Search Results - "DOUMATEY, Ayo"

Additive genetic effect of GCKR, G6PC2, and SLC30A8 variants on fasting glucose levels and risk of type 2 diabetes by Chen, Guanjie, Shriner, Daniel, Zhang, Jianhua, Zhou, Jie, Adikaram, Poorni, Doumatey, Ayo P, Bentley, Amy R, Adeyemo, Adebowale, Rotimi, Charles N

“…Impaired glucose tolerance is a major risk factor for type 2 diabetes (T2D) and several cardiometabolic disorders. To identify genetic loci underlying fasting…”
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The genomic landscape of African populations in health and disease by Rotimi, Charles N, Bentley, Amy R, Doumatey, Ayo P, Chen, Guanjie, Shriner, Daniel, Adeyemo, Adebowale

“…A deeper appreciation of the complex architecture of African genomes is critical to the global effort to understand human history, biology and differential…”
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Gut Microbiome Profiles Are Associated With Type 2 Diabetes in Urban Africans by Doumatey, Ayo P, Adeyemo, Adebowale, Zhou, Jie, Lei, Lin, Adebamowo, Sally N, Adebamowo, Clement, Rotimi, Charles N

“…Gut dysbiosis has been associated with several disease outcomes including diabetes in human populations. Currently, there are no studies of the gut microbiome…”
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High sensitivity C-reactive protein (Hs-CRP) remains highly stable in long-term archived human serum by Doumatey, Ayo P., Zhou, Jie, Adeyemo, Adebowale, Rotimi, Charles

“…The stability of biomarkers in stored biomedical samples is crucial, especially when storage is for extended periods of time. High-sensitivity CRP (Hs-CRP) is…”
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Genome-wide association study of type 2 diabetes in Africa by Chen, Ji, Sun, Meng, Adeyemo, Adebowale, Pirie, Fraser, Carstensen, Tommy, Pomilla, Cristina, Doumatey, Ayo P., Chen, Guanjie, Young, Elizabeth H., Sandhu, Manjinder, Morris, Andrew P., Barroso, Inês, McCarthy, Mark I., Mahajan, Anubha, Wheeler, Eleanor, Rotimi, Charles N., Motala, Ayesha A.

“…Aims/hypothesis Genome-wide association studies (GWAS) for type 2 diabetes have uncovered >400 risk loci, primarily in populations of European and Asian…”
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Genes, environment, and African ancestry in cardiometabolic disorders by Doumatey, Ayo P., Bentley, Amy R., Akinyemi, Rufus, Olanrewaju, Timothy O., Adeyemo, Adebowale, Rotimi, Charles

“…Cardiometabolic diseases are rising in populations of African descent and have become the leading causes of death and disability in these…”
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Serum fructosamine and glycemic status in the presence of the sickle cell mutation by Doumatey, Ayo P., Feron, Hermon, Ekoru, Kenneth, Zhou, Jie, Adeyemo, Adebowale, Rotimi, Charles N.

“…The glycated hemoglobin (HbA1c) test can be unreliable in the presence of hemoglobinopathies. The co-existence of type 2 diabetes (T2D) with sickle cell anemia…”
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Lipidomics profiling and circulating triglyceride concentrations in sub-Saharan African individuals by Bentley, Amy R., Doumatey, Ayo P., Zhou, Jie, Lei, Lin, Meeks, Karlijn A. C., Heuston, Elisabeth F., Rotimi, Charles N., Adeyemo, Adebowale A.

“…Elevated triglycerides (TG) are a risk factor for cardiometabolic disorders. There are limited data on lipidomics profiles associated with serum triglycerides…”
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Evolution of the primate trypanolytic factor APOL1 by Thomson, Russell, Genovese, Giulio, Canon, Chelsea, Kovacsics, Daniella, Higgins, Matthew K, Carrington, Mark, Winkler, Cheryl A, Kopp, Jeffrey, Rotimi, Charles, Adeyemo, Adebowale, Doumatey, Ayo, Ayodo, George, Alper, Seth L, Pollak, Martin R, Friedman, David J, Raper, Jayne

“…ApolipoproteinL1 (APOL1) protects humans and some primates against several African trypanosomes. APOL1 genetic variants strongly associated with kidney disease…”
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Genetic risk scores for cardiometabolic traits in sub-Saharan African populations by Ekoru, Kenneth, Adeyemo, Adebowale A, Chen, Guanjie, Doumatey, Ayo P, Zhou, Jie, Bentley, Amy R, Shriner, Daniel, Rotimi, Charles N

