Search Results - "DOYLE, HESTER A."

Autoantigenesis: the evolution of protein modifications in autoimmune disease by Doyle, Hester A, Mamula, Mark J

“…Highlights ► Protein modifications (PTMs) are relevant to the development of autoimmune disease. ► Protein modifications can break immune tolerance. ► Protein…”
Get full text

Vaccine-induced ErbB (EGFR/HER2)-specific immunity in spontaneous canine cancer by Doyle, Hester A., Gee, Renelle J., Masters, Tyler D., Gee, Christian R., Booth, Carmen J., Peterson-Roth, Elizabeth, Koski, Raymond A., Helfand, Stuart C., Price, Lauren, Bascombe, Deborah, Jackson, Dorothy, Ho, Rita, Post, Gerald R., Mamula, Mark J.

“…•Spontaneous dog cancers closely resemble human cancer.•Dogs with EGFR associated tumors were immunized with an EGFR/HER2 peptide vaccine.•EGFR peptide…”
Get full text

Post-translational protein modifications in antigen recognition and autoimmunity by Doyle, Hester A, Mamula, Mark J

“…It is estimated that 50–90% of the proteins in the human body are post-translationally modified. In the proper context, these modifications are necessary for…”
Get full text

Posttranslational Modifications of Self-Antigens by DOYLE, HESTER A., MAMULA, MARK J.

“…: Although the immune system has developed mechanisms to distinguish “self” from “non‐self,” the presence of autoimmune diseases demonstrates that these…”
Get full text

Protein Repair in the Brain, Proteomic Analysis of Endogenous Substrates for Protein L-Isoaspartyl Methyltransferase in Mouse Brain by Zhu, Jeff X., Doyle, Hester A., Mamula, Mark J., Aswad, Dana W.

“…Protein l-isoaspartyl methyltransferase (PIMT) catalyzes repair of l-isoaspartyl peptide bonds, a major source of protein damage under physiological…”
Get full text

Autoimmunity to isomerized histone H2B in systemic lupus erythematosus by Doyle, Hester A., Aswad, Dana W., Mamula, Mark J.

“…Histone H2B is a common target of autoantibodies in both spontaneous and drug-induced systemic lupus erythematosus (SLE). Recent studies demonstrate that Asp25…”
Get full text

Isoaspartyl Post-translational Modification Triggers Anti-tumor T and B Lymphocyte Immunity by Doyle, Hester A., Zhou, Jing, Wolff, Martin J., Harvey, Bohdan P., Roman, Robert M., Gee, Renelle J., Koski, Raymond A., Mamula, Mark J.

“…A hallmark of the immune system is the ability to ignore self-antigens. In attempts to bypass normal immune tolerance, a post-translational protein…”
Get full text

Protein L-Isoaspartyl Methyltransferase Catalyzes in Vivo Racemization of Aspartate-25 in Mammalian Histone H2B by Young, Glen W., Hoofring, Sarah A., Mamula, Mark J., Doyle, Hester A., Bunick, Gerard J., Hu, Yonglin, Aswad, Dana W.

“…Protein l-isoaspartyl methyltransferase (PIMT) has been implicated in the repair or metabolism of proteins containing atypical l-isoaspartyl peptide bonds. The…”
Get full text

Epidermal growth factor receptor peptide vaccination induces cross-reactive immunity to human EGFR, HER2, and HER3 by Doyle, Hester A., Koski, Raymond A., Bonafé, Nathalie, Bruck, Ross A., Tagliatela, Stephanie M., Gee, Renelle J., Mamula, Mark J.

“…Current treatments for tumors expressing epidermal growth factor receptor (EGFR) include anti-EGFR monoclonal antibodies, often used in conjunction with the…”
Get full text

Autoantigens: Novel forms and presentation to the immune system by Doyle, Hester A., Yang, Mei-Ling, Raycroft, Maurice T., Gee, Renelle J., Mamula, Mark J.

“…Abstract It is clear that lupus autoimmunity is marked by a variety of abnormalities, including those found at a macroscopic scale, cells and tissues, as well…”
Get full text

Synapsin I Is a Major Endogenous Substrate for Protein L-Isoaspartyl Methyltransferase in Mammalian Brain by Reissner, Kathryn J., Paranandi, Mallik V., Luc, Trang M., Doyle, Hester A., Mamula, Mark J., Lowenson, Jonathan D., Aswad, Dana W.

“…The accumulation of potentially deleterious l-isoaspartyl linkages in proteins is prevented by the action of protein l-isoaspartyl O-methyltransferase, a…”
Get full text

Altered immunogenicity of isoaspartate containing proteins by Doyle, Hester A., Gee, Renelle J., Mamula, Mark J.

“…The development of immune tolerance is dependent on the expression of self-peptides in the thymus and bone marrow during lymphocyte development. However, not…”
Get full text

Role of the C-C Chemokine, TCA3, in the Protective Anticryptococcal Cell-Mediated Immune Response by Doyle, Hester A, Murphy, Juneann W

“…Activated T lymphocytes play a crucial role in orchestrating cellular infiltration during a cell-mediated immune (CMI) reaction. TCA3, a C-C chemokine, is…”
Get full text

Posttranslational protein modifications: new flavors in the menu of autoantigens by Doyle, Hester A, Mamula, Mark J

“…Perhaps one of the most elusive areas of study in autoimmunity has been identifying the self-antigens that initially trigger the development of autoimmune…”
Get full text

A Failure to Repair Self-Proteins Leads to T Cell Hyperproliferation and Autoantibody Production by Doyle, Hester A, Gee, Renelle J, Mamula, Mark J

“…It is clear that many factors can perturb T cell homeostasis that is critical in the maintenance of immune tolerance. Defects in the molecules that regulate…”
Get full text

Intracellular Protein Modification Associated with Altered T Cell Functions in Autoimmunity by Yang, Mei-Ling, Doyle, Hester A, Gee, Renelle J, Lowenson, Jonathan D, Clarke, Steven, Lawson, Brian R, Aswad, Dana W, Mamula, Mark J

“…Posttranslational protein modifications influence a number of immunologic responses ranging from intracellular signaling to protein processing and…”
Get full text

Cytokine and chemokine expression in the central nervous system associated with protective cell-mediated immunity against Cryptococcus neoformans by Uicker, William C., Doyle, Hester A., Mccracken, James P., Langlois, Mary, Buchanan, Kent L.

“…Cryptococcus neoformans is a yeast that causes cryptococcosis, a life-threatening disease that develops following inhalation and dissemination of the…”
Get full text

Requirement for CD4+ T Lymphocytes in Host Resistance against Cryptococcus neoformans in the Central Nervous System of Immunized Mice by BUCHANAN, K. L, DOYLE, H. A

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

MIP-1 alpha contributes to the anticryptococcal delayed-type hypersensitivity reaction and protection against Cryptococcus neoformans by Doyle, Hester A., Murphy, Juneann W.

“…Leukocyte infiltration into infected tissues is essential for the clearance of microorganisms. In animals with a cell‐mediated immune (CMI) response to the…”
Get full text

Structural Integrity of Histone H2B in Vivo Requires the Activity of Protein l-IsoaspartateO-Methyltransferase, a Putative Protein Repair Enzyme by Young, Arlene L., Carter, Wayne G., Doyle, Hester A., Mamula, Mark J., Aswad, Dana W.

“…Protein l-isoaspartateO-methyltransferase (PIMT) is postulated to repair β-aspartyl linkages (isoaspartyl (isoAsp)) that accumulate at certain Asp-Xaa and…”
Get full text