Search Results - "DRISSI, Rachid"

Induced Telomere Damage to Treat Telomerase Expressing Therapy-Resistant Pediatric Brain Tumors by Sengupta, Satarupa, Sobo, Matthew, Lee, Kyungwoo, Senthil Kumar, Shiva, White, Angela R, Mender, Ilgen, Fuller, Christine, Chow, Lionel M L, Fouladi, Maryam, Shay, Jerry W, Drissi, Rachid

“…Brain tumors remain the leading cause of cancer-related deaths in children and often are associated with long-term sequelae among survivors of current…”
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Tumor-associated macrophages in SHH subgroup of medulloblastomas by Margol, Ashley S, Robison, Nathan J, Gnanachandran, Janahan, Hung, Long T, Kennedy, Rebekah J, Vali, Marzieh, Dhall, Girish, Finlay, Jonathan L, Erdreich-Epstein, Anat, Krieger, Mark D, Drissi, Rachid, Fouladi, Maryam, Gilles, Floyd H, Judkins, Alexander R, Sposto, Richard, Asgharzadeh, Shahab

“…Medulloblastoma in children can be categorized into at least four molecular subgroups, offering the potential for targeted therapeutic approaches to reduce…”
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A phase I/II study of ribociclib following radiation therapy in children with newly diagnosed diffuse intrinsic pontine glioma (DIPG) by DeWire, Mariko, Fuller, Christine, Hummel, Trent R., Chow, Lionel M. L., Salloum, Ralph, de Blank, Peter, Pater, Luke, Lawson, Sarah, Zhu, Xiaoting, Dexheimer, Phil, Carle, Adam C., Kumar, Shiva Senthil, Drissi, Rachid, Stevenson, Charles B., Lane, Adam, Breneman, John, Witte, David, Jones, Blaise V., Leach, James L., Fouladi, Maryam

“…Purpose Cyclin-dependent kinase-retinoblastoma (CDK-RB) pathway is dysregulated in some diffuse intrinsic pontine gliomas (DIPG). We evaluated safety,…”
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BMI-1 is a potential therapeutic target in diffuse intrinsic pontine glioma by Kumar, Shiva Senthil, Sengupta, Satarupa, Lee, Kyungwoo, Hura, Nanki, Fuller, Christine, DeWire, Mariko, Stevenson, Charles B, Fouladi, Maryam, Drissi, Rachid

“…Diffuse intrinsic pontine glioma (DIPG) is a poor-prognosis pediatric brain tumor. No effective curative therapy is currently available and no therapeutic…”
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Limitations of radiosensitization by direct telomerase inhibition to treat high-risk medulloblastoma by Sengupta, Satarupa, Senthil Kumar, Shiva, Bondra, Kathryn, Sobo, Matthew, Mo, Xiaokui, Drissi, Rachid

“…Medulloblastoma (MB) is the most common malignant pediatric brain tumor. Previous studies have elucidated the genomic landscape of MB leading to the…”
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Spatial genomic heterogeneity in diffuse intrinsic pontine and midline high-grade glioma: implications for diagnostic biopsy and targeted therapeutics by Hoffman, Lindsey M, DeWire, Mariko, Ryall, Scott, Buczkowicz, Pawel, Leach, James, Miles, Lili, Ramani, Arun, Brudno, Michael, Kumar, Shiva Senthil, Drissi, Rachid, Dexheimer, Phillip, Salloum, Ralph, Chow, Lionel, Hummel, Trent, Stevenson, Charles, Lu, Q Richard, Jones, Blaise, Witte, David, Aronow, Bruce, Hawkins, Cynthia E, Fouladi, Maryam

