Search Results - "DR SETCHELL, Kenneth"

Soy isoflavone phase II metabolism differs between rodents and humans: implications for the effect on breast cancer risk by DR SETCHELL, Kenneth, BROWN, Nadine M, XUEHENG ZHAO, LINDLEY, Stephanie L, HEUBI, James E, KING, Eileen C, MESSINA, Mark J

“…Human and animal studies have produced conflicting results with regard to the effect of soy isoflavones on breast cancer risk. This may be due to differences…”
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Neuromodulation by soy diets or equol: anti-depressive & anti-obesity-like influences, age- & hormone-dependent effects by Blake, Crystal, Fabick, Kimberly M, Setchell, Kenneth Dr, Lund, Trent D, Lephart, Edwin D

“…Soy-derived isoflavones potentially protect against obesity and depression. In five different studies we examined the influence of soy-containing diets or…”
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Vertical sleeve gastrectomy reduces hepatic steatosis while increasing serum bile acids in a weight‐loss‐independent manner by Myronovych, Andriy, Kirby, Michelle, Ryan, Karen K., Zhang, Wujuan, Jha, Pinky, Setchell, Kenneth DR, Dexheimer, Phillip J., Aronow, Bruce, Seeley, Randy J., Kohli, Rohit

“…Objective Our objective was to investigate the role of bile acids in hepatic steatosis reduction after vertical sleeve gastrectomy (VSG). Design and Methods…”
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A Surgical Model in Male Obese Rats Uncovers Protective Effects of Bile Acids Post-Bariatric Surgery by Kohli, Rohit, Setchell, Kenneth DR, Kirby, Michelle, Myronovych, Andriy, Ryan, Karen K, Ibrahim, Samar H, Berger, Jose, Smith, Kathi, Toure, Mouhamadoul, Woods, Stephen C, Seeley, Randy J

“…Bariatric surgery elevates serum bile acids. Conjugated bile acid administration, such as tauroursodeoxycholic acid (TUDCA), improves insulin sensitivity,…”
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Global gene expression profile progression in Gaucher disease mouse models by Xu, You-Hai, Jia, Li, Quinn, Brian, Zamzow, Matthew, Stringer, Keith, Aronow, Bruce, Sun, Ying, Zhang, Wujuan, Setchell, Kenneth D R, Grabowski, Gregory A

“…Gaucher disease is caused by defective glucocerebrosidase activity and the consequent accumulation of glucosylceramide. The pathogenic pathways resulting from…”
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Factors affecting the bioavailability of soy isoflavones in humans after ingestion of physiologically relevant levels from different soy foods by Cassidy, Aedin, Brown, Jonathan E, Hawdon, Anne, Faughnan, Marian S, King, Laurence J, Millward, Joe, Zimmer-Nechemias, Linda, Wolfe, Brian, Setchell, Kenneth D R

“…The precise role that isoflavones play in the health-related effects of soy foods, and their potential for adverse effects are controversial. This may be due…”
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Evidence for lack of absorption of soy isoflavone glycosides in humans, supporting the crucial role of intestinal metabolism for bioavailability by Setchell, Kenneth D.R, Brown, Nadine M, Zimmer-Nechemias, Linda, Brashear, Wayne T, Wolfe, Brian E, Kirschner, Abby S, Heubi, James E

“…Background: The isoflavones daidzein and genistein occur naturally in most soyfoods, conjugated almost exclusively to sugars. Controversy exists regarding the…”
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Dietary isoflavones alter regulatory behaviors, metabolic hormones and neuroendocrine function in Long-Evans male rats by Lephart, Edwin D, Porter, James P, Lund, Trent D, Bu, Lihong, Setchell, Kenneth Dr, Ramoz, Gina, Crowley, William R

“…BACKGROUND: Phytoestrogens derived from soy foods (or isoflavones) have received prevalent usage due to their 'health benefits' of decreasing: a) age-related…”
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Diets high in selenium and isoflavones decrease androgen-regulated gene expression in healthy rat dorsolateral prostate by Legg, Russell L, Tolman, Jessica R, Lovinger, Cameron T, Lephart, Edwin D, Setchell, Kenneth D R, Christensen, Merrill J

“…High dietary intake of selenium or soybean isoflavones reduces prostate cancer risk. These components each affect androgen-regulated gene expression. The…”
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Exposure of infants to phyto-oestrogens from soy-based infant formula by Setchell, K D, Zimmer-Nechemias, L, Cai, J, Heubi, J E

