Search Results - "DRUCKER, D. J"

Metformin regulates the incretin receptor axis via a pathway dependent on peroxisome proliferator-activated receptor-α in mice by Maida, A, Lamont, B. J, Cao, X, Drucker, D. J

“…Aims/hypothesis Metformin is widely used for the treatment of type 2 diabetes. Although it reduces hepatic glucose production, clinical studies show that…”
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Minireview: Glucagon-Like Peptides Regulate Cell Proliferation and Apoptosis in the Pancreas, Gut, and Central Nervous System by Brubaker, P. L, Drucker, D. J

“…Gut peptides exert diverse effects regulating satiety, gastrointestinal motility and acid secretion, epithelial integrity, and both nutrient absorption and…”
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glucagon-like peptide 1 receptor is essential for postprandial lipoprotein synthesis and secretion in hamsters and mice by Hsieh, J, Longuet, C, Baker, C. L, Qin, B, Federico, L. M, Drucker, D. J, Adeli, K

“…Aims/hypothesis Glucagon-like peptide 1 (GLP-1) receptor (GLP-1R) agonists and dipeptidyl peptidase-4 (DPP-4) inhibitors attenuate postprandial lipaemia…”
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Glucagon-like peptide-1 receptor signalling selectively regulates murine lymphocyte proliferation and maintenance of peripheral regulatory T cells by Hadjiyanni, I., Siminovitch, K. A., Danska, J. S., Drucker, D. J.

“…Aims/hypothesis Glucagon-like peptide-1 receptor (GLP-1R) agonists improve glucose control in animals and humans with type 1 diabetes. However, there is little…”
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Glucagon-like peptides by Drucker, D. J.

“…Glucagon-like peptides. D J Drucker Department of Medicine, the Toronto Hospital, Banting and Best Diabetes Centre, University of Toronto, Ontario, Canada…”
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Gut adaptation and the glucagon-like peptides by Drucker, D J

“…The glucagon-like peptides GLP-1 and GLP-2 are synthesised and then released from enteroendocrine cells in the small and large intestine. GLP-1 promotes…”
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Insulinotropic glucagon-like peptide 1 agonists stimulate expression of homeodomain protein IDX-1 and increase islet size in mouse pancreas by STOFFERS, D. A, KIEFFER, T. J, HUSSAIN, M. A, DRUCKER, D. J, BONNER-WEIR, S, HABENER, J. F, EGAN, J. M

“…Insulinotropic glucagon-like peptide 1 agonists stimulate expression of homeodomain protein IDX-1 and increase islet size in mouse pancreas. D A Stoffers , T J…”
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Glucagon-like peptide-1 (GLP-1) receptor agonists, obesity and psoriasis: diabetes meets dermatology by DRUCKER, D. J, ROSEN, C. F

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Extrahypothalamic Expression of the Glucagon-Like Peptide-2 Receptor Is Coupled to Reduction of Glutamate-Induced Cell Death in Cultured Hippocampal Cells by Lovshin, J. A, Huang, Q, Seaberg, R, Brubaker, P. L, Drucker, D. J

“…Proglucagon-derived glucagon-like peptide-2 (GLP-2) is liberated in enteroendocrine cells and neurons. GLP-2 regulates energy absorption and epithelial…”
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Double Incretin Receptor Knockout (DIRKO) Mice Reveal an Essential Role for the Enteroinsular Axis in Transducing the Glucoregulatory Actions of DPP-IV Inhibitors by HANSOTIA, Tanya, BAGGIO, Laurie L, DELMEIRE, Dominique, HINKE, Simon A, YAMADA, Yuichiro, TSUKIYAMA, Katsushi, SEINO, Yutaka, HOLST, Jens J, SCHUIT, Frans, DRUCKER, D. J

“…Double Incretin Receptor Knockout (DIRKO) Mice Reveal an Essential Role for the Enteroinsular Axis in Transducing the Glucoregulatory Actions of DPP-IV…”
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Intestinal growth-promoting properties of glucagon-like peptide-2 in mice by Tsai, C H, Hill, M, Asa, S L, Brubaker, P L, Drucker, D J

“…Glucagon-like peptide-2 (GLP-2) has been shown to promote intestinal epithelial proliferation. We studied crypt cell proliferation, enterocyte cell death, and…”
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Secretion of the intestinotropic hormone glucagon-like peptide 2 is differentially regulated by nutrients in humans by Xiao, Qiang, Boushey ‡, Robin P., Drucker ‡,§, Daniel J., Brubaker ,‡, Patricia L.

