Search Results - "DOS SANTOS, Hélcio S"

Sulfonamide derived from anacardic acid as potential antichagasic: a theoretical approach based on molecular docking, molecular dynamics, and density functional theory calculations by da Silva, Leonardo P., Almeida-Neto, Francisco Wagner Q., Bezerra, Lucas L., Silva, Jacilene, Monteiro, Norberto K. V., Marinho, Márcia M., dos Santos, Hélcio S., Teixeira, Alexandre M. R., Marinho, Emmanuel S., de Lima-Neto, Pedro

“…Chagas disease (CD) is a tropical disease caused by the parasite Trypanosoma cruzi , transmitted by the barber insect. Currently, there are approximately 7…”
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Direct antibacterial and antibiotic resistance modulatory activity of chalcones synthesized from the natural product 2-hydroxy-3,4,6-trimethoxyacetophenone by Freitas, Thiago Sampaio de, Xavier, Jayze da Cunha, Pereira, Raimundo L S, Rocha, Janaina E, Muniz, Dédora F, da Silva, Priscila T, da Hora, João P, Dos Santos, Hélcio S, Bandeira, Paulo N, Nogueira, Carlos E S, Teixeira, Alexandre M R, Coutinho, Henrique D M

“…Antibiotic for clinical use lose its effectiveness over time due to bacterial resistance. In this work, four chalcones with modifications in their ligands were…”
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Amyrin esters induce cell death by apoptosis in HL-60 leukemia cells by Barros, Francisco W.A., Bandeira, Paulo N., Lima, Daisy J.B., Meira, Assuero S., de Farias, Silvana S., Albuquerque, Maria Rose J.R., Santos, Hélcio S. dos, Lemos, Telma L.G., de Morais, Manoel Odorico, Costa-Lotufo, Letícia Veras, Pessoa, Claudia do Ó

“…Four derivatives of an α,β-amyrin mixture were synthesized by acylation with appropriate anhydrides. The structures of the compounds were confirmed by means of…”
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Evaluation of antibacterial and enhancement of antibiotic action by the flavonoid kaempferol 7-O-β-D-(6″-O-cumaroyl)-glucopyranoside isolated from Croton piauhiensis müll by Cruz, Beatriz G., dos Santos, Hélcio S., Bandeira, Paulo N., Rodrigues, Tigressa Helena S., Matos, Maria Geysillene C., Nascimento, Mariana F., de Carvalho, Guilherme G.C., Braz-Filho, Raimundo, Teixeira, Alexandre M.R., Tintino, Saulo R., Coutinho, Henrique D.M.

“…There has been a rapid increase in the incidence and prevalence of opportunistic bacterial infections. Inappropriate use of current antibiotics has…”
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Anxiolytic-like effect of chalcone N-{(4′-[(E)-3-(4-fluorophenyl)-1-(phenyl) prop-2-en-1-one]} acetamide on adult zebrafish (Danio rerio): Involvement of the GABAergic system by Ferreira, Maria Kueirislene A., da Silva, Antonio Wlisses, Silva, Francisca Crislândia O., Holanda, Carlos Leone A., Barroso, Sheila M., Lima, Joyce dos Reis, Vieira Neto, Antônio Eufrásio, Campos, Adriana R., Bandeira, Paulo N., dos Santos, Hélcio S., de Lemos, Telma Leda G., Siqueira, Sônia Maria C., Magalhães, Francisco Ernani A., de Menezes, Jane Eire S.A.

“…•The chalcone PAAPFBA is non toxic and altered, per se, the locomotor system of the adult zebrafish.•PAAPFBA presents anxiolytic-like effects on adult…”
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Anxiolytic-like effect of brominated compounds from the marine sponge Aplysina fulva on adult zebrafish (Danio rerio): Involvement of the GABAergic system by de F. Cesário, Hozana Patrícia S., Silva, Francisca Crislândia O., Ferreira, Maria Kueirislene A., de Menezes, Jane Eire S.A., dos Santos, Hélcio S., Nogueira, Carlos E.S., de L. Silva, Karísia S.B., Hajdu, Eduardo, Silveira, Edilberto R., Pessoa, Otília Deusdênia L.

“…Benzodiazepines are commonly used to treat disorders of the central nervous system, including anxiety. However, due to their adverse effects, there is a…”
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Combretum lanceolatum extract reverses anxiety and seizure behavior in adult zebrafish through GABAergic neurotransmission: an in vivo and in silico study by da Silva, Antonio Wlisses, Ferreira, Maria Kueirislene A., Pereira, Lucas Ramos, Rebouças, Emanuela L., Coutinho, Marnielle Rodrigues, Dos, Joyce, Lima, Reis, Guedes, Maria Izabel Florindo, Bandeira, Paulo N., Magalhães, Francisco Ernani A., Menezes, Jane Eire S. A. de, Marinho, Marcia Machado, Teixeira, Alexandre Magno Rodrigues, Salles Trevisan, Maria Teresa, dos Santos, Hélcio S., Marinho, Emmanuel Silva

“…Combretaceae are reported in the literature for presenting neuroprotective and anxiolytic effects in animal models. Combretum lanceolatum Pohl. has few…”
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In silico and in vitro evaluation of efflux pumps inhibition of α,β-amyrin by Oliveira, Raíssa C., Bandeira, Paulo N., Lemos, Telma L. G., dos Santos, Hélcio S., Scherf, Jackelyne R., Rocha, Janaina E., Pereira, Raimundo L. S., Freitas, Thiago S., Freitas, Priscila R., Pereira-Junior, Francisco N., Marinho, Márcia M., Marinho, Emanuelle M., Marinho, Emmanuel S., Nogueira, Carlos E. S., Coutinho, Henrique D. M., Teixeira, Alexandre M. R.