“…The isoflavones genistein, daidzein, and their glycosides, found in high concentrations in soybeans and soy-protein foods, may have beneficial effects in the…”
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Influences of dietary soy isoflavones on metabolism but not nociception and stress hormone responses in ovariectomized female rats by Bu, Lihong, Setchell, Kenneth D R, Lephart, Edwin D

“…Isoflavones, the most abundant phytoestrogens in soy foods, are structurally similar to 17beta-estradiol. Few studies have examined the nociception and stress…”
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Visual spatial memory is enhanced in female rats (but inhibited in males) by dietary soy phytoestrogens by Lund, T D, West, T W, Tian, L Y, Bu, L H, Simmons, D L, Setchell, K D, Adlercreutz, H, Lephart, E D

“…In learning and memory tasks, requiring visual spatial memory (VSM), males exhibit superior performance to females (a difference attributed to the hormonal…”
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Primary 4-3-oxosteroid 5β-reductase deficiency：Two cases in China by Zhao, Jing, Fang, Ling-Juan, Setchell, Kenneth D R, Chen, Rui, Li, Li-Ting, Wang, Jian-She

“…Aldo-keto reductase 1D1（AKR1D1） deficiency,a rare but life-threatening form of bile acid deficiency,has not been previously described in China.Here,we describe…”
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Timing of supplementation of selenium and isoflavones determines prostate cancer risk factor reduction in rats by Tolman, Jessica R, Lephart, Edwin D, Setchell, Kenneth Dr, Eggett, Dennis L, Christensen, Merrill J

“…High dietary intake of selenium or isoflavones reduces risk factors for prostate cancer. We tested whether combined supplementation of these two dietary…”
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Phytoestrogens : the biochemistry, physiology, and implications for human health of soy isoflavones by SETCHELL, K. D. R

“…The importance of estrogens in homeostatic regulation of many cellular and biochemical events is well illustrated by the pathophysiologic changes that occur…”
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Pharmacological inhibition of apical sodium‐dependent bile acid transporter changes bile composition and blocks progression of sclerosing cholangitis in multidrug resistance 2 knockout mice by Miethke, Alexander G., Zhang, Wujuan, Simmons, Julia, Taylor, Amy E., Shi, Tiffany, Shanmukhappa, Shiva Kumar, Karns, Rebekah, White, Shana, Jegga, Anil G., Lages, Celine S., Nkinin, Stephenson, Keller, Bradley T., Setchell, Kenneth D.R.

“…Deficiency of multidrug resistance 2 (mdr2), a canalicular phospholipid floppase, leads to excretion of low‐phospholipid “toxic” bile causing progressive…”
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Farnesoid X receptor antagonizes macrophage-dependent licensing of effector T lymphocytes and progression of sclerosing cholangitis by Shi, Tiffany, Malik, Astha, Yang Vom Hofe, Annika, Matuschek, Louis, Mullen, Mary, Lages, Celine S, Kudira, Ramesh, Singh, Ruchi, Zhang, Wujuan, Setchell, Kenneth D R, Hildeman, David, Pasare, Chandrashekhar, Wagner, Brandee, Miethke, Alexander G

“…Immune-mediated bile duct epithelial injury and toxicity of retained hydrophobic bile acids drive disease progression in fibrosing cholangiopathies such as…”
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Bile Acid Profiling Reveals Distinct Signatures in Undernourished Children with Environmental Enteric Dysfunction by Zhao, Xueheng, Setchell, Kenneth D R, Huang, Rong, Mallawaarachchi, Indika, Ehsan, Lubaina, Dobrzykowski Iii, Edward, Zhao, Junfang, Syed, Sana, Ma, Jennie Z, Iqbal, Najeeha T, Iqbal, Junaid, Sadiq, Kamran, Ahmed, Sheraz, Haberman, Yael, Denson, Lee A, Ali, Syed Asad, Moore, Sean R

“…Intestinal inflammation and malabsorption in environmental enteric dysfunction (EED) are associated with early childhood growth faltering in impoverished…”
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Dietary phytoestrogens and their effect on bone: evidence from in vitro and in vivo, human observational, and dietary intervention studies by Setchell, Kenneth D R, Lydeking-Olsen, Eva

“…Impressive data from the many studies on cultured bone cells and rat models of postmenopausal osteoporosis support a significant bone-sparing effect of the soy…”
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Method of defining equol-producer status and its frequency among vegetarians by Setchell, Kenneth D R, Cole, Sidney J

“…7-Hydroxy-3-(4'-hydroxyphenyl)-chroman (S-equol) is a specific end-metabolite formed in the biotransformation of the dietary soy isoflavones daidzin and…”
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