“…Abstract Background There is growing support for the use of genetic risk scores (GRS) in routine clinical settings. Due to the limited diversity of current…”
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A genome-wide association study of hypertension and blood pressure in African Americans by Adeyemo, Adebowale, Gerry, Norman, Chen, Guanjie, Herbert, Alan, Doumatey, Ayo, Huang, Hanxia, Zhou, Jie, Lashley, Kerrie, Chen, Yuanxiu, Christman, Michael, Rotimi, Charles

“…The evidence for the existence of genetic susceptibility variants for the common form of hypertension ("essential hypertension") remains weak and inconsistent…”
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Genetic Basis of Obesity and Type 2 Diabetes in Africans: Impact on Precision Medicine by Doumatey, Ayo P., Ekoru, Kenneth, Adeyemo, Adebowale, Rotimi, Charles N.

“…Purpose of Review Recent advances in genomics provide opportunities for novel understanding of the biology of human traits with the goal of improving human…”
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Mendelian randomization study reveals a causal relationship between adiponectin and LDL cholesterol in Africans by Meeks, Karlijn A. C., Bentley, Amy R., Doumatey, Ayo P., Adeyemo, Adebowale A., Rotimi, Charles N.

“…Adiponectin has been associated with cardiometabolic traits in observational studies across populations, yet it is unclear if these associations are causal. We…”
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Refining genome-wide associated loci for serum uric acid in individuals with African ancestry by Chen, Guanjie, Shriner, Daniel, Doumatey, Ayo P, Zhou, Jie, Bentley, Amy R, Lei, Lin, Adeyemo, Adebowale, Rotimi, Charles N

“…Abstract Objective Serum uric acid is the end-product of purine metabolism and at high levels is a risk factor for several human diseases including gout and…”
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Association study in African-admixed populations across the Americas recapitulates asthma risk loci in non-African populations by Daya, Michelle, Rafaels, Nicholas, Brunetti, Tonya M., Chavan, Sameer, Levin, Albert M., Shetty, Aniket, Gignoux, Christopher R., Boorgula, Meher Preethi, Wojcik, Genevieve, Campbell, Monica, Vergara, Candelaria, Torgerson, Dara G., Ortega, Victor E., Doumatey, Ayo, Johnston, Henry Richard, Acevedo, Nathalie, Araujo, Maria Ilma, Avila, Pedro C., Belbin, Gillian, Bleecker, Eugene, Bustamante, Carlos, Caraballo, Luis, Cruz, Alvaro, Dunston, Georgia M., Eng, Celeste, Faruque, Mezbah U., Ferguson, Trevor S., Figueiredo, Camila, Ford, Jean G., Gan, Weiniu, Gourraud, Pierre-Antoine, Hansel, Nadia N., Hernandez, Ryan D., Herrera-Paz, Edwin Francisco, Jiménez, Silvia, Kenny, Eimear E., Knight-Madden, Jennifer, Kumar, Rajesh, Lange, Leslie A., Lange, Ethan M., Lizee, Antoine, Maul, Pissamai, Maul, Trevor, Mayorga, Alvaro, Meyers, Deborah, Nicolae, Dan L., O’Connor, Timothy D., Oliveira, Ricardo Riccio, Olopade, Christopher O., Olopade, Olufunmilayo, Qin, Zhaohui S., Rotimi, Charles, Vince, Nicolas, Watson, Harold, Wilks, Rainford J., Wilson, James G., Salzberg, Steven, Ober, Carole, Burchard, Esteban G., Williams, L. Keoki, Beaty, Terri H., Taub, Margaret A., Ruczinski, Ingo, Mathias, Rasika A., Barnes, Kathleen C.

“…Asthma is a complex disease with striking disparities across racial and ethnic groups. Despite its relatively high burden, representation of individuals of…”
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Mendelian randomization analyses suggest a causal role for circulating GIP and IL-1RA levels in homeostatic model assessment-derived measures of β-cell function and insulin sensitivity in Africans without type 2 diabetes by Meeks, Karlijn A C, Bentley, Amy R, Assimes, Themistocles L, Franceschini, Nora, Adeyemo, Adebowale A, Rotimi, Charles N, Doumatey, Ayo P

