Search Results - "DRAKE, W. M"

Shotguns vs Lasers: Identifying barriers and facilitators to scaling-up plant molecular farming for high-value health products by Menary, Jonathan, Hobbs, Matthew, Mesquita de Albuquerque, Sara, Pacho, Agata, Drake, Pascal M W, Prendiville, Alison, Ma, Julian K-C, Fuller, Sebastian S

“…Plant molecular farming (PMF) is a convenient and cost-effective way to produce high-value recombinant proteins that can be used in the production of a range…”
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The production of recombinant pharmaceutical proteins in plants by Ma, Julian K-C, Drake, Pascal M. W, Christou, Paul

“…Imagine a world in which any protein, either naturally occurring or designed by man, could be produced safely, inexpensively and in almost unlimited quantities…”
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The endocrine system and ageing by Chahal, HS, Drake, WM

“…Complex changes occur within the endocrine system of ageing individuals. This article explores the changes that occur in the metabolism and production of…”
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A Cross-Sectional Study of the Prevalence of Cardiac Valvular Abnormalities in Hyperprolactinemic Patients Treated With Ergot-Derived Dopamine Agonists by Drake, W. M, Stiles, C. E, Howlett, T. A, Toogood, A. A, Bevan, J. S, Steeds, R. P

“…Context: Concern exists in the literature that the long-term use of ergot-derived dopamine agonist drugs for the treatment of hyperprolactinemia may be…”
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Hypothalamitis and severe hypothalamic dysfunction associated with anti–programmed cell death ligand 1 antibody treatment by Tshuma, N., Glynn, N., Evanson, J., Powles, T., Drake, W.M.

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Development of a minigenome cassette for Lettuce necrotic yellows virus: A first step in rescuing a plant cytorhabdovirus by Ibrahim, Ahmad E C, van Dolleweerd, Craig J, Drake, Pascal M W, Ma, Julian K-C

“…Rhabdoviruses are enveloped negative-sense RNA viruses that have numerous biotechnological applications. However, recovering plant rhabdoviruses from cDNA…”
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Effective Combination Treatment with Cabergoline and Low-Dose Pegvisomant in Active Acromegaly: A Prospective Clinical Trial by Higham, C. E, Atkinson, A. B, Aylwin, S, Bidlingmaier, M, Drake, W. M, Lewis, A, Martin, N. M, Moyes, V, Newell-Price, J, Trainer, P. J

“…Context: With adequate dose titration, pegvisomant normalizes IGF-I in up to 97% of patients with acromegaly. Pegvisomant is indicated for treatment-resistant…”
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Long-term experience of pegvisomant therapy as a treatment for acromegaly by Higham, C. E., Chung, T. T., Lawrance, J., Drake, W. M., Trainer, P. J.

“…Summary Aims  To evaluate the long‐term efficacy and safety of pegvisomant as a treatment for acromegaly. Design  Retrospective analysis of clinical and trial…”
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Clinical use of cabergoline as primary and adjunctive treatment for acromegaly by Moyes, V J, Metcalfe, K A, Drake, W M

“…BackgroundCabergoline is a dopamine agonist that may be used as primary or adjunctive therapy for acromegaly. Although one study suggested biochemical control…”
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Repeated colonoscopic screening of patients with acromegaly: 15-year experience identifies those at risk of new colonic neoplasia and allows for effective screening guidelines by Dworakowska, D, Gueorguiev, M, Kelly, P, Monson, J P, Besser, G M, Chew, S L, Akker, S A, Drake, W M, Fairclough, P D, Grossman, A B, Jenkins, P J

“…ObjectiveIt is suggested that patients with acromegaly have an increased risk of colorectal cancer and pre-malignant adenomatous polyps. However, the optimum…”
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Development of rhizosecretion as a production system for recombinant proteins from hydroponic cultivated tobacco by Drake, Pascal M.W, Barbi, Tommaso, Sexton, Amy, McGowan, Edward, Stadlmann, Johannes, Navarre, Catherine, Paul, Matthew J, Ma, Julian K.-C

“…Rhizosecretion is an attractive technology for the production of recombinant proteins from transgenic plants. However, to date, yields of plant-derived…”
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Optimizing GH Therapy in Adults and Children by Drake, W. M, Howell, S. J, Monson, J. P, Shalet, S. M

“…Until the advent of modern neuroradiological imaging techniques in 1989, a diagnosis of GH deficiency in adults carried little significance other than as a…”
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Immune-complex mimics as a molecular platform for adjuvant-free vaccine delivery by Pepponi, Ilaria, Stylianou, Elena, van Dolleweerd, Craig, Diogo, Gil Reynolds, Paul, Matthew J, Drake, Pascal M W, Ma, Julian K-C, Reljic, Rajko

“…Protein-based vaccine development faces the difficult challenge of finding robust yet non-toxic adjuvants suitable for humans. Here, using a molecular…”
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Treatment of Nelson's syndrome with temozolomide by Moyes, V J, Alusi, G, Sabin, H I, Evanson, J, Berney, D M, Kovacs, K, Monson, J P, Plowman, P N, Drake, W M

“…A 64-year-old woman was previously treated for Cushing's disease with trans-sphenoidal surgery, external beam radiotherapy and bilateral adrenalectomy…”
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Denosumab for management of refractory hypercalcaemia in recurrent parathyroid carcinoma by Nadarasa, K, Theodoraki, A, Kurzawinski, T R, Carpenter, R, Bull, J, Chung, T T, Drake, W M

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Plant-derived recombinant immune complexes as self-adjuvanting TB immunogens for mucosal boosting of BCG by Pepponi, Ilaria, Diogo, Gil R, Stylianou, Elena, van Dolleweerd, Craig J, Drake, Pascal M W, Paul, Matthew J, Sibley, Laura, Ma, Julian K-C, Reljic, Rajko

“…Progress with protein-based tuberculosis (TB) vaccines has been limited by poor availability of adjuvants suitable for human application. Here, we developed…”
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Transformation of Althaea officinalis L. by Agrobacterium rhizogenes for the production of transgenic roots expressing the anti-HIV microbicide cyanovirin-N by Drake, Pascal M. W, de Moraes Madeira, Luisa, Szeto, Tim H, Ma, Julian K-C

“…The marshmallow plant (Althaea officinalis L.) has been used for centuries in medicine and other applications. Valuable secondary metabolites have previously…”
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Circadian variation in serum cortisol during hydrocortisone replacement is not attributable to changes in cortisol-binding globulin concentrations by Chung, T.T., Gunganah, K., Monson, J.P., Drake, W.M.

“…Summary Background Patients taking hydrocortisone (HC) replacement for primary or secondary adrenal failure require individual adjustment of their dose. In…”
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Intra-abdominal fibrosis in a recent cohort of patients with neuroendocrine (‘carcinoid’) tumours of the small bowel by Druce, M.R., Bharwani, N., Akker, S.A., Drake, W.M., Rockall, A., Grossman, A.B.

“…Background: Fibrosis is a hallmark of neuroendocrine tumours (NETs) arising in the jejunum and ileum and may manifest in the mesentery and elsewhere. It is…”
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Clinical outcomes following unilateral adrenalectomy in patients with primary aldosteronism by Hannon, M J, Sze, W C, Carpenter, R, Parvanta, L, Matson, M, Sahdev, A, Druce, M R, Berney, D M, Waterhouse, M, Akker, S A, Drake, W M

“…In approximately half of cases of primary aldosteronism (PA), the cause is a surgically-resectable unilateral aldosterone-producing adrenal adenoma. However,…”
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