Search Results - "DREWE, John"

Discovery of 4-aryl-4H-chromenes as potent apoptosis inducers using a cell- and caspase-based Anti-cancer Screening Apoptosis Program (ASAP): SAR studies and the identification of novel vascular disrupting agents by Cai, Sui Xiong, Drewe, John, Kemnitzer, William

“…Many cancer cells are known to have defects in the apoptosis machinery. Therefore identification of compounds that can activate or promote apoptosis in cancer…”
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Discovery of 4-Aryl-4H-chromenes as a New Series of Apoptosis Inducers Using a Cell- and Caspase-Based High Throughput Screening Assay. 4. Structure–Activity Relationships of N-Alkyl Substituted Pyrrole Fused at the 7,8-Positions by Kemnitzer, William, Drewe, John, Jiang, Songchun, Zhang, Hong, Crogan-Grundy, Candace, Labreque, Denis, Bubenick, Monica, Attardo, Giorgio, Denis, Real, Lamothe, Serge, Gourdeau, Henriette, Tseng, Ben, Kasibhatla, Shailaja, Cai, Sui Xiong

“…In our continuing effort to discover and develop apoptosis inducing 4-aryl-4H-chromenes as novel anticancer agents, we explored the structure−activity…”
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Discovery and Structure−Activity Relationship of 3-Aryl-5-aryl-1,2,4-oxadiazoles as a New Series of Apoptosis Inducers and Potential Anticancer Agents by Zhang, Han-Zhong, Kasibhatla, Shailaja, Kuemmerle, Jared, Kemnitzer, William, Ollis-Mason, Kristin, Qiu, Ling, Crogan-Grundy, Candace, Tseng, Ben, Drewe, John, Cai, Sui Xiong

“…We have identified 5-(3-chlorothiophen-2-yl)-3-(4-trifluoromethylphenyl)-1,2,4-oxadiazole (1d) as a novel apoptosis inducer through our caspase- and cell-based…”
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A chemical genetics approach for the discovery of apoptosis inducers: from phenotypic cell based HTS assay and structure-activity relationship studies, to identification of potential anticancer agents and molecular targets by Cai, Sui Xiong, Drewe, John, Kasibhatla, Shailaja

“…The approach of chemical genetics has been widely used to study biological systems and to discover new drugs, signaling pathways and targets. The current…”
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Antivascular and antitumor evaluation of 2-amino-4-(3-bromo-4,5-dimethoxy-phenyl)-3-cyano-4H-chromenes, a novel series of anticancer agents by Gourdeau, Henriette, Leblond, Lorraine, Hamelin, Bettina, Desputeau, Clemence, Dong, Kelly, Kianicka, Irenej, Custeau, Dominique, Boudreau, Chantal, Geerts, Lilianne, Cai, Sui-Xiong, Drewe, John, Labrecque, Denis, Kasibhatla, Shailaja, Tseng, Ben

“…A novel series of 2-amino-4-(3-bromo-4,5-dimethoxy-phenyl)-3-cyano-4 H -chromenes was identified as potent apoptosis inducers through a cell-based high…”
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Discovery, characterization and SAR of gambogic acid as a potent apoptosis inducer by a HTS assay by ZHANG, Han-Zhong, KASIBHATLA, Shailaja, YAN WANG, HERICH, John, GUASTELLA, John, BEN TSENG, DREWE, John, SUI XIONG CAI

“…Gambogic acid (2), a natural product isolated from the resin of Garcinia hurburyi tree, was discovered to be a potent apoptosis inducer using our cell- and…”
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Discovery of 4-aryl-4H-chromenes as a new series of apoptosis inducers using a cell- and caspase-based high-throughput screening assay. 2. Structure-activity relationships of the 7- and 5-, 6-, 8-positions by KEMNITZER, William, KASIBHATLA, Shailaja, VAILLANCOURT, Louis, CHARRON, Sylvie, DODD, Jennifer, ATTARDO, Giorgio, LABRECQUE, Denis, LAMOTHE, Serge, GOURDEAU, Henriette, TSENG, Ben, DREWE, John, SUI XIONG CAI, SONGCHUN JIANG, HONG ZHANG, JIANGHONG ZHAO, SHAOJUAN JIA, LIFEN XU, CROGAN-GRUNDY, Candace, DENIS, Réal, BARRIAULT, Nancy

