Search Results - "DREW, Mark E"

Plasmodium falciparum erythrocytic stage parasites require the putative autophagy protein PfAtg7 for normal growth by Walker, Dawn M, Mahfooz, Najmus, Kemme, Katherine A, Patel, Viral C, Spangler, Maribeth, Drew, Mark E

“…Analysis of the Plasmodium falciparum genome reveals a limited number of putative autophagy genes, specifically the four genes involved in ATG8 lipidation, an…”
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The Role of Plasmodium falciparum Food Vacuole Plasmepsins by Liu, Jun, Gluzman, Ilya Y., Drew, Mark E., Goldberg, Daniel E.

“…Plasmepsins (PMs) are thought to have an important function in hemoglobin degradation in the malarial parasite Plasmodium falciparum and have generated…”
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Plasmodium Food Vacuole Plasmepsins Are Activated by Falcipains by Drew, Mark E., Banerjee, Ritu, Uffman, Eric W., Gilbertson, Scott, Rosenthal, Philip J., Goldberg, Daniel E.

“…Intraerythrocytic malaria parasites use host hemoglobin as a major nutrient source. Aspartic proteases (plasmepsins) and cysteine proteases (falcipains)…”
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Plasmodium vivax and human hexokinases share similar active sites but display distinct quaternary architectures by Srivastava, Shanti Swaroop, Darling, Joseph E, Suryadi, Jimmy, Morris, James C, Drew, Mark E, Subramaniam, Sriram

“…Malaria is a devastating disease caused by a protozoan parasite. It affects over 300 million individuals and results in over 400 000 deaths annually, most of…”
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Interrogating a Hexokinase-Selected Small-Molecule Library for Inhibitors of Plasmodium falciparum Hexokinase by HARRIS, Michael T, WALKER, Dawn M, DREW, Mark E, MITCHELL, William G, KEVIN DAO, SCHROEDER, Chad E, FLAHERTY, Daniel P, WEINER, Warren S, GOLDEN, Jennifer E, MORRIS, James C

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Induction of Oxidative Stress in Trypanosoma brucei by the Antitrypanosomal Dihydroquinoline OSU-40 by SHANSHAN HE, DAYTON, Alex, KUPPUSAMY, Periannan, WERBOVETZ, Karl A, DREW, Mark E

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Mechanisms of cellular invasion by intracellular parasites by Walker, Dawn M, Oghumu, Steve, Gupta, Gaurav, McGwire, Bradford S, Drew, Mark E, Satoskar, Abhay R

“…Numerous disease-causing parasites must invade host cells in order to prosper. Collectively, such pathogens are responsible for a staggering amount of human…”
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Overexpression of a Cytochrome b5 Reductase-like Protein Causes Kinetoplast DNA Loss in Trypanosoma brucei by Motyka, Shawn A., Drew, Mark E., Yildirir, Gokben, Englund, Paul T.

“…The mitochondrial genome of trypanosomes, termed kinetoplast DNA (kDNA), contains thousands of minicircles and dozens of maxicircles topologically interlocked…”
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The Adenosine Analog Tubercidin Inhibits Glycolysis in Trypanosoma brucei as Revealed by an RNA Interference Library by Drew, Mark E., Morris, James C., Wang, Zefeng, Wells, Lance, Sanchez, Marco, Landfear, Scott M., Englund, Paul T.

“…We used an RNA interference (RNAi) library in a forward genetic selection to study the mechanism of toxicity of tubercidin (7-deazaadenosine) to procyclic…”
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A Trypanosome Mitochondrial RNA Polymerase Is Required for Transcription and Replication by Grams, Jayleen, Morris, James C., Drew, Mark E., Wang, Zefeng, Englund, Paul T., Hajduk, Stephen L.

“…Understanding mitochondrial transcription is a requisite first step toward understanding the regulation of mitochondrial gene expression in kinetoplastids…”
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Cloning of Leishmania Nucleoside Transporter Genes by Rescue of a Transport-Deficient Mutant by Vasudevan, Gayatri, Carter, Nicola S., Drew, Mark E., Beverley, Stephen M., Sanchez, Marco A., Seyfang, Andreas, Ullman, Buddy, Landfear, Scott M.

