Search Results - "DRUCKER, Liat"

αvβ3 Integrin as a Link between the Development of Fibrosis and Thyroid Hormones in Systemic Sclerosis by Kohon, Maia Yamila, Zaaroor Levy, Mor, Hornik-Lurie, Tzipi, Shalom, Avshalom, Berl, Ariel, Drucker, Liat, Levy, Yair, Tartakover Matalon, Shelly

“…Systemic sclerosis (SSc) is an autoimmune disease characterized by fibrosis of the skin and internal organs. Key players mediating fibrosis are myofibroblasts…”
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Endocannabinoid Levels in Ulcerative Colitis Patients Correlate With Clinical Parameters and Are Affected by Cannabis Consumption by Tartakover Matalon, Shelly, Azar, Shahar, Meiri, David, Hadar, Rivka, Nemirovski, Alina, Abu Jabal, Narjes, Konikoff, Fred Meir, Drucker, Liat, Tam, Joseph, Naftali, Timna

“…Inflammatory bowel diseases (IBDs) are chronic, idiopathic, inflammatory, gastrointestinal disorders. The endocannabinoid system may have a role in the…”
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MiRNAs in Systemic Sclerosis Patients with Pulmonary Arterial Hypertension: Markers and Effectors by Zaaroor Levy, Mor, Rabinowicz, Noa, Yamila Kohon, Maia, Shalom, Avshalom, Berl, Ariel, Hornik-Lurie, Tzipi, Drucker, Liat, Tartakover Matalon, Shelly, Levy, Yair

“…Pulmonary arterial hypertension (PAH) is a major cause of death in systemic sclerosis (SSc). Early detection may improve patient outcomes. We searched for…”
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Overexpression of tetraspanins affects multiple myeloma cell survival and invasive potential by Tohami, Tali, Drucker, Liat, Shapiro, Hava, Radnay, Judith, Lishner, Michael

“…Cellular interactions with microenvironmental components are critical in multiple myeloma (MM) and impede effective disease treatment. Membranal-embedded…”
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Migration and epithelial-to-mesenchymal transition of lung cancer can be targeted via translation initiation factors eIF4E and eIF4GI by Attar-Schneider, Oshrat, Drucker, Liat, Gottfried, Maya

“…Metastasis underlies cancer morbidity and accounts for disease progression and significant death rates generally and in non-small cell lung cancer (NSCLC)…”
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The effect of mesenchymal stem cells' secretome on lung cancer progression is contingent on their origin: primary or metastatic niche by Attar-Schneider, Oshrat, Drucker, Liat, Gottfried, Maya

“…The fatality of non-small-cell lung cancer (NSCLC) and the role of the cancer microenvironment in its resistance to therapy are long recognized. Accumulating…”
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Thalidomide down-regulates transcript levels of GC-rich promoter genes in multiple myeloma by Drucker, Liat, Uziel, Orit, Tohami, Tali, Shapiro, Hava, Radnay, Judith, Yarkoni, Shai, Lahav, Meir, Lishner, Michael

“…Thalidomide (Thd), a potent teratogen, was shown to have therapeutic potential in cancer, primarily in multiple myeloma (MM), yet its mechanism of action has…”
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Niche origin of mesenchymal stem cells derived microvesicles determines opposing effects on NSCLC: Primary versus metastatic by Attar-Schneider, Oshrat, Dabbah, Mahmoud, Drucker, Liat, Gottfried, Maya

“…•Mesenchymal stem cells' (MSCs) microvesicles (MVs) alter NSCLC cells' phenotype.•Lung-MSCs' MVs promoted.•BM-MSCs' MVs suppressed NSCLC cells' cancerous…”
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Secretome of human bone marrow mesenchymal stem cells: an emerging player in lung cancer progression and mechanisms of translation initiation by Attar-Schneider, Oshrat, Zismanov, Victoria, Drucker, Liat, Gottfried, Maya

“…Non-small cell lung cancer (NSCLC) remains the most common cause of cancer-related death worldwide. Patients presenting with advanced-stage NSCLC have poor…”
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Multiple myeloma BM-MSCs increase the tumorigenicity of MM cells via transfer of VLA4-enriched microvesicles by Dabbah, Mahmoud, Jarchowsky-Dolberg, Osnat, Attar-Schneider, Oshrat, Tartakover Matalon, Shelly, Pasmanik-Chor, Metsada, Drucker, Liat, Lishner, Michael

