Search Results - "DREW, Brian G"

The Mitochondrial-Derived Peptide MOTS-c Promotes Metabolic Homeostasis and Reduces Obesity and Insulin Resistance by Lee, Changhan, Zeng, Jennifer, Drew, Brian G., Sallam, Tamer, Martin-Montalvo, Alejandro, Wan, Junxiang, Kim, Su-Jeong, Mehta, Hemal, Hevener, Andrea L., de Cabo, Rafael, Cohen, Pinchas

“…Mitochondria are known to be functional organelles, but their role as a signaling unit is increasingly being appreciated. The identification of a short open…”
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Sex differences in white adipose tissue expansion: emerging molecular mechanisms by Bond, Simon T, Calkin, Anna C, Drew, Brian G

“…The escalating prevalence of individuals becoming overweight and obese is a rapidly rising global health problem, placing an enormous burden on health and…”
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Adipose-Derived Extracellular Vesicles: Systemic Messengers and Metabolic Regulators in Health and Disease by Bond, Simon T, Calkin, Anna C, Drew, Brian G

“…Adipose tissue is comprised of a heterogeneous population of cells that co-operate to perform diverse physiological roles including endocrine-related…”
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Concordant peripheral lipidome signatures in two large clinical studies of Alzheimer’s disease by Huynh, Kevin, Lim, Wei Ling Florence, Giles, Corey, Jayawardana, Kaushala S., Salim, Agus, Mellett, Natalie A., Smith, Adam Alexander T., Olshansky, Gavriel, Drew, Brian G., Chatterjee, Pratishtha, Martins, Ian, Laws, Simon M., Bush, Ashley I., Rowe, Christopher C., Villemagne, Victor L., Ames, David, Masters, Colin L., Arnold, Matthias, Nho, Kwangsik, Saykin, Andrew J., Baillie, Rebecca, Han, Xianlin, Kaddurah-Daouk, Rima, Martins, Ralph N., Meikle, Peter J.

“…Changes to lipid metabolism are tightly associated with the onset and pathology of Alzheimer’s disease (AD). Lipids are complex molecules comprising many…”
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Activating HSP72 in Rodent Skeletal Muscle Increases Mitochondrial Number and Oxidative Capacity and Decreases Insulin Resistance by HENSTRIDGE, Darren C, BRUCE, Clinton R, CONNOR, Timothy, WATT, Matthew J, CARPENTER, Kevin, HARGREAVES, Mark, MCGEE, Sean L, HEVENER, Andrea L, FEBBRAIO, Mark A, DREW, Brian G, KALMAN, Tory, ATTILA, Kolonics, ESTEVEZ, Emma, CHUNG, Jason, WATSON, Nadine, GARDNER, Timothy, LEE-YOUNG, Robert S

“…Induction of heat shock protein (HSP)72 protects against obesity-induced insulin resistance, but the underlying mechanisms are unknown. Here, we show that…”
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Long non-coding RNAs (lncRNAs) in skeletal and cardiac muscle: potential therapeutic and diagnostic targets? by McMullen, Julie R, Drew, Brian G

“…The recent discovery that thousands of RNAs are transcribed by the cell but are never translated into protein, highlights a significant void in our current…”
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Adipose Subtype-Selective Recruitment of TLE3 or Prdm16 by PPARγ Specifies Lipid Storage versus Thermogenic Gene Programs by Villanueva, Claudio J., Vergnes, Laurent, Wang, Jiexin, Drew, Brian G., Hong, Cynthia, Tu, Yiping, Hu, Yan, Peng, Xu, Xu, Feng, Saez, Enrique, Wroblewski, Kevin, Hevener, Andrea L., Reue, Karen, Fong, Loren G., Young, Stephen G., Tontonoz, Peter

“…Transcriptional effectors of white adipocyte-selective gene expression have not been described. Here we show that TLE3 is a white-selective cofactor that acts…”
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HSP72 Is a Mitochondrial Stress Sensor Critical for Parkin Action, Oxidative Metabolism, and Insulin Sensitivity in Skeletal Muscle by DREW, Brian G, RIBAS, Vicente, WANAGAT, Jonathan, REUE, Karen, FEBBRAIO, Mark A, HEVENER, Andrea L, LE, Jamie A, HENSTRIDGE, Darren C, PHUN, Jennifer, ZHENQI ZHOU, SOLEYMANI, Teo, DARAEI, Pedram, SITZ, Daniel, VERGNES, Laurent

“…Increased heat shock protein (HSP) 72 expression in skeletal muscle prevents obesity and glucose intolerance in mice, although the underlying mechanisms of…”
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Antisense Oligonucleotide Technologies to Combat Obesity and Fatty Liver Disease by Keating, Michael F, Drew, Brian G, Calkin, Anna C

“…Synthetic oligonucleotide technologies are DNA or RNA based molecular compounds that are utilized to disrupt gene transcription or translation in target…”
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The Antioxidant Moiety of MitoQ Imparts Minimal Metabolic Effects in Adipose Tissue of High Fat Fed Mice by Bond, Simon T, Kim, Jisu, Calkin, Anna C, Drew, Brian G

“…Mitochondrial dysfunction is associated with a diverse array of diseases ranging from dystrophy and heart failure to obesity and hepatosteatosis. One of the…”
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Receptor for Advanced Glycation End Products (RAGE) Deficiency Attenuates the Development of Atherosclerosis in Diabetes by SORO-PAAVONEN, Aino, WATSON, Anna M. D, THOMAS, Merlin, FORBES, Josephine M, NAWROTH, Peter P, BIERHAUS, Angelika, COOPER, Mark E, JANDELEIT-DAHM, Karin A, JIAZE LI, PAAVONEN, Karri, KOITKA, Audrey, CALKIN, Anna C, BARIT, David, COUGHLAN, Melinda T, DREW, Brian G, LANCASTER, Graeme I