“…Background & Aims: Glucagon-like peptide 2 1-33 (GLP-2 1-33 ), an intestinally derived hormone, stimulates growth in rodent small and large bowel. To explore…”
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The HeLa Cell Glucagon-Like Peptide-2 Receptor Is Coupled to Regulation of Apoptosis and ERK1/2 Activation through Divergent Signaling Pathways by Koehler, J. A, Yusta, B, Drucker, D. J

“…Glucagon-like peptide-2 (GLP-2) regulates proliferative and cytoprotective pathways in the intestine; however GLP-2 receptor (GLP-2R) signal transduction…”
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Glucagon-like peptide 1 (GLP-1) by Müller, T.D., Finan, B., Bloom, S.R., D'Alessio, D., Drucker, D.J., Flatt, P.R., Fritsche, A., Gribble, F., Grill, H.J., Habener, J.F., Holst, J.J., Langhans, W., Meier, J.J., Nauck, M.A., Perez-Tilve, D., Pocai, A., Reimann, F., Sandoval, D.A., Schwartz, T.W., Seeley, R.J., Stemmer, K., Tang-Christensen, M., Woods, S.C., DiMarchi, R.D., Tschöp, M.H.

“…The glucagon-like peptide-1 (GLP-1) is a multifaceted hormone with broad pharmacological potential. Among the numerous metabolic effects of GLP-1 are the…”
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Glucagon-like peptide 2 by DRUCKER, Daniel J

“…Glucagon-like peptide 2 (GLP-2) is a 33 amino acid peptide-encoded carboxyterminal to the sequence of GLP-1 in the proglucagon gene. Both GLP-1 and GLP-2 are…”
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Intestinal function in mice with small bowel growth induced by glucagon-like peptide-2 by Brubaker, P L, Izzo, A, Hill, M, Drucker, D J

“…Glucagon-like peptide-2 (GLP-2) stimulates small intestinal growth through induction of intestinal epithelial proliferation. To examine the physiology of…”
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Induction of Intestinal Epithelial Proliferation by Glucagon-Like Peptide 2 by Drucker, Daniel J., Ehrlich, Peter, Asa, Sylvia L., Brubaker, Patricia L.

“…Injury, inflammation, or resection of the small intestine results in severe compromise of intestinal function. Nevertheless, therapeutic strategies for…”
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Characterization and functional role of voltage gated cation conductances in the glucagon-like peptide-1 secreting GLUTag cell line by Reimann, F., Maziarz, M., Flock, G., Habib, A. M., Drucker, D. J., Gribble, F. M.

“…Glucagon-like peptide-1 (GLP-1) is released from intestinal L -cells in response to nutrient ingestion. It is currently under therapeutic evaluation because it…”
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Glucagon-like peptide (GLP)-2 reduces chemotherapy-associated mortality and enhances cell survival in cells expressing a transfected GLP-2 receptor by BOUSHEY, Robin P, YUSTA, Bernardo, DRUCKER, Daniel J

“…Chemotherapeutic agents produce cytotoxicity via induction of apoptosis and cell cycle arrest. Rapidly proliferating cells in the bone marrow and intestinal…”
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Glucose intolerance but normal satiety in mice with a null mutation in the glucagon-like peptide 1 receptor gene by Scrocchi, L.A, Brown, T.J, Maclusky, N, Brubaker, P.L, Auerbach, A.B, Joyner, A.L, Drucker, D.J

“…Glucagon-like peptide 1 (GLP1) is postulated to regulate blood glucose and satiety, but the biological importance of GLP1 as an incretin and neuropeptide…”
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