“…Abstract Multiple myeloma (MM) cells accumulate in the bone marrow (BM) where their interactions impede disease therapy. We have shown that microvesicles (MVs)…”
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Examination of the Level of Circulating Plasmablasts and Their Characteristics as Diagnostic Tools for Immunoglobulin G4-related Disease by Tartakover Matalon, Shelly, Rabinowicz, Noa, Carmi, Or, Zitman-Gal, Tali, Drucker, Liat, Levy, Yair

“…Immunoglobulin G4-related disease (IgG4-RD) is a chronic, immune-mediated condition characterized by fibro-inflammatory lesions with lymphoplasmacytic…”
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Microvesicles derived from normal and multiple myeloma bone marrow mesenchymal stem cells differentially modulate myeloma cells' phenotype and translation initiation by Dabbah, Mahmoud, Attar-Schneider, Oshrat, Tartakover Matalon, Shelly, Shefler, Irit, Jarchwsky Dolberg, Osnat, Lishner, Michael, Drucker, Liat

“…Multiple myeloma (MM) cells' interaction with the bone marrow (BM) microenvironment critically hinders disease therapy. Previously, we showed that MM…”
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Combined inhibition of Hsp90 and the proteasome affects NSCLC proteostasis and attenuates cell migration by Zismanov, Victoria, Drucker, Liat, Gottfried, Maya

“…Lung cancer remains the most common cause of cancer-related death worldwide. This malignancy is a complex disease, and it is important to identify potential…”
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Erratum: Multiple myeloma BM-MSCs increase the tumorigenicity of MM cells via transfer of VLA4-enriched microvesicles by Dabbah, Mahmoud, Jarchowsky-Dolberg, Osnat, Attar-Schneider, Oshrat, Tartakover Matalon, Shelly, Pasmanik-Chor, Metsada, Drucker, Liat, Lishner, Michael

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Ribosomal proteins as distinct “passengers” of microvesicles: new semantics in myeloma and mesenchymal stem cells' communication by Dabbah, Mahmoud, Lishner, Michael, Jarchowsky-Dolberg, Osnat, Tartakover-Matalon, Shelly, Brin, Yaron S., Pasmanik-Chor, Metsada, Neumann, Avivit, Drucker, Liat

“…Aberrant mesenchymal stem cells (MSCs) in multiple myeloma (MM) bone marrows (BM) promote disease progression and drug resistance. Here, we assayed the protein…”
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Multiple myeloma cells promote migration of bone marrow mesenchymal stem cells by altering their translation initiation by Dabbah, Mahmoud, Attar‐Schneider, Oshrat, Zismanov, Victoria, Tartakover Matalon, Shelly, Lishner, Michael, Drucker, Liat

“…MM increases BM‐MSCs’ MAPKs/TI/migration in a proximity dependent and reversible manner; normal MSCs transformation by cancer cells marks this process for…”
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ER homeostasis and motility of NSCLC cell lines can be therapeutically targeted with combined Hsp90 and HDAC inhibitors by Zismanov, Victoria, Drucker, Liat, Gottfried, Maya

“…Abstract Background and objective Lung cancer remains the most common cause of cancer-related death in the world for which novel systemic treatments are…”
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Tamoxifen Modulates Apoptotic Pathways in Primary Endometrial Cell Cultures by STACKIEVICZ, Rodica, DRUCKER, Liat, RADNAY, Judith, BEYTH, Yoram, YARKONI, Shai, COHEN, Ilan

“…Clinical data indicate that tamoxifen (TAM) therapy may cause an increased risk of endometrial pathology in postmenopausal but not in premenopausal women…”
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BM-MSCs-derived ECM modifies multiple myeloma phenotype and drug response in a source-dependent manner by Ibraheem, Amjd, Attar-Schneider, Oshrat, Dabbah, Mahmoud, Dolberg Jarchowsky, Osnat, Tartakover Matalon, Shelly, Lishner, Michael, Drucker, Liat

“…Multiple myeloma (MM) malignant plasma cells accumulate in the bone marrow (BM) where their interaction with the microenvironment promotes disease progression…”
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Targeting eIF4GI translation initiation factor affords an attractive therapeutic strategy in multiple myeloma by Attar-Schneider, Oshrat, Drucker, Liat, Zismanov, Victoria, Tartakover-Matalon, Shelly, Lishner, Michael

“…Deregulation of protein synthesis is integral to the malignant phenotype and translation initiation is the rate limiting stage. Therefore, eIF4F translation…”
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