Search Results - "DRAETTA, Giulio F"

Post-translational Regulation of Cas9 during G1 Enhances Homology-Directed Repair by Gutschner, Tony, Haemmerle, Monika, Genovese, Giannicola, Draetta, Giulio F., Chin, Lynda

“…CRISPR/Cas9 induces DNA double-strand breaks that are repaired by cell-autonomous repair pathways, namely, non-homologous end-joining (NHEJ), or…”
Get full text

Tumors and mitochondrial respiration: a neglected connection by Viale, Andrea, Corti, Denise, Draetta, Giulio F

“…For decades, tumor cells have been considered defective in mitochondrial respiration due to their dominant glycolytic metabolism. However, a growing body of…”
Get full text

Genetics and biology of pancreatic ductal adenocarcinoma by Ying, Haoqiang, Dey, Prasenjit, Yao, Wantong, Kimmelman, Alec C, Draetta, Giulio F, Maitra, Anirban, DePinho, Ronald A

“…With 5-year survival rates remaining constant at 6% and rising incidences associated with an epidemic in obesity and metabolic syndrome, pancreatic ductal…”
Get full text

Allosteric SHP2 Inhibitor, IACS-13909, Overcomes EGFR-Dependent and EGFR-Independent Resistance Mechanisms toward Osimertinib by Sun, Yuting, Meyers, Brooke A, Czako, Barbara, Leonard, Paul, Mseeh, Faika, Harris, Angela L, Wu, Qi, Johnson, Sarah, Parker, Connor A, Cross, Jason B, Di Francesco, Maria Emilia, Bivona, Benjamin J, Bristow, Christopher A, Burke, Jason P, Carrillo, Caroline C, Carroll, Christopher L, Chang, Qing, Feng, Ningping, Gao, Guang, Gera, Sonal, Giuliani, Virginia, Huang, Justin K, Jiang, Yongying, Kang, Zhijun, Kovacs, Jeffrey J, Liu, Chiu-Yi, Lopez, Anastasia M, Ma, Xiaoyan, Mandal, Pijus K, McAfoos, Timothy, Miller, Meredith A, Mullinax, Robert A, Peoples, Michael, Ramamoorthy, Vandhana, Seth, Sahil, Spencer, Nakia D, Suzuki, Erika, Williams, Christopher C, Yu, Simon S, Zuniga, Andy M, Draetta, Giulio F, Marszalek, Joseph R, Heffernan, Timothy P, Kohl, Nancy E, Jones, Philip

“…Src homology 2 domain-containing phosphatase (SHP2) is a phosphatase that mediates signaling downstream of multiple receptor tyrosine kinases (RTK) and is…”
Get full text

Synthetic vulnerabilities of mesenchymal subpopulations in pancreatic cancer by Genovese, Giannicola, Carugo, Alessandro, Tepper, James, Robinson, Frederick Scott, Li, Liren, Svelto, Maria, Nezi, Luigi, Corti, Denise, Minelli, Rosalba, Pettazzoni, Piergiorgio, Gutschner, Tony, Wu, Chia-Chin, Seth, Sahil, Akdemir, Kadir Caner, Leo, Elisabetta, Amin, Samirkumar, Molin, Marco Dal, Ying, Haoqiang, Kwong, Lawrence N., Colla, Simona, Takahashi, Koichi, Ghosh, Papia, Giuliani, Virginia, Muller, Florian, Dey, Prasenjit, Jiang, Shan, Garvey, Jill, Liu, Chang-Gong, Zhang, Jianhua, Heffernan, Timothy P., Toniatti, Carlo, Fleming, Jason B., Goggins, Michael G., Wood, Laura D., Sgambato, Alessandro, Agaimy, Abbas, Maitra, Anirban, Roberts, Charles W. M., Wang, Huamin, Viale, Andrea, DePinho, Ronald A., Draetta, Giulio F., Chin, Lynda

“…Depletion of Smarcb1 activates the Myc network of signalling cascades, increasing protein metabolism and activation of survival pathways allowing highly…”
Get full text

Regulating mammalian checkpoints through Cdc25 inactivation by Donzelli, Maddalena, Draetta, Giulio F

“…Precise monitoring of DNA replication and chromosome segregation ensures that there is accurate transmission of genetic information from a cell to its…”
Get full text