“…In vitro and in vivo studies have shown that certain cytokines and hormones may play a role in the development and progression of type 2 diabetes (T2D)…”
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Meta-analysis of genome-wide association studies in African Americans provides insights into the genetic architecture of type 2 diabetes by Ng, Maggie C Y, Shriner, Daniel, Chen, Brian H, Li, Jiang, Chen, Wei-Min, Guo, Xiuqing, Liu, Jiankang, Bielinski, Suzette J, Yanek, Lisa R, Nalls, Michael A, Comeau, Mary E, Rasmussen-Torvik, Laura J, Jensen, Richard A, Evans, Daniel S, Sun, Yan V, An, Ping, Patel, Sanjay R, Lu, Yingchang, Long, Jirong, Armstrong, Loren L, Wagenknecht, Lynne, Yang, Lingyao, Snively, Beverly M, Palmer, Nicholette D, Mudgal, Poorva, Langefeld, Carl D, Keene, Keith L, Freedman, Barry I, Mychaleckyj, Josyf C, Nayak, Uma, Raffel, Leslie J, Goodarzi, Mark O, Chen, Y-D Ida, Taylor, Jr, Herman A, Correa, Adolfo, Sims, Mario, Couper, David, Pankow, James S, Boerwinkle, Eric, Adeyemo, Adebowale, Doumatey, Ayo, Chen, Guanjie, Mathias, Rasika A, Vaidya, Dhananjay, Singleton, Andrew B, Zonderman, Alan B, Igo, Jr, Robert P, Sedor, John R, Kabagambe, Edmond K, Siscovick, David S, McKnight, Barbara, Rice, Kenneth, Liu, Yongmei, Hsueh, Wen-Chi, Zhao, Wei, Bielak, Lawrence F, Kraja, Aldi, Province, Michael A, Bottinger, Erwin P, Gottesman, Omri, Cai, Qiuyin, Zheng, Wei, Blot, William J, Lowe, William L, Pacheco, Jennifer A, Crawford, Dana C, Grundberg, Elin, Rich, Stephen S, Hayes, M Geoffrey, Shu, Xiao-Ou, Loos, Ruth J F, Borecki, Ingrid B, Peyser, Patricia A, Cummings, Steven R, Psaty, Bruce M, Fornage, Myriam, Iyengar, Sudha K, Evans, Michele K, Becker, Diane M, Kao, W H Linda, Wilson, James G, Rotter, Jerome I, Sale, Michèle M, Liu, Simin, Rotimi, Charles N, Bowden, Donald W

“…Type 2 diabetes (T2D) is more prevalent in African Americans than in Europeans. However, little is known about the genetic risk in African Americans despite…”
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GWAS in Africans identifies novel lipids loci and demonstrates heterogenous association within Africa by Bentley, Amy R, Chen, Guanjie, Doumatey, Ayo P, Shriner, Daniel, Meeks, Karlijn A C, Gouveia, Mateus H, Ekoru, Kenneth, Zhou, Jie, Adeyemo, Adebowale, Rotimi, Charles N

“…Abstract Serum lipids are biomarkers of cardiometabolic disease risk, and understanding genomic factors contributing to their distribution is of interest…”
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Multi-omics in nasal epithelium reveals three axes of dysregulation for asthma risk in the African Diaspora populations by Szczesny, Brooke, Boorgula, Meher Preethi, Chavan, Sameer, Campbell, Monica, Johnson, Randi K., Kammers, Kai, Thompson, Emma E., Cox, Madison S., Shankar, Gautam, Cox, Corey, Morin, Andréanne, Lorizio, Wendy, Daya, Michelle, Kelada, Samir N. P., Beaty, Terri H., Doumatey, Ayo P., Cruz, Alvaro A., Watson, Harold, Naureckas, Edward T., Giles, B. Louise, Arinola, Ganiyu A., Sogaolu, Olumide, Falade, Adegoke G., Hansel, Nadia N., Yang, Ivana V., Olopade, Christopher O., Rotimi, Charles N., Landis, R. Clive, Figueiredo, Camila A., Altman, Matthew C., Kenny, Eimear, Ruczinski, Ingo, Liu, Andrew H., Ober, Carole, Taub, Margaret A., Barnes, Kathleen C., Mathias, Rasika A.

“…Asthma has striking disparities across ancestral groups, but the molecular underpinning of these differences is poorly understood and minimally studied. A goal…”
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Circulating MiR-374a-5p is a potential modulator of the inflammatory process in obesity by Doumatey, Ayo P., He, William J., Gaye, Amadou, Lei, Lin, Zhou, Jie, Gibbons, Gary H., Adeyemo, Adebowale, Rotimi, Charles N.

“…Obese individuals without expected metabolic co-morbidities are referred to as metabolically healthy obese (MHO). The molecular mechanisms underlying this…”
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