“…The use of the bacterial efflux pump mechanism to reduce the concentrations of antibiotics in the intracellular to the extracellular region is one of the main…”
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Pharmacological potential of the triterpene 3β,6β,16β‐trihidroxilup‐20 (29)‐ene isolated from Combretum leprosum: A literature review by Coutinho, Marnielle R., Oliveira, Larissa S., Evaristo, Francisco F. V., Marinho, Márcia M., Marinho, Emanuelle M., Teixeira, Edson H., Teixeira, Alexandre Magno R., Marinho, Emmanuel S., Santos, Hélcio S.

“…Globally, plant‐derived medicines have been playing an increasing and relevant role in the treatment of several diseases, thus fostering the search for new…”
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In vitro and in silico studies of chalcones derived from natural acetophenone inhibitors of NorA and MepA multidrug efflux pumps in Staphylococcus aureus by Freitas, Thiago S., Xavier, Jayze C., Pereira, Raimundo L.S., Rocha, Janaína E., Campina, Fábia F., de Araújo Neto, José B., Silva, Maria M.C., Barbosa, Cristina R.S., Marinho, Emmanuel S., Nogueira, Carlos E.S., dos Santos, Hélcio S., Coutinho, Henrique D.M., Teixeira, Alexandre M.R.

“…Bacterial resistance induced by efflux pumps is a frequent concern in clinical treatments involving multi-resistant bacteria. Staphylococcus aureus is a…”
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ADMET study, spectroscopic characterization and effect of synthetic nitro chalcone in combination with norfloxacin, ciprofloxacin, and ethidium bromide against Staphylococcus aureus efflux pumps by Rocha, Janaína E., Freitas, Thiago S., Xavier, Jayze C., Pereira, Raimundo L. S., Pereira Junior, Francisco N., Nogueira, Carlos E. S., Marinho, Márcia M., Bandeira, Paulo N., Rodrigues, Leilane G., Marinho, Emmanuel S., Lacerda, Bruna C. G. V., Andrade, Edlane Martins, Teixeira, Alexandre M. R., Santos, Hélcio S., Coutinho, Henrique D. M.

“…Chalcones are present in a wide variety of plants, having in their structure two aromatic rings that are linked together by a chain composed of three carbon…”
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Anxiolytic effects of N-(4,5-dihydro-5-oxo-1,2-dithiolo-[4,3,b]-pyrrole-6-yl)-N-methylformamide, a pyrroloformamide isolated from a marine Streptomyces sp., in adult zebrafish by the 5-HT system by Cesário, Hozana Patrícia S. de F., Silva, Francisca Crislândia O., Ferreira, Maria Kueirislene A., de Menezes, Jane Eire S. A., dos Santos, Hélcio S., Marques da Fonseca, Aluísio, Nogueira, Carlos Emídio S., Marinho, Marcia M., Marinho, Emmanuel S., Teixeira, Alexandre Magno R., Silveira, Edilberto R., Pessoa, Otília Deusdênia L.

“…General anxiety disorders are among the most prevalent mental health problems worldwide. The emergence and development of anxiety disorders can be due to…”
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Anti-inflammatory effect, antibiotic potentiating activity against multidrug-resistant strains of Escherichia coli and Staphylococcus aureus, and evaluation of antibiotic resistance mechanisms by the ibuprofen derivative methyl 2-(-4-isobutylphenyl)propanoate by Xavier, Maria R., Freitas, Thiago S., Pereira, Raimundo L.S., Marinho, Emanuelle M., Bandeira, Paulo N., de Sousa, Amanda P., Oliveira, Larissa S., Bezerra, Lucas Lima, Neto, José B.A., Silva, Maria M.C., Cruz, Beatriz G., Rocha, Janaína E., Barbosa, Cristina R.S., da Silva, Antonio W., de Menezes, Jane E.S.A., Coutinho, Henrique D.M., Marinho, Márcia M., Marinho, Emmanuel S., dos Santos, Hélcio S., Teixeira, Alexandre M.R.

