Search Results - "DRESSER, M. J"

Drug Absorption Interactions Between Oral Targeted Anticancer Agents and PPIs: Is pH-Dependent Solubility the Achilles Heel of Targeted Therapy? by Budha, N R, Frymoyer, A, Smelick, G S, Jin, J Y, Yago, M R, Dresser, M J, Holden, S N, Benet, L Z, Ware, J A

“…A majority of the novel orally administered, molecularly targeted anticancer therapies are weak bases that exhibit pH‐dependent solubility, and suppression of…”
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Dapoxetine, a novel treatment for premature ejaculation, does not have pharmacokinetic interactions with phosphodiesterase-5 inhibitors by DRESSER, M. J, DESAI, D, GIDWANI, S, SEFTEL, A. D, MODI, N. B

“…Potential pharmacokinetic interactions between dapoxetine, a serotonin transporter inhibitor developed for the treatment of premature ejaculation (PE), and the…”
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Ferroelectricity in Water Ice by Iedema, M. J, Dresser, M. J, Doering, D. L, Rowland, J. B, Hess, W. P, Tsekouras, A. A, Cowin, J. P

“…Partially proton-ordered ice I (cubic) was grown from the vapor phase, from 40 to nearly 150 K. It is believed to be metastable and oriented by the asymmetry…”
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Adsorption and decomposition of acetylene on Si(100)-(2×1) by TAYLOR, P. A, WALLACE, R. M, CHENG, C. C, WEINBERG, W. H, DRESSER, M. J, CHOYKE, W. J, YATES, J. T

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Electrophysiological analysis of the substrate selectivity of a sodium-coupled nucleoside transporter (rCNT1) expressed in Xenopus laevis oocytes by DRESSER, M. J, GERSTIN, K. M, GRAY, A. T, LOO, D. D. F, GIACOMINI, K. M

“…Nucleoside transporters that mediate cellular uptake of therapeutic nucleoside analogs are major determinants of the pharmacokinetic properties of these…”
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Molecular cloning of a Na+-dependent nucleoside transporter from rabbit intestine by GERSTIN, Karin M, DRESSER, Mark J, JUAN WANG, GIACOMINI, Kathleen M

“…Substantial species differences in the transport kinetics of nucleosides and therapeutic nucleoside analogs have been observed in various experimental systems…”
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Cloning and functional expression of a human liver organic cation transporter by Zhang, L, Dresser, M J, Gray, A T, Yost, S C, Terashita, S, Giacomini, K M

“…Polyspecific organic cation transporters in the liver mediate the elimination of a wide array of endogenous amines and xenobiotics. In contrast to our…”
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Direct Observation of Chemical Bond Dynamics on Surfaces by Yates, J. T., Alvey, M. D., Dresser, M. J., Henderson, M. A., Kiskinova, M., Ramsier, R. D., Szabó, A.

“…The dynamics of chemisorbed species as they swing to-and-fro on their adsorption sites may be directly observed with electron-stimulated desorption. The…”
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Kinetic and selectivity differences between rodent, rabbit, and human organic cation transporters (OCT1) by Dresser, M J, Gray, A T, Giacomini, K M

“…Organic cation transporters play an important role in the absorption, distribution, and elimination of clinical agents, toxic substances, and endogenous…”
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Na(+)-dependent purine nucleoside transporter from human kidney: cloning and functional characterization by Wang, J, Su, S F, Dresser, M J, Schaner, M E, Washington, C B, Giacomini, K M

“…Many purine nucleosides and their analogs are actively transported in the kidney. Using homology cloning strategies and reverse transcriptase-polymerase chain…”
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Arginine 454 and Lysine 370 Are Essential for the Anion Specificity of the Organic Anion Transporter, rOAT3 by Feng, Bo, Dresser, Mark J, Shu, Yan, Johns, Susan Jean, Giacomini, Kathleen M

“…Organic anion transporters (OATs) and organic cation transporters (OCTs) mediate the flux of xenobiotics across the plasma membranes of epithelia. Substrates…”
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The interaction of n-tetraalkylammonium compounds with a human organic cation transporter, hOCT1 by Zhang, L, Gorset, W, Dresser, M J, Giacomini, K M

“…Polyspecific organic cation transporters in epithelia play an important role in the elimination of many endogenous bioactive amines and therapeutically…”
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Adsorption and decomposition of acetylene on silicon(100)-(2.times.1) by Taylor, P. A, Wallace, R. M, Cheng, C. C, Weinberg, W. H, Dresser, M. J, Choyke, W. J, Yates, J. T

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The MDR1 C3435T polymorphism: effects on P-glycoprotein expression/function and clinical significance by Dresser, M J

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Molecular cloning and functional expression of a rabbit renal organic cation transporter by Terashita, Shigeyuki, Dresser, Mark J., Zhang, Lei, Gray, Andrew T., Yost, Spencer C., Giacomini, Kathleen M.

“…A cDNA encoding an organic cation transporter (rbOCT1) was isolated from rabbit kidney. The cDNA encodes a 554 amino acid protein that is highly homologous to…”
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Cloning and Functional Characterization of a Rat Renal Organic Cation Transporter Isoform (rOCT1A) by Zhang, Lei, Dresser, Mark J., Chun, Joanne K., Babbitt, Patricia C., Giacomini, Kathleen M.

“…Polyspecific organic cation transporters in the renal proximal tubule mediate the secretion of many clinically used drugs as well as endogenous metabolites…”
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Biochemical Characterization and Crystallographic Structure of an Escherichia coli Protein from the Phosphotriesterase Gene Family by Buchbinder, Jenny L, Stephenson, Robert C, Dresser, Mark J, Pitera, Jed W, Scanlan, Thomas S, Fletterick, Robert J

“…Phosphotriesterase homology protein (PHP) is a member of a recently discovered family of proteins related to phosphotriesterase, a hydrolytic, bacterial enzyme…”
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Absorption, Metabolism, Excretion, and the Contribution of Intestinal Metabolism to the Oral Disposition of [14C]Cobimetinib, a MEK Inhibitor, in Humans by Takahashi, Ryan H, Choo, Edna F, Ma, Shuguang, Wong, Susan, Halladay, Jason, Deng, Yuzhong, Rooney, Isabelle, Gates, Mary, Hop, Cornelis E C A, Khojasteh, S Cyrus, Dresser, Mark J, Musib, Luna

“…The pharmacokinetics, metabolism, and excretion of cobimetinib, a MEK inhibitor, were characterized in healthy male subjects (n = 6) following a single 20 mg…”
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Molecular and functional characteristics of cloned human organic cation transporters by Dresser, M J, Zhang, L, Giacomini, K M

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Transporters involved in the elimination of drugs in the kidney: organic anion transporters and organic cation transporters by Dresser, M J, Leabman, M K, Giacomini, K M

“…Transporters in the kidney mediate the secretion or reabsorption of many compounds and thereby influence the plasma levels of their substrates. Organic anion…”
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