Search Results - "DOUWES, Johannes M"

Prognostic factors in pediatric pulmonary arterial hypertension: A systematic review and meta-analysis by Ploegstra, Mark-Jan, Zijlstra, Willemijn M.H, Douwes, Johannes M, Hillege, Hans L, Berger, Rolf M.F

“…Abstract Background Despite the introduction of targeted therapies in pediatric pulmonary arterial hypertension (PAH), prognosis remains poor. For the…”
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Prognostic Value of Serial Risk Stratification in Adult and Pediatric Pulmonary Arterial Hypertension: A Systematic Review by Lokhorst, Chantal, van der Werf, Sjoukje, Berger, Rolf M F, Douwes, Johannes M

“…In pulmonary arterial hypertension, it is recommended to base therapeutic decisions on risk stratification. This systematic review aims to report the…”
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Risk stratification in adult and pediatric pulmonary arterial hypertension: A systematic review by Lokhorst, Chantal, van der Werf, Sjoukje, Berger, Rolf M F, Douwes, Johannes M

“…Currently, risk stratification is the cornerstone of determining treatment strategy for patients with pulmonary arterial hypertension (PAH). Since the 2015…”
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The Pulmonary Artery Pulsatility Index Provides No Additional Prognostic Information in Pediatric Pulmonary Arterial Hypertension by Smits, Faye E, Lokhorst, Chantal, Haarman, Marlies G, Ploegstra, Mark-Jan, Berger, Rolf M F, Douwes, Johannes M

“…The pulmonary artery pulsatility index (PAPi, calculated as (SPAP - DPAP)/mRAP) has been suggested as a measure of right ventricular-vascular coupling (RVVC)…”
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Clinical Worsening as Composite Study End Point in Pediatric Pulmonary Arterial Hypertension by Ploegstra, Mark-Jan, MD, Arjaans, Sanne, BSc, Zijlstra, Willemljn M.H., BSc, Douwes, Johannes M., MD, Vissia-Kazemier, Theresia R., RN, MANP, Roofthooft, Marcus T.R., MD, PhD, Hillege, Hans L., MD, PhD, Berger, Rolf M.F., MD, PhD

“…BACKGROUND Clinical worsening (CW), an increasingly used composite end point in adult pulmonary arterial hypertension (PAH), has not yet been evaluated in…”
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Cardiac Magnetic Resonance Derived Left Ventricular Eccentricity Index and Right Ventricular Mass Measurements Predict Outcome in Children with Pulmonary Arterial Hypertension by Haarman, Meindina G, Coenraad, Iris, Hagdorn, Quint A J, Hillege, Hans L, Willems, Tineke P, Berger, Rolf M F, Douwes, Johannes M

“…Pulmonary arterial hypertension (PAH) is associated with increased right ventricular (RV) afterload, affecting RV remodeling and RV performance, a major…”
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Pirfenidone ameliorates pulmonary arterial pressure and neointimal remodeling in experimental pulmonary arterial hypertension by suppressing NLRP3 inflammasome activation by Mavrogiannis, Emmanouil, Hagdorn, Quint A. J., Bazioti, Venetia, Douwes, Johannes M., Van Der Feen, Diederik E., Oberdorf‐Maass, Silke U., Westerterp, Marit, Berger, Rolf M. F.

“…Pulmonary arterial hypertension (PAH) is a fatal disease characterized by increased pulmonary arterial pressure, inflammation, and neointimal remodeling of…”
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Ventricular–vascular coupling is predictive of adverse clinical outcome in paediatric pulmonary arterial hypertension by Dufva, Melanie J, Ivy, Dunbar, Campbell, Kristen, Lam, Aimee, Rauff, Adam, Breeman, Karel T N, Douwes, Johannes M, Berger, Rolf M F, Kheyfets, Vitaly Oleg, Hunter, Kendall

“…AimsVentricular–vascular coupling, the ratio between the right ventricle’s contractile state (Ees) and its afterload (Ea), may be a useful metric in the…”
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Pulmonary arterial hypertension associated with pulmonary arteriovenous malformations and pulmonary veno-occlusive disease: A devastating combination by Zaaijer, Baukje M., Duppen, Nienke, Willemse, Brigitte W.M., Verhagen, Martijn V., Roofthooft, Marcus T.R., Timens, Wim, Berger, Rolf M.F., Douwes, Johannes M.