“…As a continuation of our efforts to discover and develop the apoptosis inducing 4-aryl-4H-chromenes as novel anticancer agents, we explored the SAR of…”
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A Role for Transferrin Receptor in Triggering Apoptosis When Targeted with Gambogic Acid by Kasibhatla, Shailaja, Jessen, Katayoun A, Maliartchouk, Sergei, Wang, Jean Yu, English, Nicole M, Drewe, John, Qiu, Ling, Archer, Shannon P, Ponce, Anthony E, Sirisoma, Nilantha, Jiang, Songchun, Zhang, Han-Zhong, Gehlsen, Kurt R, Cai, Sui Xiong, Green, Douglas R, Tseng, Ben

“…Transferrin receptor (TfR) has been shown to be significantly overexpressed in different types of cancers. We discovered TfR as a target for gambogic acid…”
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Discovery of 4-aryl-4H-chromenes as a new series of apoptosis inducers using a cell-and caspase-based HTS assay. Part 5: Modifications of the 2-and 3-positions by KEMNITZER, William, SONGCHUN JIANG, GOURDEAU, Henriette, TSENG, Ben, DREWE, John, SUI XIONG CAI, YAN WANG, KASIBHATLA, Shailaja, CROGAN-GRUNDY, Candace, BUBENIK, Monica, LABRECQUE, Denis, DENIS, Real, LAMOTHE, Serge, ATTARDO, Giorgio

“…As a continuation of our efforts to discover and develop apoptosis inducing 4-aryl-4H-chromenes as novel anticancer agents, we explored modifications at the 2-…”
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Discovery of 4-anilino- N-methylthieno[3,2- d]pyrimidines and 4-anilino- N-methylthieno[2,3- d]pyrimidines as potent apoptosis inducers by Kemnitzer, William, Sirisoma, Nilantha, May, Chris, Tseng, Ben, Drewe, John, Cai, Sui Xiong

“…The discovery and SAR studies of 4-anilino -N-methylthieno[3,2- d]pyrimidines and 4-anilino -N-methylthieno[2,3- d]pyrimidines as potent apoptosis inducers are…”
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Discovery of 1-benzoyl-3-cyanopyrrolo[1,2-a]quinolines as a new series of apoptosis inducers using a cell-and caspase-based high-throughput screening assay. Part 1: Structure-activity relationships of the 1-and 3-positions by KEMNITZER, William, KUEMMERLE, Jared, SONGCHUN JIANG, ZHANG, Han-Zhong, SIRISOMA, Nilantha, KASIBHATLA, Shailaja, CROGAN-GRUNDY, Candace, TSENG, Ben, DREWE, John, SUI XIONG CAI

“…1-Benzoyl-3-cyanopyrrolo[1,2-a]quinoline (2a) was identified as a novel apoptosis inducer through our caspase- and cell-based high-throughput screening assay…”
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Discovery and mechanism of action of a novel series of apoptosis inducers with potential vascular targeting activity by Kasibhatla, Shailaja, Gourdeau, Henriette, Meerovitch, Karen, Drewe, John, Reddy, Sanjeeva, Qiu, Ling, Zhang, Hong, Bergeron, Frederick, Bouffard, David, Yang, Quan, Herich, John, Lamothe, Serge, Cai, Sui Xiong, Tseng, Ben

“…A novel series of 2-amino-4-(3-bromo-4,5-dimethoxy-phenyl)-3-cyano-4 H -chromenes was identified as apoptosis-inducing agents through our cell-based apoptosis…”
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Selective activation of apoptosis by a novel set of 4-aryl-3-(3-aryl-1-oxo-2-propenyl)-2( 1H )-quinolinones through a Myc-dependent pathway by Claassen, Gisela, Brin, Elena, Crogan-Grundy, Candace, Vaillancourt, Mei Ting, Zhang, Han Zhong, Cai, Sui Xiong, Drewe, John, Tseng, Ben, Kasibhatla, Shailaja