Loss of ARID1A Promotes Epithelial-Mesenchymal Transition and Sensitizes Pancreatic Tumors to Proteotoxic Stress by Tomihara, Hideo, Carbone, Federica, Perelli, Luigi, Huang, Justin K, Soeung, Melinda, Rose, Johnathon L, Robinson, Frederick S, Lissanu Deribe, Yonathan, Feng, Ningping, Takeda, Mitsunobu, Inoue, Akira, Poggetto, Edoardo Del, Deem, Angela K, Maitra, Anirban, Msaouel, Pavlos, Tannir, Nizar M, Draetta, Giulio F, Viale, Andrea, Heffernan, Timothy P, Bristow, Christopher A, Carugo, Alessandro, Genovese, Giannicola

“…Cellular dedifferentiation is a key mechanism driving cancer progression. Acquisition of mesenchymal features has been associated with drug resistance, poor…”
Get full text

Sugar? No Thank You, Just a Deep Breath of Oxygen for Cancer Stem Cells by Viale, Andrea, Draetta, Giulio F.

“…Tumors are metabolically heterogeneous, and subpopulations of tumorigenic cells have been recently described to rely more on mitochondrial respiration than…”
Get full text

Current and Future Horizons of Patient-Derived Xenograft Models in Colorectal Cancer Translational Research by Inoue, Akira, Deem, Angela K, Kopetz, Scott, Heffernan, Timothy P, Draetta, Giulio F, Carugo, Alessandro

“…Our poor understanding of the intricate biology of cancer and the limited availability of preclinical models that faithfully recapitulate the complexity of…”
Get full text

Critical questions in ovarian cancer research and treatment: Report of an American Association for Cancer Research Special Conference by Bast, Robert C., Matulonis, Ursula A., Sood, Anil K., Ahmed, Ahmed A., Amobi, Adaobi E., Balkwill, Frances R., Wielgos‐Bonvallet, Monicka, Bowtell, David D. L., Brenton, James D., Brugge, Joan S., Coleman, Robert L., Draetta, Giulio F., Doberstein, Kai, Drapkin, Ronny I., Eckert, Mark A., Edwards, Robert P., Elias, Kevin M., Ennis, Darren, Futreal, Andrew, Gershenson, David M., Greenberg, Roger A., Huntsman, David G., Ji, Jennifer Xiao Ye, Kohn, Elise C., Iavarone, Claudia, Lengyel, Ernst R., Levine, Douglas A., Lord, Christopher J., Lu, Zhen, Mills, Gordon B., Modugno, Francesmary, Nelson, Brad H., Odunsi, Kunle, Pilsworth, Jessica A., Rottapel, Robert K., Powell, Daniel J., Shen, Li, Shih, Ie‐Ming, Spriggs, David R., Walton, Josephine, Zhang, Kaiyang, Zhang, Rugang, Zou, Lee

“…Substantial progress has been made in understanding ovarian cancer at the molecular and cellular level. Significant improvement in 5‐year survival has been…”
Get full text

Role for Histone Deacetylase 1 in Human Tumor Cell Proliferation by Senese, Silvia, Zaragoza, Katrin, Minardi, Simone, Muradore, Ivan, Ronzoni, Simona, Passafaro, Alfonso, Bernard, Loris, Draetta, Giulio F., Alcalay, Myriam, Seiser, Christian, Chiocca, Susanna

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

miR‐9 modulates and predicts the response to radiotherapy and EGFR inhibition in HNSCC by Citron, Francesca, Segatto, Ilenia, Musco, Lorena, Pellarin, Ilenia, Rampioni Vinciguerra, Gian Luca, Franchin, Giovanni, Fanetti, Giuseppe, Miccichè, Francesco, Giacomarra, Vittorio, Lupato, Valentina, Favero, Andrea, Concina, Isabella, Srinivasan, Sanjana, Avanzo, Michele, Castiglioni, Isabella, Barzan, Luigi, Sulfaro, Sandro, Petrone, Gianluigi, Viale, Andrea, Draetta, Giulio F, Vecchione, Andrea, Belletti, Barbara, Baldassarre, Gustavo

“…Radiotherapy (RT) plus the anti‐EGFR monoclonal antibody Cetuximab (CTX) is an effective combination therapy for a subset of head and neck squamous cell…”
Get full text

Targeting mitochondrial respiration and the BCL2 family in high‐grade MYC‐associated B‐cell lymphoma by Donati, Giulio, Ravà, Micol, Filipuzzi, Marco, Nicoli, Paola, Cassina, Laura, Verrecchia, Alessandro, Doni, Mirko, Rodighiero, Simona, Parodi, Federica, Boletta, Alessandra, Vellano, Christopher P., Marszalek, Joseph R., Draetta, Giulio F., Amati, Bruno

