Search Results - "DOYLE, STEPHEN"

Improving helminth genome resources in the post-genomic era by Doyle, Stephen R

“…Rapid advancement in high-throughput sequencing and analytical approaches has seen a steady increase in the generation of genomic resources for helminth…”
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Genome-wide Approaches to Investigate Anthelmintic Resistance by Doyle, Stephen R., Cotton, James A.

“…The rapid evolution of anthelmintic resistance in a number of parasites of livestock and domesticated animals has occurred in response to widespread use of…”
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Genomic introgression mapping of field-derived multiple-anthelmintic resistance in Teladorsagia circumcincta by Choi, Young-Jun, Bisset, Stewart A, Doyle, Stephen R, Hallsworth-Pepin, Kymberlie, Martin, John, Grant, Warwick N, Mitreva, Makedonka

“…Preventive chemotherapy has long been practiced against nematode parasites of livestock, leading to widespread drug resistance, and is increasingly being…”
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A genetic TRP down the channel to praziquantel resistance by Cotton, James A., Doyle, Stephen R.

“…The anthelmintic praziquantel (PZQ) is an essential tool in controlling schistosomiasis, so reports of reduced PZQ efficacy are of great public health concern…”
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Whole genome amplification and sequencing of individual Dirofilaria immitis microfilariae by Power, Rosemonde I., Doyle, Stephen R., Šlapeta, Jan

“…Dirofilaria immitis is a filarial parasitic nematode of veterinary significance. With the emergence of drug-resistant isolates in the USA, it is imperative to…”
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Transcriptomic analyses implicate neuronal plasticity and chloride homeostasis in ivermectin resistance and response to treatment in a parasitic nematode by Laing, Roz, Doyle, Stephen R, McIntyre, Jennifer, Maitland, Kirsty, Morrison, Alison, Bartley, David J, Kaplan, Ray, Chaudhry, Umer, Sargison, Neil, Tait, Andy, Cotton, James A, Britton, Collette, Devaney, Eileen

“…The antiparasitic drug ivermectin plays an essential role in human and animal health globally. However, ivermectin resistance is widespread in veterinary…”
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Genome-wide analysis of ivermectin response by Onchocerca volvulus reveals that genetic drift and soft selective sweeps contribute to loss of drug sensitivity by Doyle, Stephen R, Bourguinat, Catherine, Nana-Djeunga, Hugues C, Kengne-Ouafo, Jonas A, Pion, Sébastien D S, Bopda, Jean, Kamgno, Joseph, Wanji, Samuel, Che, Hua, Kuesel, Annette C, Walker, Martin, Basáñez, Maria-Gloria, Boakye, Daniel A, Osei-Atweneboana, Mike Y, Boussinesq, Michel, Prichard, Roger K, Grant, Warwick N

“…Treatment of onchocerciasis using mass ivermectin administration has reduced morbidity and transmission throughout Africa and Central/South America. Mass drug…”
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Single-cell atlas of the first intra-mammalian developmental stage of the human parasite Schistosoma mansoni by Diaz Soria, Carmen Lidia, Lee, Jayhun, Chong, Tracy, Coghlan, Avril, Tracey, Alan, Young, Matthew D., Andrews, Tallulah, Hall, Christopher, Ng, Bee Ling, Rawlinson, Kate, Doyle, Stephen R., Leonard, Steven, Lu, Zhigang, Bennett, Hayley M., Rinaldi, Gabriel, Newmark, Phillip A., Berriman, Matthew

“…Over 250 million people suffer from schistosomiasis, a tropical disease caused by parasitic flatworms known as schistosomes. Humans become infected by…”
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Biology and genome of a newly discovered sibling species of Caenorhabditis elegans by Kanzaki, Natsumi, Tsai, Isheng J., Tanaka, Ryusei, Hunt, Vicky L., Liu, Dang, Tsuyama, Kenji, Maeda, Yasunobu, Namai, Satoshi, Kumagai, Ryohei, Tracey, Alan, Holroyd, Nancy, Doyle, Stephen R., Woodruff, Gavin C., Murase, Kazunori, Kitazume, Hiromi, Chai, Cynthia, Akagi, Allison, Panda, Oishika, Ke, Huei-Mien, Schroeder, Frank C., Wang, John, Berriman, Matthew, Sternberg, Paul W., Sugimoto, Asako, Kikuchi, Taisei

“…A ‘sibling’ species of the model organism Caenorhabditis elegans has long been sought for use in comparative analyses that would enable deep evolutionary…”
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Challenges and opportunities for the adoption of molecular diagnostics for anthelmintic resistance by Kotze, Andrew C., Gilleard, John S., Doyle, Stephen R., Prichard, Roger K.