“…We describe a case of an adolescent male with the rare combination of pulmonary arterial hypertension (PAH) and pulmonary arteriovenous malformations (PAVM's)…”
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Frequency and Prognostic Significance of Hemoptysis in Pediatric Pulmonary Arterial Hypertension by Roofthooft, Marcus T.R., MD, Douwes, Johannes M., MD, Vrijlandt, Elianne J.L.E., MD, PhD, Berger, Rolf M.F., MD, PhD

“…Data concerning the prevalence, risk factors, and prognostic significance of hemoptysis in pediatric pulmonary arterial hypertension (PAH) are scarce. A Dutch…”
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Survival Differences in Pediatric Pulmonary Arterial Hypertension by Zijlstra, Willemijn M.H., BSc, Douwes, Johannes M., MD, Rosenzweig, Erika B., MD, Schokker, Sandor, BSc, Krishnan, Usha, MD, Roofthooft, Marcus T.R., MD, PhD, Miller-Reed, Kathleen, RN, Hillege, Hans L., MD, PhD, Ivy, D. Dunbar, MD, Berger, Rolf M.F., MD, PhD

“…Objectives In order to describe survival and treatment strategies in pediatric pulmonary arterial hypertension (PAH) in the current era of PAH-targeted drugs…”
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Survival Differences in Pediatric Pulmonary Arterial Hypertension: Clues to a Better Understanding of Outcome and Optimal Treatment Strategies by ZIJLSTRA, Willemijn M. H, DOUWES, Johannes M, ROSENZWEIG, Erika B, SCHOKKER, Sandor, KRISHNAN, Usha, ROOFTHOOFT, Marcus T. R, MILLER-REED, Kathleen, HILLEGE, Hans L, IVY, D. Dunbar, BERGER, Rolf M. F

“…In order to describe survival and treatment strategies in pediatric pulmonary arterial hypertension (PAH) in the current era of PAH-targeted drugs and to…”
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Impaired Right Ventricular-Vascular Coupling in Young Adults Born Preterm by Mulchrone, Ashley, Bellofiore, Alessandro, Douwes, Johannes M, Duong, Neal, Beshish, Arij G, Barton, Gregory P, Francois, Christopher J, Eldridge, Marlowe W, Goss, Kara N, Chesler, Naomi C

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Upfront triple combination therapy in severe paediatric pulmonary arterial hypertension by Haarman, Meindina G, Lévy, Marilyne, Roofthooft, Marcus T R, Douwes, Johannes M, Vissia-Kazemier, Theresia R, Szezepanski, Isabelle, Berger, Rolf M F, Bonnet, Damien

“…Treatment strategies in paediatric pulmonary arterial hypertension (PAH) have evolved over the last years, but survival is still poor. Recently, in adults with…”
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The Clinical Value of Proposed Risk Stratification Tools in Pediatric Pulmonary Arterial Hypertension by Haarman, Meindina G, Douwes, Johannes M, Ploegstra, Mark-Jan, Roofthooft, Marcus T R, Vissia-Kazemier, Theresia R, Hillege, Hans L, Berger, Rolf M F

“…Haarman et al discuss their study on the clinical value of proposed risk stratification tools in pediatric pulmonary arterial hypertension (PAH) which is a…”
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Identification of treatment goals in paediatric pulmonary arterial hypertension by PLOEGSTRA, Mark-Jan, DOUWES, Johannes M, ROOFTHOOFT, Marcus T. R, ZIJLSTRA, Willemijn M. H, HILLEGE, Hans L, BERGER, Rolf M. F

“…To be able to design goal-oriented treatment strategies in paediatric pulmonary arterial hypertension (PAH), we aimed to identify treatment goals by…”
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Novel measures of left ventricular electromechanical discoordination predict clinical outcomes in children with pulmonary arterial hypertension by Frank, Benjamin S, Schäfer, Michal, Douwes, Johannes M, Ivy, D Dunbar, Abman, Steven H, Davidson, Jesse A, Burzlaff, Sandra, Mitchell, Max B, Morgan, Gareth J, Browne, Lorna P, Barker, Alex J, Truong, Uyen, von Alvensleben, Johannes C

“…Adverse ventricle-ventricle interaction and resultant left ventricular (LV) dysfunction are a recognized pathophysiological component of disease progression in…”
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Acute Vasodilator Response in Pediatric Pulmonary Arterial Hypertension: Current Clinical Practice From the TOPP Registry by Douwes, Johannes M, Humpl, Tilman, Bonnet, Damien, Beghetti, Maurice, Ivy, D Dunbar, Berger, Rolf M F

“…In pulmonary arterial hypertension (PAH), acute vasodilator response testing (AVT) is considered important to identify adult patients with favorable prognosis…”
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Echocardiography in pediatric pulmonary arterial hypertension: early study on assessing disease severity and predicting outcome by Ploegstra, Mark-Jan, Roofthooft, Marcus T R, Douwes, Johannes M, Bartelds, Beatrijs, Elzenga, Nynke J, van de Weerd, Dick, Hillege, Hans L, Berger, Rolf M F

“…The value of echocardiography in assessing disease severity and predicting outcome in pediatric pulmonary arterial hypertension (PAH) is insufficiently…”
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Six-minute walking distance and decrease in oxygen saturation during the six-minute walk test in pediatric pulmonary arterial hypertension by Douwes, Johannes M, Hegeman, Anneke K, van der Krieke, Merel B, Roofthooft, Marcus T.R, Hillege, Hans L, Berger, Rolf M.F

“…Abstract Objective To investigate the prognostic value of the 6-minute walking distance (6-MWD), transcutaneous saturation (tcSO2) and heart rate (HR) obtained…”
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