“…Diffuse intrinsic pontine glioma (DIPG) and midline high-grade glioma (mHGG) are lethal childhood brain tumors. Spatial genomic heterogeneity has been…”
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Overcoming barriers to establishing autopsy procurement programs in pediatric patients with central nervous system tumors: a call to develop regional centers by DeWire, Mariko, Erker, Craig, Hummel, Trent R., Chow, Lionel M. L, de Blank, Peter, Salloum, Ralph, Pillay-Smiley, Natasha, Hoffman, Lindsey, Gilger, Elizabeth, Gallagher, Maureen, Driver, Lori, Meister, Dinah, Ward, Heather, Drissi, Rachid, Kumar, Shiva Senthil, Sengupta, Satarupa, Kikta, Bridget, Meriwether, Wanda, Jelinek, Susan, Asher, Anthony, Jones, Blaise, Leach, James, Miles, Lili, Fuller, Christine, Fouladi, Maryam

“…Background While autopsy-repository programs with a variety of pediatric central nervous system (CNS) tumor types are a critical resource for preclinical…”
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A pilot radiogenomic study of DIPG reveals distinct subgroups with unique clinical trajectories and therapeutic targets by Zhu, Xiaoting, Lazow, Margot A, Schafer, Austin, Bartlett, Allison, Senthil Kumar, Shiva, Mishra, Deepak Kumar, Dexheimer, Phillip, DeWire, Mariko, Fuller, Christine, Leach, James L, Fouladi, Maryam, Drissi, Rachid

“…An adequate understanding of the relationships between radiographic and genomic features in diffuse intrinsic pontine glioma (DIPG) is essential, especially in…”
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The transcription factor Olig2 is important for the biology of diffuse intrinsic pontine gliomas by Anderson, Jane L, Muraleedharan, Ranjithmenon, Oatman, Nicole, Klotter, Amanda, Sengupta, Satarupa, Waclaw, Ronald R, Wu, Jianqiang, Drissi, Rachid, Miles, Lili, Raabe, Eric H, Weirauch, Matthew L, Fouladi, Maryam, Chow, Lionel M, Hoffman, Lindsey, DeWire, Mariko, Dasgupta, Biplab

“…Diffuse intrinsic pontine glioma (DIPG) is a high-grade brainstem glioma of children with dismal prognosis. There is no single unifying model about the cell of…”
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Characterizing temporal genomic heterogeneity in pediatric high-grade gliomas by Salloum, Ralph, McConechy, Melissa K, Mikael, Leonie G, Fuller, Christine, Drissi, Rachid, DeWire, Mariko, Nikbakht, Hamid, De Jay, Nicolas, Yang, Xiaodan, Boue, Daniel, Chow, Lionel M L, Finlay, Jonathan L, Gayden, Tenzin, Karamchandani, Jason, Hummel, Trent R, Olshefski, Randal, Osorio, Diana S, Stevenson, Charles, Kleinman, Claudia L, Majewski, Jacek, Fouladi, Maryam, Jabado, Nada

“…Pediatric high-grade gliomas (pHGGs) are aggressive neoplasms representing approximately 20% of brain tumors in children. Current therapies offer limited…”
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Characterizing temporal genomic heterogeneity in pediatric low-grade gliomas by Lazow, Margot A, Hoffman, Lindsey, Schafer, Austin, Osorio, Diana S, Boué, Daniel R, Rush, Sarah, Wright, Erin, Lane, Adam, DeWire-Schottmiller, Mariko D, Smolarek, Teresa, Sipple, Jared, Taggert, Heather, Reuss, Jaime, Salloum, Ralph, Hummel, Trent R, de Blank, Peter, Pillay-Smiley, Natasha, Sutton, Mary E, Asher, Anthony, Stevenson, Charles B, Drissi, Rachid, Finlay, Jonathan L, Fouladi, Maryam, Fuller, Christine

“…Recent discoveries have provided valuable insight into the genomic landscape of pediatric low-grade gliomas (LGGs) at diagnosis, facilitating molecularly…”
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Telomerase Expression Predicts Unfavorable Outcome in Osteosarcoma by SANDERS, Robert P, DRISSI, Rachid, BILLUPS, Catherine A, DAW, Najat C, VALENTINE, Marcus B, DOME, Jeffrey S

