng, Yang, Kim, NamHoon, Zeng, Victoria Z, Wisniewski, Jasmine P, Hou, Siyu, Jackson, Bailey, Cao, Xuhong, Su, Fengyun, Wang, Rui, Chang, Yu, Kuila, Bilash, Mukherjee, Subhendu, Dukare, Sandeep, Aithal, Kiran B, D S, Samiulla, Abbineni, Chandrasekhar, Vaishampayan, Ulka, Lyssiotis, Costas A, Parolia, Abhijit, Xiao, Lanbo, Chinnaiyan, Arul M

“…Mammalian switch/sucrose nonfermentable (mSWI/SNF) ATPase degraders have been shown to be effective in enhancer-driven cancers by functioning to impede…”
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Abstract 1266: Discovery and preclinical evaluation of a novel covalent inhibitor of FABP5 for cancer therapy by Chikkanna, Dinesh, Satyam, Leena Khare, Pnaigrahi, Sunil Kumar, Khairnar, Vinayak, Pothuganti, Manoj, Kaza, Lakshmi Narayan, Kalidindi, Narasimha Raju, Nataraj, Vijaya Shankar, Gatta, Aditya Kiran, Krishnamurthy, Narasimha Rao, Patil, Sandeep, Samiulla, DS, Aithal, Kiran, Ahuja, Vijay Kamal, Tiwari, Nirbhay Kumar, Charamannna, KB, Pise, Pravin, Anthony, Thomas, Nellore, Kavitha, Giri, Sanjeev, Chelur, Shekar, Samajdar, Susanta, Ramachandra, Murali

“…Abstract Dysregulated fatty acid metabolism is thought to be a hallmark of cancer, wherein fatty acids function both as an energy source and as signals for…”
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Abstract 4086: Preclinical evaluation of pharmacokinetics, pharmacodynamics and efficacy of the dual CD73-A2AR Inhibitors by Chikkanna, Dinesh, Narayanan, Kishore, Panigrahi, Sunil, Priyadarshini, Garima, Goyal, Megha, Mani, Jiju, Samiulla, DS, dadhania, Sagar, Aravind, AB, Daginakatte, Girish, Anthony, Thomas, Nellore, Kavitha, Samajdar, Susanta, Ramachandra, Murali

“…Abstract As a potent immunosuppressor adenosine is essential for maintaining tissue homeostasis and preventing an overzealous immune response during…”
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Abstract 1753: Targeting cancer with selective cbp/p300 bromodomain inhibitors by Jaleel, Mahaboobi, Senaiar, Ramesh S., Abbineni, Chandrasekhar, Renukappa, Girish A., Mukherjee, Subhendu, Marappan, Sivapriya, Samiulla, DS, Aravind, AB, Kumar, Naveen R., Reddy, Venkata Siva N., Babu, Asha, Srinivas, Akhila P., Yadlapalli, Prasad, Tgore, Suraj, NR, Raghavendra, Naik, Chandranath D., Giri, Sanjeev, Antony, Thomas, Nellore, Kavitha, Chelur, Shekar, Daginakatte, Girish, Ravanti, laura, Myllymäki, Mikko, Wohlfahrt, Gerd, Mattila, Elina, Karlsson, Stefan, Björkman, Mari, Riikonen, Reetta, Ikonen, Tarja, Leimu, Laura, Mälmström, Chira, Korjamo, Timo, Moilanen, Anu, Ramachandra, Murali, Samajdar, Susanta

