Search Results - "DOZ, Francois"

Larotrectinib in patients with TRK fusion-positive solid tumours: a pooled analysis of three phase 1/2 clinical trials by Hong, David S, DuBois, Steven G, Kummar, Shivaani, Farago, Anna F, Albert, Catherine M, Rohrberg, Kristoffer S, van Tilburg, Cornelis M, Nagasubramanian, Ramamoorthy, Berlin, Jordan D, Federman, Noah, Mascarenhas, Leo, Geoerger, Birgit, Dowlati, Afshin, Pappo, Alberto S, Bielack, Stefan, Doz, François, McDermott, Ray, Patel, Jyoti D, Schilder, Russell J, Tahara, Makoto, Pfister, Stefan M, Witt, Olaf, Ladanyi, Marc, Rudzinski, Erin R, Nanda, Shivani, Childs, Barrett H, Laetsch, Theodore W, Hyman, David M, Drilon, Alexander

“…The selective TRK inhibitor larotrectinib was approved for paediatric and adult patients with advanced TRK fusion-positive solid tumours based on a primary…”
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Risk stratification of childhood medulloblastoma in the molecular era: the current consensus by Ramaswamy, Vijay, Remke, Marc, Bouffet, Eric, Bailey, Simon, Clifford, Steven C., Doz, Francois, Kool, Marcel, Dufour, Christelle, Vassal, Gilles, Milde, Till, Witt, Olaf, von Hoff, Katja, Pietsch, Torsten, Northcott, Paul A., Gajjar, Amar, Robinson, Giles W., Padovani, Laetitia, André, Nicolas, Massimino, Maura, Pizer, Barry, Packer, Roger, Rutkowski, Stefan, Pfister, Stefan M., Taylor, Michael D., Pomeroy, Scott L.

“…Historical risk stratification criteria for medulloblastoma rely primarily on clinicopathological variables pertaining to age, presence of metastases, extent…”
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The risk of valvular heart disease in the French Childhood Cancer Survivors’ Study: Contribution of dose-volume histogram parameters by Chounta, Stefania, Lemler, Sarah, Haddy, Nadia, Fresneau, Brice, Mansouri, Imene, Bentriou, Mahmoud, Demoor-Goldschmidt, Charlotte, Diallo, Ibrahima, Souchard, Vincent, Do, Thi-Duyen, Veres, Cristina, Surun, Aurore, Doz, François, Llanas, Damien, Vu-Bezin, Giao, Rubino, Carole, de Vathaire, Florent, Letort, Véronique, Allodji, Rodrigue Setcheou

“…•Late valvular heart disease after treatment for a childhood cancer was statistically associated with the mean radiation dose to the heart.•Late valvular heart…”
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Risk factors for obesity in adulthood among survivors of childhood cancer by Delacourt, Laurène, Allodji, Rodrigue, Chappat, Juliette, Haddy, Nadia, El‐Fayech, Chiraz, Demoor‐Goldschmidt, Charlotte, Journy, Neige, Bolle, Stéphanie, Thomas‐Teinturier, Cécile, Zidane, Monia, Rubino, Carole, Veres, Cristina, Vu‐Bezin, Giao, Berchery, Delphine, Pluchart, Claire, Bondiau, Pierre‐Yves, Dumas, Agnès, Bougas, Nicolas, Grill, Jacques, Dufour, Christelle, Fresneau, Brice, Pacquement, Hélène, Diallo, Ibrahima, Doz, François, Vathaire, Florent

“…Objective The aim of this study was to identify risk factors for obesity in childhood cancer survivors (CCSs). Methods The study included 3199 patients of the…”
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High-grade gliomas in adolescents and young adults highlight histomolecular differences from their adult and pediatric counterparts by Roux, Alexandre, Pallud, Johan, Saffroy, Raphaël, Edjlali-Goujon, Myriam, Debily, Marie-Anne, Boddaert, Nathalie, Sanson, Marc, Puget, Stéphanie, Knafo, Steven, Adam, Clovis, Faillot, Thierry, Cazals-Hatem, Dominique, Mandonnet, Emmanuel, Polivka, Marc, Dorfmüller, Georges, Dauta, Aurélie, Desplanques, Mathilde, Gareton, Albane, Pages, Mélanie, Tauziede-Espariat, Arnault, Grill, Jacques, Bourdeaut, Franck, Doz, François, Dhermain, Frédéric, Mokhtari, Karima, Chretien, Fabrice, Figarella-Branger, Dominique, Varlet, Pascale