“…Anthelmintic resistance is a significant threat to livestock production systems worldwide and is emerging as an important issue in companion animal parasite…”
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Population genomic and evolutionary modelling analyses reveal a single major QTL for ivermectin drug resistance in the pathogenic nematode, Haemonchus contortus by Doyle, Stephen R, Illingworth, Christopher J R, Laing, Roz, Bartley, David J, Redman, Elizabeth, Martinelli, Axel, Holroyd, Nancy, Morrison, Alison A, Rezansoff, Andrew, Tracey, Alan, Devaney, Eileen, Berriman, Matthew, Sargison, Neil, Cotton, James A, Gilleard, John S

“…Infections with helminths cause an enormous disease burden in billions of animals and plants worldwide. Large scale use of anthelmintics has driven the…”
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Faecal egg counts and nemabiome metabarcoding highlight the genomic complexity of equine cyathostomin communities and provide insight into their dynamics in a Scottish native pony herd by Sargison, Neil, Chambers, Alex, Chaudhry, Umer, Costa Júnior, Livio, Doyle, Stephen R, Ehimiyein, Ajoke, Evans, Mike, Jennings, Amy, Kelly, Rob, Sargison, Fiona, Sinclair, Margaret, Zahid, Osama

“…Understanding the composition of gastrointestinal nematode communities may help to mitigate or exploit parasite adaptations within their host. We have used…”
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Genomic landscape of drug response reveals mediators of anthelmintic resistance by Doyle, Stephen R., Laing, Roz, Bartley, David, Morrison, Alison, Holroyd, Nancy, Maitland, Kirsty, Antonopoulos, Alistair, Chaudhry, Umer, Flis, Ilona, Howell, Sue, McIntyre, Jennifer, Gilleard, John S., Tait, Andy, Mable, Barbara, Kaplan, Ray, Sargison, Neil, Britton, Collette, Berriman, Matthew, Devaney, Eileen, Cotton, James A.

“…Like other pathogens, parasitic helminths can rapidly evolve resistance to drug treatment. Understanding the genetic basis of anthelmintic drug resistance in…”
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Trophic ecology of Octopus vulgaris paralarvae along the Iberian Canary current eastern boundary upwelling system by Roura, Álvaro, Doyle, Stephen R., Castro-Bugallo, Alexandra, Hall, Nathan E., Gonzalez, Ángel F., Strugnell, Jan M.

“…Our knowledge of the diet of wild octopus paralarvae, Octopus vulgaris, is restricted to the first 2 weeks of its planktonic phase when they are selective…”
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Allele specific PCR for a major marker of levamisole resistance in Haemonchus contortus by Antonopoulos, Alistair, Doyle, Stephen R., Bartley, David J., Morrison, Alison A., Kaplan, Ray, Howell, Sue, Neveu, Cedric, Busin, Valentina, Devaney, Eileen, Laing, Roz

“…Haemonchus contortus is a haematophagous parasitic nematode that infects small ruminants and causes significant animal health concerns and economic losses…”
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Genome structure and population genomics of the canine heartworm Dirofilaria immitis by Gandasegui, Javier, Power, Rosemonde I, Curry, Emily, Lau, Daisy Ching-Wai, O'Neill, Connor M, Wolstenholme, Adrian, Prichard, Roger, Šlapeta, Jan, Doyle, Stephen R

“…The heartworm, Dirofilaria immitis, is a filarial parasitic nematode responsible for significant morbidity and mortality in wild and domesticated canids…”
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Population genomic evidence that human and animal infections in Africa come from the same populations of Dracunculus medinensis by Durrant, Caroline, Thiele, Elizabeth A, Holroyd, Nancy, Doyle, Stephen R, Sallé, Guillaume, Tracey, Alan, Sankaranarayanan, Geetha, Lotkowska, Magda E, Bennett, Hayley M, Huckvale, Thomas, Abdellah, Zahra, Tchindebet, Ouakou, Wossen, Mesfin, Logora, Makoy Samuel Yibi, Coulibaly, Cheick Oumar, Weiss, Adam, Schulte-Hostedde, Albrecht I, Foster, Jeremy M, Cleveland, Christopher A, Yabsley, Michael J, Ruiz-Tiben, Ernesto, Berriman, Matthew, Eberhard, Mark L, Cotton, James A

“…Guinea worm-Dracunculus medinensis-was historically one of the major parasites of humans and has been known since antiquity. Now, Guinea worm is on the brink…”
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Genome-based tools for onchocerciasis elimination: utility of the mitochondrial genome for delineating Onchocerca volvulus transmission zones by Crawford, Katie E, Hedtke, Shannon M, Doyle, Stephen R, Kuesel, Annette C, Armoo, Samuel, Osei-Atweneboana, Mike Y, Grant, Warwick N

“…[Display omitted] •The neglected tropical disease onchocerciasis is targeted for elimination of transmission.•Transmission zones could be identified using…”
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Real-time single-base specific detection of the Haemonchus contortus S168T variant associated with levamisole resistance using loop-primer endonuclease cleavage loop-mediated isothermal amplification by Antonopoulos, Alistair, Higgins, Owen, Doyle, Stephen R., Bartley, David, Morrison, Alison, Shalaby, Maha Mansour, Reboud, Julien, Devaney, Eileen, Smith, Terry J., Laing, Roz, Busin, Valentina

“…Haemonchus contortus is a parasitic haematophagous nematode that primarily affects small ruminants and causes significant economic loss to the global livestock…”
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You Are What You Eat: A Genomic Analysis of the Gut Microbiome of Captive and Wild Octopus vulgaris Paralarvae and Their Zooplankton Prey by Roura, Álvaro, Doyle, Stephen R, Nande, Manuel, Strugnell, Jan M

“…The common octopus ( ) is an attractive species for aquaculture, however, several challenges inhibit sustainable commercial production. Little is known about…”
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