“…Abstract Background: The Bromodomain (BRD) and Extra-Terminal domain (BET) family of proteins are key regulators of epigenetic control. Although pan BET…”
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Abstract 1754: First in class orally bioavailable BETBRD degraders by Abbineni, Chandrasekhar, Jaleel, Mahaboobi, Mukherjee, Subhendu, Marappan, Sivapriya, Tiwari, Nirbhay Kumar, Samiulla, DS, Aravind, AB, Kumar, Naveen R, Bansal, Indu, Reddy, Raghurami B, Bandaru, NVM Rao, Srinivas, Akhila, Maben, Janith Mary, Tgore, Suraj, Kumar, Avainash, Nankar, Rakesh P., Naik, Chandranath D., Antony, Thomas, Nellore, Kavitha, Giri, Sanjeev, Daginakatte, Girish, Chelur, Shekar, Törmäkangas, Olli, Wohlfahrt, Gerd, Björkman, Mari, Mattila, Elina, Ravanti, Laura, Moilanen, Anu, Ramachandra, Murali, Samajdar, Susanta

“…Abstract Background: Inhibition of Bromodomain and extra-terminal (BET) family proteins by small molecules is actively being pursued as a therapeutic strategy…”
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Abstract 6537: A novel CCR4 antagonist induces potent anti-tumor response through inhibition of Treg migration into the tumor microenvironment by Nair, Rashmi, Abbineni, Chandrasekhar, Talluri, Krishna Chaitanya, Dhudashiya, Amit A, AB, Aravind, R, Naveen Kumar, R, Ramya, Balasubramanyam, D, Obanna, Pathur, Madhaiyan, Rabin, Samiulla, DS, Daginakatte, Girish, Narayanan, Kishore, Nellore, Kavitha, Chelur, Shekar, Samajdar, Susanta, Ramachandra, Murali

“…Abstract Regulatory T cells (Tregs), an immunosuppressive subset of CD4+ T cells, play a vital role in maintaining immune homeostasis by regulating response to…”
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Rational selection of structurally diverse natural product scaffolds with favorable ADME properties for drug discovery by Samiulla, D S, Vaidyanathan, V V, Arun, P C, Balan, G, Blaze, M, Bondre, S, Chandrasekhar, G, Gadakh, A, Kumar, R, Kharvi, G, Kim, H O, Kumar, S, Malikayil, J A, Moger, M, Mone, M K, Nagarjuna, P, Ogbu, C, Pendhalkar, D, Rao, A V S Raja, Rao, G Venkateshwar, Sarma, V K, Shaik, S, Sharma, G V R, Singh, S, Sreedhar, C, Sonawane, R, Timmanna, U, Hardy, L W

“…Natural product analogs are significant sources for therapeutic agents. To capitalize efficiently on the effective features of naturally occurring substances,…”
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Abstract 1144: Orally bioavailable SMARCA2 degraders with exceptional selectivity and potency by Abbineni, Chandrasekhar, Satyam, Leena Khare, Kuila, Bilash, Ettam, Ashok, Rawoof, Khaji Abdul, MR, Sreevidya, Dukare, Sandeep Vitthal, Gore, Suraj T., Nankar, Rakesh P., Ahuja, Vijay Kamal, KB, Charamanna, Goyal, Megha, Aithal, Kiran, DS, Samiulla, Mukherjee, Subhendu, Antony, Thomas, Giri, Sanjeev, Chelur, Shekar, Nellore, Kavitha, Daginakatte, Girish, Ramachandra, Murali, Samajdar, Susanta

“…Abstract Background: SMARCA2 (BRM) and SMARCA4 (BRG1) are two mutually exclusive DNA-dependent ATPases of the SWI/SNF complex, which function in mobilizing…”
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Abstract 3852: Combination efficacy and safety profile of an orally bioavailable small molecule agent targeting CD47/SIRPα axis by Daginakatte, Girish, Pottayil, Sasikumar, Chennakrishna, Gundala, Balasubramanian, Wesley Roy, Naremaddepalli, Sudarshan, Bhumireddy, Archana, Patil, Sandeep, Nellore, Kavitha, Chand, Priyabrata, Aithal, Kiran, Dhudashiya, Amit, DS, Samiulla, Eswarappa, Rajesh, Ramachandra, Murali