“…Osteosarcoma is distinct from most cancers in that the majority of osteosarcomas lack telomerase expression and use the alternative lengthening of telomeres…”
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Accessible approaches for vibrational zero point energy calculation of organoboron compounds by Rahal, Mahmoud, Bouimadaghene, Ibtissam, Drissi El Bouzaidi, Rachid, Bouabdallah, Ibrahim, Malek, Fouad, El Hajbi, Abdeslam

“…[Display omitted] •Vibrational zero-point energies of organoboron compounds are estimated by two empirical approaches.•The estimated ZPEs are compared with…”
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Disappearance of the telomere dysfunction-induced stress response in fully senescent cells by BAKKENIST, Christopher J, DRISSI, Rachid, JING WU, KASTAN, Michael B, DOME, Jeffrey S

“…Replicative senescence is a natural barrier to cellular proliferation that is triggered by telomere erosion and dysfunction. Here, we demonstrate that ATM…”
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Erratum: Spatial genomic heterogeneity in diffuse intrinsic pontine and midline high-grade glioma: implications for diagnostic biopsy and targeted therapeutics by Hoffman, Lindsey M, DeWire, Mariko, Ryall, Scott, Buczkowicz, Pawel, Leach, James, Miles, Lili, Ramani, Arun K, Brudno, Michael, Kumar, Shiva Senthil, Drissi, Rachid, Dexheimer, Phillip, Salloum, Ralph, Chow, Lionel, Hummel, Trent, Stevenson, Charles, Lu, Q Richard, Jones, Blaise, Witte, David, Aronow, Bruce, Hawkins, Cynthia E, Fouladi, Maryam

“…Through inadvertent oversight of the authors, the paper failed to acknowledge funding support from Genome Canada. The Acknowledgement section should include…”
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A comprehensive conformational space analysis of N-formyl-l-tryptophanamide system by using a genetic algorithm for multi-modal search by El Guerdaoui, Anouar, Tijar, Rachida, El Merbouh, Brahim, Bourjila, Malika, El Bouzaidi, Rachid Drissi, El Gridani, Abderrahman

“…[Display omitted] •The potential energy surface of N-formyl-l-Tryptophanamide was explored using stochastic method combined with electronic structure…”
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Functional Analysis of Human Replication Protein A in Nucleotide Excision Repair by Stigger, Evelyn, Drissi, Rachid, Lee, Suk-Hee

“…Human replication protein A (RPA) is a three-subunit protein complex (70-, 34-, and 11-kDa subunits) involved in DNA replication, repair, and recombination…”
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DIPG-06. PRECLINICAL EVALUATION OF A NOVEL ACVR1 INHIBITOR IN DIFFUSE INTRINSIC PONTINE GLIOMAS by Kumar, Shiva Senthil, Shoffner, Rebecca, Devine, Brendan, Drissi, Rachid

“…Diffuse intrinsic pontine glioma (DIPG) is an incurable brain disease in children. DIPG is refractory to current available therapies. Hence, new therapeutic…”
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DIPG-12. Induced mitotic abnormalities associated with BMI-1 modulation sensitize diffuse intrinsic pontine glioma cells to ionizing radiation by Kumar, Shiva Senthil, Mishra, Deepak, Mchugh, Todd, Drissi, Rachid

“…Diffuse intrinsic pontine glioma (DIPG) remains an incurable childhood brain cancer with a median overall survival of less than 12 months, affecting 200-300…”
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c-Myc-mediated Regulation of Telomerase Activity Is Disabled in Immortalized Cells by Drissi, R, Zindy, F, Roussel, M F, Cleveland, J L

“…Myc overexpression is a hallmark of human cancer and promotes transformation by facilitating immortalization. This function has been linked to the ability of…”
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