“…Abstract Background Considering that pediatric high-grade gliomas (HGGs) are biologically distinct from their adult counterparts, the objective of this study…”
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SIOP PNET5 MB Trial: History and Concept of a Molecularly Stratified Clinical Trial of Risk-Adapted Therapies for Standard-Risk Medulloblastoma by Mynarek, Martin, Milde, Till, Padovani, Laetitia, Janssens, Geert O., Kwiecien, Robert, Mosseri, Veronique, Clifford, Steven C., Doz, François, Rutkowski, Stefan

“…Background. SIOP PNET5 MB was initiated in 2014 as the first European trial using clinical, histological, and molecular parameters to stratify treatments for…”
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LEF-1 immunohistochemistry, a better diagnostic biomarker than β-catenin for medulloblastoma, WNT-activated subtyping by Aboubakr, Oumaima, Métais, Alice, Doz, François, Saffroy, Raphaël, Masliah-Planchon, Julien, Hasty, Lauren, Beccaria, Kevin, Ayrault, Olivier, Dufour, Christelle, Varlet, Pascale, Tauziède-Espariat, Arnault

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Nivolumab with or without ipilimumab in pediatric patients with high-grade CNS malignancies: Safety, efficacy, biomarker, and pharmacokinetics—CheckMate 908 by Dunkel, Ira J, Doz, François, Foreman, Nicholas K, Hargrave, Darren, Lassaletta, Alvaro, André, Nicolas, Hansford, Jordan R, Hassall, Tim, Eyrich, Matthias, Gururangan, Sridharan, Bartels, Ute, Gajjar, Amar, Howell, Lisa, Warad, Deepti, Pacius, Misena, Tam, Rachel, Wang, Yu, Zhu, Li, Cohen, Kenneth

“…Abstract Background Therapeutic options are limited in pediatric CNS malignancies. CheckMate 908 (NCT03130959) is an open-label, sequential-arm, phase 1b/2…”
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Specific brain MRI features of constitutional mismatch repair deficiency syndrome in children with high-grade gliomas by Raveneau, Magali, Guerrini-Rousseau, Léa, Levy, Raphael, Roux, Charles-Joris, Bolle, Stéphanie, Doz, François, Bourdeaut, Franck, Colas, Chrystelle, Blauwblomme, Thomas, Beccaria, Kevin, Tauziède-Espariat, Arnault, Varlet, Pascale, Dufour, Christelle, Grill, Jacques, Boddaert, Nathalie, Dangouloff-Ros, Volodia

“…Background Children with constitutional mismatch repair deficiency (CMMRD) syndrome have an increased risk of high-grade gliomas (HGG), and brain imaging…”
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Feasibility and clinical integration of molecular profiling for target identification in pediatric solid tumors by Pincez, Thomas, Clément, Nathalie, Lapouble, Eve, Pierron, Gaëlle, Kamal, Maud, Bieche, Ivan, Bernard, Virginie, Fréneaux, Paul, Michon, Jean, Orbach, Daniel, Aerts, Isabelle, Pacquement, Hélène, Bourdeaut, Franck, Jiménez, Irene, Thébaud, Estelle, Oudot, Caroline, Vérité, Cécile, Taque, Sophie, Owens, Cormac, Doz, François, Tourneau, Christophe, Delattre, Olivier, Schleiermacher, Gudrun

