Search Results - "DRAGUNOW, M"

Valproic acid enhances microglial phagocytosis of amyloid-beta(1-42) by Smith, A M, Gibbons, H M, Dragunow, M

“…Alzheimer's disease (AD) is a prevalent neurodegenerative disorder manifested by memory loss, confusion and changes in mood. A principal pathology of this…”
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Human Neuroblasts Migrate to the Olfactory Bulb via a Lateral Ventricular Extension by Curtis, Maurice A, Kam, Monica, Nannmark, Ulf, Anderson, Michelle F, Axell, Mathilda Zetterstrom, Wikkelso, Carsten, Holtås, Stig, van Roon-Mom, Willeke M.C, Björk-Eriksson, Thomas, Nordborg, Claes, Frisén, Jonas, Dragunow, Michael, Faull, Richard L.M, Eriksson, Peter S

“…The rostral migratory stream (RMS) is the main pathway by which newly born subventricular zone cells reach the olfactory bulb (OB) in rodents. However, the RMS…”
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Cannabinoid receptors in the human brain: a detailed anatomical and quantitative autoradiographic study in the fetal, neonatal and adult human brain by Glass, M, Faull, R.L.M, Dragunow, M

“…The anatomical distribution and density of cannabinoid receptors in the human brain was studied in one fetal (33 weeks gestation), two neonatal (aged three to…”
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The pattern of neurodegeneration in Huntington's disease: a comparative study of cannabinoid, dopamine, adenosine and GABA A receptor alterations in the human basal ganglia in Huntington's disease by Glass, M., Dragunow, M., Faull, R.L.M.

“…In order to investigate the sequence and pattern of neurodegeneration in Huntington's disease, the distribution and density of cannabinoid CB 1, dopamine D 1…”
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Doublecortin expression in the normal and epileptic adult human brain by Liu, Y. W. J., Curtis, M. A., Gibbons, H. M., Mee, E. W., Bergin, P. S., Teoh, H. H., Connor, B., Dragunow, M., Faull, R. L. M.

“…Mesial temporal lobe epilepsy (MTLE) is a neurological disorder associated with spontaneous recurrent complex partial seizures and hippocampal sclerosis…”
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Neuroprotective potential of CB 1 receptor agonists in an in vitro model of Huntington's disease by Scotter, EL, Goodfellow, CE, Graham, ES, Dragunow, M, Glass, M

“…Background and purpose:  The therapeutic potential of cannabinoids in Huntington's disease (HD) has been investigated by several groups with complex and…”
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Neuroprotective potential of CB1 receptor agonists in an in vitro model of Huntington's disease by Scotter, EL, Goodfellow, CE, Graham, ES, Dragunow, M, Glass, M

“…Background and purpose:  The therapeutic potential of cannabinoids in Huntington's disease (HD) has been investigated by several groups with complex and…”
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Adenosine kinase, glutamine synthetase and EAAT2 as gene therapy targets for temporal lobe epilepsy by Young, D, Fong, D M, Lawlor, P A, Wu, A, Mouravlev, A, McRae, M, Glass, M, Dragunow, M, During, M J

“…Astrocytes are an attractive cell target for gene therapy, but the validation of new therapeutic candidates is needed. We determined whether adeno-associated…”
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A role for immediate-early transcription factors in learning and memory by Dragunow, M

“…This article summarizes recent studies from the long-term potentiation (LTP), long-term depression (LTD), and behavioral learning literature, indicating that…”
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The distribution of progenitor cells in the subependymal layer of the lateral ventricle in the normal and Huntington’s disease human brain by Curtis, M.A., Penney, E.B., Pearson, J., Dragunow, M., Connor, B., Faull, R.L.M.

“…The recent demonstration of endogenous stem/progenitor cells in the adult mammalian brain raises the exciting possibility that these undifferentiated cells may…”
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First human hNT neurons patterned on parylene-C/silicon dioxide substrates: Combining an accessible cell line and robust patterning technology for the study of the pathological adult human brain by Unsworth, C.P., Graham, E.S., Delivopoulos, E., Dragunow, M., Murray, A.F.

“…In this communication, we describe a new method which has enabled the first patterning of human neurons (derived from the human teratocarcinoma cell line…”
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The role of neuronal growth factors in neurodegenerative disorders of the human brain by Connor, B, Dragunow, M

“…Recent evidence suggests that neurotrophic factors that promote the survival or differentiation of developing neurons may also protect mature neurons from…”
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No change in progenitor cell proliferation in the hippocampus in Huntington's disease by Low, V.F, Dragunow, M, Tippett, L.J, Faull, R.L.M, Curtis, M.A

“…Abstract Increases in cell proliferation in the hippocampus have been robustly demonstrated in animal models of neurodegenerative diseases like Huntington's…”
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The use of c-fos as a metabolic marker in neuronal pathway tracing by Dragunow, M, Faull, R

“…The use of c-fos protein (Fos) immunocytochemistry as a metabolic marker for tracing neuroanatomical connections, seizure pathways and sites of action of…”
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Purinergic Mechanisms in Epilepsy by Dragunow, M.

“…Adenosine is a powerful neuromodulator that has a range of functions in various cells and tissues throughout the body. In the brain adenosine controls many…”
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Valproic acid enhances microglial phagocytosis of amyloid-β1–42 by Smith, A.M, Gibbons, H.M, Dragunow, M

“…Abstract Alzheimer's disease (AD) is a prevalent neurodegenerative disorder manifested by memory loss, confusion and changes in mood. A principal pathology of…”
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Nucleolar enlargement, nuclear eccentricity and altered cell body immunostaining characteristics of large-sized sensory neurons following treatment of rats with paclitaxel by Jamieson, S.M.F., Liu, J.J., Connor, B., Dragunow, M., McKeage, M.J.

“…Paclitaxel-induced sensory neuropathy is a problematic side-effect of cancer chemotherapy. Previous studies in rodents have shown paclitaxel treatment to have…”
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Quantitative comparison of expression with adeno-associated virus (AAV-2) brain-specific gene cassettes by XU, R, JANSON, C. G, LEONE, P, CHEN, Q, DICKER, B, DURING, M. J, MASTAKOV, M, LAWLOR, P, YOUNG, D, MOURAVLEV, A, FITZSIMONS, H, CHOI, K-L, MA, H, DRAGUNOW, M

“…This study compared a range of mammalian CNS expression cassettes in recombinant adeno-associated virus (AAV-2) vectors using strong endogenous promoter…”
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Valproic acid induces caspase 3-mediated apoptosis in microglial cells by Dragunow, M., Greenwood, J.M., Cameron, R.E., Narayan, P.J., O’Carroll, S.J., Pearson, A.G., Gibbons, H.M.

“…Valproic acid is widely used for the treatment of epilepsy and mood disorders, but its mode of action is unclear. Treatment of neuronal cells with valproic…”
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Activated c-Jun is present in neurofibrillary tangles in Alzheimer's disease brains by Pearson, A.G., Byrne, U.T.E., MacGibbon, G.A., Faull, R.L.M., Dragunow, M.

“…Alzheimer's disease (AD) pathology is characterized by the presence of insoluble β-amyoid deposits and neurofibrillary tangles containing hyperphosphorylated…”
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