“…All parasitic protozoa studied to date are incapable of purine biosynthesis and must therefore salvage purine nucleobases or nucleosides from their hosts. This…”
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Methylomic correlates of autophagy activity in cystic fibrosis by Caution, Kyle, Pan, Alexander, Krause, Kathrin, Badr, Asmaa, Hamilton, Kaitlin, Vaidya, Anup, Gosu, Hawin, Daily, Kylene, Estfanous, Shady, Gavrilin, Mikhail A., Drew, Mark E., Cormet-Boyaka, Estelle, Chen, Xi, Frankhouser, David E., Bundschuh, Ralf, Yan, Pearlly, Dakhlallah, Duaa, Amer, Amal O.

“…Autophagy is a highly regulated, biological process that provides energy during periods of stress and starvation. This conserved process also acts as a defense…”
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Identification of Novel Plasmodium falciparum Hexokinase Inhibitors with Antiparasitic Activity by Davis, Mindy I, Patrick, Stephen L, Blanding, Walker M, Dwivedi, Varun, Suryadi, Jimmy, Golden, Jennifer E, Coussens, Nathan P, Lee, Olivia W, Shen, Min, Boxer, Matthew B, Hall, Matthew D, Sharlow, Elizabeth R, Drew, Mark E, Morris, James C

“…Plasmodium falciparum, the deadliest species of malaria parasites, is dependent on glycolysis for the generation of ATP during the pathogenic red blood cell…”
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Inhibition of Trypanosoma brucei Gene Expression by RNA Interference Using an Integratable Vector with Opposing T7 Promoters by Wang, Zefeng, Morris, James C., Drew, Mark E., Englund, Paul T.

“…RNA interference is a powerful method for inhibition of gene expression in Trypanosoma brucei(Ngo, H., Tschudi, C., Gull, K., and Ullu, E. (1998) Proc. Natl…”
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Potent antiprotozoal activity of a novel semi-synthetic berberine derivative by Bahar, Mark, Deng, Ye, Zhu, Xiaohua, He, Shanshan, Pandharkar, Trupti, Drew, Mark E., Navarro-Vázquez, Armando, Anklin, Clemens, Gil, Roberto R., Doskotch, Raymond W., Werbovetz, Karl A., Kinghorn, A. Douglas

“…Treatment of diseases such as African sleeping sickness and leishmaniasis often depends on relatively expensive or toxic drugs, and resistance to current…”
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Glycolysis modulates trypanosome glycoprotein expression as revealed by an RNAi library by Morris, James C., Wang, Zefeng, Drew, Mark E., Englund, Paul T.

“…RNA interference (RNAi) is a powerful tool for identifying gene function in Trypanosoma brucei. We generated an RNAi library, the first of its kind in any…”
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8,8-Dialkyldihydroberberines with Potent Antiprotozoal Activity by Endeshaw, Molla, Zhu, Xiaohua, He, Shanshan, Pandharkar, Trupti, Cason, Emily, Mahasenan, Kiran V, Agarwal, Hitesh, Li, Chenglong, Munde, Manoj, Wilson, W. David, Bahar, Mark, Doskotch, Raymond W, Kinghorn, A. Douglas, Kaiser, Marcel, Brun, Reto, Drew, Mark E, Werbovetz, Karl A

“…Semisynthetic 8,8-dialkyldihydroberberines (8,8-DDBs) were found to possess mid- to low-nanomolar potency against Plasmodium falciparum blood-stage parasites,…”
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Intramitochondrial Location and Dynamics of Crithidia fasciculata Kinetoplast Minicircle Replication Intermediates by Drew, Mark E., Englund, Paul T.

“…Kinetoplast DNA, the mitochondrial DNA of Crithidia fasciculata, is organized into a network containing 5,000 topologically interlocked minicircles. This…”
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Intramitochondrial Localization of Universal Minicircle Sequence-Binding Protein, a Trypanosomatid Protein That Binds Kinetoplast Minicircle Replication Origins by Abu-Elneel, Kawther, Robinson, Derrick R., Drew, Mark E., Englund, Paul T., Shlomai, Joseph

“…Kinetoplast DNA (kDNA), the mitochondrial DNA of the trypanosomatid Crithidia fasciculata, is a unique structure containing 5,000 DNA minicircles topologically…”
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Asymmetrical division of the kinetoplast DNA network of the trypanosome by Wang, Zefeng, Drew, Mark E., Morris, James C., Englund, Paul T.

“…Trypanosome mitochondrial DNA is a network containing thousands of interlocked minicircles. Silencing of a mitochondrial topoisomerase II by RNA interference…”
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