“…Abstract Oncogene addiction due to Myc deregulation has been identified in a variety of tumor types. In order to identify pharmacological agents that cause…”
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Discovery of substituted N′-(2-oxoindolin-3-ylidene)benzohydrazides as new apoptosis inducers using a cell- and caspase-based HTS assay by Sirisoma, Nilantha, Pervin, Azra, Drewe, John, Tseng, Ben, Cai, Sui Xiong

“…The discovery and SAR studies of substituted N′-(2-oxoindolin-3-ylidene)benzohydrazides as novel and potent apoptosis inducers are reported. We report the…”
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Discovery of N-methyl-4-(4-methoxyanilino)quinazolines as potent apoptosis inducers. Structure–activity relationship of the quinazoline ring by Sirisoma, Nilantha, Pervin, Azra, Zhang, Hong, Jiang, Songchun, Adam Willardsen, J., Anderson, Mark B., Mather, Gary, Pleiman, Christopher M., Kasibhatla, Shailaja, Tseng, Ben, Drewe, John, Cai, Sui Xiong

“…The synthesis and SAR studies of the quinazoline ring of N-methyl-4-(4-methoxyanilino)quinazolines as novel apoptosis inducers are reported. As a continuation…”
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Discovery and SAR of indole-2-carboxylic acid benzylidene-hydrazides as a new series of potent apoptosis inducers using a cell-based HTS assay by Zhang, Han-Zhong, Drewe, John, Tseng, Ben, Kasibhatla, Shailaja, Cai, Sui Xiong

“…The discovery of indole-2-carboxylic acid benzylidene-hydrazides as a new series of potent inducers of apoptosis using a cell- and caspase-based HTS assay, as…”
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Discovery of Substituted N-Phenyl Nicotinamides as Potent Inducers of Apoptosis Using a Cell- and Caspase-Based High Throughput Screening Assay by Cai, Sui Xiong, Nguyen, Bao, Jia, Shaojuan, Herich, John, Guastella, John, Reddy, Sanjeeva, Tseng, Ben, Drewe, John, Kasibhatla, Shailaja

“…By applying a novel cell- and caspase-based HTS assay, a series of N-phenyl nicotinamides has been identified as a new class of potent inducers of apoptosis…”
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The discovery and mechanism of action of novel tumor-selective and apoptosis-inducing 3,5-diaryl-1,2,4-oxadiazole series using a chemical genetics approach by Jessen, Katayoun A, English, Nicole M, Yu Wang, Jean, Maliartchouk, Sergei, Archer, Shannon P, Qiu, Ling, Brand, Regina, Kuemmerle, Jared, Zhang, Han-Zhong, Gehlsen, Kurt, Drewe, John, Tseng, Ben, Cai, Sui Xiong, Kasibhatla, Shailaja

“…A novel series of 3,5-diaryl-oxadiazoles was identified as apoptosis-inducing agents through our cell and chemical genetics–based screening assay for compounds…”
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Exchange of Conduction Pathways Between Two Related K$^+$ Channels by Hartmann, Hali A., Kirsch, Glenn E., Drewe, John A., Taglialatela, Maurizio, Joho, Rolf H., Brown, Arthur M.

“…The structure of the ion conduction pathway or pore of voltage-gated ion channels is unknown, although the linker between the membrane spanning segments S5 and…”
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[3H]Ethynylbicycloorthobenzoate ([3H]EBOB) binding in recombinant GABAA receptors by YAGLE, Monica A, MARTIN, Michael W, DE FIEBRE, Christopher M, DE FIEBRE, Nancyellen C, DREWE, John A, DILLON, Glenn H

“…Ethynylbicycloorthobenzoate (EBOB) is a recently developed ligand that binds to the convulsant site of the GABAA receptor. While a few studies have examined…”
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