“…Background The role of tumor molecular profiling in directing targeted therapy utilization remains to be defined for pediatric tumors. We aimed to evaluate the…”
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Hyperfractionated Versus Conventional Radiotherapy Followed by Chemotherapy in Standard-Risk Medulloblastoma: Results From the Randomized Multicenter HIT-SIOP PNET 4 Trial by LANNERING, Birgitta, RUTKOWSKI, Stefan, TAYLOR, Roger, GANDOLA, Lorenza, BJÖRK-ERIKSSON, Thomas, GIRALT, Jordi, OLDENBURGER, Foppe, PIETSCH, Torsten, FIGARELLA-BRANGER, Dominique, ROBSON, Keith, FORNI, Marco, CLIFFORD, Steven C, DOZ, Francois, WARMUTH-METZ, Monica, HOFF, Katja Von, FALDUM, Andreas, MOSSERI, Véronique, KORTMANN, Rolf, PIZER, Barry, GUSTAFSSON, Goran, NAVAJAS, Aurora, MASSIMINO, Maura, REDDINGIUS, Roel, BENESCH, Martin, CARRIE, Christian

“…To compare event-free survival (EFS), overall survival (OS), pattern of relapse, and hearing loss in children with standard-risk medulloblastoma treated by…”
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Relapse patterns and outcome after relapse in standard risk medulloblastoma: a report from the HIT-SIOP-PNET4 study by Sabel, Magnus, Fleischhack, Gudrun, Tippelt, Stephan, Gustafsson, Göran, Doz, François, Kortmann, Rolf, Massimino, Maura, Navajas, Aurora, von Hoff, Katja, Rutkowski, Stefan, Warmuth-Metz, Monika, Clifford, Steven C., Pietsch, Torsten, Pizer, Barry, Lannering, Birgitta

“…The HIT-SIOP-PNET4 randomised trial for standard risk medulloblastoma (MB) (2001–2006) included 338 patients and compared hyperfractionated and conventional…”
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NRL and CRX Define Photoreceptor Identity and Reveal Subgroup-Specific Dependencies in Medulloblastoma by Garancher, Alexandra, Lin, Charles Y., Morabito, Morgane, Richer, Wilfrid, Rocques, Nathalie, Larcher, Magalie, Bihannic, Laure, Smith, Kyle, Miquel, Catherine, Leboucher, Sophie, Herath, Nirmitha I., Dupuy, Fanny, Varlet, Pascale, Haberler, Christine, Walczak, Christine, El Tayara, Nadine, Volk, Andreas, Puget, Stéphanie, Doz, François, Delattre, Olivier, Druillennec, Sabine, Ayrault, Olivier, Wechsler-Reya, Robert J., Eychène, Alain, Bourdeaut, Franck, Northcott, Paul A., Pouponnot, Celio

“…Cancer cells often express differentiation programs unrelated to their tissue of origin, although the contribution of these aberrant phenotypes to malignancy…”
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Neonatal cancer by Orbach, Daniel, MD, Sarnacki, Sabine, Prof, Brisse, Hervé J, MD, Gauthier-Villars, Marion, MD, Jarreau, Pierre-Henri, Prof, Tsatsaris, Vassilis, Prof, Baruchel, André, Prof, Zerah, Michel, Prof, Seigneur, Etienne, MD, Peuchmaur, Michel, Prof, Doz, François, Prof

“…Summary Neonatal cancer is rare and comprises a heterogeneous group of neoplasms with substantial histological diversity. Almost all types of paediatric cancer…”
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Molecular diagnosis of retinoblastoma by circulating tumor DNA analysis by Jiménez, Irene, Frouin, Éléonore, Chicard, Mathieu, Dehainault, Catherine, Le Gall, Jessica, Benoist, Camille, Gauthier, Arnaud, Lapouble, Eve, Houdayer, Claude, Radvanyi, François, Bernard, Virginie, Brisse, Hervé J., Gauthier-Villars, Marion, Stoppa-Lyonnet, Dominique, Baulande, Sylvain, Cassoux, Nathalie, Lumbroso, Livia, Matet, Alexandre, Aerts, Isabelle, Renault, Victor, Doz, François, Golmard, Lisa, Delattre, Olivier, Schleiermacher, Gudrun