“…The prevalence of multidrug-resistant (MDR) bacteria and the limited efficacy of current available antibiotics cause every year approximately 700 000 deaths…”
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Structural and Microbiological Characterization of 5-Hydroxy-3,7,4'-Trimethoxyflavone: A Flavonoid Isolated from Vitex gardneriana Schauer Leaves by Macedo, Iasminy, da Silva, João H, da Silva, Priscila T, Cruz, Beatriz G, do Vale, Jean P C, Dos Santos, Hélcio S, Bandeira, Paulo N, de Souza, Elnatan B, Xavier, Maria R, Coutinho, Henrique D M, Braz-Filho, Raimundo, Teixeira, Alexandre M R

“…Staphylococcus aureus represents the most common etiologic agent of purulent infections, affecting humans and animals. Escherichia coli is one of the principal…”
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Antiproliferative activity on Trypanosoma cruzi (Y strain) of the triterpene 3β,6β,16β-trihidroxilup-20 (29)-ene isolated from Combretum leprosum by de Araújo, José Ismael F., Aires, Natália L., Almeida-Neto, Francisco W. Q., Marinho, Márcia M., Marinho, Emanuelle M., Paula Magalhães, Emanuel, de Menezes, Ramon R. P. P. B., Sampaio, Tiago L., Maria Costa Martins, Alice, Teixeira, Edson H., Rafaela Freitas Dotto, Ana, Amaral, Wanderlei do, Teixeira, Alexandre Magno R., de Lima-Neto, Pedro, Marinho, Emmanuel S., dos Santos, Hélcio S.

“…Chagas disease infects approximately seven million people worldwide. Benznidazole is effective only in the acute phase of the disease, with an average cure…”
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Toxicity of methyl eugenol against Drosophila melanogaster and its myorelaxant activity in bronchioles isolated from Sus scrofa domesticus by de Souza, Mikael A., Pereira-de-Morais, Luís, Silveira, Zildene de S., Macêdo, Nair S., Araujo, Isaac M., Neto, Luiz J. de L., Delmondes, Gyllyandeson de A., da Costa, Roger H. S., de Oliveira, Lígia C. C., Coutinho, Henrique D. M., Barbosa, Roseli, dos Santos, Hélcio S., da Cunha, Francisco Assis Bezerra

“…This study aimed to evaluate the toxic action of methyl eugenol against Drosophila melanogaster and to evaluate the myorelaxant effect of this constituent on…”
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Furanoflavones and other chemical constituents of Lonchocarpus obtusos by Cavalcante, Maria Gilvânia B., Silva, Rochanne M., Bandeira, Paulo N., Santos, Hélcio S. dos, Pessoa, Otília Deusdênia L., Braz-Filho, Raimundo, Albuquerque, Maria Rose Jane R.

“…Two new furanoflavonoids, 5-hydroxy-2’’-isopropenyl-3-methoxyfurane-(2",3":7,8)-flavone and…”
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Spectroscopic analysis by NMR, FT-Raman, ATR-FTIR, and UV-Vis, evaluation of antimicrobial activity, and in silico studies of chalcones derived from 2-hydroxyacetophenone by Xavier, Jayze da Cunha, de Almeida-Neto, Francisco W.Q., Rocha, Janaína E., Freitas, Thiago S., Freitas, Priscila R., de Araújo, Ana C.J., da Silva, Priscila T., Nogueira, Carlos E.S., Bandeira, Paulo N., Marinho, Márcia M., Marinho, Emmanuel S., Kumar, Nitin, Barreto, Antônio C.H., Coutinho, Henrique D.M., Julião, Murilo S.S., dos Santos, Hélcio S., Teixeira, Alexandre M.R.

“…[Display omitted] •Spectroscopic characterization of six synthetic chalcones.•Antimicrobial activities assays were done.•Bacterial resistance mechanisms were…”
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Synthesis, structural and spectroscopic analysis, and antiproliferative activity of chalcone derivate (E)-1-(4-aminophenyl)-3-(benzo[b]thiophen-2-yl)prop‑2-en-1-one in Trypanosoma cruzi by de Brito, Débora H. Almeida, Almeida-Neto, Francisco W.Q., Ribeiro, Lyanna R., Magalhães, Emanuel P., de Menezes, Ramon R.P.P. Bezerra, Sampaio, Tiago L., Martins, Alice M.C., Bandeira, Paulo N., Marinho, Márcia M., Marinho, Emmanuel S., Barreto, Antônio C.H., de Lima-Neto, Pedro, Saraiva, Gilberto D., Canuto, Kirley M., dos Santos, Hélcio S., Teixeira, Alexandre M.R., Ricardo, Nágila M.P. Silva

“…•Structural and spectroscopic characterization of a chalcone.•NMR, FT-IR, and UV–Vis spectra were analyzed by DFT calculations.•Conformational analysis, and in…”
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Molecular Docking and Antibacterial Activity of Campesterol Derivatives Against Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa multiresistant strains by Oliveira-Tintino, Cicera, Silva, Francisco, Santiago, Gilvandete, Pinto, Francisco, Pessoa, Otilia, Fonseca, Aluisio, Paulo, Cicera, Santos, Helcio, Marinho, Marcia, Santos, Jaqueline, Moura, Talyson, Freitas, Priscilla, Araújo, Ana Carolina, Almeida, Ray, Tintino, Saulo, Coutinho, Henrique

“…This work describes the evaluation the potentiating activity of antibiotics by campesterol (1) and its derivatives (2-11) against multiresistant strains of…”
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