Search Results - "DOUGLAS McMILLIN, W."

Antimyeloma Activity of the Orally Bioavailable Dual Phosphatidylinositol 3-Kinase/Mammalian Target of Rapamycin Inhibitor NVP-BEZ235 by MCMILLIN, Douglas W, OOI, Melissa, MUNSHI, Nikhil C, RICHARDSON, Paul G, ANDERSON, Kenneth C, MITSIADES, Constantine S, DELMORE, Jake, NEGRI, Joseph, HAYDEN, Patrick, MITSIADES, Nicolas, JAKUBIKOVA, Jana, MAIRA, Sauveur-Michel, GARCIA-ECHEVERRIA, Carlos, SCHLOSSMAN, Robert

“…The phosphatidylinositol 3-kinase (PI3K)-Akt-mammalian target of rapamycin (mTOR) pathway mediates proliferation, survival, and drug resistance in multiple…”
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The Akt pathway regulates survival and homing in Waldenstrom macroglobulinemia by Leleu, Xavier, Jia, Xiaoying, Runnels, Judith, Ngo, Hai T., Moreau, Anne-Sophie, Farag, Mena, Spencer, Joel A., Pitsillides, Costas M., Hatjiharissi, Evdoxia, Roccaro, Aldo, O'Sullivan, Garrett, McMillin, Douglas W., Moreno, Daisy, Kiziltepe, Tanyel, Carrasco, Ruben, Treon, Steven P., Hideshima, Teru, Anderson, Kenneth C., Lin, Charles P., Ghobrial, Irene M.

“…Waldenstrom macroglobulinemia (WM) is an incurable low-grade lymphoplasmacytic lymphoma. We demonstrate up-regulated Akt activity in WM, and that Akt…”
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The role of tumour–stromal interactions in modifying drug response: challenges and opportunities by McMillin, Douglas W., Negri, Joseph M., Mitsiades, Constantine S.

“…Key Points It is increasingly recognized that the tumour microenvironment has a crucial role in modulating tumour sensitivity to drugs. Stromal influence can…”
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Interactions of the Hdm2/p53 and Proteasome Pathways May Enhance the Antitumor Activity of Bortezomib by OOI, Melissa G, HAYDEN, Patrick J, BUON, Leutz, CLYNES, Martin, O'GORMAN, Peter, RICHARDSON, Paul G, MITSIADES, Constantine S, ANDERSON, Kenneth C, MITSIADES, Nicholas, KOTOULA, Vassiliki, MCMILLIN, Douglas W, CHARALAMBOUS, Elpida, DASKALAKI, Emily, RAJE, Noopur S, MUNSHI, Nikhil C, CHAUHAN, Dharminder, HIDESHIMA, Teru

“…Purpose: p53 is inactivated in many human malignancies through missense mutations or overexpression of the human homologue of Mdm2 (Hdm2), an E3 ubiquitin…”
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Anti-tumor activity and signaling events triggered by the isothiocyanates, sulforaphane and phenethyl isothiocyanate, in multiple myeloma by JAKUBIKOVA, Jana, CERVI, David, NEGRI, Joseph, BLOTTA, Simona, MCMILLIN, Douglas W, HIDESHIMA, Teru, RICHARDSON, Paul G, SEDLAK, Jan, ANDERSON, Kenneth C, MITSIADES, Constantine S, OOI, Melissa, KIM, Kihyun, NAHAR, Sabikun, KLIPPEL, Steffen, CHOLUJOVA, Dana, LEIBA, Merav, DALEY, John F, DELMORE, Jake

“…Isothiocyanates, a family of phytochemicals found in cruciferous vegetables, have cytotoxic effects against several types of tumor cells. Multiple myeloma is a…”
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The Role of the Bone Marrow Microenvironment in the Pathophysiology of Myeloma and Its Significance in the Development of More Effective Therapies by Mitsiades, Constantine S., MD, PhD, McMillin, Douglas W., PhD, Klippel, Steffen, PhD, Hideshima, Teru, MD, PhD, Chauhan, Dharminder, PhD, Richardson, Paul G., MD, Munshi, Nikhil C., MD, Anderson, Kenneth C., MD

“…Multiple myeloma (MM) is viewed as a prototypic disease state for the study of how neoplastic cells interact with their local bone marrow (BM)…”
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Stromal-mediated protection of tyrosine kinase inhibitor-treated BCR-ABL-expressing leukemia cells by Weisberg, Ellen, Wright, Renee D, McMillin, Douglas W, Mitsiades, Constantine, Ray, Arghya, Barrett, Rosemary, Adamia, Sophia, Stone, Richard, Galinsky, Ilene, Kung, Andrew L, Griffin, James D

“…Clinical studies of patients with chronic myeloid leukemia revealed that a common pattern of response is a dramatic fall in the circulating population of blast…”
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Microenvironmental influence on pre-clinical activity of polo-like kinase inhibition in multiple myeloma: implications for clinical translation by McMillin, Douglas W, Delmore, Jake, Negri, Joseph, Ooi, Melissa, Klippel, Steffen, Miduturu, Chandrasekhar V, Gray, Nathanael S, Richardson, Paul G, Anderson, Kenneth C, Kung, Andrew L, Mitsiades, Constantine S

“…Polo-like kinases (PLKs) play an important role in cell cycle progression, checkpoint control and mitosis. The high mitotic index and chromosomal instability…”
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Potentiation of antileukemic therapies by Smac mimetic, LBW242: effects on mutant FLT3-expressing cells by Weisberg, Ellen, Kung, Andrew L, Wright, Renee D, Moreno, Daisy, Catley, Laurie, Ray, Arghya, Zawel, Leigh, Tran, Mary, Cools, Jan, Gilliland, Gary, Mitsiades, Constantine, McMillin, Douglas W, Jiang, Jingrui, Hall-Meyers, Elizabeth, Griffin, James D

“…Members of the inhibitor of apoptosis protein (IAP) family play a role in mediating apoptosis. Studies suggest that these proteins may be a viable target in…”
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Introduction to the “Has the Fed Failed?” Special Section by Douglas McMillin, W.