“…Multiple molecular features, such as activation of specific oncogenes (e.g., MYC, BCL2) or a variety of gene expression signatures, have been associated with…”
Get full text

Predictive Signatures Inform the Effective Repurposing of Decitabine to Treat KRAS-Dependent Pancreatic Ductal Adenocarcinoma by Mottini, Carla, Tomihara, Hideo, Carrella, Diego, Lamolinara, Alessia, Iezzi, Manuela, Huang, Justin K, Amoreo, Carla A, Buglioni, Simonetta, Manni, Isabella, Robinson, Frederick S, Minelli, Rosalba, Kang, Ya'an, Fleming, Jason B, Kim, Michael P, Bristow, Christopher A, Trisciuoglio, Daniela, Iuliano, Antonella, Del Bufalo, Donatella, Di Bernardo, Diego, Melisi, Davide, Draetta, Giulio F, Ciliberto, Gennaro, Carugo, Alessandro, Cardone, Luca

“…Mutated KRAS protein is a pivotal tumor driver in pancreatic cancer. However, despite comprehensive efforts, effective therapeutics that can target oncogenic…”
Get full text

In Vivo Genetic Screens of Patient-Derived Tumors Revealed Unexpected Frailty of the Transformed Phenotype by Bossi, Daniela, Cicalese, Angelo, Dellino, Gaetano I, Luzi, Lucilla, Riva, Laura, D'Alesio, Carolina, Diaferia, Giuseppe R, Carugo, Alessandro, Cavallaro, Elena, Piccioni, Rossana, Barberis, Massimo, Mazzarol, Giovanni, Testori, Alessandro, Punzi, Simona, Pallavicini, Isabella, Tosti, Giulio, Giacó, Luciano, Melloni, Giorgio, Heffernan, Timothy P, Natoli, Gioacchino, Draetta, Giulio F, Minucci, Saverio, Pelicci, PierGiuseppe, Lanfrancone, Luisa

“…The identification of genes maintaining cancer growth is critical to our understanding of tumorigenesis. We report the first in vivo genetic screen of…”
Get more information

Frequent alterations in the expression of serine/threonine kinases in human cancers by CAPRA, Maria, NUCIFORO, Paolo Giovanni, DRAETTA, Giulio F, DI FIORE, Pier Paolo, CONFALONIERI, Stefano, QUARTO, Micaela, BIANCHI, Marco, NEBULONI, Manuela, BOLDORINI, Renzo, PALLOTTI, Francesco, VIALE, Giuseppe, GISHIZKY, Mikhail L

“…Protein kinases constitute a large family of regulatory enzymes involved in the homeostasis of virtually every cellular process. Subversion of protein kinases…”
Get full text

Cdc25A phosphatase: combinatorial phosphorylation, ubiquitylation and proteolysis by Busino, Luca, Chiesa, Massimo, Draetta, Giulio F, Donzelli, Maddalena

“…In eukaryotic cells, control mechanisms of cell-cycle progression have evolved to accurately monitor the integrity of genetic information to be transferred to…”
Get full text

The KRAS mutational spectrum and its clinical implications in pancreatic cancer by Perelli, Luigi, Genovese, Giannicola, Draetta, Giulio F

“…In this issue of Cancer Cell, McIntyre et al. show that specific mutations in the KRAS proto-oncogene shape clinical progression of pancreatic ductal…”
Get more information

Immune landscape of a genetically engineered murine model of glioma compared with human glioma by Zamler, Daniel B, Shingu, Takashi, Kahn, Laura M, Huntoon, Kristin, Kassab, Cynthia, Ott, Martina, Tomczak, Katarzyna, Liu, Jintan, Li, Yating, Lai, Ivy, Zorilla-Veloz, Rocio, Yee, Cassian, Rai, Kunal, Kim, Betty Ys, Watowich, Stephanie S, Heimberger, Amy B, Draetta, Giulio F, Hu, Jian

“…Novel therapeutic strategies targeting glioblastoma (GBM) often fail in the clinic, partly because preclinical models in which hypotheses are being tested do…”
Get full text

A Mechanism for Inhibiting the SUMO Pathway by Boggio, Roberto, Colombo, Riccardo, Hay, Ronald T., Draetta, Giulio F., Chiocca, Susanna

“…The SUMO pathway parallels the classical ubiquitinylation pathway with three discrete steps: activation involving the enzyme E1, conjugation involving the E2…”
Get full text