“…The analysis of circulating tumor DNA (ctDNA), a fraction of total cell-free DNA (cfDNA), might be of special interest in retinoblastoma patients. Because the…”
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Quality of Survival and Growth in Children and Young Adults in the PNET4 European Controlled Trial of Hyperfractionated Versus Conventional Radiation Therapy for Standard-Risk Medulloblastoma by Kennedy, Colin, MBBS, MD, Bull, Kim, PhD, Chevignard, Mathilde, MD, Culliford, David, MSc, Dörr, Helmuth G., MD, Doz, François, MD, Kortmann, Rolf-Dieter, MD, Lannering, Birgitta, MD, Massimino, Maura, MD, Navajas Gutiérrez, Aurora, MD, Rutkowski, Stefan, MD, Spoudeas, Helen A., MD, Calaminus, Gabriele, MD

“…Purpose To compare quality of survival in “standard-risk” medulloblastoma after hyperfractionated radiation therapy of the central nervous system with that…”
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Phase II results from a phase I/II study to assess the safety and efficacy of weekly nab-paclitaxel in paediatric patients with recurrent or refractory solid tumours: A collaboration with the European Innovative Therapies for Children with Cancer Network by Amoroso, Loredana, Castel, Victoria, Bisogno, Gianni, Casanova, Michela, Marquez-Vega, Catalina, Chisholm, Julia C., Doz, François, Moreno, Lucas, Ruggiero, Antonio, Gerber, Nicolas U., Fagioli, Franca, Hingorani, Pooja, Melcón, Soledad G., Slepetis, Ruta, Chen, Nianhang, le Bruchec, Yvan, Simcock, Mathew, Vassal, Gilles

“…The phase I component of a phase I/II study defined the recommended phase II dose and established the tolerability of nab-paclitaxel monotherapy in paediatric…”
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Association Between Genotype and Phenotype in Consecutive Unrelated Individuals With Retinoblastoma by Salviat, Flore, Gauthier-Villars, Marion, Carton, Matthieu, Cassoux, Nathalie, Lumbroso-Le Rouic, Livia, Dehainault, Catherine, Levy, Christine, Golmard, Lisa, Aerts, Isabelle, Doz, François, Bonnet-Serrano, Fidéline, Hayek, Stéphanie, Savignoni, Alexia, Stoppa-Lyonnet, Dominique, Houdayer, Claude

“…Retinoblastoma (RB) is the most common pediatric intraocular neoplasm. RB is a complex model in which atypical pathogenic variants, modifier genes, imprinting,…”
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Genomic and Transcriptomic Tumor Heterogeneity in Bilateral Retinoblastoma by Winter, Ursula, Ganiewich, Daiana, Ottaviani, Daniela, Zugbi, Santiago, Aschero, Rosario, Sendoya, Juan Martin, Cafferata, Eduardo G, Mena, Marcela, Sgroi, Mariana, Sampor, Claudia, Lubieniecki, Fabiana, Fandiño, Adriana, Abba, Martin C, Doz, François, Podhjacer, Osvaldo, Carcaboso, Angel Montero, Letouzé, Eric, Radvanyi, François, Chantada, Guillermo L, Llera, Andrea S, Schaiquevich, Paula

“…Comprehensive understanding of the genomic and gene-expression differences between retinoblastoma tumors from patients with bilateral disease may help to…”
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GH and Childhood-onset Craniopharyngioma: When to Initiate GH Replacement Therapy? by Nguyen Quoc, Adrien, Beccaria, Kévin, González Briceño, Laura, Pinto, Graziella, Samara-Boustani, Dinane, Stoupa, Athanasia, Beltrand, Jacques, Besançon, Alix, Thalassinos, Caroline, Puget, Stéphanie, Blauwblomme, Thomas, Alapetite, Claire, Bolle, Stéphanie, Doz, François, Grill, Jacques, Dufour, Christelle, Bourdeaut, Franck, Abbou, Samuel, Guerrini-Rousseau, Léa, Leruste, Amaury, Brabant, Séverine, Cavadias, Iphigénie, Viaud, Magali, Boddaert, Nathalie, Polak, Michel, Kariyawasam, Dulanjalee

“…Abstract Context Craniopharyngioma is a benign brain tumor with frequent local recurrence or progression after treatment. GH replacement therapy (GHRT) is…”
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