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Stem Cell Implants for Cancer Therapy: TRAIL-Expressing Mesenchymal Stem Cells Target Cancer Cells In Situ by Reagan, Michaela R, Seib, F Philipp, McMillin, Douglas W, Sage, Elizabeth K, Mitsiades, Constantine S, Janes, Sam M, Ghobrial, Irene M, Kaplan, David L

“…Tumor-specific delivery of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), an apoptosis-inducing peptide, at effective doses remains…”
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High-throughput approaches to discover novel immunomodulatory agents for cancer by McMillin, Douglas W., Mitsiades, Constantine S.

“…The clinical success of immunomodulatory thalidomide derivatives has renewed the general interest in immunomodulatory anticancer compounds and prompted us to…”
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In vitro anti‐myeloma activity of the Aurora kinase inhibitor VE‐465 by Negri, Joseph M., McMillin, Douglas W., Delmore, Jake, Mitsiades, Nicholas, Hayden, Patrick, Klippel, Steffen, Hideshima, Teru, Chauhan, Dharminder, Munshi, Nikhil C., Buser, Carolyn A., Pollard, John, Richardson, Paul G., Anderson, Kenneth C., Mitsiades, Constantine S.

“…Summary This study characterized the preclinical anti‐myeloma activity of VE465, a low molecular weight pan‐Aurora kinase inhibitor. After 96‐h drug exposure,…”
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Tumor cell-specific bioluminescence platform to identify stroma-induced changes to anticancer drug activity by Mitsiades, Constantine S, McMillin, Douglas W, Delmore, Jake, Weisberg, Ellen, Negri, Joseph M, Geer, D Corey, Klippel, Steffen, Mitsiades, Nicholas, Schlossman, Robert L, Munshi, Nikhil C, Kung, Andrew L, Griffin, James D, Richardson, Paul G, Anderson, Kenneth C

“…McMillin et al . describe a drug screening platform that takes into account the tumor microenvironment, in particular tumor-stromal interactions, enabling the…”
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Author Correction: Tumor cell-specific bioluminescence platform to identify stroma-induced changes to anticancer drug activity by McMillin, Douglas. W, Delmore, Jake, Weisberg, Ellen, Negri, Joseph. M, Geer, Corey. D, Klippel, Steffen, Mitsiades, Nicholas, Schlossman, Robert. L, Munshi, Nikhil. C, Kung, Andrew. L, Griffin, James. D, Richardson, Paul. G, Anderson, Kenneth. C, Mitsiades, Constantine. S

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Nominal GDP versus price level targeting: An empirical evaluation by Fackler, James S., McMillin, W. Douglas

“…•Two alternatives to inflation targeting are discussed.•Policy simulations of price level and nominal GDP targets are analyzed.•Loss functions comparing policy…”
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Inhibition of Tumor Cells Interacting with Stromal Cells by Xanthones Isolated from a Costa Rican Penicillium sp by Cao, Shugeng, McMillin, Douglas W, Tamayo, Giselle, Delmore, Jake, Mitsiades, Constantine S, Clardy, Jon

“…CR1642D, an endophytic isolate of Penicillium sp. collected from a Costa Rican rainforest, was identified through a high-throughput approach to identify…”
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Discovery of a Potent, Covalent BTK Inhibitor for B‑Cell Lymphoma by Wu, Hong, Wang, Wenchao, Liu, Feiyang, Weisberg, Ellen L, Tian, Bei, Chen, Yongfei, Li, Binhua, Wang, Aoli, Wang, Beilei, Zhao, Zheng, McMillin, Douglas W, Hu, Chen, Li, Hong, Wang, Jinhua, Liang, Yanke, Buhrlage, Sara J, Liang, Junting, Liu, Jing, Yang, Guang, Brown, Jennifer R, Treon, Steven P, Mitsiades, Constantine S, Griffin, James D, Liu, Qingsong, Gray, Nathanael S

“…BTK is a member of the TEC family of non-receptor tyrosine kinases whose deregulation has been implicated in a variety of B-cell-related diseases. We have used…”
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Accessory Cells of the Microenvironment Protect Multiple Myeloma from T-Cell Cytotoxicity through Cell Adhesion-Mediated Immune Resistance by DE HAART, Sanne J, VAN DE DONK, Niels W. C. J, LOKHORST, Henk M, MARTENS, Anton C, MITSIADES, Constantine S, MUTIS, Tuna, MINNEMA, Monique C, HUANG, Julie H, AARTS-RIEMENS, Tineke, BOVENSCHEN, Niels, HUIPIN YUAN, GROEN, Richard W. J, MCMILLIN, Douglas W, JAKUBIKOVA, Jana

“…Cellular immunotherapy frequently fails to induce sustained remissions in patients with multiple myeloma, indicating the ability of multiple myeloma cells to…”
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Cross-Country Variation in the Liquidity Effect: The Role of Financial Markets by Lastrapes, William D., Douglas McMillin, W.

“…This paper examines cross-country variation in the liquidity effect - the negative response of interest rates to money supply shocks - focusing on the role of…”
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