“…Receptor for Advanced Glycation End Products (RAGE) Deficiency Attenuates the Development of Atherosclerosis in Diabetes Aino Soro-Paavonen 1 , Anna M.D…”
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The impact of ERα action on muscle metabolism and insulin sensitivity – Strong enough for a man, made for a woman by Hevener, Andrea L., Zhou, Zhenqi, Moore, Timothy M., Drew, Brian G., Ribas, Vicent

“…The incidence of chronic disease is elevated in women after menopause. Natural variation in muscle expression of the estrogen receptor (ER)α is inversely…”
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Myeloid-specific estrogen receptor α deficiency impairs metabolic homeostasis and accelerates atherosclerotic lesion development by Ribas, Vicent, Drew, Brian G, Le, Jamie A, Soleymani, Teo, Daraei, Pedram, Sitz, Daniel, Mohammad, Laila, Henstridge, Darren C, Febbraio, Mark A, Hewitt, Sylvia C, Korach, Kenneth S, Bensinger, Steven J, Hevener, Andrea L

“…ERα is expressed in macrophages and other immune cells known to exert dramatic effects on glucose homeostasis. We investigated the impact of ERα expression on…”
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The potential of integrating human and mouse discovery platforms to advance our understanding of cardiometabolic diseases by Jurrjens, Aaron W, Seldin, Marcus M, Giles, Corey, Meikle, Peter J, Drew, Brian G, Calkin, Anna C

“…Cardiometabolic diseases encompass a range of interrelated conditions that arise from underlying metabolic perturbations precipitated by genetic,…”
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Acute effects of single and repeated mild traumatic brain injury on levels of neurometabolites, lipids, and mitochondrial function in male rats by Allen, Josh, Pham, Louise, Bond, Simon T, O'Brien, William T, Spitz, Gershon, Shultz, Sandy R, Drew, Brian G, Wright, David K, McDonald, Stuart J

“…Mild traumatic brain injuries (mTBIs) are the most common form of acquired brain injury. Symptoms of mTBI are thought to be associated with a neuropathological…”
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Deletion of Trim28 in committed adipocytes promotes obesity but preserves glucose tolerance by Bond, Simon T., King, Emily J., Henstridge, Darren C., Tran, Adrian, Moody, Sarah C., Yang, Christine, Liu, Yingying, Mellett, Natalie A., Nath, Artika P., Inouye, Michael, Tarling, Elizabeth J., de Aguiar Vallim, Thomas Q., Meikle, Peter J., Calkin, Anna C., Drew, Brian G.

“…The effective storage of lipids in white adipose tissue (WAT) critically impacts whole body energy homeostasis. Many genes have been implicated in WAT lipid…”
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Reconstituted High-Density Lipoprotein Increases Plasma High-Density Lipoprotein Anti-Inflammatory Properties and Cholesterol Efflux Capacity in Patients With Type 2 Diabetes by Patel, Sanjay, MBBS, Drew, Brian G., PhD, Nakhla, Shirley, MApplSc, Duffy, Stephen J., PhD, MBBS, Murphy, Andrew J., PhD, Barter, Phillip J., PhD, MBBS, Rye, Kerry-Anne, PhD, Chin-Dusting, Jaye-, PhD, Hoang, Anh, BSc(Hons), Sviridov, Dmitri, PhD, Celermajer, David S., PhD, MBBS, Kingwell, Bronwyn A., PhD

“…Objectives Our aim was to investigate the effects of reconstituted high-density lipoprotein (rHDL) infusions on plasma high-density lipoprotein (HDL)…”
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Mdivi-1 Protects Human W8B2 + Cardiac Stem Cells from Oxidative Stress and Simulated Ischemia-Reperfusion Injury by Rosdah, Ayeshah A, Bond, Simon T, Sivakumaran, Priyadharshini, Hoque, Ashfaqul, Oakhill, Jonathan S, Drew, Brian G, Delbridge, Lea M D, Lim, Shiang Y

“…Cardiac stem cell (CSC) therapy is a promising approach to treat ischemic heart disease. However, the poor survival of transplanted stem cells in the ischemic…”
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SOD2 in skeletal muscle: New insights from an inducible deletion model by Zhuang, Aowen, Yang, Christine, Liu, Yingying, Tan, Yanie, Bond, Simon T., Walker, Shannen, Sikora, Tim, Laskowski, Adrienne, Sharma, Arpeeta, de Haan, Judy B., Meikle, Peter J., Shimizu, Takahiko, Coughlan, Melinda T., Calkin, Anna C., Drew, Brian G.

“…Metabolic conditions such as obesity, insulin resistance and glucose intolerance are frequently associated with impairments in skeletal muscle function and…”
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Mechanism of cholesterol efflux in humans after infusion of reconstituted high-density lipoprotein by HOANG, Anh, DREW, Brian G, LOW, Hann, REMALEY, Alan T, NESTEL, Paul, KINGWELL, Bronwyn A, SVIRIDOV, Dmitri

“…Infusion of reconstituted HDL (rHDL) leads to changes in HDL metabolism as well as to an increased capacity of plasma to support cholesterol efflux providing…”
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