“…Abstract Introduction: Most of the immunotherapies currently approved in the clinic target immune checkpoint proteins that suppress T-cell responses. There is…”
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Abstract 3844: Anti-tumor efficacy of SMARCA degraders in pre-clinical models of cancer by Satyam, Leena Khare, Sasmal, Sanjita, Pothuganti, Manoj K., M.R., Sreevidya, Ettam, Ashokk, Nunna, Sireesha, Roshaiah, Marla, Chithaluru, Shankaraiah, Pallepati, Rangarao, Pawar, Amitkumar A., Narukulla, Leela P., Sripathi, Raghunadh A., Tgore, Suraj, Nankar, Rakesh P., KB, Charamanna, S, Nagesh Gowda, Aithal, Kiran, DS, Samiulla, Mukherjee, Subhendu, Chelur, Shekar, Nellore, Kavitha, Daginakatte, Girish, Ramachandra, Murali, Samajdar, Susanta

“…Abstract SMARCA2/BRM and SMARCA4/BRG1 are the mutually exclusive DNA-dependent ATPases within the SWI/SNF complexes, which function in mobilizing nucleosomes…”
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Abstract 4432: A highly differentiated A2AR inhibitor for potential use in cancer therapy by Venkateshappa, Chandregowda, Narayanan, Kishore, Nair, Rashmi, AB, Aravind, Putta, Ramakishore VP, Nagaraj, Jwala, Goyal, Megha, Ahuja, Vijay Kamal, Dhudashiya, Amith A, DS, Samiulla, Daginakatte, Girish, Antony, Thomas, Nellore, Kavitha, Samajdar, Susanta, Ramachandra, Murali

“…Abstract As a potent immunosuppressor adenosine is essential for maintaining tissue homeostasis and preventing an overzealous immune response during…”
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Abstract 4133: ODM-203, a novel, selective and balanced FGFR and VEGFR inhibitor with strong activity on primary and metastatic tumor growth in FGFR-dependent and angiogenic cancer models by Holmström, Tim, Moilanen, Anu, Björkman, Mari, Linnanen, Tero, Wohlfahrt, Gerd, Karlsson, Stefan, Oksala, Riikka, Korjamo, Timo, Samajdar, Susanta, Rajagopalan, Srinivasan, Chelur, Shekar, Narayan, Kishore, Ramachandra, Raghuveer, Anthony, Thomas, DS, Samiulla, Ramachandra, Murali, Kallio, Pekka

“…Abstract Genomic alterations in fibroblast growth factor receptors (FGFR) and upregulation of vascular endothelial growth factor receptors (VEGFR) are often…”
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Mast cell stabilising activity of Bacopa monnieri by Samiulla, D.S., Prashanth, D., Amit, A.

“…Successive petroleum ether, chloroform, methanol and water extracts of Bacopa monnieri were tested (in vitro) for mast cell stabilising effect. The methanolic…”
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Effect of certain plant extracts on α-amylase activity by Prashanth, D., Padmaja, R., Samiulla, D.S.

“…Ethanolic extracts of Punica granatum, Mangifera indica, Boerhaavia diffusa, Embelia ribes, Phyllanthus maderaspatensis, and Withania somnifera, were tested…”
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Trypsin inhibitory activity of Lawsonia inermis by Yogisha, S., Samiulla, D.S., Prashanth, D., Padmaja, R., Amit, A.

“…The ethanolic extract of Lawsonia inermis leaves and lawsone tested for trypsin inhibitory activity showed an IC 50 value of 64.87 and 48.6 μg/ml, respectively…”
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α-Glucosidase inhibitory activity of Mangifera indica bark by Prashanth, D., Amit, A., Samiulla, D.S., Asha, M.K., Padmaja, R.

“…The ethanolic extracts of Lawsonia inermis leaves, Holarrhena antidysenterica bark, Swertia chirata whole plant and Mangifera indica bark were tested…”
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