Search Results - "DOWNES, C. P"

Understanding PTEN regulation: PIP2, polarity and protein stability by Leslie, N R, Batty, I H, Maccario, H, Davidson, L, Downes, C P

“…The PTEN tumour suppressor is a lipid and protein phosphatase that inhibits phosphoinositide 3-kinase (PI3K)-dependent signalling by dephosphorylating…”
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Suppression of cellular proliferation and invasion by the concerted lipid and protein phosphatase activities of PTEN by Davidson, L, Maccario, H, Perera, N M, Yang, X, Spinelli, L, Tibarewal, P, Glancy, B, Gray, A, Weijer, C J, Downes, C P, Leslie, N R

“…PTEN is a tumour suppressor with phosphatase activity in vitro against both lipids and proteins and other potential non-enzymatic mechanisms of action…”
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Ceramide impairs the insulin-dependent membrane recruitment of protein kinase B leading to a loss in downstream signalling in L6 skeletal muscle cells by HAJDUCH, E, BALENDRAN, A, BATTY, I. H, LITHERLAND, G. J, BLAIR, A. S, DOWNES, C. P, HUNDAL, H. S

“…Increased cellular production of ceramide has been implicated in the pathogenesis of insulin resistance and in the impaired utilisation of glucose. In this…”
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Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities by Dowler, S, Currie, R A, Campbell, D G, Deak, M, Kular, G, Downes, C P, Alessi, D R

“…The second messenger phosphatidylinositol 3,4,5-trisphosphate [PtdIns(3,4,5)P(3)] is generated by the action of phosphoinositide 3-kinase (PI 3-kinase), and…”
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Loss of PTEN selectively desensitizes upstream IGF1 and insulin signaling by LACKEY, J, BARNETT, J, DAVIDSON, L, BATTY, I. H, LESLIE, N. R, DOWNES, C. P

“…Many tumors have chronically elevated activity of PI 3-kinase-dependent signaling pathways, caused largely by oncogenic mutation of PI 3-kinase itself or loss…”
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The role of PI 3-kinase in insulin action by Alessi, D.R., Downes, C.P.

“…This review focuses on the recent advances made in our understanding of the mechanism by which insulin induces the activation of PI 3-kinase(s) whose role is…”
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Regulation of the Rac1-specific exchange factor Tiam1 involves both phosphoinositide 3-kinase-dependent and -independent components by Fleming, I N, Gray, A, Downes, C P

“…The small GTPase Rac1 is involved in regulating membrane ruffling, gene transcription, cell-cycle progression and cell transformation, and some of these events…”
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Targeting mutants of PTEN reveal distinct subsets of tumour suppressor functions by Leslie, N R, Bennett, D, Gray, A, Pass, I, Hoang-Xuan, K, Downes, C P

“…The tumour suppressor protein PTEN (phosphatase and tensin homolog deleted on chromosome 10) is a lipid phosphatase which can antagonize the phosphoinositide…”
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Phosphatidylinositol 3-kinase is activated by nerve growth factor and epidermal growth factor in PC12 cells by NIGEL CARTER, A, DOWNES, C. P

“…The effects of nerve growth factor (NGF) and epidermal growth factor (EGF) on the regulation of phosphatidylinositol 3-kinase (PtdIns 3-kinase) activity were…”
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Activation of phospholipase D by metabotropic glutamate receptor agonists in rat cerebrocortical synaptosomes by Shinomura, T, Del Río, E, Breen, K C, Downes, C P, McLaughlin, M

“…The pharmacological profile of metabotropic glutamate receptor (mGluR) activation of phospholipase D (PLD), and the associated signalling pathways, were…”
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Redox regulation of phosphatase function by Leslie, N R, Lindsay, Y, Ross, S H, Downes, C P

“…Although reactive oxygen species play important roles in cellular physiology as signalling molecules, their molecular targets are largely unknown. A probable…”
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Acute regulation of the tumour suppressor phosphatase, PTEN, by anionic lipids and reactive oxygen species by Downes, C P, Walker, S, McConnachie, G, Lindsay, Y, Batty, I H, Leslie, N R

“…PTEN (phosphatase and tensin homologue deleted on chromosome 10) is a member of the protein tyrosine phosphatase family that is structurally adapted to…”
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Kinetics of Activation of Phospholipase C by P2Y Purinergic Receptor Agonists and Guanine Nucleotides by Boyer, J L, Downes, C P, Harden, T K

“…Membranes prepared from [3H]inositol-labeled turkey erythrocytes express a phospholipase C that is markedly stimulated by stable analogs of GTP (Harden, T. K.,…”
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Lithium amplifies agonist-dependent phosphatidylinositol responses in brain and salivary glands by Berridge, M J, Downes, C P, Hanley, M R

“…1. The effect of Li+ on the agonist-dependent metabolism of [3H]inositol has been studied in rat brain, rat parotid and the insect salivary gland. 2. When…”
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A G-protein beta gamma-subunit-responsive phosphoinositide 3-kinase activity in human platelet cytosol by Thomason, P A, James, S R, Casey, P J, Downes, C P

“…Thrombin activates phosphoinositide 3-kinase (PI 3-kinase) in platelets via a mechanism involving G-proteins, possibly of both the heterotrimeric and the low…”
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Changes in the levels of inositol phosphates after agonist-dependent hydrolysis of membrane phosphoinositides by Berridge, M J, Dawson, R M, Downes, C P, Heslop, J P, Irvine, R F

“…The formation of inositol phosphates in response to agonists was studied in brain slices, parotid gland fragments and in the insect salivary gland. The tissues…”
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The inhibition of phosphoinositide synthesis and muscarinic-receptor-mediated phospholipase C activity by Li+ as secondary, selective consequences of inositol depletion in 1321N1 cells by BATTY, I. H, DOWNES, C. P

“…Conditions are described for culture of 1321N1 cells under which cellular inositol is decreased from approximately 20 mM to < 0.5 mM but phosphoinositide…”
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Metabolism of inositol 1,4,5-trisphosphate and inositol 1,3,4-trisphosphate in rat parotid glands by Irvine, R F, Anggård, E E, Letcher, A J, Downes, C P

“…A complete separation of myo-inositol 1,4,5-[4,5-(32)P]trisphosphate prepared from human erythrocytes, and myo-[2-3H]inositol 1,3,4-trisphosphate prepared from…”
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A Crucial Role for the p110δ Subunit of Phosphatidylinositol 3-Kinase in B Cell Development and Activation by Clayton, Elizabeth, Bardi, Giuseppe, Bell, Sarah E., Chantry, David, Downes, C. Peter, Gray, Alexander, Humphries, Lisa A., Rawlings, David, Reynolds, Helen, Vigorito, Elena, Turner, Martin

“…Mice lacking the p110δ catalytic subunit of phosphatidylinositol 3-kinase have reduced numbers of B1 and marginal zone B cells, reduced levels of serum…”
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Tumor suppressor and anti-inflammatory actions of PPARγ agonists are mediated via upregulation of PTEN by Patel, Lisa, Pass, Ian, Coxon, Phil, Downes, C.Peter, Smith, Stephen A., Macphee, Colin H.

“…The PTEN tumor suppressor gene modulates several cellular functions, including cell migration, survival, and proliferation [1] by antagonizing…”
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