Search Results - "DOWNEY, P G"

Detrimental role of the airway mucin Muc5ac during ventilator-induced lung injury by Koeppen, M, McNamee, E N, Brodsky, K S, Aherne, C M, Faigle, M, Downey, G P, Colgan, S P, Evans, C M, Schwartz, D A, Eltzschig, H K

“…Acute lung injury (ALI) is associated with high morbidity and mortality in critically ill patients. At present, the functional contribution of airway mucins to…”
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Leukocyte elastase: Physiological functions and role in acute lung injury by LEE, Warren L, DOWNEY, Gregory P

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Topical tacrolimus in the management of lichen sclerosus by Luesley, DM, Downey, GP

“…The effective management of vulval lichen sclerosus (LS) currently depends upon the use of topical steroids and emollients. There are concerns with regard to…”
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Neutrophil-mediated epithelial injury during transmigration: role of elastase by Ginzberg, H H, Cherapanov, V, Dong, Q, Cantin, A, McCulloch, C A, Shannon, P T, Downey, G P

“…Neutrophil-mediated injury to gut epithelium may lead to disruption of the epithelial barrier function with consequent organ dysfunction, but the mechanisms of…”
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Effects of the stress response in septic rats and LPS-stimulated alveolar macrophages: evidence for TNF-alpha posttranslational regulation by Ribeiro, S P, Villar, J, Downey, G P, Edelson, J D, Slutsky, A S

“…We have previously demonstrated that induction of the stress response, by heat stress or sodium arsenite, administered 18 h before initiation of sepsis in…”
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Coagulation inhibitors in sepsis and disseminated intravascular coagulation by LEE, W. L, DOWNEY, G. P

“…Sepsis is a syndrome that is increasing in frequency and continues to be associated with an unacceptably high mortality. DIC is an important and common sequel…”
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Mechanics of Stimulated Neutrophils: Cell Stiffening Induces Retention in Capillaries by Worthen, G. Scott, Schwab, Bill, Elson, Elliot L., Downey, Gregory P.

“…The effect of peptide chemoattractants on neutrophil mechanical properties was studied to test the hypothesis that stimulated neutrophils (diameter, 8…”
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Focal localization of the NHE‐1 isoform of the Na+/H+ antiport: assessment of effects on intracellular pH by Grinstein, S., Woodside, M., Waddell, T.K., Downey, G.P., Orlowski, J., Pouyssegur, J., Wong, D.C., Foskett, J.K.

“…Na+/H+ exchange (antiport) is a major pathway for the regulation of intracellular pH. Antiport activity is stimulated when suspended cells adhere to the…”
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Potentiation of the oxidative burst of human neutrophils. A signaling role for L-selectin by WADDELL, T. K, FIALKOW, L, CHI KIN CHAN, KISHIMOTO, T. K, DOWNEY, G. P

“…Production of reactive oxygen intermediates (ROI) by the NADPH oxidase of neutrophils is a major mechanism of bacterial killing and, in pathologic…”
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Sodium arsenite induces heat shock protein-72 kilodalton expression in the lungs and protects rats against sepsis by Ribeiro, S P, Villar, J, Downey, G P, Edelson, J D, Slutsky, A S

“…To examine the hypothesis that induction of heat shock proteins by a nonthermal mechanism would confer protection against experimental sepsis. Prospective,…”
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Regulation of tyrosine phosphorylation in neutrophils by the NADPH oxidase. Role of reactive oxygen intermediates by Fialkow, L, Chan, C K, Grinstein, S, Downey, G P

“…Neutrophils possess a multicomponent NADPH-oxidase that produces large quantities of superoxide, which can in turn generate other reactive oxygen…”
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Underlying chronic granulomatous disease in a patient with bronchocentric granulomatosis by Moltyaner, Y, Geerts, W H, Chamberlain, D W, Heyworth, P G, Noack, D, Rae, J, Doyle, J J, Downey, G P

“…We present a case of bronchocentric granulomatosis in a woman with no history of asthma who was colonised with Aspergillusfumigatus. A family history of…”
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Activation of the mitogen-activated protein kinase signaling pathway in neutrophils. Role of oxidants by Fialkow, L, Chan, C K, Rotin, D, Grinstein, S, Downey, G P

“…In addition to their role in bacterial killing, reactive oxygen intermediates (ROI) produced by the NADPH oxidase may participate in the regulation of…”
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Signaling functions of L-selectin. Enhancement of tyrosine phosphorylation and activation of MAP kinase by Waddell, T K, Fialkow, L, Chan, C K, Kishimoto, T K, Downey, G P

“…L-selectin is a leukocyte cell surface glycoprotein involved in carbohydrate-specific ligand binding which mediates rolling of leukocytes along endothelial…”
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Deficiency of Src Homology 2-Containing Phosphatase 1 Results in Abnormalities in Murine Neutrophil Function: Studies in Motheaten Mice by Kruger, Joshua, Butler, Jeffrey R, Cherapanov, Vera, Dong, Qin, Ginzberg, Hedy, Govindarajan, Anand, Grinstein, Sergio, Siminovitch, Katherine A, Downey, Gregory P

“…Neutrophils, an essential component of the innate immune system, are regulated in part by signaling pathways involving protein tyrosine phosphorylation. While…”
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An SH3 binding region in the epithelial Na+ channel (alpha rENaC) mediates its localization at the apical membrane by Rotin, D., Bar‐Sagi, D., O'Brodovich, H., Merilainen, J., Lehto, V.P., Canessa, C.M., Rossier, B.C., Downey, G.P.

“…The amiloride‐sensitive Na+ channel constitutes the rate‐limiting step for Na+ transport in epithelia. Immunolocalization and electrophysiological studies have…”
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Enhanced susceptibility to pulmonary infection with Burkholderia cepacia in Cftr-/- mice by SAJJAN, Uma, THANASSOULIS, George, FORSTNER, Janet, DOWNEY, Gregory P, CHERAPANOV, Vera, LU, Annie, SJOLIN, Carola, STEER, Brent, YI JUN WU, ROTSTEIN, Ori D, KENT, Geraldine, MCKERLIE, Colin

“…Progressive pulmonary infection is the dominant clinical feature of cystic fibrosis (CF), but the molecular basis for this susceptibility remains incompletely…”
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Neutrophil activation and acute lung injury by Lee, W L, Downey, G P

“…Neutrophils are considered to be central to the pathogenesis of most forms of acute lung injury (ALI). For the sake of clarity, neutrophil involvement in ALI…”
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Phorbol Ester-Induced Actin Assembly in Neutrophils: Role of Protein Kinase C by Downey, Gregory P., Chan, Chi Kin, Lea, Peter, Takai, Akira, Grinstein, Sergio

“…The shape changes and membrane ruffling that accompany neutrophil activation are dependent on the assembly and reorganization of the actin cytoskeleton, the…”
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Intracellular pH Regulation during Spreading of Human Neutrophils by Demaurex, Nicolas, Downey, Gregory P., Waddell, Thomas K., Grinstein, Sergio

“…The regulation of the intracellular pH (pHi) during spreading of human neutrophils was studied by a combination of fluorescence imaging and video microscopy…”
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